Stromal cell‐derived small extracellular vesicles enhance radioresistance of prostate cancer cells via interleukin‐8‐induced autophagy by Xiumei Wang, Fan Xu, Hengyuan Kou, Yawen Zheng, Jing Yang, Zhi Xu, Yao Fang, Wenbo Sun, Shuyi Zhu, Qin Jiang, Xiaowei Wei, Yong Xu

“…Intriguingly, the uptake of stromal cells‐derived sEVs by radiosensitive PCa cells enhanced their radioresistance, which could be attenuated by silencing CXCL8 in stromal cells or inhibiting its receptor CXCR2 in PCa cells. sEV‐mediated radioresistance has been validated in zebrafish and mouse xenograft tumours. …”
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Biomedical applications of gold nanoparticles in thermofluids flow through a porous medium by Shafiq Ahmad, Farhad Ali, Ilyas Khan, Sami Ul Haq

“…Gold nanoparticles have a variety of applications in medical sciences, including photothermal (PT), gene transfection agents, radiosensitizing, drug delivery, therapeutic etc. Especially in a lab, gold metallic nanoparticles are commonly utilized as a tracer to indicate the existence of certain proteins or DNA in a sample and identify the different antibiotics. …”
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Fingolimod Augments Monomethylfumarate Killing of GBM Cells by Paul Dent, Laurence Booth, Jane L. Roberts, Andrew Poklepovic, John F. Hancock

“…MMF and fingolimod radiosensitized glioma cells and enhanced the lethality of temozolomide. …”
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Optimum Radiation Fractionation Schedule in Advanced Cancer Cervix; A Study from Low Resource North Indian Cancer Center by Taruna Singh, Yogesh Verma, Rahat Hadi, Fareha Khatoon, Mashkoor Ahmed

“…The primary curative treatment option for women suffering from locally advanced cervical cancer includes external beam radiotherapy (EBRT) with concurrent weekly platinum-based radiosensitizing chemotherapy and brachytherapy (BT) to obtain finest treatment outcomes. …”
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Clinical wIRA-hyperthermia: heating properties and effectiveness in lower trunk regions and its accordance with ESHO quality criteria for superficial hyperthermia by Helmut Piazena, Peter Vaupel, Andreas R. Thomsen

“…Corresponding temperatures were ≤42.2 °C for CEM43 and ≤41.8 °C for CEM43T90, i.e., they are inadequate for direct thermal cell killing.Conclusions Thermography-controlled wIRA-HT complies with the ESHO criteria for superficial HT as a radiosensitizer and avoids the risk of thermal skin toxicity.…”
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Protracted Oxidative Alterations in the Mechanism of Hematopoietic Acute Radiation Syndrome by Nikolai V. Gorbunov, Pushpa Sharma

“…Onset of MOF in hARS can be presented as “two-hit phenomenon” where the “first hit” is the underlying consequences of the IR-induced radiolysis in cells and biofluids, non-septic inflammation, metabolic up-regulation of pro-oxidative metabolic reactions, suppression of the radiosensitive hematopoietic and lymphoid tissues and the damage to gut mucosa and vascular endothelium. …”
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Efficacy of 15 nm Gold Nanoparticles for Image-Guided Gliosarcoma Radiotherapy by Elette Engels, Michael Lerch, Stéphanie Corde, Moeava Tehei

“…Confocal imaging showed that 50–500 µg/mL of the GNPs was well-internalized into the 9L cells within 24–48 h. γ-H2AX assays showed that 50–500 µg/mL of the GNPs radiosensitized the 9L cells irradiated with 125 and 150 kVp X-rays. …”
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DNA methylation changes following DNA damage in prostate cancer cells by Laura P. Sutton, Sarah A. Jeffreys, Jessica L. Phillips, Phillippa C. Taberlay, Adele F. Holloway, Mark Ambrose, Ji-Hoon E. Joo, Arabella Young, Rachael Berry, Marketa Skala, Kate H. Brettingham-Moore

“…While the radioresistant and radiosensitive cells displayed distinct basal DNA methylation profiles, their susceptibility to DNA damage appeared similar demonstrating that basal DNA methylation has a limited influence on DSB induction at the regions examined. …”
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Could posterior-anterior projection cervical spine radiographs improve image quality and dose reduction by Rebecca Faulkner, Paul Lockwood

“… Introduction: Anterior-posterior (AP) cervical spine X-rays are routine examinations to assess degenerative change, persistent pain and traumatic injuries. Multiple radiosensitive organs lie anteriorly within this anatomical region, increasing the stochastic risk of cancer. …”
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Radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr by Fedrigo Carlos A, Grivicich Ivana, Schunemann Daniel P, Chemale Ivan M, Santos Daiane, Jacovas Thais, Boschetti Patryck S, Jotz Geraldo P, Filho Aroldo, da Rocha Adriana B

“…Furthermore, treatment with inhibitors of activation of ERK (PD098059) and Akt (wortmannin) leads to radiosensitization of MO59J spheroids.</p> <p>Conclusions</p> <p>These results indicate that the PI3K-Akt and MEK-ERK pathways triggered by EGFr confer GBM radioresistance.…”
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Radio Protective Effects of Ginseng Extract in Gamma-Rays Induced Chromosomal Damages of Human Lymphocyte by M. Syaifudin, Jie- Young Song, Yun- Sil Lee, Chang- Mo Kang

“…Opposite results that ginseng suspected to be a weak radiosensitizer was found in some cases. This may be due to discrepancies exist in route of treatment and its fundamental mechanisms of protective action between both studies. …”
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Current Status of Management and Outcome for Patients with Ewing Sarcoma by Asle Charles Hesla, Andri Papakonstantinou, Panagiotis Tsagkozis

“…There are also controversies regarding local treatment of Ewing sarcoma. The radiosensitive nature of the disease and the tendency for Ewing sarcoma to arise in the axial skeleton make local treatment very challenging. …”
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ALDH1A1 Deficiency in Gorlin Syndrome Suggests a Central Role for Retinoic Acid and ATM Deficits in Radiation Carcinogenesis by Thomas J. Weber, Thierry Magnaldo, Yijia Xiong

“…Long-term (5 Day) retinoic acid treatment functioned as a radiosensitizer and was associated with downregulation of ATM protein levels. …”
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Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer. by Brunner, T, Geiger, M, Grabenbauer, G, Lang-Welzenbach, M, Mantoni, T, Cavallaro, A, Sauer, R, Hohenberger, W, Mckenna, W

“…PURPOSE: Preclinically, HIV protease inhibitors radiosensitize tumors with activated PI3-kinase/Akt pathway. …”

Imaging the craniofacial skeleton: Is MRI a viable alternative to ionising radiation? by Eley, K, Dr Karen A Eley

“…The craniofacial region is a key anatomical area for radiation protection in view of the radiosensitive lens and thyroid gland. CT scanning is routinely employed to image this region in view of its superior imaging of bone and ability to create 3D rendered images and anatomical models for diagnosis and surgical planning. …”

A parallel analysis of cancer mortality among atomic bomb survivors and patients with ankylosing spondylitis given X-ray therapy. by Darby, S, Nakashima, E, Kato, H

“…A previous subdivision of cancer sites into radiosensitive and other tissues was not supported by the atomic bomb survivor data. …”

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ by Ghezraoui, H, Oliveira, C, Becker, J, Bilham, K, Moralli, D, Anzilotti, C, Fischer, R, Deobagkar-Lele, M, Sanchiz-Calvo, M, Fueyo-Marcos, E, Bonham, S, Kessler, B, Rottenberg, S, Cornall, R, Green, C, Chapman, J

“…Cells that lack core non-homologous end joining proteins are profoundly radiosensitive8, unlike 53BP1-deficient cells9,10, which suggests that 53BP1 and its co-factors act on specific DNA substrates. …”

A comparative study of radiation doses between phantom and patients via CT angiography of the intra-/extra-cranial, pulmonary, and abdominal/pelvic arteries by Karim, Muhammad Khalis Abdul, Sabarudin, Akmal, Muhammad, N.A., Ng, Kwan Hoong

“…However, the highest absorbed dose in abdominal/pelvic CTA was the gonads (8.98 ± 0.30 mGy), while other radiosensitive organs in intra- and extra-cranial CTA, CTPA, and abdominal/pelvic CTA did not demonstrate significant differences between organs/structures with p value 0.88, 0.11, and 0.54, respectively. …”

The impact of tube current and iterative reconstruction algorithm on dose and image quality of infant CT head examination by Muhammad, N.A., Karim, M.K.A., Harun, H.H., Rahman, M.A.A., Azlan, R.N.R.M., Sumardi, N.F.

“…Hence, this study aimed to investigate optimized CT acquisition parameter on radiosensitive organs of infant CT head examination and its influence on the image quality. …”

Adaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion by Christine Hansel, Julian Hlouschek, Kexu Xiang, Margarita Melnikova, Juergen Thomale, Thomas Helleday, Verena Jendrossek, Johann Matschke

“…Combination of TH1579 treatment with radiotherapy (RT) led to radiosensitization but was not able to counteract increased radioresistance induced by adaptation to chronic-cycling hypoxia/reoxygenation stress. …”
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