Farnesyltransferase inhibitors as radiation sensitizers. by Mckenna, W, Muschel, R, Gupta, A, Hahn, S, Bernhard, E

“…Thus, therapies that inhibit Ras function could be an effective means to radiosensitize selected types of solid tumors. Inhibition of Ras prenylation using a variety of farnesyltransferase inhibitors resulted in radiosensitization of tumor cells that expressed activated Ras, both in vitro and in xenograft models. …”

Oxygen switches: Refueling for cancer radiotherapy by Xianghui Li, Xianghui Li, Xianghui Li, Haoran Wang, Haoran Wang, Zhiyan Li, Feng Tao, Jinhui Wu, Wenxian Guan, Song Liu

“…Recently, a burgeoning number of nano-radiosensitizers designed to increase the oxygen concentration in tumors were reported. …”
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Ceramide-Enriched Membrane Domains Contribute to Targeted and Nontargeted Effects of Radiation through Modulation of PI3K/AKT Signaling in HNSCC Cells by Riad Ladjohounlou, Safa Louati, Alexandra Lauret, Arnaud Gauthier, Dominique Ardail, Nicolas Magne, Gersende Alphonse, Claire Rodriguez-Lafrasse

“…We investigated the potential involvement of ceramide-enriched membrane domains in radiation-induced targeted and nontargeted effects using head and neck squamous cell carcinoma with opposite radiosensitivities. In radiosensitive SCC61 cells, the proportion of targeted effects was 34% and nontargeted effects killed 32% of cells. …”
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Novel Implications of Nanoparticle-Enhanced Radiotherapy and Brachytherapy: Z-Effect and Tumor Hypoxia by Runze Zhou, Di Zhao, Narasimha M. Beeraka, Xiaoyan Wang, Pengwei Lu, Ruixia Song, Kuo Chen, Junqi Liu

“…Technological advancements in nanotechnology have resulted in synthesis of high atomic elements such as nanomaterials, which can be used as radiosensitizers due to their photoelectric characteristics. …”
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The hedgehog inhibitor GANT61 sensitizes prostate cancer cells to ionizing radiation both in vitro and in vivo by Gonnissen, A, Isebaert, S, McKee, C, Dok, R, Haustermans, K, Muschel, R

“…Furthermore, we confirmed the radiosensitization effect of GANT61 in two in vivo xenograft PCa models. …”

Improving outcomes for resistant rectal cancer by O'Cathail, S

“…</p> <p>Using RNAi and clonogenic assays, NRF2 knockdown produced a radiosensitive phenotype in intrinsically resistant cell line models but had no effect in the most radiosensitive cell line. …”

Nanotechnology Driven Cancer Chemoradiation: Exploiting the Full Potential of Radiotherapy with a Unique Combination of Gold Nanoparticles and Bleomycin by Ocean Han, Kyle Bromma, Nicholas Palmerley, Ariadne T. Bido, Mesa Monica, Abdulaziz Alhussan, Perry L. Howard, Alexandre G. Brolo, Wayne Beckham, Abraham S. Alexander, Devika B. Chithrani

“…Enhancement of the RT effect with novel radiosensitizers can address this need. In this study, gold nanoparticles (GNPs) and bleomycin (BLM) were used as a unique combination of radiosensitizers. …”
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Connection between Radiation-Regulating Functions of Natural Products and miRNAs Targeting Radiomodulation and Exosome Biogenesis by Jen-Yang Tang, Ya-Ting Chuang, Jun-Ping Shiau, Ching-Yu Yen, Fang-Rong Chang, Yi-Hong Tsai, Ammad Ahmad Farooqi, Hsueh-Wei Chang

“…As a result, the miRNA–radiomodulation (radioprotection and radiosensitization)–exosome biogenesis axis in regard to natural-product-mediated radiotherapeutic effects is well organized. …”
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Comparative Proton and Photon Irradiation Combined with Pharmacological Inhibitors in 3D Pancreatic Cancer Cultures by Josephine Görte, Elke Beyreuther, Erik H. J. Danen, Nils Cordes

“…The targeting of proteins identified in the phosphoproteome that were uniquely altered by protons or photons failed to cause radiation-type-specific radiosensitization. Targeting DNA repair proteins associated with non-homologous endjoining, however, revealed a strong radiosensitizing potential independent of the radiation type. …”
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A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer. by Martin, N, Brunner, T, Kiel, K, DeLaney, T, Regine, W, Mohiuddin, M, Rosato, E, Haller, D, Stevenson, J, Smith, D, Pramanik, B, Tepper, J, Tanaka, W, Morrison, B, Deutsch, P, Gupta, A, Muschel, R, Mckenna, W, Bernhard, E, Hahn, S

“… PURPOSE: Preclinical and clinical studies have demonstrated that inhibition of prenylation can radiosensitize cell lines with activation of Ras and produce clinical response in patients with cancer. …”

Unraveling the Radioprotective Mechanisms of UV-Resistant <i>Bacillus subtilis</i> ASM-1 Extracted Compounds through Molecular Docking by Asim Ur Rahman, Aftab Ali, Faisal Ahmad, Sajjad Ahmad, Metab Alharbi, Abdullah F. Alasmari, Amna Fayyaz, Qurrat ul ain Rana, Samiullah Khan, Fariha Hasan, Malik Badshah, Aamer Ali Shah

“…However, the existence of radiosensitive microorganisms inhabiting such an inhospitable environment is still a mystery. …”
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Engineering nanoparticles to reprogram radiotherapy and immunotherapy: recent advances and future challenges by Jing Jin, Qijie Zhao

“…Abstract Nanoparticles (NPs) have been increasingly studied for radiosensitization. The principle of NPs radio-enhancement is to use high-atomic number NPs (e.g. gold, hafnium, bismuth and gadolinium) or deliver radiosensitizing substances, such as cisplatin and selenium. …”
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Theranostic RGD@Fe3O4-Au/Gd NPs for the targeted radiotherapy and MR imaging of breast cancer by Azadeh Amraee, Zahra Alamzadeh, Rasoul Irajirad, Abolfazl Sarikhani, Habib Ghaznavi, Hossein Ghadiri Harvani, Seied Rabi Mahdavi, Sakine Shirvalilou, Samideh Khoei

“…Abstract Background As a radiosensitizing agent in magnetic resonance imaging (MRI), gadolinium is disadvantageous in that it confers a rather high toxicity and low longitudinal comfort time (r1). …”
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Impact of secondary particles on microdistribution of deposited dose in biological tissue in the presence of gold and gadolinium nanoparticles under photon beam irradiation by Ivan A. Konobeev, Yurij A. Kurachenko, Igor’ N. Sheino

“…It was established that interaction of electrons and positrons with nanoparticles does not lead to significant increase of additional dose in the vicinity of their surfaces and can be most likely excluded from consideration in the analysis of radiosensitization mechanism of nanoparticles.…”
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Investigating the adjacent patient radiation dose received during a simulated ward chest X-ray examination by Hayley Langfield, Paul Lockwood

“…The scattered radiation dose to radiosensitive organs (thyroid, breast, and gonads) was recorded using Thermoluminescent Dosimeters (TLDs). …”
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COMBINATION NEOADJUVANT THERMOCHEMICAL THERAPY IN PATIENTS WITH RECTAL CANCER by Yu. A. Barsukov, D. V. Kuzmichev, S. I. Tkachev, V. A. Aliev, R. I. Tamrazov, A. G. Malikhov, Z. Z. Mamedli, I. Sh. Tataev, O. A. Vlasov, S. S. Gordeev

“…All patients received 5 Ч 5 Gy radiotherapy with capecitabine 1300 mg/m2 days 1–5 per os and radiosensitization with local hyperthermia and metronidazole.Results. …”
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An Orthotopic Model of Glioblastoma Is Resistant to Radiodynamic Therapy with 5-AminoLevulinic Acid by Charles Dupin, Jade Sutter, Samuel Amintas, Marie-Alix Derieppe, Magalie Lalanne, Soule Coulibaly, Joris Guyon, Thomas Daubon, Julian Boutin, Jean-Marc Blouin, Emmanuel Richard, François Moreau-Gaudry, Aurélie Bedel, Véronique Vendrely, Sandrine Dabernat

“…Radiosensitization of glioblastoma is a major ambition to increase the survival of this incurable cancer. …”
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A Comparison of in vivo Cellular Responses to CS-137 Gamma Rays and 320-KV X Rays by B. R. Scott, K. M. Gott, C. A. Potter, J. Wilder

“…We show that cytotoxicity dose-response relationships for bone marrow cells and splenocytes are complex, involving negative curvature (decreasing slope as dose increases), presumably implicating a mixed cell population comprised of large numbers of hypersensitive, modestly radiosensitive, and resistant cells. The radiosensitive cells appear to respond with 50% being killed by a dose < 0.5 Gy. …”
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Organ-Specific Endothelial Dysfunction Following Total Body Irradiation Exposure by Guru Prasad Sharma, Heather A. Himburg

“…The purpose of this review is to summarize the pathogenesis of endothelial dysfunction following total or near total body irradiation exposure at the level of individual radiosensitive organs.…”
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The Ras radiation resistance pathway. by Gupta, A, Bakanauskas, V, Cerniglia, G, Cheng, Y, Bernhard, E, Muschel, R, Mckenna, W

“…The phosphoinositide-3-kinase (PI3K) inhibitor LY294002 radiosensitized cells bearing mutant ras oncogenes, but the survival of cells with wild-type ras was not affected. …”