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1041
Epsilon-Globin HBE1 Enhances Radiotherapy Resistance by Down-Regulating BCL11A in Colorectal Cancer Cells
Published 2019-04-01“…Then, compared to radiosensitive (RS) cell lines, the overexpression of HBE1 in RR cell lines was used to measure various forms of radiation-induced cellular damage. …”
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1042
Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy
Published 2011-06-01“…The mean follow-up of survivors (n = 13) was 197.23 months. Radiosensitivity of lymphocytes was quantified as the initial number of DNA double-strand breaks induced per Gy and per DNA unit (200 Mbp). …”
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1043
Cooperation effects of radiation and ferroptosis on tumor suppression and radiation injury
Published 2022-09-01“…Furthermore, ferroptosis can enhance radiosensitivity by causing an iron overload, destruction of the antioxidant system, and lipid peroxidation. …”
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1044
Peripheral Blood Inflammation Indicators as Predictive Factors for Treatment Response Assessed by MRI in Cervical Cancer Patients Referred for Radiotherapy
Published 2023-03-01“…Conclusions: The result revealed that a TRL-negative or lower PLR tumor was associated with radiosensitivity, which may provide important information for the prediction of treatment response in cervical cancer patients referred for RT.…”
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1045
A two-stage genome-wide association study identifies novel germline genetic variations in CACNA2D3 associated with radiotherapy response in nasopharyngeal carcinoma
Published 2023-01-01“…However, due to individual differences in radiosensitivity, biomarkers are needed to tailored radiotherapy to cancer patients. …”
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1046
Knockdown of RRM1 in tumor cells promotes radio-/chemotherapy induced ferroptosis by regulating p53 ubiquitination and p21-GPX4 signaling axis
Published 2022-08-01“…On the basis of our collective findings, we propose that RRM1 is an essential negative mediator of radiosensitivity through regulating ferroptosis, which could serve as a potential target to inhibit the tumor’s antioxidant system and enhance the efficiency of radio/chemotherapy.…”
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1047
Germline genetic biomarkers to stratify patients for personalized radiation treatment
Published 2022-08-01“…However, in the field of radiation oncology there is limited use of genetic profiling and the impact of germline genetic biomarkers on radiosensitivity, radioresistance, or patient outcomes after radiation therapy is poorly understood. …”
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1048
Epigenetic-Like Stimulation of Receptor Expression in SSTR2 Transfected HEK293 Cells as a New Therapeutic Strategy
Published 2022-05-01“…VPA and 5-aza-dC did not induce changes to the intrinsic radiosensitivity of the cells after X-ray irradiation. …”
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1049
The Role of Patient- and Treatment-Related Factors and Early Functional Imaging in Late Radiation-Induced Xerostomia in Oropharyngeal Cancer Patients
Published 2021-12-01“…The advent of quantitative imaging in personalized radiotherapy (RT) has offered the opportunity for a better understanding of individual variations in intrinsic radiosensitivity. We aimed to assess the role of magnetic resonance imaging (MRI) biomarkers, patient-related factors, and treatment-related factors in predicting xerostomia 12 months after RT (XER<sub>12</sub>) in patients affected by oropharyngeal squamous cell carcinoma (OSCC). …”
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1050
Case report: Severe combined immunodeficiency with ligase 1 deficiency and Omenn-like manifestation
Published 2022-10-01“…Most common manifestations include radiosensitivity, macrocytic anemia, lymphopenia with an increased percentage of gamma-delta T cells, and hypogammaglobulinemia requiring replacement therapy. …”
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1051
TXNL4B regulates radioresistance by controlling the PRP3‐mediated alternative splicing of FANCI
Published 2023-06-01“…As a result, cell cycle G2/M arrest was induced, DNA damage repair was delayed, and radiosensitivity was improved. Collectively, our study highlights potential novel underlying mechanisms of the involvement of TXNL4B and alternative splicing in radioresistance. …”
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1052
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1053
On-demand generation of peroxynitrite from an integrated two-dimensional system for enhanced tumor therapy
Published 2023“…Nanosystem-mediated tumor radiosensitization strategy combining the features of X-ray with infinite penetration depth and high atomic number elements shows considerable application potential in clinical cancer therapy. …”
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Journal Article -
1054
ARCII: Nelfinavir, a hypoxia-modifying agent, in combination with chemoradiotherapy (CRT) in locally-advanced pancreatic cancer (LAPC)–mechanism and clinical outcomes
Published 2017“…Nelfinavir is thought to enhance radiosensitivity through hypoxia reduction by increasing tumour blood flow. …”
Conference item -
1055
Perfusion imaging and tissue biomarkers for colorectal cancer
Published 2015“…Tumour perfusion and oxygenation is known to influence radiosensitivity and chemosensitivity. In this thesis, I propose that the evaluation of changes in tumour perfusion using perfusion CT (pCT) and dynamic contrast-enhanced (Dce) MRI can guide the rational sequencing of drugs and radiation.…”
Thesis -
1056
Modelling carcinogenesis after radiotherapy using Poisson statistics: implications for IMRT, protons and ions.
Published 2009“…The classical turnover point in carcinogenesis occurring after a single exposure is a feature of the model; also, the dose-response relationship becomes pseudo-linear with extended fractionation and when heterogeneity of the radiosensitivity parameters is introduced; there is also an inverse relationship between dose per fraction and cancer induction. …”
Journal article -
1057
Novel multifunctional platinum nanodendrites as theranostic agents in cancer imaging and radiotherapy treatment
Published 2021“…The maximum radiosensitization effect was observed in the combination of 29 nm PtNDs with PhT (SER=2.54). 36 nm and 42 nm PtNDs produced the highest radiosensitization in PrT (SER=1.38) and EBT (SER=1.83), respectively. …”
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Thesis -
1058
An Overview on Radiation Sensitivity in Hereditary Breast and Ovarian Cancer Syndrome
Published 2022-07-01“…Individuals with this syndrome are often subjected to diagnostic imaging techniques, as well as therapeutic options, that use ionizing radiation, so it is crucial to understand whether these individuals may present higher radiosensitivity and, therefore, its consequences. Several studies have been carried out to understand if the exposure to different ionizing radiation doses can induce cancer in individuals with HBOC. …”
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1059
PARPi increases radiotherapy sensitivity of esophageal squamous cell carcinoma by inhibiting XRCC1 expression
Published 2023-06-01“…AZD2281 effectively inhibited the radiation-induced up-regulation of XRCC1 expression and increased the radiosensitivity of ECA109 cells. A possible mechanism is that PARPi inhibited DNA-PKcs and then down-regulated XRCC1 expression. …”
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1060
VMAT-Based Planning Allows Sparing of a Spatial Dose Pattern Associated with Radiation Pneumonitis in Patients Treated with Radiotherapy for a Locally Advanced Lung Cancer
Published 2022-07-01“…Conclusion: Our approach appears to be both easily implementable on a daily basis and efficient at reducing the risk of APT. Regional radiosensitivity should be considered in usual lung dose constraints, opening the possibility of new treatment strategies, such as dose escalation or innovative treatment associations.…”
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