NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells—A Potential Target for Adjuvant Radiotherapy by Adriana Müller-Längle, Henrik Lutz, Stephanie Hehlgans, Franz Rödel, Kerstin Rau, Bodo Laube

“…Since the FDA-approved NMDAR antagonists memantine and ifenprodil showed differential radiosensitizing effects, these compounds may constitute novel optimizations for therapeutic interventions in glioblastoma.…”
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Evaluation of Novel 64Cu-Labeled Theranostic Gadolinium-Based Nanoprobes in HepG2 Tumor-Bearing Nude Mice by Pengcheng Hu, Dengfeng Cheng, Tao Huang, Anna B. Banizs, Jie Xiao, Guobing Liu, Quan Chen, Yuenan Wang, Jiang He, Hongcheng Shi

“…Abstract Radiation therapy of liver cancer is limited by low tolerance of the liver to radiation. Radiosensitizers can effectively reduce the required radiation dose. …”
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Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling by Catarina Macedo-Silva, Vera Miranda-Gonçalves, Nuno Tiago Tavares, Daniela Barros-Silva, Joana Lencart, João Lobo, Ângelo Oliveira, Margareta P. Correia, Lucia Altucci, Carmen Jerónimo

“…Overall, this work contributes to improve the understanding of p53 as a mediator of signaling transduction in DNA damage repair, as well as the impact of epigenetic targeting for PCa radiosensitization.…”
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The benefit of co-targeting PARP-1 and c-Met on the efficacy of radiotherapy in wild type BRAF melanoma by Malak Sabbah, Ahmad Najem, Christophe Vanderkerkhove, Fabien Kert, Younes Jourani, Fabrice Journe, Ahmad Awada, Dirk Van Gestel, Ghanem E. Ghanem, Mohammad Krayem, Mohammad Krayem

“…Similarly, specific inhibition of c-Met by Crizotinib or its KO radiosensitizes the melanoma cell lines. Mechanistically, we show that RT causes c-Met nuclear translocation to interact with PARP-1 promoting its activity. …”
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Engineering of gold nanorods as multifunctional theranostic agent for photothermal-enhanced radiotherapy of cancer by Lina Xie, Xia Ying, Xinyue Li, Xinyue Tan, Tianzi Zhang, Xujia Zhang, Wen Cai, Feifei An, Xiaoli Liu, Suxia Han

“…Devising conveniently synthesizable and smart multifunctional radiosensitizers is of tremendous significance to improve the cure rate of RT. …”
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Effects of Polar Steroids from the Starfish <i>Patiria (=Asterina) pectinifera</i> in Combination with X-Ray Radiation on Colony Formation and Apoptosis Induction of Human Colorect... by Olesya S. Malyarenko, Timofey V. Malyarenko, Alla A. Kicha, Natalia V. Ivanchina, Svetlana P. Ermakova

“…The molecular mechanism of the radiosensitizing activity of asterosaponin P₁ was elucidated by western blotting and the DNA comet assay. …”
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Ionizing radiation effects modelling in cells population with gold nanoparticles by Rashid, Hamizah, Mohd. Siam, Fuaada, Maan, Normah, Wan Abd. Rahman, Wan Nordiana

“…Radiosensitizer such as gold nanoparticle is a promising agent to be used in radiotherapy to increase the number of cancer cell death. …”
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Adaptive Radiotherapy for an Uncommon Chloroma by Soufya Majdoul, Laurianne Colson-Durand, Nu Hanh To, Yazid Belkacemi

“…This uncommon disease is known to be radiosensitive. However, the total dose and dose per fraction are not standardized. …”
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The Emerging Role of Carbon-Ion Radiotherapy by Daniel K Ebner, Daniel K Ebner, Tadashi eKamada

“…Owing to a focused dose distribution in addition to high linear energy transfer and subsequently high relative biological effect, CIRT is uniquely able to target otherwise untreatable hypoxic and radioresistant disease, while opening the door for substantially hypofractionated treatment of normal and radiosensitive disease. CIRT has increasingly garnered international attention, and is nearing the tipping point for international adoption.…”
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Accessing radiation damage to biomolecules on the nanoscale by particle-scattering simulations by Marc Benjamin Hahn

“…In the present review we aim to give an overview over MCS based approaches to understand radiation interaction on a broad scale, ranging from cancerous tissue, cells and their organelles including the nucleus, mitochondria and membranes, over radiosensitizer such as metallic nanoparticles, and water with additional radical scavenger, down to isolated biomolecules in the form of DNA, RNA, proteins and DNA-protein complexes. …”
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Feline XRCC4 undergoes rapid Ku‐dependent recruitment to DNA damage sites by Manabu Koike, Yasutomo Yutoku, Aki Koike

“…XRCC4, an essential molecule for nonhomologous end joining repair, is a promising target for radiosensitizers. Genetic variants and mutations of XRCC4 contribute to cancer susceptibility, and XRCC4 is also the causative gene of microcephalic primordial dwarfism (MPD) in humans. …”
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Environmental dose rate assessment of ITER using the Monte Carlo method by Karimian Alireza, Beheshti Amir, Abdi Mohammadreza, Jabbari Iraj

“…Also, equivalent dose rates of radiosensitive organs have shown that the maximum dose rate belongs to the kidney. …”
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Development of a human peripheral blood ex vivo model for rapid protein biomarker detection and applications to radiation biodosimetry. by Leah Nemzow, Thomas Boehringer, Bezalel Bacon, Helen C Turner

“…In our earlier work, we previously identified and validated a panel of radiosensitive protein biomarkers in blood leukocytes, using the humanized-mouse and non-human primate (NHP) models. …”
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CDK1 inhibition sensitizes normal cells to DNA damage in a cell cycle dependent manner by Prevo, R, Pirovano, G, Puliyadi, R, Herbert, K, Rodriguez-Berriguete, G, O'Docherty, A, Greaves, W, McKenna, W, Higgins, G

“…Initial results showed that CDK1 inhibition radiosensitized tumor cells, but did not sensitize normal fibroblasts and epithelial cells in colony formation assays despite effective inhibition of CDK1 signaling. …”

Intracranial germinoma – a case report by Subha, Sethu Thakachy, Puraviappan, Periyannan, Narenthiranathan, N. Ramesh, Banarsi Dass, Dipak

“…Early recognition of this neoplasm is vital as germinomas are highly radiosensitive and effective/early radiation therapy can result in relatively favourable overall prognosis. …”
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Lipid-Nanoparticle-Mediated Delivery of Docetaxel Prodrug for Exploiting Full Potential of Gold Nanoparticles in the Treatment of Pancreatic Cancer by Abdulaziz Alhussan, Nolan Jackson, Sarah Eaton, Nancy Dos Santos, Ingrid Barta, Josh Zaifman, Sam Chen, Yuen Yi C. Tam, Sunil Krishnan, Devika B. Chithrani

“…Because of their minimal toxicity to normal tissues, both GNPs and LNP_DTX-P could be ideal radiosensitization candidates in radiotherapy and would produce very promising synergistic therapeutic outcomes.…”
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Novel MRI-guided focussed ultrasound stimulated microbubble radiation enhancement treatment for breast cancer by Archya Dasgupta, Murtuza Saifuddin, Evan McNabb, Ling Ho, Lin Lu, Danny Vesprini, Irene Karam, Hany Soliman, Edward Chow, Sonal Gandhi, Maureen Trudeau, William Tran, Belinda Curpen, Greg Stanisz, Arjun Sahgal, Michael Kolios, Gregory J. Czarnota

“…Promising response rates suggest potential strong radiosensitization effects of the investigational modality. …”
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Combined Treatment with Cryptocaryone and Ultraviolet C Promotes Antiproliferation and Apoptosis of Oral Cancer Cells by Sheng-Chieh Wang, Hsun-Shuo Chang, Jen-Yang Tang, Ammad Ahmad Farooqi, Yun-Tzu Kuo, Yan-Der Hsuuw, Jai-Wei Lee, Hsueh-Wei Chang

“…Cryptocaryone (CPC) was previously reported as preferential for killing natural products in oral cancer cells. However, its radiosensitizing potential combined with ultraviolet C (UVC) cell killing of oral cancer cells remains unclear. …”
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CT and MRI Imaging of Theranostic Bimodal Fe₃O₄@Au NanoParticles in Tumor Bearing Mice by Alexey A. Lipengolts, Yulia A. Finogenova, Vsevolod A. Skribitsky, Kristina E. Shpakova, Adi Anaki, Menachem Motiei, Alevtina S. Semkina, Maxim A. Abakumov, Anna V. Smirnova, Elena Y. Grigorieva, Rachela Popovtzer

“…Gold-containing nanoparticles are proven to be an effective radiosensitizer in the radiotherapy of tumors. Reliable imaging of nanoparticles in a tumor and surrounding normal tissues is crucial both for diagnostics and for nanoparticle application as radiosensitizers. …”
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Validation of CD98hc as a Therapeutic Target for a Combination of Radiation and Immunotherapies in Head and Neck Squamous Cell Carcinoma by Ayşe Sedef Köseer, Liliana R. Loureiro, Justyna Jureczek, Nicola Mitwasi, Karla Elizabeth González Soto, Julia Aepler, Tabea Bartsch, Anja Feldmann, Leoni A. Kunz-Schughart, Annett Linge, Mechthild Krause, Michael Bachmann, Claudia Arndt, Anna Dubrovska

“…Low <i>SLC3A2</i> (solute carrier family 3 member 2) mRNA and protein (CD98hc) expression levels are associated with higher locoregional control in HNSCC patients treated with primary radiochemotherapy or postoperative radiochemotherapy, suggesting that CD98hc could be a target for HNSCC radiosensitization. One of the targeted strategies for tumor radiosensitization is precision immunotherapy, e.g., the use of chimeric antigen receptor (CAR) T cells. …”
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