Theranostic applications of selenium nanomedicines against lung cancer by Shaowei Liu, Weifeng Wei, Jinlin Wang, Tianfeng Chen

“…This review summarizes the application of Se-based species and materials in lung cancer diagnosis, including fluorescence, MR, CT, photoacoustic imaging and other diagnostic methods, as well as treatments, including direct killing, radiosensitization, chemotherapeutic sensitization, photothermodynamics, and enhanced immunotherapy. …”
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Survivability of Soil and Permafrost Microbial Communities after Irradiation with Accelerated Electrons under Simulated Martian and Open Space Conditions by Vladimir Cheptsov, Elena Vorobyova, Andrey Belov, Anatoly Pavlov, Denis Tsurkov, Vladimir Lomasov, Sergey Bulat

“…Thanks to the protective properties of the heterophase environment and the interaction between microbial populations even radiosensitive microorganisms as members of the native microbial communities are able to withstand very high doses of ionizing radiation.…”
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[18F]PARPi Imaging Is Not Affected by HPV Status In Vitro by Navjot Guru, Paula Demétrio De Souza França, Giacomo Pirovano, Cien Huang, Snehal G. Patel, Thomas Reiner

“…Clonogenic assays confirm HPV-positive cell lines to be significantly more radiosensitive. PARP1 expression levels were similar, irrespective of HPV status. …”
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RUVBL1 ubiquitination by DTL promotes RUVBL1/2-β-catenin-mediated transcriptional regulation of NHEJ pathway and enhances radiation resistance in breast cancer by Jie Tian, Mingxin Wen, Peng Gao, Maoxiao Feng, Guangwei Wei

“…From the aforementioned, it is evident that targeting DTL-RUVBL1/2-β-catenin provides a potential radiosensitization approach when treating breast cancer.…”
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Intracellular Signaling Responses Induced by Radiation within an In Vitro Bone Metastasis Model after Pre-Treatment with an Estrone Analogue by Jolene Helena, Anna Joubert, Peace Mabeta, Magdalena Coetzee, Roy Lakier, Anne Mercier

“…In this proof-of-concept study, the potential radiosensitizing effects of ESE-16 were investigated in an in vitro deconstructed bone metastasis model. …”
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Comparison of Proton and Photon Beam Irradiation in Radiation-Induced Intestinal Injury Using a Mouse Model by Changhoon Choi, Chansu Lee, Sung-Won Shin, Shin-Yeong Kim, Sung Noh Hong, Hee Chul Park

“…Both types of radiation therapy decreased the number of radiosensitive, active cycling ISC populations. However, a higher number of radioresistant, reserve ISC populations and Paneth cells were eradicated by proton irradiation than X-ray irradiation, as shown in the IHC analyses. …”
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Enhanced Therapeutic Effects of ¹⁷⁷Lu-DOTA-M5A in Combination with Heat Shock Protein 90 Inhibitor Onalespib in Colorectal Cancer Xenografts by Tabassom Mohajershojai, Douglas Spangler, Saloni Chopra, Fredrik Y. Frejd, Paul J. Yazaki, Marika Nestor

“…Moreover, the novel combination of ¹⁷⁷Lu-DOTA-M5A with the heat shock protein 90 inhibitor onalespib, suggested to mediate radiosensitizing properties, was assessed <i>in vivo</i> for the first time. …”
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Differential expression of 12 histone deacetylase (<it>HDAC</it>) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas by Lucio-Eterovic Agda KB, Cortez Maria AA, Valera Elvis T, Motta Fabio JN, Queiroz Rosane GP, Machado Helio R, Carlotti Carlos G, Neder Luciano, Scrideli Carlos A, Tone Luiz G

“…In the past several years, HDAC inhibitors (HDACis) have been used as radiosensitizers in glioblastoma treatment. However, no study has demonstrated the status of global <it>HDAC </it>expression in gliomas and its possible correlation to the use of HDACis. …”
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Orthovoltage X-ray Minibeam Radiation Therapy for the Treatment of Ocular Tumours—An In Silico Evaluation by Tim Schneider, Denis Malaise, Frédéric Pouzoulet, Yolanda Prezado

“…(1) Background: Radiotherapeutic treatments of ocular tumors are often challenging because of nearby radiosensitive structures and the high doses required to treat radioresistant cancers such as uveal melanomas. …”
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Independent Mechanisms Lead to Genomic Instability in Hodgkin Lymphoma: Microsatellite or Chromosomal Instability † by Corina Cuceu, Bruno Colicchio, Eric Jeandidier, Steffen Junker, François Plassa, Grace Shim, Justyna Mika, Monika Frenzel, Mustafa AL Jawhari, William M. Hempel, Grainne O’Brien, Aude Lenain, Luc Morat, Theodore Girinsky, Alain Dieterlen, Joanna Polanska, Christophe Badie, Patrice Carde, Radhia M’Kacher

“…In addition, the NS-HL cell lines were radiosensitive and the MC-cell lines resistant to apoptosis after radiation exposure. …”
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BiVO4/Fe3O4@polydopamine superparticles for tumor multimodal imaging and synergistic therapy by Ze Wang, Guan Wang, Tingting Kang, Shuwei Liu, Lu Wang, Haoyang Zou, Yu Chong, Yi Liu

“…On the one hand, BiVO4 NPs endow BiVO4/Fe3O4@PDA SPs with impressive X-ray absorption capability due to the high X-ray attenuation coefficient of Bi, which is beneficial for their utilization as radiosensitizers for CT imaging and RT. On the other hand, Fe3O4 NPs impart BiVO4/Fe3O4@PDA SPs with the superparamagnetic property as a T2-weighted contrast agent for MR imaging. …”
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EPR Investigations to Study the Impact of Mito-Metformin on the Mitochondrial Function of Prostate Cancer Cells by Donatienne d’Hose, Barbara Mathieu, Lionel Mignion, Micael Hardy, Olivier Ouari, Bénédicte F. Jordan, Pierre Sonveaux, Bernard Gallez

“…Here, we hypothesized that this compound may decrease the oxygen consumption rate (OCR) in prostate cancer cells, increase the level of mitochondrial ROS, alleviate tumor hypoxia, and radiosensitize tumors. Methods: OCR and mitochondrial superoxide production were assessed by EPR (9 GHz) in vitro in PC-3 and DU-145 prostate cancer cells. …”
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Nanodosimetric Calculations of Radiation-Induced DNA Damage in a New Nucleus Geometrical Model Based on the Isochore Theory by Yann Thibaut, Nicolas Tang, Hoang Ngoc Tran, Aurélie Vaurijoux, Carmen Villagrasa, Sébastien Incerti, Yann Perrot

“…These new results indicate that the genome core is more radiosensitive than the genome desert, with a 3–8% increase in damage depending on the LET. …”
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K_Ca3.1 Channels Confer Radioresistance to Breast Cancer Cells by Corinna J. Mohr, Dominic Gross, Efe C. Sezgin, Friederike A. Steudel, Peter Ruth, Stephan M. Huber, Robert Lukowski

“…Since K_Ca3.1 is druggable, K_Ca3.1 targeting concomitant to radiotherapy seems to be a promising strategy to radiosensitize breast tumors.…”
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Repurposing Disulfiram for Targeting of Glioblastoma Stem Cells: An In Vitro Study by Lisa Zirjacks, Nicolai Stransky, Lukas Klumpp, Lukas Prause, Franziska Eckert, Daniel Zips, Sabine Schleicher, Rupert Handgretinger, Stephan M. Huber, Katrin Ganser

“…This effect was additive to the impairment of clonogenic survival by radiation, but not associated with radiosensitization. Of note, cotreatment with temozolomide blunted the DSF inhibition of clonogenic survival. …”
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A narrative review of 35 years of meta-[131I]iodobenzylguanidine therapy in neuroblastoma by Atia Samim, Gitta Bleeker, Kathelijne C.J.M. Kraal, Max M. van Noesel, Bart de Keizer, Godelieve A.M. Tytgat

“…In current applications, [131I]mIBG therapy is combined with chemotherapy, radiosensitizers, and/or immunotherapy, and is increasingly integrated in the first-line treatment of HR-NBL. …”
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HIF2alpha-Associated Pseudohypoxia Promotes Radioresistance in Pheochromocytoma: Insights from 3D Models by Verena Seifert, Susan Richter, Nicole Bechmann, Michael Bachmann, Christian G. Ziegler, Jens Pietzsch, Martin Ullrich

“…Furthermore, the external irradiation and [¹⁷⁷Lu]LuCl₃ exposure of MPC spheroids provide surrogate models for radiation treatments to further investigate the metabolic and molecular determinants of radiation responses in PCCs/PGLs and evaluate the effects of neo-adjuvant—in particular, radiosensitizing—treatments in combination with targeted radionuclide therapies.…”
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Antineoplastic Effect of a Combined Mitotane Treatment/Ionizing Radiation in Adrenocortical Carcinoma: A Preclinical Study by Lidia Cerquetti, Barbara Bucci, Giulia Carpinelli, Pina Lardo, Antonella Proietti, Raffaele Saporito, Guido Rindi, Elisa Petrangeli, Vincenzo Toscano, Antonio Stigliano

“…In conclusion, MTT seems to have a radiosensitizing property and, when given in combination with IR, is able to promote neoplastic growth inhibition, leading to a significant reduction in tumor size due to cell death.…”
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Cerium Oxide Nanoparticles Sensitize Pancreatic Cancer to Radiation Therapy through Oxidative Activation of the JNK Apoptotic Pathway by Melissa S. Wason, Heng Lu, Lin Yu, Satadru K. Lahiri, Debarati Mukherjee, Chao Shen, Soumen Das, Sudipta Seal, Jihe Zhao

“…Taken together, these data demonstrate an important mechanism for CONPs in specifically killing cancer cells and provide novel insights into the utilization of CONPs as a radiosensitizer and therapeutic agent for pancreatic cancer.…”
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Micro-RNA and Proteomic Profiles of Plasma-Derived Exosomes from Irradiated Mice Reveal Molecular Changes Preventing Apoptosis in Neonatal Cerebellum by Simonetta Pazzaglia, Barbara Tanno, Ilaria De Stefano, Paola Giardullo, Simona Leonardi, Caterina Merla, Gabriele Babini, Seda Tuncay Cagatay, Ammar Mayah, Munira Kadhim, Fiona M. Lyng, Christine von Toerne, Zohaib N. Khan, Prabal Subedi, Soile Tapio, Anna Saran, Mariateresa Mancuso

“…In this study, particular emphasis was also given to the determination of the in vivo effect of exosome transfer by intracranial injection in the highly radiosensitive neonatal cerebellum at postnatal day 3. …”
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