Co-Adjuvant Nanoparticles for Radiotherapy Treatments of Oncological Diseases by Roberta Crapanzano, Valeria Secchi, Irene Villa

“…High-Z nanoparticles are proposed as radiosensitizers due to their ability to stop the ionizing radiation and to increase the locally delivered therapeutic dose. …”
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Focused Ultrasound and Ultrasound Stimulated Microbubbles in Radiotherapy Enhancement for Cancer Treatment by Kai Xuan Leong MSc, Deepa Sharma PhD, Gregory J. Czarnota PhD, MD, FRCPC

“…Ultrasound-stimulated microbubbles have recently proved to be a novel way of enhancing RT as a radioenhancing agent on its own, or as a delivery vector for radiosensitizing agents such as oxygen. In this mini-review article, we discuss the bio-effects of FUS and RT in various preclinical models and highlight the applicability of this combined therapy in clinical settings.…”
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Interaction of amphiphilic gold nanoparticles with lipid membranes and their application to cancer radiotherapy by Yang, Yu-Sang Sabrina

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Preclinical testing of an ATR inhibitor demonstrates improved response to standard therapies for esophageal cancer by Leszczynska, K, Dobrynin, G, Leslie, R, Ient, J, Boumelha, A, Senra, J, Hawkins, M, Maughan, T, Mukherjee, S, Hammond, E

“…</p> <h4>Conclusions</h4> <p>VX-970 is an effective chemo/radiosensitizer which could be readily integrated in the current treatment paradigm to improve the treatment response in esophageal cancer and we plan to test it prospectively in the forthcoming phase I dose escalation safety study combining the ATR inhibitor VX-970 with chemoradiotherapy in esophageal cancer (EudraCT number: 2015-003965-27).…”

Radiotherapy combined with nano-biomaterials for cancer radio-immunotherapy by Qingrong Dong, Tingyu Xue, Haili Yan, Fang Liu, Ruixue Liu, Kun Zhang, Yu Chong, Jiangfeng Du, Hui Zhang

“…We first discuss the combination of different radiosensitizing nano-biomaterials and immune checkpoint inhibitors to enhance tumor immune response and improve radiotherapy efficacy. …”
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An inorganic mineral-based protocell with prebiotic radiation fitness by Shang Dai, Zhenming Xie, Binqiang Wang, Rui Ye, Xinwen Ou, Chen Wang, Ning Yu, Cheng Huang, Jie Zhao, Chunhui Cai, Furong Zhang, Damiano Buratto, Taimoor Khan, Yan Qiao, Yuejin Hua, Ruhong Zhou, Bing Tian

“…Among the coacervate droplets, only the polyP-Mn droplet is radiotolerant and provides strong protection for recruited proteins. The radiosensitive polyP-tripeptide droplet sequestered with both proteins and DNA could be encapsulated inside the polyP-Mn droplet, and form into a compartmentalized protocell. …”
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Why Concurrent CDDP and Radiotherapy Has Synergistic Antitumor Effects: A Review of In Vitro Experimental and Clinical-Based Studies by Shinsuke Nagasawa, Junko Takahashi, Gen Suzuki, Yamazaki Hideya, Kei Yamada

“…In fact, the two concepts are inseparable, but conceptualizing them separately will help us understand the mechanism underlying the synergism between radiation therapy and other anticancer drugs, and help us to design future radiosensitizers.…”
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Nanobiotechnology‐mediated radioimmunotherapy treatment for triple‐negative breast cancer by Mei Zhu, Xi Yang, Jia You, Lingnan Zheng, Cheng Yi, Ying Huang

“…It is mainly characterized by the controlled release of drugs locally, enhanced radiosensitization, and avoidance of systemic toxicity. …”
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Recent Research on Combination of Radiotherapy with Targeted Therapy or Immunotherapy in Head and Neck Squamous Cell Carcinoma: A Review for Radiation Oncologists by Daniel Tao Xing, Richard Khor, Hui Gan, Morikatsu Wada, Tai Ermongkonchai, Sweet Ping Ng

“…Concurrent radiotherapy with radiosensitizing cisplastin chemotherapy is the standard of care (SOC) for non-operable locally advanced HNSCC. …”
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Repurposing Antimalarial Pyronaridine as a DNA Repair Inhibitor to Exploit the Full Potential of Gold-Nanoparticle-Mediated Radiation Response by Nolan Jackson, Abdulaziz Alhussan, Kyle Bromma, David Jay, James C. Donnelly, Frederick G. West, Afsaneh Lavasanifar, Michael Weinfeld, Wayne Beckham, Devika B. Chithrani

“…One of the major issues in RT is normal tissue toxicity; thus, it is necessary to limit dose escalation for enhanced local control in patients that have locally advanced tumors. Integrating radiosensitizing agents such as gold nanoparticles (GNPs) into RT has been shown to greatly increase the cure rate of solid tumors. …”
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m6A demethylase FTO renders radioresistance of nasopharyngeal carcinoma via promoting OTUB1-mediated anti-ferroptosis by Wei-Mei Huang, Zhi-Xun Li, Ying-Hui Wu, Zhi-Ling Shi, Jing-Lin Mi, Kai Hu, Ren-Sheng Wang

“…In this study, we observed that the m6A mRNA demethylase fat mass and obesity-associated protein (FTO) was significantly upregulated in radioresistant NPC tissues and cells relative to parental radiosensitive NPC tissues and cells. FTO enhances radioresistance by repressing radiation-induced ferroptosis in NPC. …”
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Synthesis of Radioluminescent CaF₂:Ln Core, Mesoporous Silica Shell Nanoparticles for Use in X-ray Based Theranostics by Hayden Winter, Megan J. Neufeld, Lydia Makotamo, Conroy Sun, Andrea M. Goforth

“…The potential of these nanomaterials to act as radiosensitizers for enhancing X-ray radiotherapy was supported by reactive oxygen species generation assays. …”
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Evaluation of Organ and Effective Doses to Patients Arising From Some Common X-Ray Examinations by PCXMC Program in Sabzevar, Iran by Hasan Zarghani, Mohammad Taghi Bahreyni Toossi

“…Conclusion Radiation doses to radiosensitive organs such as the ovaries, testicles, and thyroid may induce harmful effects, e.g., cancer and genetic effects. …”
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Human Serum Albumin in the Presence of AGuIX Nanoagents: Structure Stabilisation without Direct Interaction by Xiaomin Yang, Marta Bolsa-Ferruz, Laurent Marichal, Erika Porcel, Daniela Salado-Leza, François Lux, Olivier Tillement, Jean-Philippe Renault, Serge Pin, Frank Wien, Sandrine Lacombe

“…The gadolinium-based nanoagent named AGuIX^® is a unique radiosensitizer and contrast agent which improves the performance of radiotherapy and medical imaging. …”
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A review of bismuth‐based nanoparticles and their applications in radiosensitising and dose enhancement for cancer radiation therapy by Daryoush Shahbazi‐Gahrouei, Yazdan Choghazardi, Arezoo Kazemzadeh, Paria Naseri, Saghar Shahbazi‐Gahrouei

“…Targeted and non‐targeted bismuth‐based NPs used in radiotherapy as radiosensitizers and dose enhancement effects are described. …”
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Radioembolization Treatment for Liver Cancer by Ezgi Başak ERDOĞAN, Hüseyin ÖZDEMİR, Mehmet AYDIN

“…It is hoped that the effectiveness of radioembolization is further increased in the future by technological developments, researches on dosimetry, its use along with radiosensitizing agents, and various treatment combinations.…”
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Endoscopic Ultrasound–Guided Fiducial Placement for Stereotactic Body Radiation Therapy in Pancreatic Malignancy by Seong-Hun Kim, Eun Ji Shin

“…However, the high radiation doses delivered during SBRT may cause damage to adjacent radiosensitive organs. To minimize such damage, fiducial markers are used for localization during SBRT for pancreatic cancer. …”
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A Synergetic Approach Utilizing Nanotechnology, Chemotherapy, and Radiotherapy for Pancreatic Cancer Treatment by Abdulaziz Alhussan, Reinali Calisin, Nolan Jackson, Jessica Morgan, Sam Chen, Yuen Yi C. Tam, Wayne Beckham, Sunil Krishnan, Devika Chithrani

“…The combination of GNPs and LNPDTX-P with RT showed a synergetic effect due to their radiosensitizing properties, improving the ther-apeutic efficacy of each treatment modality alone. …”
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The drug-resistance to gefitinib in PTEN low expression cancer cells is reversed by irradiation in vitro by Zhao Lu-Jun, Yuan Zhi-Yong, Wang Jun, Zhuang Hong-Qing, Wang Ping, Wang Chang-Li

“…The PTEN expressions and radiosensitizing effects of tyrosine kinase inhibitor before and after irradiation were observed. …”
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The Evaluation of Melatonin Effect Against The Early Effect of Ionizing Radiation Induced Lung Injury by raziyeh tahamtan, gholam hassan haddadi, ali reza tavassoli

“…Background & Objective: Lung is a radiosensitive organ. Patients who are undergoing radiation therapy in their chest are subjected to radiation pneumonitis in the early phase and pulmonary fibrosis in the late one. …”
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