Attenuating DNA damage response and immunosuppression radiosensitizes pancreatic cancer by Yuqing Zhang, Courtney W. Houchen, Min Li

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Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer by Mohammad Habash, Luis C. Bohorquez, Elizabeth Kyriakou, Tomas Kron, Olga A. Martin, Benjamin J. Blyth

Subjects: “…radiosensitivity…”
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Radiosensitization of colorectal carcinoma cell lines by histone deacetylase inhibition by Rasmussen Heidi, Bratland Åse, Folkvord Sigurd, Nome Ragnhild V, Flatmark Kjersti, Ellefsen Mali, Fodstad Øystein, Ree Anne

“…<p>Abstract</p> <p>Background</p> <p>The tumor response to preoperative radiotherapy of locally advanced rectal cancer varies greatly, warranting the use of experimental models to assay the efficacy of molecular targeting agents in rectal cancer radiosensitization. Histone deacetylase (HDAC) inhibitors, agents that cause hyperacetylation of histone proteins and thereby remodeling of chromatin structure, may override cell cycle checkpoint responses to DNA damage and amplify radiation-induced tumor cell death.…”
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Radiosensitization to γ-Ray by Functional Inhibition of APOBEC3G by Ying Tong, Sota Kikuhara, Takae Onodera, Lichao Chen, Aung Bhone Myat, Shoji Imamichi, Yuka Sasaki, Yasufumi Murakami, Tadashige Nozaki, Hiroaki Fujimori, Mitsuko Masutani

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Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells by Yanzhu Lin, Hui Zhai, Yi Ouyang, Zhiyuan Lu, Chengbiao Chu, Qianting He, Xinping Cao

Subjects: “…Radiosensitivity…”
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Bench to bedside radiosensitizer development strategy for newly diagnosed glioblastoma by Charlotte Degorre, Philip Tofilon, Kevin Camphausen, Peter Mathen

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Improving the Efficacy of Tumor Radiosensitization Through Combined Molecular Targeting by Katharina Hintelmann, Katharina Hintelmann, Malte Kriegs, Kai Rothkamm, Thorsten Rieckmann, Thorsten Rieckmann

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Dual enhancement in the radiosensitivity of prostate cancer through nanoparticles and chemotherapeutics by Nolan Jackson, Iona Hill, Abdulaziz Alhussan, Kyle Bromma, Jessica Morgan, Belal Abousaida, Yasmin Zahra, Yuri Mackeyev, Wayne Beckham, Steven Herchko, Sunil Krishnan, Devika Basnagge Chithrani

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Enhancement of radiosensitization by metal-based nanoparticles in cancer radiation therapy by Xiang-Yu Su, Pei-Dang Liu, Hao Wu, Ning Gu

“…However, resistance of tumor cells to radiation therapy still remains a serious concern, so the study of radiosensitizers has emerged as a persistent hotspot in radiation oncology. …”
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Proof of Concept of a Binary Blood Assay for Predicting Radiosensitivity by Sophie Deneuve, Céline Mirjolet, Thierry Bastogne, Mirlande Duclos, Paul Retif, Philippe Zrounba, Pierre-Eric Roux, Marc Poupart, Guillaume Vogin, Nicolas Foray, Sandrine Pereira

“…Recent studies stressed the role of the phosphorylated ATM (pATM) protein in RT-toxicity genesis and its ability in predicting individual radiosensitivity (IRS) in fibroblasts. Here we assessed the reliability of the pATM quantification in lymphocytes to predict IRS. …”
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Repurposing Sulfasalazine as a Radiosensitizer in Hypoxic Human Colorectal Cancer by Lisa Kerkhove, Febe Geirnaert, Amir Laraki Rifi, Ka Lun Law, Adrián Gutiérrez, Inge Oudaert, Cyril Corbet, Thierry Gevaert, Inès Dufait, Mark De Ridder

“…Our principal finding in human HCT116 and DLD-1 cells was that SSZ enhances the radiosensitivity of hypoxic CRC cells but does not alter the intrinsic radiosensitivity. …”
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Active caspase-3 expression levels as bioindicator of individual radiosensitivity by NEYLIANE F.G. DOS SANTOS, RAFAEL F. SILVA, MARCELA M.P.L. PINTO, EDVANE B. DA SILVA, DEBORAH R. TASAT, ADEMIR AMARAL

“…For each radiation dose, it was observed a significant inter-individual variation in active caspase-3 expression intensity, suggesting that this parameter may be suitable for evidence individual radiosensitivity. The methodology presented and discussed in this work may help to predict healthy tissues response to radiation exposure toward the better patient outcome.…”
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Radiosensitivity of Cancer Cells Is Regulated by Translationally Controlled Tumor Protein by Jiwon Jung, Ji-Sun Lee, Yun-Sil Lee, Kyunglim Lee

“…This study reveals that the regulation of radiosensitivity of cancer cells is yet another function of TCTP. …”
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Veliparib Is an Effective Radiosensitizing Agent in a Preclinical Model of Medulloblastoma by Jessica Buck, Jessica Buck, Patrick J. C. Dyer, Hilary Hii, Brooke Carline, Mani Kuchibhotla, Jacob Byrne, Meegan Howlett, Meegan Howlett, Jacqueline Whitehouse, Jacqueline Whitehouse, Martin A. Ebert, Martin A. Ebert, Kerrie L. McDonald, Nicholas G. Gottardo, Nicholas G. Gottardo, Raelene Endersby, Raelene Endersby

“…In summary, PARP inhibition enhanced radiation-induced cytotoxicity of medulloblastoma cells; thus, veliparib or other brain-penetrant PARP inhibitors are potential radiosensitizing agents for the treatment of medulloblastoma.…”
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Antibody Delivery into the Brain by Radiosensitizer Nanoparticles for Targeted Glioblastoma Therapy by Omer Gal, Oshra Betzer, Liat Rousso-Noori, Tamar Sadan, Menachem Motiei, Maxim Nikitin, Dinorah Friedmann-Morvinski, Rachela Popovtzer, Aron Popovtzer

“…The inability of drugs to enter the brain, in particular antibody-based drugs and radiosensitizers, is a crucial limitation to effective glioblastoma therapy. …”
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A Robust Oxygen Microbubble Radiosensitizer for Iodine‐125 Brachytherapy by Sheng Peng, Ruyuan Song, Qingguang Lin, Yanling Zhang, Yuanzhong Yang, Ma Luo, Zhihui Zhong, Xiaonan Xu, Ligong Lu, Shuhuai Yao, Fujun Zhang

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Circ_0062020 Knockdown Strengthens the Radiosensitivity of Prostate Cancer Cells by Li H, Zhi Y, Ma C, Shen Q, Sun F, Cai C

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Rh factor is associated with individual radiosensitivity: A cytogenetic study by Meysam Khosravifarsani, Ali Shabestani Monfared, Sajad Borzoueisileh

Subjects: “…Radiosensitivity…”
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Selective targeting of brain tumors with gold nanoparticle-induced radiosensitization. by Daniel Y Joh, Lova Sun, Melissa Stangl, Ajlan Al Zaki, Surya Murty, Phillip P Santoiemma, James J Davis, Brian C Baumann, Michelle Alonso-Basanta, Dongha Bhang, Gary D Kao, Andrew Tsourkas, Jay F Dorsey

“…Prior treatment of mice with brain tumors resulted in increased extravasation and in-tumor deposition of GNP, suggesting that RT-induced BBB disruption can be leveraged to improve the tumor-tissue targeting of GNP and thus further optimize the radiosensitization of brain tumors by GNP. These exciting results together suggest that GNP may be usefully integrated into the RT treatment of brain tumors, with potential benefits resulting from increased tumor cell radiosensitization to preferential targeting of tumor-associated vasculature.…”
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Low Dose Rate Radiosensitization of Hepatocellular Carcinoma In Vitro and in Patients by Kyle C. Cuneo, Mary A. Davis, Mary U. Feng, Paula M. Novelli, William D. Ensminger, Theodore S. Lawrence

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