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1421
Cernunnos defect in an Iranian patient with T− B+ NK+ severe combined immunodeficiency: A case report and review of the literature
Published 2022-08-01“…Abstract Background Defective Cernunnos gene in nonhomologous end‐joining (NHEJ) pathway of the DNA repair is responsible for radiosensitive severe combined immunodeficiency (SCID). …”
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1422
Monte Carlo simulation of physical dose enhancement in core-shell magnetic gold nanoparticles with TOPAS
Published 2022-09-01“…The Fe3O4@AuNPs were proved as an effective sensitization materials when combined with the magnetic field in MC simulation for the first time, which contributes to the research on in vitro tests on radiosensitization as well as clinical research in future.…”
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1423
Gut microbiota modulate radiotherapy-associated antitumor immune responses against hepatocellular carcinoma Via STING signaling
Published 2022-12-01“…Our study highlights the therapeutic potential of modulating the gut microbiome in HCC patients receiving RT and provides a new strategy for the radiosensitization of liver cancer.…”
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1424
Effects of Ultrafine Single-Nanometer Oxygen Bubbles on Radiation Sensitivity in a Tumor-Bearing Mouse Model
Published 2022-06-01“…This study aimed to elucidate whether NBO<sub>2</sub> water could act as a radiosensitizer via regulation of HIF-1α in a tumor-bearing mouse model. …”
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1425
Octahedral Molybdenum Cluster-Based Nanomaterials for Potential Photodynamic Therapy
Published 2022-09-01“…Photo/radiosensitizers, such as octahedral molybdenum clusters (Mo<sub>6</sub>), have been intensively studied for photodynamic applications to treat various diseases. …”
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1426
Target Definition in MR-Guided Adaptive Radiotherapy for Head and Neck Cancer
Published 2022-06-01“…Because of the close proximity of target areas and radiosensitive organs at risk (OARs) during HNSCC treatment, MRgRT could provide a more accurate treatment in which OARs receive less radiation dose. …”
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1427
CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer
Published 2022-01-01“…Our results support the use of CRISPR-Cas9 screening to identify new therapeutic targets, develop radiosensitizers, and provide novel strategies for overcoming the tolerance of pancreatic cancer to radiotherapy.…”
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1428
Transient Vasodilation in Mouse 4T1 Tumors after Intragastric and Intravenous Administration of Gold Nanoparticles
Published 2021-02-01“…Gold nanoparticles (AuNPs) are foreseen as a promising tool in nanomedicine, both as drug carriers and radiosensitizers. They have been also proposed as a potential anticancer drug due to the anti-angiogenic effect in tumor tissue. …”
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1429
Erb‐(IL10)2 induces abscopal antitumor effects of radiotherapy through the activation and recruitment of lymph node CD8+ T cells
Published 2021-12-01“…Conclusion This study provides evidence for the radiosensitive role of Erb‐(IL10)2 in the B16‐EGFR‐OVA tumor model. …”
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1430
Nanotechnology-based radiation therapy to cure cancer and the challenges in its clinical applications
Published 2023-06-01“…Potential applications of nanoparticles as radiosensitizers is hindered by the difficulties associated with ensuring their production at a large scale with improved characterizations and because of certain biological challenges. …”
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1431
Proton and Heavy Particle Intracranial Radiosurgery
Published 2021-01-01“…This has traditionally been accomplished in a single fraction; however, fractionated approaches involving five or fewer treatments have been delivered for larger lesions, as well as lesions in close proximity to radiosensitive structures. The clinical utilization of SRS has overwhelmingly involved photon-based sources via dedicated radiosurgery platforms (e.g., Gamma Knife<sup>®</sup> and Cyberknife<sup>®</sup>) or specialized linear accelerators. …”
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1432
HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells
Published 2019-01-01“…Using genetically identical HIF-α isoform-deficient cells we identified a strong radiosensitizing of HIF1, but not of HIF2, which was associated with a reduced extracellular pH and reduced glycolysis.…”
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1433
Statin-Sensitive Akt1/Src/Caveolin-1 Signaling Enhances Oxidative Stress Resistance in Rhabdomyosarcoma
Published 2024-02-01“…Synthetic inhibition of Akt1 and Src phosphorylation increased ROS levels in all RMS lines, promoting cellular radiosensitization. Accordingly, the elevated activation of the Akt1/Src/Cav1 pathway, as detected in two RD lines characterized by overexpression of a myristoylated Akt1 form (myrAkt1) or Cav1 (RDCav1), was correlated with reduced levels of ROS, higher expression of catalase, and increased radioresistance. …”
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1434
The radiation- and chemo-sensitizing capacity of diclofenac can be predicted by a decreased lactate metabolism and stress response
Published 2024-01-01“…The impaired lactate metabolism and stress response in diclofenac-sensitive colorectal cancer cells was associated with a significantly increased sensitivity to radiation and 5Fluorouracil in vitro, and in a human colorectal cancer xenograft mouse model diclofenac causes radiosensitization. Conclusion These findings suggest that a decrease in the LDH activity and/or stress response upon diclofenac treatment predicts its radiation/chemo-sensitizing capacity.…”
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1435
Development of anthropomorphic computational phantoms at the UFPE
Published 2023-03-01“… To evaluate the amount of energy deposited in radiosensitive organs and tissues of the human body, when an anthropomorphic phantom is irradiated, researchers in numerical dosimetry use the so-called exposure computational models (ECMs). …”
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1436
Targeting Cancer Stem Cells for Treatment of Glioblastoma Multiforme
Published 2013-04-01“…A second is to use a radiosensitizer to enhance the radiotherapy effect on CSCs. …”
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1437
Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (H...
Published 2024-12-01“…In this context, in-silico biophysical models that translate deviations in the treatment conditions into clinical outcome variations may be used to study the extent of such processes and their influence on combined hyperthermia plus radiotherapy (HT + RT) treatments under varying conditions.Methods An extended linear-quadratic model calibrated for SiHa and HeLa cell lines (cervical cancer) was used to theoretically study the impact of varying HT treatment conditions on radiosensitization and direct HT cell killing effect. Simulated patients were generated to compute the Tumor Control Probability (TCP) under different HT conditions (number of HT sessions, temperature and time interval), which were randomly selected within margins based on reported patient data.Results Under the studied conditions, model-based simulations suggested a treatment improvement with a total CEM43 thermal dose of approximately 10 min. …”
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1438
Exposure computational models with voxel phantoms coupled to EGSnrc Monte Carlo code
Published 2023-10-01“… In computational dosimetry of ionizing radiation, the energy deposited in radiosensitive organs and tissues is evaluated when an anthropomorphic simulator (phantom) is irradiated using Exposure Computational Models (ECMs). …”
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1439
Estimation of absorbed doses in patients’ organs from the released radionuclide-label during radionuclide therapy with <sup>225</sup>Ac
Published 2022-04-01“…A change in the biodistribution of 225Ac in a patient’s body, associated with the release of a radionuclide from the radiopharmaceuticals, can lead to an increase in doses in healthy radiosensitive organs and tissues, as well as to a decrease in the effectiveness of treatment.…”
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1440
Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation
Published 2017-07-01“…In this study, we investigated the endogenous DNA methylation status of the 5′ untranslated region (UTR) of LINE-1 elements in the bone marrow hematopoietic stem cells (HSCs), hematopoietic progenitor cells (HPCs), and mononuclear cells (MNCs) in radioresistant C57BL/6J and radiosensitive CBA/J mice and in response to ionizing radiation (IR). …”
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