Does partial expander deflation exacerbate the adverse effects of radiotherapy in two-stage breast reconstruction? by Celet Ozden Burcu, Guven Erdem, Aslay Isik, Kemikler Gonul, Olgac Vakur, Soluk Tekkesin Merva, Serarslan Bengul, Tumerdem Ulug Burcak, Bilgin Karabulut Aylin, Arinci Atilla, Emekli Ufuk

“…</p> <p>Conclusions</p> <p>Expander deflation immediately prior to radiotherapy, may augment the adverse effects, especially in the lower expander pole, possibly via enhanced radiosensitization due to a relative increase in the blood flow and tissue oxygenation.…”
Get full text

Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells by Kazuko Fujita, Taku Kuwabara, Bing Wang, Kaoru Tanaka, Kei Ito, Yuri Akishima-Fukasawa, Tetuo Mikami, Yoshikiyo Akasaka, Toshiharu Ishii

“…We previously demonstrated that CD180-negative cells, these are radiosensitive, contribute to the development of SLE-like morbidity in NZBWF1 mice. …”
Get full text

The First Stereotactic Linear-based Radiosurgery in Iran by Ali Reza Khoshbin Khoshnazar, Mohammad Taghi Bahreini Tousi, Abdul Reza Hashemian, Roham Salek

“…CONCLUSION: Stereotactic treatment gets its own importance in view of two parameter: a) precision: as intracranial targets dose not exceed of 40 mm in diameter so localization must be performed with a high precision; b) high dose: as doses in range of 10 to 40 Gy is delivered to target in one fraction, any error may yield a irreparable damage to radiosensitive critical organs in brain. Possibility of designing and constructing any modern radiotherapy modality in our country was a direct deduction of this project. …”
Get full text

Gold Nanoparticle DNA Damage by Photon Beam in a Magnetic Field: A Monte Carlo Study by Mehwish Jabeen, James C. L. Chow

“…Ever since the emergence of magnetic resonance (MR)-guided radiotherapy, it is important to investigate the impact of the magnetic field on the dose enhancement in deoxyribonucleic acid (DNA), when gold nanoparticles are used as radiosensitizers during radiotherapy. Gold nanoparticle-enhanced radiotherapy is known to enhance the dose deposition in the DNA, resulting in a double-strand break. …”
Get full text

Magnetic Resonance Imaging-Guided Adaptive Radiotherapy for Colorectal Liver Metastases by Paul B. Romesser, Neelam Tyagi, Christopher H. Crane

“…For larger tumors, the safe delivery of SABR can be challenging due to a more limited volume of healthy normal liver parenchyma and the proximity of the tumor to radiosensitive organs such as the stomach, duodenum, and large intestine. …”
Get full text

Combined use of NK cells and radiotherapy in the treatment of solid tumors by Wang Zheng, Sunkai Ling, Yuandong Cao, Chunlin Shao, Xinchen Sun

“…Noteworthy, the puissant cytotoxic activity of NK cells not only kills tumor cells directly, but also increases the response of tumors to radiation via activating several radiosensitization pathways. Herein, we review the mechanisms by which NK cells and radiotherapy mutually promote their killing function against solid malignancies. …”
Get full text

Single-cell map of dynamic cellular microenvironment of radiation-induced intestinal injury by Hao Lu, Hua Yan, Xiaoyu Li, Yuan Xing, Yumeng Ye, Siao Jiang, Luyu Ma, Jie Ping, Hongyan Zuo, Yanhui Hao, Chao Yu, Yang Li, Gangqiao Zhou, Yiming Lu

“…We showed that the various cell types of intestine exhibited heterogeneous radiosensitivities. We revealed the distinct dynamic patterns of three subtypes of intestinal stem cells (ISCs), and the cellular trajectory analysis suggested a complex interconversion pattern among them. …”
Get full text

The first solid-state route to luminescent Au(I)—glutathionate and its pH-controlled transformation into ultrasmall oligomeric Au10–12(SG)10–12 nanoclusters for application in canc... by Andrea Deák, Pál T. Szabó, Vendula Bednaříková, Jaroslav Cihlář, Attila Demeter, Michaela Remešová, Evelina Colacino, Ladislav Čelko

“…Therefore, we present herein a new and eco-friendly methodology to access oligomeric glutathione-based gold nanoclusters, already finding applications in biomedical field as efficient radiosensitizers in cancer radiotherapy.…”
Get full text

GDF15 Contributes to Radioresistance by Mediating the EMT and Stemness of Breast Cancer Cells by Xinrui Zhao, Xinglong Liu, Songling Hu, Yan Pan, Jianghong Zhang, Guomei Tai, Chunlin Shao

“…In this study, using bioinformatic analysis of GSE59732 and GSE59733 datasets in the Gene Expression Omnibus (GEO) database together with the prognosis database of breast cancer patients after radiotherapy, the <i>GDF15</i> gene was screened out to be related to the poor prognosis of breast cancer after radiotherapy. Compared with radiosensitive parental breast cancer cells, breast cancer cells with acquired radioresistance exhibited a high level of GDF15 expression and enhanced epithelial-to-mesenchymal transition (EMT) properties of migration and invasion, as well as obvious stem-like traits, including the increases of mammosphere formation ability, the proportion of stem cells (CD44⁺ CD24⁻ cells), and the expressions of stem cell-related markers (SOX2, NANOG). …”
Get full text

Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways by Yu-An Chen, David T. W. Tzeng, Yi-Ping Huang, Chun-Jung Lin, U-Ging Lo, Chia-Lin Wu, Ho Lin, Jer-Tsong Hsieh, Chih-Hsin Tang, Chih-Ho Lai

“…In this study, we emphasized the effects of antrocin on radioresistant PCa cells and addressed the molecular mechanism underlying the radiosensitization induced by antrocin. Our results showed that a combination treatment with antrocin and ionizing radiation (IR) synergistically inhibited cell proliferation and induced apoptosis in radioresistant PCa cells. …”
Get full text

Hypofractionated Radiotherapy in Locally Advanced Myxoid Liposarcomas of Extremities or Trunk Wall: Results of a Single-Arm Prospective Clinical Trial by Hanna Koseła-Paterczyk, Mateusz Spałek, Aneta Borkowska, Paweł Teterycz, Michał Wągrodzki, Anna Szumera-Ciećkiewicz, Tadeusz Morysiński, Patrycja Castaneda-Wysocka, Andrzej Cieszanowski, Marcin Zdzienicki, Tomasz Goryń, Piotr Rutkowski

“…Introduction: Myxoid liposarcoma (MLPS) has been reported to be more radiosensitive compared with other soft tissue sarcomas. …”
Get full text

Prognostic value of hypoxia-responsive gene expression profile in patients diagnosed with head and neck squamous cell carcinoma by Natasa Matic, Lina Pettersson, Felicia Sellebjerg, Lina Lindberg, Karin Roberg, Emilia Wiechec

“…Further studies demonstrated that knockdown of KIF14 reverses its radiosensitizing capability. Additionally, low expression of KIF14 mRNA correlated with significantly shorter OS (overall survival). …”
Get full text

Improving the Efficacy of Common Cancer Treatments via Targeted Therapeutics towards the Tumour and Its Microenvironment by Daniel Cecchi, Nolan Jackson, Wayne Beckham, Devika B. Chithrani

“…To improve the therapeutic efficacy of radiotherapy and chemotherapy, multiple conjunctive modalities have been proposed, which include the targeting of components of the tumour microenvironment inhibiting tumour spread and anti-therapeutic pathways, increasing the oxygen content within the tumour to revert the hypoxic nature of the malignancy, improving the local dose deposition with metal nanoparticles, and the restriction of the cell cycle within radiosensitive phases. The tumour microenvironment is largely responsible for inhibiting nanoparticle capture within the tumour itself and improving resistance to various forms of cancer therapy. …”
Get full text

Radiation-Activated PI3K/AKT Pathway Promotes the Induction of Cancer Stem-Like Cells via the Upregulation of SOX2 in Colorectal Cancer by Ji-Hye Park, Young-Heon Kim, Sehwan Shim, Areumnuri Kim, Hyosun Jang, Su-Jae Lee, Sunhoo Park, Songwon Seo, Won Il Jang, Seung Bum Lee, Min-Jung Kim

“…In this study, we investigated the induction and regulatory role of SOX2 following the irradiation of radioresistant and radiosensitive colorectal cancer cells. We used FACS and western blotting to analyze SOX2 expression in cells. …”
Get full text

Deciphering Differential Life Stage Radioinduced Reproductive Decline in <i>Caenorhabditis elegans</i> through Lipid Analysis by Elizabeth Dufourcq-Sekatcheff, Stephan Cuiné, Yonghua Li-Beisson, Loïc Quevarec, Myriam Richaud, Simon Galas, Sandrine Frelon

“…In invertebrates, reproduction, which directly impacts population dynamics, has been found to be the most radiosensitive endpoint. Understanding the underlying molecular pathways inducing this reproduction decrease can help in predicting the effects at larger scales (i.e., population). …”
Get full text

Combined Modality Bladder-Sparing Therapy for Muscle-Invasive Bladder Cancer: How (Should) We Do It? A Narrative Review by Artur Lemiński, Wojciech Michalski, Bartłomiej Masojć, Krystian Kaczmarek, Bartosz Małkiewicz, Jakub Kienitz, Barbara Zawisza-Lemińska, Michał Falco, Marcin Słojewski

“…A hypofractionated, continuous radiotherapy regimen of 55 Gy in 20 fractions with concurrent radiosensitizing chemotherapy with gemcitabine, cisplatin, or 5-fluorouracil and mitomycin C is currently preferred based on clinical trials. …”
Get full text

PARP Inhibitors Talazoparib and Niraparib Sensitize Melanoma Cells to Ionizing Radiation by Stephanie Jonuscheit, Tina Jost, Fritzi Gajdošová, Maximilian Wrobel, Markus Hecht, Rainer Fietkau, Luitpold Distel

“…Finally, a lower percentage of cells in the radiosensitive G2/M phase is present in the healthy fibroblasts compared to the melanoma cells. (4) Conclusions: Both PARP inhibitors sensitize melanoma cells to IR. …”
Get full text

FEN1 Inhibition as a Potential Novel Targeted Therapy against Breast Cancer and the Prognostic Relevance of FEN1 by Johanna Berfelde, Laura S. Hildebrand, Lukas Kuhlmann, Rainer Fietkau, Luitpold V. Distel

“…FEN1-IN-4 has cytotoxic, cytostatic and radiosensitizing effects, expressed through increasing cell death by apoptosis and necrosis, G2M share, senescence, double-strand breaks and a reduced survival fraction. …”
Get full text

Radioprotection to the Gonads in Pediatric Pelvic Radiography: Effectiveness of Developed Bismuth Shield by Vahid Karami, Mansour Zabihzadeh, Nasim Shams, Mehrdad Golami

“…Moreover, we added a lead piece at the cranial position of the bismuth garment to absorb the scatter radiations to the radiosensitive organs. In girls, 49 radiographs with shield and 46 radiographs without shield was taken. …”
Get full text

Effects of Electron Beam Irradiation on Acaricide-Resistant and Susceptible Strains of <i>Tetranychus</i><i>urticae</i> (Acari: Tetranychidae) by Hyun-Na Koo, Jin-Hyun Oh, Jong-Chan Jeon, Won-Jin Kang, Sun-Ran Cho, Yuri Kim, Gil-Hah Kim

“…These results indicate that a dose of 400 Gy was required to inhibit the normal development and reproduction of <i>T. urticae</i>, and susceptible and acaricide-resistant strains of <i>T. urticae</i> had identical radiosensitivities.…”
Get full text