PARP inhibitor olaparib enhances the efficacy of radiotherapy on XRCC2-deficient colorectal cancer cells by Changjiang Qin, Zhiyu Ji, Ertao Zhai, Kaiwu Xu, Yijie Zhang, Quanying Li, Hong Jing, Xiaoliang Wang, Xinming Song

“…These findings suggest that XRCC2-deficient CRC acquires high sensitivity to PARP inhibition after IR treatment and supports the clinical development for the use of olaparib as a radiosensitizer for treatment of XRCC2-deficient CRC.…”
Get full text

Synergistic cerium oxide nanozymes: targeting DNA damage and alleviating tumor hypoxia for improved NSCLC radiotherapy efficiency by Jie Liu, Chengxiang Liu, Jinghua Tang, Qiao Chen, Yan Yu, Yan Dong, Jie Hao, Wei Wu

“…Under the protection and targeted delivery of Zeolitic Imidazolate Framework-8 (ZIF-8), the nanocomplexes exhibited excellent catalytic mimetic activity in decomposing H2O2 into O2, thus significantly reversing the hypoxia of TME, while the radiosensitizer QT caused DNA damage directly after RT. …”
Get full text

Clinical advances in nasopharyngeal carcinoma surgery and a video demonstration by Ding Xi, Liu You-Ping, Hua Yi-Jun, Zou Xiong, Wang Zhi-Qiang, Xie Yu-Long, Chen Ming-Yuan

“…Nasopharyngeal carcinoma (NPC) is highly radiosensitive, and radiotherapy is recommended for newly diagnosed NPC. …”
Get full text

Energy Metabolism Is Altered in Radioresistant Rectal Cancer by Croí E. Buckley, Xiaofei Yin, Sebastian Meltzer, Anne Hansen Ree, Kathrine Røe Redalen, Lorraine Brennan, Jacintha O’Sullivan, Niamh Lynam-Lennon

“…Real-time metabolic profiling demonstrated decreased reliance on glycolysis and enhanced mitochondrial spare respiratory capacity in radioresistant SW837 cells when compared to radiosensitive HCT116 cells. Metabolomic profiling of pre-treatment serum samples from rectal cancer patients (<i>n</i> = 52) identified 16 metabolites significantly associated with subsequent pathological response to neoadjuvant chemoradiation therapy. …”
Get full text

Vinorelbine Augments Radiotherapy in Hepatocellular Carcinoma by Kheng Wei Yeoh, Aldo Prawira, Muhammad Zafrie Bin Saad, Kok Ming Lee, Eric Ming Hon Lee, Gee Keng Low, Mohamed Hakim Bin Mohd Nasir, Jun Hao Phua, Wendy Wan Li Chow, Iris Jiu Hia Lim, Yusnita Binte Omar, Rebecca Zhi Wen Ho, Thi Bich Uyen Le, Thanh Chung Vu, Khee Chee Soo, Hung Huynh

“…Therefore, the purpose of this study was to explore the efficacy and toxicity of the anti-microtubule agent Vinorelbine as a radiosensitizer in HCC. The radio sensitivity of 16 HCC patient-derived xenograft (PDX) models was determined by quantifying the survival fraction following irradiation in vitro, and Vinorelbine radio sensitization was determined by clonogenic assay. …”
Get full text

Survey of the Use of X-ray Beam Collimator and Shielding Tools during Infant Chest Radiography by Vahid Karami, Mansour Zabihzadeh, Abdolreza Gilavand, Nasim Shams

“…Shielding tools were used regularly only by 5% of radiographers. Conclusion The radiosensitive organs of infants located outside of ADI in hospitals investigated are at risk. …”
Get full text

Development of a Single-Neurosphere Culture to Assess Radiation Toxicity and Pre-Clinical Cancer Combination Therapy Safety by Bedika Pathak, Taylor E. Lange, Kristin Lampe, Ella Hollander, Marina Oria, Kendall P. Murphy, Nathan Salomonis, Mathieu Sertorio, Marc Oria

“…Neural progenitor cells (NPCs) are highly radiosensitive, resulting in decreased neurogenesis in the hippocampus. …”
Get full text

Impact of proton therapy on the DNA damage induction and repair in hematopoietic stem and progenitor cells by Simon Sioen, Oniecha Vanhove, Barbara Vanderstraeten, Carlos De Wagter, Monique Engelbrecht, Charlot Vandevoorde, Evan De Kock, Marc-Jan Van Goethem, Anne Vral, Ans Baeyens

“…In view of healthy tissue damage and the increased risk of secondary cancers, we investigated DNA damage induction and repair of radiosensitive hematopoietic stem and progenitor cells (HSPCs) exposed to therapeutic proton and photon irradiation due to their role in radiation-induced leukemia. …”
Get full text

Merkel Cell Carcinoma from Molecular Pathology to Novel Therapies by Karolina Stachyra, Monika Dudzisz-Śledź, Elżbieta Bylina, Anna Szumera-Ciećkiewicz, Mateusz J. Spałek, Ewa Bartnik, Piotr Rutkowski, Anna M. Czarnecka

“…The basis of MCC treatment is surgical excision. MCC is highly radiosensitive. It becomes chemoresistant within a few months. …”
Get full text

An oncolytic virus as a promising candidate for the treatment of radioresistant oral squamous cell carcinoma by Shunsuke Gohara, Kosuke Shinohara, Ryoji Yoshida, Ryusho Kariya, Hiroshi Tazawa, Masashi Hashimoto, Junki Inoue, Ryuta Kubo, Hikaru Nakashima, Hidetaka Arita, Sho Kawaguchi, Keisuke Yamana, Yuka Nagao, Asuka Iwamoto, Junki Sakata, Yuichiro Matsuoka, Hisashi Takeshita, Masatoshi Hirayama, Kenta Kawahara, Masashi Nagata, Akiyuki Hirosue, Yoshikazu Kuwahara, Manabu Fukumoto, Seiji Okada, Yasuo Urata, Toshiyoshi Fujiwara, Hideki Nakayama

“…We evaluated: (1) the antitumor effects of OBP-301 alone and in combination with radiotherapy on radioresistant cell lines, (2) the molecular mechanism underlying the radiosensitizing effect and cell death increased by the combination therapy, and (3) the antitumor effect of the combination therapy in vivo using xenograft models (a radioresistant cell line-derived xenograft in mouse and a patient-derived xenograft). …”
Get full text

Proton Therapy, Magnetic Nanoparticles and Hyperthermia as Combined Treatment for Pancreatic BxPC3 Tumor Cells by Francesca Brero, Paola Calzolari, Martin Albino, Antonio Antoccia, Paolo Arosio, Francesco Berardinelli, Daniela Bettega, Mario Ciocca, Angelica Facoetti, Salvatore Gallo, Flavia Groppi, Claudia Innocenti, Anna Laurenzana, Cristina Lenardi, Silvia Locarno, Simone Manenti, Renato Marchesini, Manuel Mariani, Francesco Orsini, Emanuele Pignoli, Claudio Sangregorio, Francesca Scavone, Ivan Veronese, Alessandro Lascialfari

“…Noticeably, the magnetic nanoparticles’ presence induces radiosensitization effects, and hyperthermia increases the production of ROS, which contributes to cytotoxic cellular effects and to a wide variety of lesions including DNA damage. …”
Get full text

NEDD8-conjugating enzyme E2s: critical targets for cancer therapy by Lisha Zhou, Xiongzhi Lin, Jin Zhu, Luyi Zhang, Siyuan Chen, Hui Yang, Lijun Jia, Baofu Chen

“…It is currently reported to inhibit apoptosis and then induce cell growth; hence, targeting UBE2F serves as an effective chemo-/radiosensitizing strategy by triggering apoptosis. This review highlights the most recent advances in the roles of UBE2M and UBE2F in tumor progression, indicating these E2s as two promising anti-tumor targets.…”
Get full text

Quantification of Nanoscale Dose Enhancement in Gold Nanoparticle-Aided External Photon Beam Radiotherapy by Elena Vlastou, Evaggelos Pantelis, Efstathios P. Efstathopoulos, Pantelis Karaiskos, Vasileios Kouloulias, Kalliopi Platoni

“…The recent progress in Nanotechnology has introduced Gold Nanoparticles (AuNPs) as promising radiosensitizing agents in radiation oncology. This work aims to estimate dose enhancement due to the presence of AuNPs inside an irradiated water region through Monte Carlo calculations. …”
Get full text

Synthesis and Biological Evaluation of ^99mTc(I) Tricarbonyl Complexes Dual-Targeted at Tumoral Mitochondria by Diogo Figueiredo, Célia Fernandes, Francisco Silva, Elisa Palma, Paula Raposinho, Ana Belchior, Pedro Vaz, António Paulo

“…For effective Auger therapy of cancer, the Auger-electron emitters must be delivered to the tumor cells in close proximity to a radiosensitive cellular target. Nuclear DNA is considered the most relevant target of Auger electrons to have augmented radiotoxic effects and significant cell death. …”
Get full text

Effect of ionizing radiation on the proliferation of human embryonic stem cells by Panyutin, Irina V., Holar, Sonia A., Neumann, Ronald D., Panyutin, Igor G.

“…We found that the RCS values of hESC lines correlated directly with their DT, i.e. the faster cells grow the more radiosensitive they are. We also found that DT and RCS values of individual colonies varied significantly within all hESC lines. …”
Get full text

PERBANDINGAN DOSIS RADIASI GONAD PRIA DENGAN SHIELDING 0,35 mmPb DAN SHIELDING 0,50 mmPb PADA PEMERIKSAAN HEAD MULTISLICE COMPUTED TOMOGRAPHY SCAN by , Estu Setya Andari, , dr. Sri Retna Dwidanarti, Sp.Rad(K)Onk

“…The usage of X-ray in CT gives primary radiation on examined organs and scattered radiation on the surrounding organs. Gonad is a radiosensitive organ, so that radiation protection is required to minimize radiation effects. …”

Definitive radiotherapy for locally advanced squamous cell carcinoma of the vulva and technical issues: a case report by Appalanaido, Gokula Kumar, I, Norhafizah, I, Shazril, AR, Nursyatina, MZ, Abdul Aziz, Mohd Zin, Mohd Hafiz, MK, Zakir, J, Norjayadi, AS, Norliza, A, Ismail, N, Khairun

“…At completion of planned radiotherapy, patient had a complete clinical response, grade 2-3 skin toxicity, grade 2 rectal toxicity, and grade 2 dysuria Vulval Squamous Cell Carcinomas are very radiosensitive tumours and the skills of the treating Radiation Oncologist, Dosimetrists, Physicist, Radiation Therapist and also nurses is of foremost importance is ensuring good clinical outcomes.…”
Get full text

Intercellular Communication of Tumor Cells and Immune Cells after Exposure to Different Ionizing Radiation Qualities by Sebastian Diegeler, Christine E. Hellweg

“…Lymphocytes for example are known to be highly radiosensitive. One important factor in indirect interactions is the radiation-induced bystander effect which can be initiated in unexposed cells by expression of cytokines of the irradiated cells and by direct exchange of molecules via gap junctions. …”
Get full text

Orthovoltage X-Ray Therapy of Large Cell Invasive Nasal Lymphoma in Cat by Rogachev Alexander, Gazin Alexey, Zuenkova Yuliia

“…Feline nasal lymphoma is generally a localized radiosensitive tumor. Treatment options include radiation therapy, chemotherapy, or a combination of both modalities. …”
Get full text

Phase I prospective trial of TAS-102 (trifluridine and tipiracil) and radioembolization with 90Y resin microspheres for chemo-refractory colorectal liver metastases by Nicholas Fidelman, Chloe E. Atreya, Madeline Griffith, M. Alexandra Milloy, Julia Carnevale, Pelin Cinar, Alan P. Venook, Katherine Van Loon

“…Trifluridine and tipiracil (TAS-102) has overall survival benefit for patients with refractory mCRC and may be a radiosensitizer. Methods Sequential lobar TARE using 90Y resin microspheres in combination with TAS-102 in 28-day cycles were used to treat adult patients with bilobar liver-dominant chemo-refractory mCRC according to 3 + 3 dose escalation design with a 12-patient dose expansion cohort. …”
Get full text