Detection of repair activity during the DNA damage-induced G2 delay in human cancer cells. by Kao, G, Mckenna, W, Yen, T

“…Caffeine and okadaic acid, both established radiosensitizers, inhibit the incorporation of BrdU in G2 cells. …”

205 Targeting Homologous Repair to Overcome Genotoxic Therapy Resistance in Pancreatic Cancer by Adam Wolfe, Oscar Zuniga, Kirk West, Justin Leung

“…USP7 inhibition successfully reduced RAD18 expression and resulted in enhanced radiosensitization.…”
Get full text

Exploring Nitric Oxide (NO)-Releasing Celecoxib Derivatives as Modulators of Radioresponse in Pheochromocytoma Cells by Florian Brandt, Martin Ullrich, Verena Seifert, Cathleen Haase-Kohn, Susan Richter, Torsten Kniess, Jens Pietzsch, Markus Laube

“…COX-2 can be considered as a clinically relevant molecular target for adjuvant, in particular radiosensitizing treatments. In this regard, using selective COX-2 inhibitors, e.g., in combination with radiotherapy or endoradiotherapy, represents an interesting treatment option. …”
Get full text

Adult Medulloblastoma Demographic, Tumor and Treatment Impact since 2006: A Canadian University Experience by Maria Camila Quinones, Karl Bélanger, Émilie Lemieux Blanchard, Bernard Lemieux, Jean-Paul Bahary, Laura G. Masucci, David Roberge, Cynthia Menard, Carole Lambert, France Berthelet, Robert Moumdjian, Marie Florescu

“…The presence of radiosensitizing chemotherapy was associated with a more favorable PFS. …”
Get full text

Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy by Dina V. Hingorani, Michael M. Allevato, Maria F. Camargo, Jacqueline Lesperance, Maryam A. Quraishi, Joseph Aguilera, Ida Franiak-Pietryga, Daniel J. Scanderbeg, Zhiyong Wang, Alfredo A. Molinolo, Diego Alvarado, Andrew B. Sharabi, Jack D. Bui, Ezra E. W. Cohen, Stephen R. Adams, J. Silvio Gutkind, Sunil J. Advani

“…Monomethyl auristatin (MMAE), also known for its radiosensitizer properties, is a common antibody drug conjugate used for cancer therapy. …”
Get full text

Chemical Inhibition of RPA by HAMNO Alters Cell Cycle Dynamics by Impeding DNA Replication and G2-to-M Transition but Has Little Effect on the Radiation-Induced DNA Damage Response by Rositsa Dueva, Lisa Marie Krieger, Fanghua Li, Daxian Luo, Huaping Xiao, Martin Stuschke, Eric Metzen, George Iliakis

“…Despite these marked effects on the cell cycle and the DNA damage response, radiosensitization could neither be detected in exponentially growing cultures, nor in cultures enriched in G2-phase cells. …”
Get full text

Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer by Shuting Zuo, Zhenyu Wang, Liping Zhao, Jing Wang

“…Herein, we constructed gold nanocages (GNCs) loaded with a hyperpyrexia-sensitive nitric oxide (NO) donor (thiolate cupferron) to integrate extrinsic radiosensitization, local photothermal therapy, and near-infrared-activated NO gas therapy. …”
Get full text

ASSESSMENT OF THE EFFICACY OF DOSE RADIATION THERAPY REGIMENS FOR TREATING CANCER ACCORDING TO CRITERIA FOR EARLY TOXICITY OF RADIOTHERAPY by V. A. Lisin

“…Using this algorithm, the tumor regression patterns were found at various quantitative ratios between the radiosensitivities of the normal and tumor tissues. Results. …”
Get full text

Improving Localized Radiotherapy for Glioblastoma via Small Molecule Inhibition of KIF11 by Miranda M. Tallman, Abigail A. Zalenski, Ian Stabl, Morgan S. Schrock, Luke Kollin, Eliane de Jong, Kuntal De, Treg M. Grubb, Matthew K. Summers, Monica Venere

“…In this study, we wanted to investigate if enriching cells in the most radiosensitive cell cycle phase, mitosis, could improve localized radiotherapy for GBM. …”
Get full text

Multiscale Modelling of Nanoparticle Distribution in a Realistic Tumour Geometry Following Local Injection by George Caddy, Justin Stebbing, Gareth Wakefield, Megan Adair, Xiao Yun Xu

“…Radiosensitizers have proven to be an effective method of improving radiotherapy outcomes, with the distribution of particles being a crucial element to delivering optimal treatment outcomes due to the short range of effect of these particles. …”
Get full text

Understanding the Radiobiological Mechanisms Induced by ¹⁷⁷Lu-DOTATATE in Comparison to External Beam Radiation Therapy by Wendy Delbart, Jirair Karabet, Gwennaëlle Marin, Sébastien Penninckx, Jonathan Derrien, Ghanem E. Ghanem, Patrick Flamen, Zéna Wimana

“…Our study showed that common radiobiological mechanisms were induced by both ¹⁷⁷Lu-DOTATATE and EBRT, but to a different extent and/or with variable kinetics, including in the DNA damage response. A higher radiosensitizing potential of PARPi was observed for EBRT compared to ¹⁷⁷Lu-DOTATATE. …”
Get full text

Lipid droplets and ferritin heavy chain: a devilish liaison in human cancer cell radioresistance by Luca Tirinato, Maria Grazia Marafioti, Francesca Pagliari, Jeannette Jansen, Ilenia Aversa, Rachel Hanley, Clelia Nisticò, Daniel Garcia-Calderón, Geraldine Genard, Joana Filipa Guerreiro, Francesco Saverio Costanzo, Joao Seco

“…In fact, breast and lung cancer cells silenced for the FTH1 gene showed a reduction in the LD numbers and, by consequence, became radiosensitive. FTH1 overexpression as well as iron-chelating treatment by Deferoxamine were able to restore the LD amount and RR. …”
Get full text

A bioconvergence study on platinum-free concurrent chemoradiotherapy for the treatment of HPV-negative head and neck carcinoma by Alessandra Gonnelli, Patrizia Sarogni, Noemi Giannini, Stefania Linsalata, Fabio Di Martino, Agata Zamborlin, Valentina Frusca, Maria Laura Ermini, Paola Puccini, Valerio Voliani, Fabiola Paiar

“…On a broader basis, our bioconvergence approach provides an advance for the translation of Pt-free radiosensitizer to the clinical practice, positively shifting the therapeutic vs. side effects equilibrium for the management of HNSCCs.…”
Get full text

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses by Bipasha Mukherjee, Nozomi Tomimatsu, Kaushik Amancherla, Cristel V. Camacho, Nandini Pichamoorthy, Sandeep Burma

“…As a result, NVP-BEZ235 confers an extreme degree of radiosensitization and impairs DSB repair in a panel of GBM cell lines irrespective of their Akt activation status. …”
Get full text

Modification of DNA damage mechanisms by nitric oxide during ionizing radiation. by Folkes, L, O'Neill, P

“…Nitric oxide ((•)NO) is a very effective radiosensitizer of hypoxic mammalian cells. In vivo (•)NO may have effects on tumor vasculature and hence on tumor oxygenation and it may also interact with radiation-produced radicals to modify DNA lesions. …”

New Frontiers in Colorectal Cancer Treatment Combining Nanotechnology with Photo- and Radiotherapy by Sara C. Freitas, Daniel Sanderson, Sofia Caspani, Ricardo Magalhães, Belén Cortés-Llanos, Andreia Granja, Salette Reis, João Horta Belo, José Azevedo, Maria Victoria Gómez-Gaviro, Célia Tavares de Sousa

“…Although the results using nanoparticles as a photo- and radiosensitizers in photo- and radiotherapy are promising, preliminary studies showed that the possibility of combining both therapies must be explored to improve the treatment efficiency.…”
Get full text

Downregulation of Mcl-1 by Panobinostat Potentiates Proton Beam Therapy in Hepatocellular Carcinoma Cells by Changhoon Choi, Ga Haeng Lee, Arang Son, Gyu Sang Yoo, Jeong Il Yu, Hee Chul Park

“…Clonogenic survival assays revealed that radiosensitization of Huh7 and Hep3B cells by panobinostat was more evident when combined with protons than X-rays. …”
Get full text

Clinical Feasibility Study of Gold Nanoparticles as Theragnostic Agents for Precision Radiotherapy by José Antonio López-Valverde, Elisa Jiménez-Ortega, Antonio Leal

“…Mass concentration of AuNP as an efficient contrast agent in clinical CT was found and implemented in a Monte Carlo simulation method for dose calculation under different proposed therapeutic beams. The radiosensitization effect was determined in irradiated cells with AuNP. …”
Get full text

PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy by Dushek, O, Azad, A, Lim, S, D'Costa, Z, Jones, K, Diana, A, Sansom, O, Kruger, P, Liu, S, McKenna, W, Muschel, R, Fokas, E

“…Depletion of CD8+ T cells abrogated radiosensitization by anti-PD-L1. Blockade of PD-L1 further augmented the effect of high RT doses (12 Gy) in preventing development of liver metastases. …”

SN38-loaded nanomedicine mediates chemo-radiotherapy against CD44-expressing cancer growth by Shu-Jyuan Yang, Jui-An Pai, Cheng-Jung Yao, Chung-Huan Huang, Jenny Ling‑Yu Chen, Chung-Hao Wang, Ke-Cheng Chen, Ming-Jium Shieh

“…Abstract Background Chemo-radiotherapy is the combined chemotherapy and radiotherapy on tumor treatment to obtain the local radiosensitization and local cytotoxicity of the tumor and to control the microscopic metastatic disease. …”
Get full text