Zebrafish Avatars of rectal cancer patients validate the radiosensitive effect of metformin by Bruna Costa, Laura M. Fernandez, Oriol Parés, Ricardo Rio-Tinto, Inês Santiago, Mireia Castillo-Martin, Amjad Parvaiz, Rita Fior

“…Also, pre-clinical studies using cell lines provide evidence for the radiosensitive effect of metformin. However, no studies have been performed using rectal cancer patient samples to test this radiosensitive effect of metformin and compared it to the standard 5FU. …”
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PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats by Laure Balasse, Julia Maerk, Frédéric Pain, Aurelie Genoux, Sylvain Fieux, Françoise Lefebvre, Christian Morel, Pascale Gisquet-Verrier, Philippe Lanièce, Luc Zimmer

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Molecular Biomarkers for Predicting Cancer Patient Radiosensitivity and Radiotoxicity in Clinical Practice by Angeliki Gkikoudi, Spyridon A. Kalospyros, Sotiria Triantopoulou, Stella Logotheti, Vasiliki Softa, Constantin Kappas, Kiki Theodorou, Evagelia C. Laiakis, Gina Manda, Georgia I. Terzoudi, Alexandros G. Georgakilas

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Influence of Hypoxia on Radiosensitization of Cancer Cells by 5-Bromo-2′-deoxyuridine by Magdalena Zdrowowicz, Paulina Spisz, Aleksandra Hać, Anna Herman-Antosiewicz, Janusz Rak

Subjects: “…radiosensitizer…”
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The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells by Roberto Gomez-Casal, Chitralekha Bhattacharya, Michael W. Epperly, Per H. Basse, Hong Wang, Xinhui Wang, David A. Proia, Joel S. Greenberger, Mark A. Socinski, Vera Levina

“…Both pretreatment and post-radiation treatment with ganetespib at low nanomolar concentrations induced radiosensitization in lung AC cells in vitro. Ganetespib may impart radiosensitization through multiple mechanisms: such as down regulation of the PI3K/Akt pathway; diminished DNA repair capacity and promotion of cellular senescence. …”
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Microdosimetric Investigation and a Novel Model of Radiosensitization in the Presence of Metallic Nanoparticles by Huagang Yan, David J. Carlson, Ramin Abolfath, Wu Liu

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Gadolinium-Based Nanoparticles for Theranostic MRI-Guided Radiosensitization in Hepatocellular Carcinoma by Pengcheng Hu, Zhequan Fu, Guobing Liu, Hui Tan, Jie Xiao, Hongcheng Shi, Hongcheng Shi, Dengfeng Cheng, Dengfeng Cheng

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Individual Radiosensitivity as a Risk Factor for the Radiation-Induced Acute Radiodermatitis by Juras Kišonas, Jonas Venius, Olga Sevriukova, Mindaugas Grybauskas, Daiva Dabkevičienė, Arvydas Burneckis, Ričardas Rotomskis

Subjects: “…individual radiosensitivity…”
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Radiosensitization by Gold Nanoparticles: Impact of the Size, Dose Rate, and Photon Energy by Kirill V. Morozov, Maria A. Kolyvanova, Maria E. Kartseva, Elena M. Shishmakova, Olga V. Dement’eva, Alexandra K. Isagulieva, Magomet H. Salpagarov, Alexandr V. Belousov, Victor M. Rudoy, Alexander A. Shtil, Alexander S. Samoylov, Vladimir N. Morozov

Subjects: “…radiosensitizers…”
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Limitations of radiosensitization by direct telomerase inhibition to treat high-risk medulloblastoma by Satarupa Sengupta, Shiva Senthil Kumar, Kathryn Bondra, Matthew Sobo, Xiaokui Mo, Rachid Drissi, Rachid Drissi

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ADNP is associated with immune infiltration and radiosensitivity in hepatocellular carcinoma for predicting the prognosis by Xuan Wang, Honghua Peng, Ganghua Zhang, Zeyuan Li, Zhangyan Du, Bin Peng, Peiguo Cao

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Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer by Kimi Drobin, Michal Marczyk, Martin Halle, Daniel Danielsson, Anna Papiez, Traimate Sangsuwan, Annika Bendes, Mun-Gwan Hong, Ulrika Qundos, Mats Harms-Ringdahl, Peter Wersäll, Joanna Polanska, Jochen M. Schwenk, Siamak Haghdoost

Subjects: “…radiosensitivity…”
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The effect of metformin and GANT61 combinations on the radiosensitivity of prostate cancer cells by Gonnissen, A, Isebaert, S, McKee, C, Muschel, R, Haustermans, K

“…Nevertheless, neither the growth inhibitory effect nor the radiosensitization effect of the combination treatment observed in vitro was seen in vivo. …”

Depletion of Signal Recognition Particle 72kDa increases radiosensitivity by Prevo, R, Tiwana, G, Maughan, T, Buffa, F, McKenna, W, Higgins, G

“…The identification of genetic determinants that underpin tumor radioresistance can help the development of targeted radiosensitizers or aid personalization of radiotherapy treatment. …”

The radiosensitizing effects of Nelfinavir on pancreatic cancer with and without pancreatic stellate cells by Al-Assar, O, Bittner, M, Lunardi, S, Stratford, M, McKenna, W, Brunner, T

“…Reverse translationally, we aimed to test the influence of PSCs on nelfinavir mediated radiosensitization to PDAC preclinically, because PDAC is very rich in desmoplasia and PSCs are known to mediate radioresistance.…”

Modifying radiosensitivity in tumors: Targeting the Ras-PI-3 kinase pathway. by Muschel, R, Gupta, A, Bernhard, E, McKenna, G

A siRNA screen to identify molecular determinants of tumour radiosensitivity by Higgins, G, Geoffrey Higgins

“…However, many of the key mechanisms that determine intrinsic tumour radiosensitivity are largely unknown. This thesis is concerned with the identification of novel determinants of tumour radiosensitivity. …”

Radiosensitivity of colorectal cancer to 90Y and the radiobiological implications for radioembolisation therapy by Lee, B, Abbott, E, Able, S, Thompson, J, Hill, M, Kartsonaki, C, Vallis, K, Falzone, N

“…Statistical regression based on the linear-quadratic model was used to determine the radiosensitivity parameters α and β using R. These results were compared to radiosensitivity parameters determined for 6 MV clinical x-rays and 137Cs γ-ray exposure. …”

Mechanism and clinical value of exosomes and exosomal contents in regulating solid tumor radiosensitivity by Huihui Sun, Rui Sun, Xing Song, Wendong Gu, Yingjie Shao

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Murine Breast Cancer Radiosensitization Using Oxygen Microbubbles and Metformin: Vessels Are the Key by Agnieszka Drzał, Gabriela Dziurman, Paweł Hoła, Jakub Lechowski, Anthony Delalande, Jan Swakoń, Chantal Pichon, Martyna Elas

“…The investigated therapy protocols led to nearly twice the radiosensitivity of 4T1 tumors; however, no significant differences in radiosensitivity were observed between the various treatment groups. …”
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