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1101
Mutant p53 Mediates Sensitivity to Cancer Treatment Agents in Oesophageal Adenocarcinoma Associated with MicroRNA and SLC7A11 Expression
Published 2021-05-01“…<i>SLC7A11</i> knockdown restored radiosensitivity (2 Gy SF: 46% vs. 73%; <i>p</i> = 0.0239), possibly via enhanced sensitivity to oxidative stress. …”
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1102
Comparison of pharmacological inhibitors of lysine-specific demethylase 1 in glioblastoma stem cells reveals inhibitor-specific efficacy profiles
Published 2023-04-01“…Efficacy of various LSD1 inhibitors was assessed in nine patient-derived glioblastoma stem cell (GSC) lines and an orthotopic xenograft mouse model.ResultsLSD1 inhibitors had cytotoxic and selective effects regardless of GSC radiosensitivity or molecular subtype. In vivo, LSD1 inhibition via GSK-LSD1 led to a delayed reduction in tumor burden; however, tumor regrowth occurred. …”
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1103
Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells
Published 2020-03-01“…In a top-down approach, matched radiosensitive and radioresistant SQD9 cells were generated and metabolically compared, focusing on glycolysis, oxidative phosphorylation (OXPHOS) and ROS production. …”
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1104
Toward an Early Diagnosis for Alzheimer’s Disease Based on the Perinuclear Localization of the ATM Protein
Published 2023-06-01“…In order to examine the molecular basis of this radiosensitivity, the ATM-dependent DNA double-strand breaks (DSB) signaling and repair were investigated by applying an approach based on the radiation-induced ataxia telangiectasia-mutated (ATM) protein nucleoshuttling (RIANS) model. …”
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1105
Seedling Biometry of <i>nud</i> Knockout and <i>win1</i> Knockout Barley Lines under Ionizing Radiation
Published 2022-09-01“…Approximately 30 physiological parameters were evaluated, combined into groups: (1) viability, (2) radiosensitivity, and (3) mutability of barley seed progeny. …”
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1106
Mutation induction of chrysanthemum (dendranthema grandiflora tzvelev) using gamma and ion beam irradiation
Published 2013“…Subsequent subcultures were done in medium with 0.5 mg/L NAA and 2.0 mg/L BAP for shoot development. A radiosensitivity (radiation sensitivity) test was carried out to determine the optimum dose for mutation using acute gamma (0 to 120.0 Gy) and ion beam (0 to 30.0 Gy) for two types of explants (ray florets and nodal explants) based on their in vitro survival and shoot regeneration. …”
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Thesis -
1107
Identification of lncRNAs involved in response to ionizing radiation in fibroblasts of long-term survivors of childhood cancer and cancer-free controls
Published 2023-04-01“…These transcripts may be targets in cancer therapy against radiosensitivity, as well as provide grounds for the identification of at-risk patients for immediate adverse reactions in healthy tissues. …”
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1108
The role of IGF-1R signaling in the DNA damage response of prostate cancer
Published 2013“…Prior work in melanoma cells indicated that IGF-1R down-regulation enhances radiosensitivity and impairs the function of ATM, a key protein in the response to DNA DSB. …”
Thesis -
1109
Associations between voxel-level accumulated dose and rectal toxicity in prostate radiotherapy
Published 2020-04-01“…Conclusions: Voxel-level analysis of dose to the RW revealed SRRs associated with rectal toxicity, suggesting non-homogeneous intra-organ radiosensitivity. Incorporating spatial features of accumulated delivered dose improved dose-toxicity associations. …”
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1110
Metformin is a metabolic modulator and radiosensitiser in rectal cancer
Published 2023-08-01“…Metformin treatment was demonstrated to significantly radiosensitise both radiosensitive and radioresistant colorectal cancer cells in vitro. …”
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1111
Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer
Published 2023-10-01“…Directly interfering with tumor-cell-derived CXCL1 or inhibiting the CXCL1-CXCR2 pathway effectively restores the radiosensitivity of radioresistant xenografts in vivo. …”
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1112
A Lack of Effectiveness in the ATM-Orchestrated DNA Damage Response Contributes to the DNA Repair Defect of HPV-Positive Head and Neck Cancer Cells
Published 2022-05-01“…Interestingly, our expression screen revealed minimal levels of the central DNA damage response kinase ATM in the two most radiosensitive HPV+ strains. We therefore tested whether insufficient ATM activity may contribute to the enhanced cellular radiosensitivity. …”
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1113
In Vitro Propagation and Mutation Induction of Dendranthema Grandiflora Tzvelev
Published 2006“…In the radiation-induced mutagenesis study, irradiation treatments was performed on callus derived from ray florets, and on fresh ray florets using gamma rays from 60Co source at levels of 0 Gy, 10 Gy, 20 Gy, 30 Gy, 40 Gy and 50 Gy at a dose rate of 1.858 Gy/sec. Radiosensitivity test recorded a 100 % survival rate of callus on control treatment and subsequent decrease on treatments at higher doses. …”
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Thesis -
1114
Sensitization of rat C6 glioma cells to ionizing radiation by porphyrins
Published 2011-04-01“…Background. Radiosensitizers are used in order to increase the efficacy of radiotherapy. …”
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1115
Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells.
Published 2007“…Treatment with the EGFR inhibitor gefitinib led to similar levels of radiosensitization, and the combinations of tipifarnib or gefitinib plus inhibition of K-Ras, H-Ras, or EGFR expression did not provide additional radiosensitization compared with tipifarnib or gefitinib alone. …”
Journal article -
1116
The histone deacetylase inhibitor romidepsin spares normal tissues while acting as an effective radiosensitiser in bladder tumours in vivo
Published 2020“…Pan-HDAC inhibition, using panobinostat, is a good strategy for radiosensitization, but more selective agents may be more useful radiosensitizers in a clinical setting, resulting in fewer systemic side effects. …”
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1117
DNA damage induced by nitric oxide during ionizing radiation is enhanced at replication.
Published 2013“…Nitric oxide (NO) is a very effective radiosensitizer of hypoxic mammalian cells, at least as efficient as oxygen in enhancing cell death in vitro. …”
Journal article -
1118
DNA damage induced by nitric oxide during ionizing radiation is enhanced at replication
Published 2013“…Nitric oxide (•NO) is a very effective radiosensitizer of hypoxic mammalian cells, at least as efficient as oxygen in enhancing cell death in vitro. …”
Journal article -
1119
Ferroptosis: Frenemy of Radiotherapy
Published 2024-03-01“…In this review, we focus on the implications of hypoxic conditions on ferroptosis, contemplating the plausibility of using ferroptosis inducers as clinical radiosensitizers. Furthermore, we dive into the prospects of drug repurposing in the domain of ferroptosis inducers and radiosensitizers. …”
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1120
Syntaxin 18 regulates the DNA damage response and epithelial-to-mesenchymal transition to promote radiation resistance of lung cancer
Published 2022-06-01“…Downregulation of endogenous syntaxin 18 specifically reduced clonogenic survival of radioresistant and radiosensitive lung cancer cells following X-radiation. …”
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