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1141
Detection of repair activity during the DNA damage-induced G2 delay in human cancer cells.
Published 2001“…Caffeine and okadaic acid, both established radiosensitizers, inhibit the incorporation of BrdU in G2 cells. …”
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1142
205 Targeting Homologous Repair to Overcome Genotoxic Therapy Resistance in Pancreatic Cancer
Published 2022-04-01“…USP7 inhibition successfully reduced RAD18 expression and resulted in enhanced radiosensitization.…”
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1143
Exploring Nitric Oxide (NO)-Releasing Celecoxib Derivatives as Modulators of Radioresponse in Pheochromocytoma Cells
Published 2022-10-01“…COX-2 can be considered as a clinically relevant molecular target for adjuvant, in particular radiosensitizing treatments. In this regard, using selective COX-2 inhibitors, e.g., in combination with radiotherapy or endoradiotherapy, represents an interesting treatment option. …”
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1144
Adult Medulloblastoma Demographic, Tumor and Treatment Impact since 2006: A Canadian University Experience
Published 2021-08-01“…The presence of radiosensitizing chemotherapy was associated with a more favorable PFS. …”
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1145
Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy
Published 2022-07-01“…Monomethyl auristatin (MMAE), also known for its radiosensitizer properties, is a common antibody drug conjugate used for cancer therapy. …”
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1146
Chemical Inhibition of RPA by HAMNO Alters Cell Cycle Dynamics by Impeding DNA Replication and G2-to-M Transition but Has Little Effect on the Radiation-Induced DNA Damage Response
Published 2023-10-01“…Despite these marked effects on the cell cycle and the DNA damage response, radiosensitization could neither be detected in exponentially growing cultures, nor in cultures enriched in G2-phase cells. …”
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1147
Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer
Published 2023-01-01“…Herein, we constructed gold nanocages (GNCs) loaded with a hyperpyrexia-sensitive nitric oxide (NO) donor (thiolate cupferron) to integrate extrinsic radiosensitization, local photothermal therapy, and near-infrared-activated NO gas therapy. …”
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1148
ASSESSMENT OF THE EFFICACY OF DOSE RADIATION THERAPY REGIMENS FOR TREATING CANCER ACCORDING TO CRITERIA FOR EARLY TOXICITY OF RADIOTHERAPY
Published 2018-05-01“…Using this algorithm, the tumor regression patterns were found at various quantitative ratios between the radiosensitivities of the normal and tumor tissues. Results. …”
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1149
Improving Localized Radiotherapy for Glioblastoma via Small Molecule Inhibition of KIF11
Published 2023-06-01“…In this study, we wanted to investigate if enriching cells in the most radiosensitive cell cycle phase, mitosis, could improve localized radiotherapy for GBM. …”
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1150
Multiscale Modelling of Nanoparticle Distribution in a Realistic Tumour Geometry Following Local Injection
Published 2022-11-01“…Radiosensitizers have proven to be an effective method of improving radiotherapy outcomes, with the distribution of particles being a crucial element to delivering optimal treatment outcomes due to the short range of effect of these particles. …”
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1151
Understanding the Radiobiological Mechanisms Induced by <sup>177</sup>Lu-DOTATATE in Comparison to External Beam Radiation Therapy
Published 2022-10-01“…Our study showed that common radiobiological mechanisms were induced by both <sup>177</sup>Lu-DOTATATE and EBRT, but to a different extent and/or with variable kinetics, including in the DNA damage response. A higher radiosensitizing potential of PARPi was observed for EBRT compared to <sup>177</sup>Lu-DOTATATE. …”
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1152
Lipid droplets and ferritin heavy chain: a devilish liaison in human cancer cell radioresistance
Published 2021-09-01“…In fact, breast and lung cancer cells silenced for the FTH1 gene showed a reduction in the LD numbers and, by consequence, became radiosensitive. FTH1 overexpression as well as iron-chelating treatment by Deferoxamine were able to restore the LD amount and RR. …”
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1153
A bioconvergence study on platinum-free concurrent chemoradiotherapy for the treatment of HPV-negative head and neck carcinoma
Published 2024-12-01“…On a broader basis, our bioconvergence approach provides an advance for the translation of Pt-free radiosensitizer to the clinical practice, positively shifting the therapeutic vs. side effects equilibrium for the management of HNSCCs.…”
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1154
The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses
Published 2012-01-01“…As a result, NVP-BEZ235 confers an extreme degree of radiosensitization and impairs DSB repair in a panel of GBM cell lines irrespective of their Akt activation status. …”
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1155
Modification of DNA damage mechanisms by nitric oxide during ionizing radiation.
Published 2013“…Nitric oxide ((•)NO) is a very effective radiosensitizer of hypoxic mammalian cells. In vivo (•)NO may have effects on tumor vasculature and hence on tumor oxygenation and it may also interact with radiation-produced radicals to modify DNA lesions. …”
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1156
New Frontiers in Colorectal Cancer Treatment Combining Nanotechnology with Photo- and Radiotherapy
Published 2023-01-01“…Although the results using nanoparticles as a photo- and radiosensitizers in photo- and radiotherapy are promising, preliminary studies showed that the possibility of combining both therapies must be explored to improve the treatment efficiency.…”
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1157
Downregulation of Mcl-1 by Panobinostat Potentiates Proton Beam Therapy in Hepatocellular Carcinoma Cells
Published 2021-03-01“…Clonogenic survival assays revealed that radiosensitization of Huh7 and Hep3B cells by panobinostat was more evident when combined with protons than X-rays. …”
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1158
Clinical Feasibility Study of Gold Nanoparticles as Theragnostic Agents for Precision Radiotherapy
Published 2022-05-01“…Mass concentration of AuNP as an efficient contrast agent in clinical CT was found and implemented in a Monte Carlo simulation method for dose calculation under different proposed therapeutic beams. The radiosensitization effect was determined in irradiated cells with AuNP. …”
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1159
PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy
Published 2016“…Depletion of CD8+ T cells abrogated radiosensitization by anti-PD-L1. Blockade of PD-L1 further augmented the effect of high RT doses (12 Gy) in preventing development of liver metastases. …”
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1160
SN38-loaded nanomedicine mediates chemo-radiotherapy against CD44-expressing cancer growth
Published 2023-01-01“…Abstract Background Chemo-radiotherapy is the combined chemotherapy and radiotherapy on tumor treatment to obtain the local radiosensitization and local cytotoxicity of the tumor and to control the microscopic metastatic disease. …”
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