Mutant p53 Mediates Sensitivity to Cancer Treatment Agents in Oesophageal Adenocarcinoma Associated with MicroRNA and SLC7A11 Expression by Ann-Kathrin Eichelmann, George C. Mayne, Karen Chiam, Steven L. Due, Isabell Bastian, Frederike Butz, Tingting Wang, Pamela J. Sykes, Nicholas J. Clemons, David S. Liu, Michael Z. Michael, Christos S. Karapetis, Richard Hummel, David I. Watson, Damian J. Hussey

“…<i>SLC7A11</i> knockdown restored radiosensitivity (2 Gy SF: 46% vs. 73%; <i>p</i> = 0.0239), possibly via enhanced sensitivity to oxidative stress. …”
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Comparison of pharmacological inhibitors of lysine-specific demethylase 1 in glioblastoma stem cells reveals inhibitor-specific efficacy profiles by Lea M. Stitzlein, Lea M. Stitzlein, Achintyan Gangadharan, Leslie M. Walsh, Deokhwa Nam, Alexsandra B. Espejo, Melissa M. Singh, Kareena H. Patel, Yue Lu, Xiaoping Su, Ravesanker Ezhilarasan, Joy Gumin, Sanjay Singh, Erik Sulman, Frederick F. Lang, Joya Chandra, Joya Chandra, Joya Chandra

“…Efficacy of various LSD1 inhibitors was assessed in nine patient-derived glioblastoma stem cell (GSC) lines and an orthotopic xenograft mouse model.ResultsLSD1 inhibitors had cytotoxic and selective effects regardless of GSC radiosensitivity or molecular subtype. In vivo, LSD1 inhibition via GSK-LSD1 led to a delayed reduction in tumor burden; however, tumor regrowth occurred. …”
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Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells by Debora Grasso, Hyllana C. D. Medeiros, Hyllana C. D. Medeiros, Luca X. Zampieri, Vanesa Bol, Pierre Danhier, Marike W. van Gisbergen, Caroline Bouzin, Davide Brusa, Vincent Grégoire, Vincent Grégoire, Hubert Smeets, Alphons P. M. Stassen, Ludwig J. Dubois, Philippe Lambin, Marie Dutreix, Pierre Sonveaux

“…In a top-down approach, matched radiosensitive and radioresistant SQD9 cells were generated and metabolically compared, focusing on glycolysis, oxidative phosphorylation (OXPHOS) and ROS production. …”
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Toward an Early Diagnosis for Alzheimer’s Disease Based on the Perinuclear Localization of the ATM Protein by Elise Berthel, Laurent Pujo-Menjouet, Eymeric Le Reun, Laurène Sonzogni, Joëlle Al-Choboq, Abdennasser Chekroun, Adeline Granzotto, Clément Devic, Mélanie L. Ferlazzo, Sandrine Pereira, Michel Bourguignon, Nicolas Foray

“…In order to examine the molecular basis of this radiosensitivity, the ATM-dependent DNA double-strand breaks (DSB) signaling and repair were investigated by applying an approach based on the radiation-induced ataxia telangiectasia-mutated (ATM) protein nucleoshuttling (RIANS) model. …”
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Seedling Biometry of <i>nud</i> Knockout and <i>win1</i> Knockout Barley Lines under Ionizing Radiation by Elena V. Antonova, Nadezhda S. Shimalina, Anna M. Korotkova, Ekaterina V. Kolosovskaya, Sophia V. Gerasimova, Elena K. Khlestkina

“…Approximately 30 physiological parameters were evaluated, combined into groups: (1) viability, (2) radiosensitivity, and (3) mutability of barley seed progeny. …”
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Mutation induction of chrysanthemum (dendranthema grandiflora tzvelev) using gamma and ion beam irradiation by Salleh, Shakinah

“…Subsequent subcultures were done in medium with 0.5 mg/L NAA and 2.0 mg/L BAP for shoot development. A radiosensitivity (radiation sensitivity) test was carried out to determine the optimum dose for mutation using acute gamma (0 to 120.0 Gy) and ion beam (0 to 30.0 Gy) for two types of explants (ray florets and nodal explants) based on their in vitro survival and shoot regeneration. …”
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Identification of lncRNAs involved in response to ionizing radiation in fibroblasts of long-term survivors of childhood cancer and cancer-free controls by Caine Lucas Grandt, Caine Lucas Grandt, Lara Kim Brackmann, Alicia Poplawski, Heike Schwarz, Federico Marini, Thomas Hankeln, Danuta Galetzka, Sebastian Zahnreich, Johanna Mirsch, Claudia Spix, Maria Blettner, Heinz Schmidberger, Manuela Marron

“…These transcripts may be targets in cancer therapy against radiosensitivity, as well as provide grounds for the identification of at-risk patients for immediate adverse reactions in healthy tissues. …”
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The role of IGF-1R signaling in the DNA damage response of prostate cancer by Lodhia, K

“…Prior work in melanoma cells indicated that IGF-1R down-regulation enhances radiosensitivity and impairs the function of ATM, a key protein in the response to DNA DSB. …”

Associations between voxel-level accumulated dose and rectal toxicity in prostate radiotherapy by Leila E.A. Shelley, Michael P.F. Sutcliffe, Simon J. Thomas, David J. Noble, Marina Romanchikova, Karl Harrison, Amy M. Bates, Neil G. Burnet, Raj Jena

“…Conclusions: Voxel-level analysis of dose to the RW revealed SRRs associated with rectal toxicity, suggesting non-homogeneous intra-organ radiosensitivity. Incorporating spatial features of accumulated delivered dose improved dose-toxicity associations. …”
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Metformin is a metabolic modulator and radiosensitiser in rectal cancer by Croí E. Buckley, Croí E. Buckley, Rebecca M. O’Brien, Rebecca M. O’Brien, Timothy S. Nugent, Timothy S. Nugent, Timothy S. Nugent, Noel E. Donlon, Noel E. Donlon, Noel E. Donlon, Noel E. Donlon, Fiona O’Connell, Fiona O’Connell, John V. Reynolds, John V. Reynolds, Adnan Hafeez, Diarmuid S. O’Ríordáin, Robert A. Hannon, Paul Neary, Reza Kalbassi, Brian J. Mehigan, Brian J. Mehigan, Paul H. McCormick, Paul H. McCormick, Cara Dunne, Cara Dunne, Michael E. Kelly, Michael E. Kelly, John O. Larkin, John O. Larkin, Jacintha O’Sullivan, Jacintha O’Sullivan, Niamh Lynam-Lennon, Niamh Lynam-Lennon

“…Metformin treatment was demonstrated to significantly radiosensitise both radiosensitive and radioresistant colorectal cancer cells in vitro. …”
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Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer by Xinyu Yang, Xinjie Chen, Shaosen Zhang, Wenyi Fan, Ce Zhong, Tianyuan Liu, Guoyu Cheng, Liang Zhu, Qingyi Liu, Yiyi Xi, Wen Tan, Dongxin Lin, Chen Wu

“…Directly interfering with tumor-cell-derived CXCL1 or inhibiting the CXCL1-CXCR2 pathway effectively restores the radiosensitivity of radioresistant xenografts in vivo. …”
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A Lack of Effectiveness in the ATM-Orchestrated DNA Damage Response Contributes to the DNA Repair Defect of HPV-Positive Head and Neck Cancer Cells by Sabrina Köcher, Sabrina Köcher, Henrike Barbara Zech, Henrike Barbara Zech, Leonie Krug, Leonie Krug, Fruzsina Gatzemeier, Fruzsina Gatzemeier, Sabrina Christiansen, Sabrina Christiansen, Felix Meyer, Ruth Rietow, Ruth Rietow, Ruth Rietow, Nina Struve, Nina Struve, Wael Yassin Mansour, Wael Yassin Mansour, Malte Kriegs, Cordula Petersen, Christian Betz, Kai Rothkamm, Thorsten Rieckmann, Thorsten Rieckmann

“…Interestingly, our expression screen revealed minimal levels of the central DNA damage response kinase ATM in the two most radiosensitive HPV+ strains. We therefore tested whether insufficient ATM activity may contribute to the enhanced cellular radiosensitivity. …”
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In Vitro Propagation and Mutation Induction of Dendranthema Grandiflora Tzvelev by Mon, Mi Chan

“…In the radiation-induced mutagenesis study, irradiation treatments was performed on callus derived from ray florets, and on fresh ray florets using gamma rays from 60Co source at levels of 0 Gy, 10 Gy, 20 Gy, 30 Gy, 40 Gy and 50 Gy at a dose rate of 1.858 Gy/sec. Radiosensitivity test recorded a 100 % survival rate of callus on control treatment and subsequent decrease on treatments at higher doses. …”
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Sensitization of rat C6 glioma cells to ionizing radiation by porphyrins by Laimutė RUTKOVSKIENĖ, Laima PLĖŠNIENĖ, Daiva SENDIULIENĖ, Alfonsas STANČIUS, Jurgita LIUTKEVIČIŪTĖ-NAVICKIENĖ

“…Background. Radiosensitizers are used in order to increase the efficacy of radiotherapy. …”
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Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells. by Cengel, K, Voong, K, Chandrasekaran, S, Maggiorella, L, Brunner, T, Stanbridge, E, Kao, G, Mckenna, W, Bernhard, E

“…Treatment with the EGFR inhibitor gefitinib led to similar levels of radiosensitization, and the combinations of tipifarnib or gefitinib plus inhibition of K-Ras, H-Ras, or EGFR expression did not provide additional radiosensitization compared with tipifarnib or gefitinib alone. …”

The histone deacetylase inhibitor romidepsin spares normal tissues while acting as an effective radiosensitiser in bladder tumours in vivo by Paillas, S, Then, C, Kilgas, S, Ruan, J, Thompson, J, Elliott, A, Smart, S, Kiltie, A

“…Pan-HDAC inhibition, using panobinostat, is a good strategy for radiosensitization, but more selective agents may be more useful radiosensitizers in a clinical setting, resulting in fewer systemic side effects. …”

DNA damage induced by nitric oxide during ionizing radiation is enhanced at replication. by Folkes, L, O'Neill, P

“…Nitric oxide (NO) is a very effective radiosensitizer of hypoxic mammalian cells, at least as efficient as oxygen in enhancing cell death in vitro. …”

DNA damage induced by nitric oxide during ionizing radiation is enhanced at replication by Folkes, L, O'Neill, P

“…Nitric oxide (•NO) is a very effective radiosensitizer of hypoxic mammalian cells, at least as efficient as oxygen in enhancing cell death in vitro. …”

Ferroptosis: Frenemy of Radiotherapy by Lisa Kerkhove, Febe Geirnaert, Inès Dufait, Mark De Ridder

“…In this review, we focus on the implications of hypoxic conditions on ferroptosis, contemplating the plausibility of using ferroptosis inducers as clinical radiosensitizers. Furthermore, we dive into the prospects of drug repurposing in the domain of ferroptosis inducers and radiosensitizers. …”
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Syntaxin 18 regulates the DNA damage response and epithelial-to-mesenchymal transition to promote radiation resistance of lung cancer by Clotilde Thumser-Henner, Sebastian Oeck, Sophie Kalmbach, Jan Forster, Franziska Kindl, Ali Sak, Alexander Schramm, Martin Schuler

“…Downregulation of endogenous syntaxin 18 specifically reduced clonogenic survival of radioresistant and radiosensitive lung cancer cells following X-radiation. …”
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