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1281
Co-Adjuvant Nanoparticles for Radiotherapy Treatments of Oncological Diseases
Published 2021-07-01“…High-Z nanoparticles are proposed as radiosensitizers due to their ability to stop the ionizing radiation and to increase the locally delivered therapeutic dose. …”
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1282
Focused Ultrasound and Ultrasound Stimulated Microbubbles in Radiotherapy Enhancement for Cancer Treatment
Published 2023-05-01“…Ultrasound-stimulated microbubbles have recently proved to be a novel way of enhancing RT as a radioenhancing agent on its own, or as a delivery vector for radiosensitizing agents such as oxygen. In this mini-review article, we discuss the bio-effects of FUS and RT in various preclinical models and highlight the applicability of this combined therapy in clinical settings.…”
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1283
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1284
Preclinical testing of an ATR inhibitor demonstrates improved response to standard therapies for esophageal cancer
Published 2016“…</p> <h4>Conclusions</h4> <p>VX-970 is an effective chemo/radiosensitizer which could be readily integrated in the current treatment paradigm to improve the treatment response in esophageal cancer and we plan to test it prospectively in the forthcoming phase I dose escalation safety study combining the ATR inhibitor VX-970 with chemoradiotherapy in esophageal cancer (EudraCT number: 2015-003965-27).…”
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1285
Radiotherapy combined with nano-biomaterials for cancer radio-immunotherapy
Published 2023-10-01“…We first discuss the combination of different radiosensitizing nano-biomaterials and immune checkpoint inhibitors to enhance tumor immune response and improve radiotherapy efficacy. …”
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1286
An inorganic mineral-based protocell with prebiotic radiation fitness
Published 2023-12-01“…Among the coacervate droplets, only the polyP-Mn droplet is radiotolerant and provides strong protection for recruited proteins. The radiosensitive polyP-tripeptide droplet sequestered with both proteins and DNA could be encapsulated inside the polyP-Mn droplet, and form into a compartmentalized protocell. …”
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1287
Why Concurrent CDDP and Radiotherapy Has Synergistic Antitumor Effects: A Review of In Vitro Experimental and Clinical-Based Studies
Published 2021-03-01“…In fact, the two concepts are inseparable, but conceptualizing them separately will help us understand the mechanism underlying the synergism between radiation therapy and other anticancer drugs, and help us to design future radiosensitizers.…”
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1288
Nanobiotechnology‐mediated radioimmunotherapy treatment for triple‐negative breast cancer
Published 2023-03-01“…It is mainly characterized by the controlled release of drugs locally, enhanced radiosensitization, and avoidance of systemic toxicity. …”
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1289
Recent Research on Combination of Radiotherapy with Targeted Therapy or Immunotherapy in Head and Neck Squamous Cell Carcinoma: A Review for Radiation Oncologists
Published 2021-11-01“…Concurrent radiotherapy with radiosensitizing cisplastin chemotherapy is the standard of care (SOC) for non-operable locally advanced HNSCC. …”
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1290
Repurposing Antimalarial Pyronaridine as a DNA Repair Inhibitor to Exploit the Full Potential of Gold-Nanoparticle-Mediated Radiation Response
Published 2022-12-01“…One of the major issues in RT is normal tissue toxicity; thus, it is necessary to limit dose escalation for enhanced local control in patients that have locally advanced tumors. Integrating radiosensitizing agents such as gold nanoparticles (GNPs) into RT has been shown to greatly increase the cure rate of solid tumors. …”
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1291
m6A demethylase FTO renders radioresistance of nasopharyngeal carcinoma via promoting OTUB1-mediated anti-ferroptosis
Published 2023-01-01“…In this study, we observed that the m6A mRNA demethylase fat mass and obesity-associated protein (FTO) was significantly upregulated in radioresistant NPC tissues and cells relative to parental radiosensitive NPC tissues and cells. FTO enhances radioresistance by repressing radiation-induced ferroptosis in NPC. …”
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1292
Synthesis of Radioluminescent CaF<sub>2</sub>:Ln Core, Mesoporous Silica Shell Nanoparticles for Use in X-ray Based Theranostics
Published 2020-07-01“…The potential of these nanomaterials to act as radiosensitizers for enhancing X-ray radiotherapy was supported by reactive oxygen species generation assays. …”
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1293
Evaluation of Organ and Effective Doses to Patients Arising From Some Common X-Ray Examinations by PCXMC Program in Sabzevar, Iran
Published 2016-04-01“…Conclusion Radiation doses to radiosensitive organs such as the ovaries, testicles, and thyroid may induce harmful effects, e.g., cancer and genetic effects. …”
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1294
Human Serum Albumin in the Presence of AGuIX Nanoagents: Structure Stabilisation without Direct Interaction
Published 2020-06-01“…The gadolinium-based nanoagent named AGuIX<sup>®</sup> is a unique radiosensitizer and contrast agent which improves the performance of radiotherapy and medical imaging. …”
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1295
A review of bismuth‐based nanoparticles and their applications in radiosensitising and dose enhancement for cancer radiation therapy
Published 2023-06-01“…Targeted and non‐targeted bismuth‐based NPs used in radiotherapy as radiosensitizers and dose enhancement effects are described. …”
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1296
Radioembolization Treatment for Liver Cancer
Published 2016-04-01“…It is hoped that the effectiveness of radioembolization is further increased in the future by technological developments, researches on dosimetry, its use along with radiosensitizing agents, and various treatment combinations.…”
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1297
Endoscopic Ultrasound–Guided Fiducial Placement for Stereotactic Body Radiation Therapy in Pancreatic Malignancy
Published 2021-05-01“…However, the high radiation doses delivered during SBRT may cause damage to adjacent radiosensitive organs. To minimize such damage, fiducial markers are used for localization during SBRT for pancreatic cancer. …”
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1298
A Synergetic Approach Utilizing Nanotechnology, Chemotherapy, and Radiotherapy for Pancreatic Cancer Treatment
Published 2023-11-01“…The combination of GNPs and LNPDTX-P with RT showed a synergetic effect due to their radiosensitizing properties, improving the ther-apeutic efficacy of each treatment modality alone. …”
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1299
The drug-resistance to gefitinib in PTEN low expression cancer cells is reversed by irradiation in vitro
Published 2009-09-01“…The PTEN expressions and radiosensitizing effects of tyrosine kinase inhibitor before and after irradiation were observed. …”
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1300
The Evaluation of Melatonin Effect Against The Early Effect of Ionizing Radiation Induced Lung Injury
Published 2014-05-01“…Background & Objective: Lung is a radiosensitive organ. Patients who are undergoing radiation therapy in their chest are subjected to radiation pneumonitis in the early phase and pulmonary fibrosis in the late one. …”
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Article