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PARP inhibitor olaparib enhances the efficacy of radiotherapy on XRCC2-deficient colorectal cancer cells
Published 2022-05-01“…These findings suggest that XRCC2-deficient CRC acquires high sensitivity to PARP inhibition after IR treatment and supports the clinical development for the use of olaparib as a radiosensitizer for treatment of XRCC2-deficient CRC.…”
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Synergistic cerium oxide nanozymes: targeting DNA damage and alleviating tumor hypoxia for improved NSCLC radiotherapy efficiency
Published 2024-01-01“…Under the protection and targeted delivery of Zeolitic Imidazolate Framework-8 (ZIF-8), the nanocomplexes exhibited excellent catalytic mimetic activity in decomposing H2O2 into O2, thus significantly reversing the hypoxia of TME, while the radiosensitizer QT caused DNA damage directly after RT. …”
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Clinical advances in nasopharyngeal carcinoma surgery and a video demonstration
Published 2021-01-01“…Nasopharyngeal carcinoma (NPC) is highly radiosensitive, and radiotherapy is recommended for newly diagnosed NPC. …”
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1344
Energy Metabolism Is Altered in Radioresistant Rectal Cancer
Published 2023-04-01“…Real-time metabolic profiling demonstrated decreased reliance on glycolysis and enhanced mitochondrial spare respiratory capacity in radioresistant SW837 cells when compared to radiosensitive HCT116 cells. Metabolomic profiling of pre-treatment serum samples from rectal cancer patients (<i>n</i> = 52) identified 16 metabolites significantly associated with subsequent pathological response to neoadjuvant chemoradiation therapy. …”
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1345
Vinorelbine Augments Radiotherapy in Hepatocellular Carcinoma
Published 2020-04-01“…Therefore, the purpose of this study was to explore the efficacy and toxicity of the anti-microtubule agent Vinorelbine as a radiosensitizer in HCC. The radio sensitivity of 16 HCC patient-derived xenograft (PDX) models was determined by quantifying the survival fraction following irradiation in vitro, and Vinorelbine radio sensitization was determined by clonogenic assay. …”
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1346
Survey of the Use of X-ray Beam Collimator and Shielding Tools during Infant Chest Radiography
Published 2016-04-01“…Shielding tools were used regularly only by 5% of radiographers. Conclusion The radiosensitive organs of infants located outside of ADI in hospitals investigated are at risk. …”
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1347
Development of a Single-Neurosphere Culture to Assess Radiation Toxicity and Pre-Clinical Cancer Combination Therapy Safety
Published 2023-10-01“…Neural progenitor cells (NPCs) are highly radiosensitive, resulting in decreased neurogenesis in the hippocampus. …”
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1348
Impact of proton therapy on the DNA damage induction and repair in hematopoietic stem and progenitor cells
Published 2023-10-01“…In view of healthy tissue damage and the increased risk of secondary cancers, we investigated DNA damage induction and repair of radiosensitive hematopoietic stem and progenitor cells (HSPCs) exposed to therapeutic proton and photon irradiation due to their role in radiation-induced leukemia. …”
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Merkel Cell Carcinoma from Molecular Pathology to Novel Therapies
Published 2021-06-01“…The basis of MCC treatment is surgical excision. MCC is highly radiosensitive. It becomes chemoresistant within a few months. …”
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An oncolytic virus as a promising candidate for the treatment of radioresistant oral squamous cell carcinoma
Published 2022-12-01“…We evaluated: (1) the antitumor effects of OBP-301 alone and in combination with radiotherapy on radioresistant cell lines, (2) the molecular mechanism underlying the radiosensitizing effect and cell death increased by the combination therapy, and (3) the antitumor effect of the combination therapy in vivo using xenograft models (a radioresistant cell line-derived xenograft in mouse and a patient-derived xenograft). …”
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Proton Therapy, Magnetic Nanoparticles and Hyperthermia as Combined Treatment for Pancreatic BxPC3 Tumor Cells
Published 2023-02-01“…Noticeably, the magnetic nanoparticles’ presence induces radiosensitization effects, and hyperthermia increases the production of ROS, which contributes to cytotoxic cellular effects and to a wide variety of lesions including DNA damage. …”
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NEDD8-conjugating enzyme E2s: critical targets for cancer therapy
Published 2023-01-01“…It is currently reported to inhibit apoptosis and then induce cell growth; hence, targeting UBE2F serves as an effective chemo-/radiosensitizing strategy by triggering apoptosis. This review highlights the most recent advances in the roles of UBE2M and UBE2F in tumor progression, indicating these E2s as two promising anti-tumor targets.…”
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1353
Quantification of Nanoscale Dose Enhancement in Gold Nanoparticle-Aided External Photon Beam Radiotherapy
Published 2022-04-01“…The recent progress in Nanotechnology has introduced Gold Nanoparticles (AuNPs) as promising radiosensitizing agents in radiation oncology. This work aims to estimate dose enhancement due to the presence of AuNPs inside an irradiated water region through Monte Carlo calculations. …”
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1354
Synthesis and Biological Evaluation of <sup>99m</sup>Tc(I) Tricarbonyl Complexes Dual-Targeted at Tumoral Mitochondria
Published 2021-01-01“…For effective Auger therapy of cancer, the Auger-electron emitters must be delivered to the tumor cells in close proximity to a radiosensitive cellular target. Nuclear DNA is considered the most relevant target of Auger electrons to have augmented radiotoxic effects and significant cell death. …”
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Effect of ionizing radiation on the proliferation of human embryonic stem cells
Published 2017“…We found that the RCS values of hESC lines correlated directly with their DT, i.e. the faster cells grow the more radiosensitive they are. We also found that DT and RCS values of individual colonies varied significantly within all hESC lines. …”
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PERBANDINGAN DOSIS RADIASI GONAD PRIA DENGAN SHIELDING 0,35 mmPb DAN SHIELDING 0,50 mmPb PADA PEMERIKSAAN HEAD MULTISLICE COMPUTED TOMOGRAPHY SCAN
Published 2014“…The usage of X-ray in CT gives primary radiation on examined organs and scattered radiation on the surrounding organs. Gonad is a radiosensitive organ, so that radiation protection is required to minimize radiation effects. …”
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Definitive radiotherapy for locally advanced squamous cell carcinoma of the vulva and technical issues: a case report
Published 2017“…At completion of planned radiotherapy, patient had a complete clinical response, grade 2-3 skin toxicity, grade 2 rectal toxicity, and grade 2 dysuria Vulval Squamous Cell Carcinomas are very radiosensitive tumours and the skills of the treating Radiation Oncologist, Dosimetrists, Physicist, Radiation Therapist and also nurses is of foremost importance is ensuring good clinical outcomes.…”
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Intercellular Communication of Tumor Cells and Immune Cells after Exposure to Different Ionizing Radiation Qualities
Published 2017-06-01“…Lymphocytes for example are known to be highly radiosensitive. One important factor in indirect interactions is the radiation-induced bystander effect which can be initiated in unexposed cells by expression of cytokines of the irradiated cells and by direct exchange of molecules via gap junctions. …”
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Orthovoltage X-Ray Therapy of Large Cell Invasive Nasal Lymphoma in Cat
Published 2023-03-01“…Feline nasal lymphoma is generally a localized radiosensitive tumor. Treatment options include radiation therapy, chemotherapy, or a combination of both modalities. …”
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Phase I prospective trial of TAS-102 (trifluridine and tipiracil) and radioembolization with 90Y resin microspheres for chemo-refractory colorectal liver metastases
Published 2022-12-01“…Trifluridine and tipiracil (TAS-102) has overall survival benefit for patients with refractory mCRC and may be a radiosensitizer. Methods Sequential lobar TARE using 90Y resin microspheres in combination with TAS-102 in 28-day cycles were used to treat adult patients with bilobar liver-dominant chemo-refractory mCRC according to 3 + 3 dose escalation design with a 12-patient dose expansion cohort. …”
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