SapC–DOPS as a Novel Therapeutic and Diagnostic Agent for Glioblastoma Therapy and Detection: Alternative to Old Drugs and Agents by Ahmet Kaynak, Harold W. Davis, Subrahmanya D. Vallabhapurapu, Koon Y. Pak, Brian D. Gray, Xiaoyang Qi

“…Nanocarriers also can be used for delivery of radiosensitizers to the tumor to enhance the efficacy of the radiation therapy. …”
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Dosimetry Effects Due to the Presence of Fe Nanoparticles for Potential Combination of Hyperthermic Cancer Treatment with MRI-Based Image-Guided Radiotherapy by Amiel Gayol, Francisco Malano, Clara Ribo Montenovo, Pedro Pérez, Mauro Valente

“…A theoretical temperature-dependent model for the thermal enhancement ratio (<i>TER</i>) has been used to account for radiosensitization due to hyperthermia. The outcomes demonstrated the reliability of the Monte Carlo approach in accounting for strong magnetic fields and mass distributions from patient-specific anatomy CT scans to assess dose distributions in MRI-based image-guided radiotherapy combined with magnetic nanoparticles, while the hyperthermic radiosensitization provides further and synergic contributions.…”
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Effect of combined modality treatment on morphofunctional state of bronchial epithelium in lung cancer patients by A. Yu. Dobrodeev, O. V. Pankova, A. A. Zavyalov, S. A. Tuzikov, O, V. Cheremisina

“…Surgery with intraoperative radiation therapy at a single dose of 10 Gy or 15 Gy with cisplatin radiosensitization caused mucosal damage as alteration, dystrophy and desqumation of the covering epithelium. …”
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The Role of Radiotherapy in Treating Kaposi’s Sarcoma in HIV Infected Patients by Laurent Quéro, Romain Palich, Marc-Antoine Valantin, on behalf of CANCERVIH Working Group

“…Kaposi’s sarcoma (KS) is a radiosensitive cancer regardless of its form (classical, endemic, AIDS-related, and immunosuppressant therapy-related). …”
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Radiation therapy for hepatocellular carcinoma: current status and perspectives from our experience by Wei Jiang, Zhao-chong Zeng

“…Following the initial observation that HCC is radiosensitive and with the development of radiation technology, radiotherapy has become a feasible and promising treatment modality for HCC, particularly for advanced forms of the disease. …”
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Harnessing the potential of multimodal radiotherapy in prostate cancer by Philippou, Y, Sjoberg, H, Lamb, AD, Camilleri, P, Bryant, RJ

“…However, emerging clinical evidence suggests that radiotherapy can be incorporated into multimodality therapy regimens beyond ADT, in combinations that include chemotherapy, radiosensitizing agents, immunotherapy and surgery for the treatment of men with localized and locally advanced prostate cancer, and those with oligometastatic disease, in whom the low metastatic burden in particular might be treatable with these combinations. …”

Molecular fingerprinting of radiation resistant tumors: Can we apprehend and rehabilitate the suspects? by Gaar Micah, Rosser Charles J, Porvasnik Stacy

“…In this article, we summarize the findings of recent investigations of radiosensitizing agents in the treatment of prostate cancer.…”
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GSK3β and β-Catenin Modulate Radiation Cytotoxicity in Pancreatic Cancer by Richard L. Watson, Aaron C. Spalding, Steven P. Zielske, Meredith Morgan, Alex C. Kim, Guido T. Bommer, Hagit Eldar-Finkelman, Thomas Giordano, Eric R. Fearon, Gary D. Hammer, Theodore S. Lawrence, Edgar Ben-Josef

“…Silencing of β-catenin resulted in radiosensitization, whereas a nondegradable β-catenin construct induced radioresistance. …”
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Evaluation of a Developed MRI-Guided Focused Ultrasound System in 7 T Small Animal MRI and Proof-of-Concept in a Prostate Cancer Xenograft Model to Improve Radiation Therapy by Xinrui Zhang, Sebastian Greiser, Upasana Roy, Franziska Lange, Robbert van Gorkum, Marc Fournelle, Daniel Speicher, Steffen Tretbar, Andreas Melzer, Lisa Landgraf

“…Here, we studied radiosensitization as a combination therapy of FUS and RT in a xenograft mouse model using newly developed MRI-compatible FUS equipment. …”
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Comparative Proteomic Analysis of Irradiation-Induced Radioresistant Breast Cancer Cells Using Label-Free Quantitation by Yingxia Ying, Lei Bian, Yiling Meng, Meichao Zhang, Yuan Yao, Fang Bo, Dong Li

“…It is worth noting that the functions and pathways related to ribosomes were significantly enriched, therefore ribosomal proteins (RPL6 and RPS13) were identified through western blot and highly expressed in relatively radiosensitive cells. Additionally, several identified proteins, including S100A4, RanBP9, and ISG15, were also verified to be differentially expressed in different radiosensitive cells. …”
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Genotoxic stress induces Sca‐1‐expressing metastatic mammary cancer cells by Jianlin Gong, Benjamin J. Lang, Desheng Weng, Takanori Eguchi, Ayesha Murshid, Thiago J. Borges, Sachin Doshi, Baizheng Song, Mary A. Stevenson, Stuart K. Calderwood

“…The Sca‐1+, metastatic phenotype was inhibited by both Cox2 inhibitors and PGE2 receptor antagonists, suggesting novel approaches to radiosensitization.…”
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Multimodality treatment in patients with operable distal rectal cancer by Yu. A. Barsukov, S. I. Tkachev, D. V. Kuzmichev, Z. Z. Mamedli, A. M. Pavlova

“…An original treatment scheme has been developed, incorporating radiotherapy (short course 5 Ч 5 Gy) with 2 radiosensitizers and systemic cytotoxic therapy with fluorpyrimidines (capecitabine). …”
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The Impact of Nanomedicine on Soft Tissue Sarcoma Treated by Radiotherapy and/or Hyperthermia: A Review by Maria-Eleni Zachou, Vassilis Kouloulias, Marina Chalkia, Efstathios Efstathopoulos, Kalliopi Platoni

“…This review focuses on recent research in nanoparticle applications, including their role in enhancing RT and HT efficacy through improved drug delivery systems, novel radiosensitizers, and imaging agents. Reviewing the current state of nanoparticle-assisted therapies, this paper sheds light on their potential to revolutionize soft tissue sarcoma treatment and improve patient therapy outcomes.…”
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P38 MAPK and Radiotherapy: Foes or Friends? by Natalia García-Flores, Jaime Jiménez-Suárez, Cristina Garnés-García, Diego M. Fernández-Aroca, Sebastia Sabater, Ignacio Andrés, Antonio Fernández-Aramburo, María José Ruiz-Hidalgo, Borja Belandia, Ricardo Sanchez-Prieto, Francisco J. Cimas

“…In this review, we summarize the current knowledge on this family of MAPKs in response to IR as well as in different aspects related to radiotherapy, such as their role in the control of REDOX, fibrosis, and in the radiosensitizing effect of several compounds.…”
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Targeting GSTP1-dependent ferroptosis in lung cancer radiotherapy: Existing evidence and future directions by Xin Tan, Xin Tan, Xiang Huang, Baolong Niu, Xingdong Guo, Xingdong Guo, Xiao Lei, Baolin Qu

“…The potential mechanism of targeting GSTP1 to inhibit tumor cells from evading ferroptosis leading to radioresistance has been proposed in this review, which implies that GSTP1 may play a key role in radiosensitization of lung cancer via ferroptosis pathway.…”
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Metal-organic frameworks for hepatocellular carcinoma therapy and mechanism by Yingqi Feng, Wei Wu, Muzi Li

“…In addition, MOFs can be used to combine with a variety of therapeutic drugs, including chemotherapeutics drugs, photosensitizers, and radiosensitizers, to efficiently deliver drugs to tumor tissue and achieve desired treatment. …”
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Radiation-induced hypopituitarism. by Fernandez, A, Brada, M, Zabuliene, L, Karavitaki, N, Wass, J

“…The hypothalamic-pituitary unit is a particularly radiosensitive region in the central nervous system. As a consequence, hypopituitarism commonly develops after radiation treatments for sellar and parasellar neoplasms, extrasellar brain tumours, head and neck tumours, and following whole body irradiation for systemic malignancies. …”

Unusual Manifestation of Extraosseous Ewing Sarcoma: Report of 3 Cases by Ioannidou M., Tsotridou E., Samoladas E., Tragiannidis A., Kouskouras K., Sfougaris D., Spyridakis I., Foroulis C., Galli-Tsinopoulou A., Hatzipantelis E.

“…Their clinical presentation depends mainly on the primary location of the tumor and are highly chemosensitive and radiosensitive. The purpose of this study was to describe the clinical characteristics and outcomes of 3 children with EES and uncommon presentation treated in our Unit. …”
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A radiolabeled antibody targeting CD123+ leukemia stem cells – initial radioimmunotherapy studies in NOD/SCID mice engrafted with primary human AML by Jeffrey V. Leyton, Catherine Gao, Brent Williams, Armand Keating, Mark Minden, Raymond M. Reilly

“…However, NOD/SCID mice were very radiosensitive to these doses. At low non-toxic treatment doses, 111In-NLS-CSL360 demonstrated a trend towards improved survival associated with decreased spleen/body weight ratio, an indicator of leukemia burden, and almost complete eradication of leukemia from the bone marrow in some mice.…”
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Metallacarboranes for proton therapy using research accelerators: a pilot study by Teresa Pinheiro, Luís C. Alves, Victoria Corregidor, Francesc Teixidor, Clara Viñas, Fernanda Marques

“…A pilot study on the effect of boron-rich metallacarboranes as radiosensitizers towards human glioblastoma cells was carried out. …”
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