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1161
NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells—A Potential Target for Adjuvant Radiotherapy
Published 2019-04-01“…Since the FDA-approved NMDAR antagonists memantine and ifenprodil showed differential radiosensitizing effects, these compounds may constitute novel optimizations for therapeutic interventions in glioblastoma.…”
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1162
Evaluation of Novel 64Cu-Labeled Theranostic Gadolinium-Based Nanoprobes in HepG2 Tumor-Bearing Nude Mice
Published 2017-09-01“…Abstract Radiation therapy of liver cancer is limited by low tolerance of the liver to radiation. Radiosensitizers can effectively reduce the required radiation dose. …”
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1163
Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling
Published 2023-10-01“…Overall, this work contributes to improve the understanding of p53 as a mediator of signaling transduction in DNA damage repair, as well as the impact of epigenetic targeting for PCa radiosensitization.…”
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1164
The benefit of co-targeting PARP-1 and c-Met on the efficacy of radiotherapy in wild type BRAF melanoma
Published 2023-05-01“…Similarly, specific inhibition of c-Met by Crizotinib or its KO radiosensitizes the melanoma cell lines. Mechanistically, we show that RT causes c-Met nuclear translocation to interact with PARP-1 promoting its activity. …”
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1165
Engineering of gold nanorods as multifunctional theranostic agent for photothermal-enhanced radiotherapy of cancer
Published 2023-01-01“…Devising conveniently synthesizable and smart multifunctional radiosensitizers is of tremendous significance to improve the cure rate of RT. …”
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1166
Effects of Polar Steroids from the Starfish <i>Patiria (=Asterina) pectinifera</i> in Combination with X-Ray Radiation on Colony Formation and Apoptosis Induction of Human Colorect...
Published 2019-08-01“…The molecular mechanism of the radiosensitizing activity of asterosaponin P<sub>1</sub> was elucidated by western blotting and the DNA comet assay. …”
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1167
Ionizing radiation effects modelling in cells population with gold nanoparticles
Published 2021“…Radiosensitizer such as gold nanoparticle is a promising agent to be used in radiotherapy to increase the number of cancer cell death. …”
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Article -
1168
Adaptive Radiotherapy for an Uncommon Chloroma
Published 2016-10-01“…This uncommon disease is known to be radiosensitive. However, the total dose and dose per fraction are not standardized. …”
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1169
The Emerging Role of Carbon-Ion Radiotherapy
Published 2016-06-01“…Owing to a focused dose distribution in addition to high linear energy transfer and subsequently high relative biological effect, CIRT is uniquely able to target otherwise untreatable hypoxic and radioresistant disease, while opening the door for substantially hypofractionated treatment of normal and radiosensitive disease. CIRT has increasingly garnered international attention, and is nearing the tipping point for international adoption.…”
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1170
Accessing radiation damage to biomolecules on the nanoscale by particle-scattering simulations
Published 2023-01-01“…In the present review we aim to give an overview over MCS based approaches to understand radiation interaction on a broad scale, ranging from cancerous tissue, cells and their organelles including the nucleus, mitochondria and membranes, over radiosensitizer such as metallic nanoparticles, and water with additional radical scavenger, down to isolated biomolecules in the form of DNA, RNA, proteins and DNA-protein complexes. …”
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1171
Feline XRCC4 undergoes rapid Ku‐dependent recruitment to DNA damage sites
Published 2022-04-01“…XRCC4, an essential molecule for nonhomologous end joining repair, is a promising target for radiosensitizers. Genetic variants and mutations of XRCC4 contribute to cancer susceptibility, and XRCC4 is also the causative gene of microcephalic primordial dwarfism (MPD) in humans. …”
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1172
Environmental dose rate assessment of ITER using the Monte Carlo method
Published 2014-01-01“…Also, equivalent dose rates of radiosensitive organs have shown that the maximum dose rate belongs to the kidney. …”
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1173
Development of a human peripheral blood ex vivo model for rapid protein biomarker detection and applications to radiation biodosimetry.
Published 2023-01-01“…In our earlier work, we previously identified and validated a panel of radiosensitive protein biomarkers in blood leukocytes, using the humanized-mouse and non-human primate (NHP) models. …”
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1174
CDK1 inhibition sensitizes normal cells to DNA damage in a cell cycle dependent manner
Published 2018“…Initial results showed that CDK1 inhibition radiosensitized tumor cells, but did not sensitize normal fibroblasts and epithelial cells in colony formation assays despite effective inhibition of CDK1 signaling. …”
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1175
Intracranial germinoma – a case report
Published 2013“…Early recognition of this neoplasm is vital as germinomas are highly radiosensitive and effective/early radiation therapy can result in relatively favourable overall prognosis. …”
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1176
Lipid-Nanoparticle-Mediated Delivery of Docetaxel Prodrug for Exploiting Full Potential of Gold Nanoparticles in the Treatment of Pancreatic Cancer
Published 2022-12-01“…Because of their minimal toxicity to normal tissues, both GNPs and LNP<sub>DTX-P</sub> could be ideal radiosensitization candidates in radiotherapy and would produce very promising synergistic therapeutic outcomes.…”
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1177
Novel MRI-guided focussed ultrasound stimulated microbubble radiation enhancement treatment for breast cancer
Published 2023-08-01“…Promising response rates suggest potential strong radiosensitization effects of the investigational modality. …”
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1178
Combined Treatment with Cryptocaryone and Ultraviolet C Promotes Antiproliferation and Apoptosis of Oral Cancer Cells
Published 2022-03-01“…Cryptocaryone (CPC) was previously reported as preferential for killing natural products in oral cancer cells. However, its radiosensitizing potential combined with ultraviolet C (UVC) cell killing of oral cancer cells remains unclear. …”
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1179
CT and MRI Imaging of Theranostic Bimodal Fe<sub>3</sub>O<sub>4</sub>@Au NanoParticles in Tumor Bearing Mice
Published 2022-12-01“…Gold-containing nanoparticles are proven to be an effective radiosensitizer in the radiotherapy of tumors. Reliable imaging of nanoparticles in a tumor and surrounding normal tissues is crucial both for diagnostics and for nanoparticle application as radiosensitizers. …”
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1180
Validation of CD98hc as a Therapeutic Target for a Combination of Radiation and Immunotherapies in Head and Neck Squamous Cell Carcinoma
Published 2022-03-01“…Low <i>SLC3A2</i> (solute carrier family 3 member 2) mRNA and protein (CD98hc) expression levels are associated with higher locoregional control in HNSCC patients treated with primary radiochemotherapy or postoperative radiochemotherapy, suggesting that CD98hc could be a target for HNSCC radiosensitization. One of the targeted strategies for tumor radiosensitization is precision immunotherapy, e.g., the use of chimeric antigen receptor (CAR) T cells. …”
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Article