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1121
Farnesyltransferase inhibitors as radiation sensitizers.
Published 2002“…Thus, therapies that inhibit Ras function could be an effective means to radiosensitize selected types of solid tumors. Inhibition of Ras prenylation using a variety of farnesyltransferase inhibitors resulted in radiosensitization of tumor cells that expressed activated Ras, both in vitro and in xenograft models. …”
Journal article -
1122
Oxygen switches: Refueling for cancer radiotherapy
Published 2023-02-01“…Recently, a burgeoning number of nano-radiosensitizers designed to increase the oxygen concentration in tumors were reported. …”
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Article -
1123
Ceramide-Enriched Membrane Domains Contribute to Targeted and Nontargeted Effects of Radiation through Modulation of PI3K/AKT Signaling in HNSCC Cells
Published 2020-09-01“…We investigated the potential involvement of ceramide-enriched membrane domains in radiation-induced targeted and nontargeted effects using head and neck squamous cell carcinoma with opposite radiosensitivities. In radiosensitive SCC61 cells, the proportion of targeted effects was 34% and nontargeted effects killed 32% of cells. …”
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1124
Novel Implications of Nanoparticle-Enhanced Radiotherapy and Brachytherapy: Z-Effect and Tumor Hypoxia
Published 2022-10-01“…Technological advancements in nanotechnology have resulted in synthesis of high atomic elements such as nanomaterials, which can be used as radiosensitizers due to their photoelectric characteristics. …”
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Article -
1125
The hedgehog inhibitor GANT61 sensitizes prostate cancer cells to ionizing radiation both in vitro and in vivo
Published 2016“…Furthermore, we confirmed the radiosensitization effect of GANT61 in two in vivo xenograft PCa models. …”
Journal article -
1126
Improving outcomes for resistant rectal cancer
Published 2019“…</p> <p>Using RNAi and clonogenic assays, NRF2 knockdown produced a radiosensitive phenotype in intrinsically resistant cell line models but had no effect in the most radiosensitive cell line. …”
Thesis -
1127
Nanotechnology Driven Cancer Chemoradiation: Exploiting the Full Potential of Radiotherapy with a Unique Combination of Gold Nanoparticles and Bleomycin
Published 2022-01-01“…Enhancement of the RT effect with novel radiosensitizers can address this need. In this study, gold nanoparticles (GNPs) and bleomycin (BLM) were used as a unique combination of radiosensitizers. …”
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Article -
1128
Connection between Radiation-Regulating Functions of Natural Products and miRNAs Targeting Radiomodulation and Exosome Biogenesis
Published 2023-08-01“…As a result, the miRNA–radiomodulation (radioprotection and radiosensitization)–exosome biogenesis axis in regard to natural-product-mediated radiotherapeutic effects is well organized. …”
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Article -
1129
Comparative Proton and Photon Irradiation Combined with Pharmacological Inhibitors in 3D Pancreatic Cancer Cultures
Published 2020-10-01“…The targeting of proteins identified in the phosphoproteome that were uniquely altered by protons or photons failed to cause radiation-type-specific radiosensitization. Targeting DNA repair proteins associated with non-homologous endjoining, however, revealed a strong radiosensitizing potential independent of the radiation type. …”
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Article -
1130
A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer.
Published 2004“… PURPOSE: Preclinical and clinical studies have demonstrated that inhibition of prenylation can radiosensitize cell lines with activation of Ras and produce clinical response in patients with cancer. …”
Journal article -
1131
Unraveling the Radioprotective Mechanisms of UV-Resistant <i>Bacillus subtilis</i> ASM-1 Extracted Compounds through Molecular Docking
Published 2023-08-01“…However, the existence of radiosensitive microorganisms inhabiting such an inhospitable environment is still a mystery. …”
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Article -
1132
Engineering nanoparticles to reprogram radiotherapy and immunotherapy: recent advances and future challenges
Published 2020-05-01“…Abstract Nanoparticles (NPs) have been increasingly studied for radiosensitization. The principle of NPs radio-enhancement is to use high-atomic number NPs (e.g. gold, hafnium, bismuth and gadolinium) or deliver radiosensitizing substances, such as cisplatin and selenium. …”
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Article -
1133
Theranostic RGD@Fe3O4-Au/Gd NPs for the targeted radiotherapy and MR imaging of breast cancer
Published 2023-06-01“…Abstract Background As a radiosensitizing agent in magnetic resonance imaging (MRI), gadolinium is disadvantageous in that it confers a rather high toxicity and low longitudinal comfort time (r1). …”
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Article -
1134
Impact of secondary particles on microdistribution of deposited dose in biological tissue in the presence of gold and gadolinium nanoparticles under photon beam irradiation
Published 2019-05-01“…It was established that interaction of electrons and positrons with nanoparticles does not lead to significant increase of additional dose in the vicinity of their surfaces and can be most likely excluded from consideration in the analysis of radiosensitization mechanism of nanoparticles.…”
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Article -
1135
Investigating the adjacent patient radiation dose received during a simulated ward chest X-ray examination
Published 2023-07-01“…The scattered radiation dose to radiosensitive organs (thyroid, breast, and gonads) was recorded using Thermoluminescent Dosimeters (TLDs). …”
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Article -
1136
COMBINATION NEOADJUVANT THERMOCHEMICAL THERAPY IN PATIENTS WITH RECTAL CANCER
Published 2015-02-01“…All patients received 5 Ч 5 Gy radiotherapy with capecitabine 1300 mg/m2 days 1–5 per os and radiosensitization with local hyperthermia and metronidazole.Results. …”
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1137
An Orthotopic Model of Glioblastoma Is Resistant to Radiodynamic Therapy with 5-AminoLevulinic Acid
Published 2022-08-01“…Radiosensitization of glioblastoma is a major ambition to increase the survival of this incurable cancer. …”
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Article -
1138
A Comparison of in vivo Cellular Responses to CS-137 Gamma Rays and 320-KV X Rays
Published 2013-10-01“…We show that cytotoxicity dose-response relationships for bone marrow cells and splenocytes are complex, involving negative curvature (decreasing slope as dose increases), presumably implicating a mixed cell population comprised of large numbers of hypersensitive, modestly radiosensitive, and resistant cells. The radiosensitive cells appear to respond with 50% being killed by a dose < 0.5 Gy. …”
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Article -
1139
Organ-Specific Endothelial Dysfunction Following Total Body Irradiation Exposure
Published 2022-12-01“…The purpose of this review is to summarize the pathogenesis of endothelial dysfunction following total or near total body irradiation exposure at the level of individual radiosensitive organs.…”
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Article -
1140
The Ras radiation resistance pathway.
Published 2001“…The phosphoinositide-3-kinase (PI3K) inhibitor LY294002 radiosensitized cells bearing mutant ras oncogenes, but the survival of cells with wild-type ras was not affected. …”
Journal article