Epsilon-Globin HBE1 Enhances Radiotherapy Resistance by Down-Regulating BCL11A in Colorectal Cancer Cells by Sang Yoon Park, Seon-Jin Lee, Hee Jun Cho, Jong-Tae Kim, Hyang Ran Yoon, Kyung Ho Lee, Bo Yeon Kim, Younghee Lee, Hee Gu Lee

“…Then, compared to radiosensitive (RS) cell lines, the overexpression of HBE1 in RR cell lines was used to measure various forms of radiation-induced cellular damage. …”
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Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy by Bordón Elisa, Pinar Beatriz, Carmona-Vigo Ruth, Henríquez-Hernández Luis, Lloret Marta, Núñez María, Rodríguez-Gallego Carlos, Lara Pedro C

“…The mean follow-up of survivors (n = 13) was 197.23 months. Radiosensitivity of lymphocytes was quantified as the initial number of DNA double-strand breaks induced per Gy and per DNA unit (200 Mbp). …”
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Cooperation effects of radiation and ferroptosis on tumor suppression and radiation injury by Jing Su, Jing Su, Jing Su, Chenbin Bian, Chenbin Bian, Chenbin Bian, Zhuangzhuang Zheng, Zhuangzhuang Zheng, Zhuangzhuang Zheng, Huanhuan Wang, Huanhuan Wang, Huanhuan Wang, Lingbin Meng, Ying Xin, Xin Jiang, Xin Jiang, Xin Jiang

“…Furthermore, ferroptosis can enhance radiosensitivity by causing an iron overload, destruction of the antioxidant system, and lipid peroxidation. …”
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Peripheral Blood Inflammation Indicators as Predictive Factors for Treatment Response Assessed by MRI in Cervical Cancer Patients Referred for Radiotherapy by Chunyu Liang, Zhiyuan Xu, Guohui Yang, Jianxun Lv, Xinping Shen, Kusheng Wu

“…Conclusions: The result revealed that a TRL-negative or lower PLR tumor was associated with radiosensitivity, which may provide important information for the prediction of treatment response in cervical cancer patients referred for RT.…”
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A two-stage genome-wide association study identifies novel germline genetic variations in CACNA2D3 associated with radiotherapy response in nasopharyngeal carcinoma by Lu-Lu Yu, Bi-Wen Hu, Han-Xue Huang, Bing Yu, Qi Xiao, Qiao-Li Lv, Chen-Hui Luo, Cheng-Xian Guo, Jin-Gao Li, Xiao-Xue Xie, Ji-Ye Yin

“…However, due to individual differences in radiosensitivity, biomarkers are needed to tailored radiotherapy to cancer patients. …”
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Knockdown of RRM1 in tumor cells promotes radio-/chemotherapy induced ferroptosis by regulating p53 ubiquitination and p21-GPX4 signaling axis by Yang Gao, Bin Chen, Ruru Wang, An Xu, Lijun Wu, Huayi Lu, Guoping Zhao

“…On the basis of our collective findings, we propose that RRM1 is an essential negative mediator of radiosensitivity through regulating ferroptosis, which could serve as a potential target to inhibit the tumor’s antioxidant system and enhance the efficiency of radio/chemotherapy.…”
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Germline genetic biomarkers to stratify patients for personalized radiation treatment by Ida Deichaite, Austin Hopper, Lena Krockenberger, Timothy J. Sears, Leisa Sutton, Xenia Ray, Andrew Sharabi, Ami Navon, Parag Sanghvi, Hannah Carter, Vitali Moiseenko

“…However, in the field of radiation oncology there is limited use of genetic profiling and the impact of germline genetic biomarkers on radiosensitivity, radioresistance, or patient outcomes after radiation therapy is poorly understood. …”
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Epigenetic-Like Stimulation of Receptor Expression in SSTR2 Transfected HEK293 Cells as a New Therapeutic Strategy by Joerg Kotzerke, Dorothee Buesser, Anne Naumann, Roswitha Runge, Lisa Huebinger, Andrea Kliewer, Robert Freudenberg, Claudia Brogsitter

“…VPA and 5-aza-dC did not induce changes to the intrinsic radiosensitivity of the cells after X-ray irradiation. …”
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The Role of Patient- and Treatment-Related Factors and Early Functional Imaging in Late Radiation-Induced Xerostomia in Oropharyngeal Cancer Patients by Simona Marzi, Alessia Farneti, Laura Marucci, Pasqualina D’Urso, Antonello Vidiri, Emma Gangemi, Giuseppe Sanguineti

“…The advent of quantitative imaging in personalized radiotherapy (RT) has offered the opportunity for a better understanding of individual variations in intrinsic radiosensitivity. We aimed to assess the role of magnetic resonance imaging (MRI) biomarkers, patient-related factors, and treatment-related factors in predicting xerostomia 12 months after RT (XER₁₂) in patients affected by oropharyngeal squamous cell carcinoma (OSCC). …”
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Case report: Severe combined immunodeficiency with ligase 1 deficiency and Omenn-like manifestation by Nel Dabrowska-Leonik, Agata Karolina Pastorczak, Katarzyna Bąbol-Pokora, Katarzyna Bernat-Sitarz, Barbara Piątosa, Edyta Heropolitańska-Pliszka, Magdalena M. Kacprzak, Krzysztof Kalwak, Katarzyna Gul, Mirjam van der Burg, Marek Ussowicz, Malgorzata Pac

“…Most common manifestations include radiosensitivity, macrocytic anemia, lymphopenia with an increased percentage of gamma-delta T cells, and hypogammaglobulinemia requiring replacement therapy. …”
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TXNL4B regulates radioresistance by controlling the PRP3‐mediated alternative splicing of FANCI by Zhao Ju, Jing Xiang, Liang Xiao, Yan He, Le Zhang, Yin Wang, Ridan Lei, Yunfeng Nie, Long Yang, Justyna Miszczyk, Pingkun Zhou, Ruixue Huang

“…As a result, cell cycle G2/M arrest was induced, DNA damage repair was delayed, and radiosensitivity was improved. Collectively, our study highlights potential novel underlying mechanisms of the involvement of TXNL4B and alternative splicing in radioresistance. …”
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Dose-rate-effects in XRCC1 wild-type and mutant CHO cell lines using An ²⁴¹AM source by Chambers, Dwight McCoy

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On-demand generation of peroxynitrite from an integrated two-dimensional system for enhanced tumor therapy by Liu, Shikai, Li, Wenting, Chen, Hengxing, Zhou, Jialing, Dong, Shuming, Zang, Pengyu, Tian, Boshi, Ding, He, Gai, Shili, Yang, Piaoping, Zhao, Yanli

“…Nanosystem-mediated tumor radiosensitization strategy combining the features of X-ray with infinite penetration depth and high atomic number elements shows considerable application potential in clinical cancer therapy. …”
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ARCII: Nelfinavir, a hypoxia-modifying agent, in combination with chemoradiotherapy (CRT) in locally-advanced pancreatic cancer (LAPC)–mechanism and clinical outcomes by Wilson, J, Dutton, S, Hackett, S, Durrant, L, Chu, K, Eccles, C, Abraham, A, O'Neill, E, Partridge, M, Hawkins, M, McKenna, W, Maughan, T, Brunner, T, Mukherjee, S

“…Nelfinavir is thought to enhance radiosensitivity through hypoxia reduction by increasing tumour blood flow. …”

Perfusion imaging and tissue biomarkers for colorectal cancer by Hill, E

“…Tumour perfusion and oxygenation is known to influence radiosensitivity and chemosensitivity. In this thesis, I propose that the evaluation of changes in tumour perfusion using perfusion CT (pCT) and dynamic contrast-enhanced (Dce) MRI can guide the rational sequencing of drugs and radiation.…”

Modelling carcinogenesis after radiotherapy using Poisson statistics: implications for IMRT, protons and ions. by Jones, B

“…The classical turnover point in carcinogenesis occurring after a single exposure is a feature of the model; also, the dose-response relationship becomes pseudo-linear with extended fractionation and when heterogeneity of the radiosensitivity parameters is introduced; there is also an inverse relationship between dose per fraction and cancer induction. …”

Novel multifunctional platinum nanodendrites as theranostic agents in cancer imaging and radiotherapy treatment by Anuar, Muhammad Afiq Khairil

“…The maximum radiosensitization effect was observed in the combination of 29 nm PtNDs with PhT (SER=2.54). 36 nm and 42 nm PtNDs produced the highest radiosensitization in PrT (SER=1.38) and EBT (SER=1.83), respectively. …”
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An Overview on Radiation Sensitivity in Hereditary Breast and Ovarian Cancer Syndrome by Diana Gonçalves, Ana Salomé Pires, Inês A. Marques, Inês Gomes, Gabriela Sousa, Maria Filomena Botelho, Ana Margarida Abrantes

“…Individuals with this syndrome are often subjected to diagnostic imaging techniques, as well as therapeutic options, that use ionizing radiation, so it is crucial to understand whether these individuals may present higher radiosensitivity and, therefore, its consequences. Several studies have been carried out to understand if the exposure to different ionizing radiation doses can induce cancer in individuals with HBOC. …”
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PARPi increases radiotherapy sensitivity of esophageal squamous cell carcinoma by inhibiting XRCC1 expression by LI Yiping, ZHANG Yufei, SUN Guangzhi, YE Yunyao, SHEN Xiaozhou, HAN Gaohua

“…AZD2281 effectively inhibited the radiation-induced up-regulation of XRCC1 expression and increased the radiosensitivity of ECA109 cells. A possible mechanism is that PARPi inhibited DNA-PKcs and then down-regulated XRCC1 expression. …”
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VMAT-Based Planning Allows Sparing of a Spatial Dose Pattern Associated with Radiation Pneumonitis in Patients Treated with Radiotherapy for a Locally Advanced Lung Cancer by Vincent Bourbonne, Francois Lucia, Vincent Jaouen, Julien Bert, Olivier Pradier, Dimitris Visvikis, Ulrike Schick

“…Conclusion: Our approach appears to be both easily implementable on a daily basis and efficient at reducing the risk of APT. Regional radiosensitivity should be considered in usual lung dose constraints, opening the possibility of new treatment strategies, such as dose escalation or innovative treatment associations.…”
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