Searching for a Paradigm Shift in Auger-Electron Cancer Therapy with Tumor-Specific Radiopeptides Targeting the Mitochondria and/or the Cell Nucleus by Célia Fernandes, Elisa Palma, Francisco Silva, Ana Belchior, Catarina I. G. Pinto, Joana F. Guerreiro, Hugo M. Botelho, Filipa Mendes, Paula Raposinho, António Paulo

“…These differences can be attributed to the augmented uptake of <b>^99mTc-TPP-BBN</b> in the mitochondria and enhanced uptake of <b>^99mTc-AO-BBN</b> in the nucleus, allowing the irradiation of these radiosensitive organelles with the short path-length AEs emitted by ^99mTc. …”
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The RelB-BLNK Axis Determines Cellular Response to a Novel Redox-Active Agent Betamethasone during Radiation Therapy in Prostate Cancer by Luksana Chaiswing, Fangfang Xu, Yanming Zhao, Jon Thorson, Chi Wang, Daheng He, Jinpeng Lu, Sally R. Ellingson, Weixiong Zhong, Kristy Meyer, Wei Luo, William St. Clair, Daret St. Clair

“…Targeted disruptions of RelB-BLNK expressions mitigate the radioprotective effect of BET on normal cells and the radiosensitizing effect of BET on PCa cells. Our study identified a novel RelB complementary partner and reveals a complex redox-mediated mechanism showing that the RelB-BLNK axis, at least in part, triggers differential responses to the redox-active agent BET by stimulating adaptive responses in normal cells but pushing PCa cells into oxidative stress overload.…”
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From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy by Peter Vaupel, Helmut Piazena, Markus Notter, Andreas R. Thomsen, Anca-L. Grosu, Felix Scholkmann, Alan Graham Pockley, Gabriele Multhoff

“…(1) Background: Mild hyperthermia (mHT, 39–42 °C) is a potent cancer treatment modality when delivered in conjunction with radiotherapy. mHT triggers a series of therapeutically relevant biological mechanisms, e.g., it can act as a radiosensitizer by improving tumor oxygenation, the latter generally believed to be the commensurate result of increased blood flow, and it can positively modulate protective anticancer immune responses. …”
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The addition of arginine deiminase potentiates Mithramycin A-induced cell death in patient-derived glioblastoma cells via ATF4 and cytochrome C by Charlotte Linke, Thomas Freitag, Christin Riess, Jana Vanessa Scheffler, Katharina del Moral, Nina Schoenwaelder, Tomas Fiedler, Adina Fiebig, Philipp Kaps, Daniel Dubinski, Björn Schneider, Wendy Bergmann, Carl Friedrich Classen, Claudia Maletzki

“…Results MitA monotherapy induced a time- and dose-dependent cytotoxicity in eight patient-derived GBM cell lines and had a radiosensitizing effect in all but one cell line. Combination treatment boosted the effects of the monotherapy in 2D- and 3D models. …”
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Stereotactic Magnetic Resonance-Guided Adaptive and Non-Adaptive Radiotherapy on Combination MR-Linear Accelerators: Current Practice and Future Directions by John Michael Bryant, Joseph Weygand, Emily Keit, Ruben Cruz-Chamorro, Maria L. Sandoval, Ibrahim M. Oraiqat, Jacqueline Andreozzi, Gage Redler, Kujtim Latifi, Vladimir Feygelman, Stephen A. Rosenberg

“…Stereotactic MR-guided adaptive radiation therapy (SMART) has enabled the safe delivery of ablative doses to tumors adjacent to radiosensitive tissues throughout the body. Although it is still a relatively new RT technique, SMART has demonstrated significant opportunities to improve disease control and reduce toxicity. …”
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Effects of neoadjuvant zoledronate and radiation therapy on cell survival, cell cycle distribution, and clinical status in canine osteosarcoma by Carissa J. Norquest, Anita Rogic, Phyllis A. Gimotty, Charles A. Maitz, Hansjorg Rindt, Hayley L. Ashworth, Jeffrey N. Bryan, Lindsay L. Donnelly, Angela L. McCleary-Wheeler, Brian K. Flesner, Brian K. Flesner

“…However, the exact mechanism of ZOL’s radiosensitization has not been fully elucidated.MethodsWe investigated ZOL’s ability to induce apoptosis in canine osteosarcoma cell lines treated with various doses of megavoltage external beam radiotherapy. …”
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European survey on the use of patient contact shielding during radiological examinations by Claudio Granata, Erik Briers, Cristian Candela-Juan, John Damilakis, Timo De Bondt, Dario Faj, Shane Foley, Guy Frija, Hugo de las Heras Gala, Peter Hiles, Ruben Pauwels, Marta Sans Merce, Georgios Simantirakis, Eliseo Vano, Patrick Gilligan, the ESR, ESPR, EFOMP, EFRS, and EURADOS

“…Abstract Objectives Contact shielding (CS) of patients during X-ray studies has been used for decades to protect radiosensitive organs. This practice has not changed much despite increasing evidence that CS is not useful in many cases. …”
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METHOD OF TREATMENT FOR ANAL CANCER AFFECTING THE SKIN by O. I. Kit, L. Ya. Rozenko, E. M. Frantsiyants, M. A. Gusareva, N. G. Kosheleva, A. A. Solntseva, Yu. N. Krokhmal

“…The positive effect of the proposed method for ARC treatment is determined by the combination of therapeutic factors including the action of a radiosensitizing agent introduced into tumor tissues.…”
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Immunogenic cell death after combined treatment with radiation and ATR inhibitors is dually regulated by apoptotic caspases by Adrian Eek Mariampillai, Adrian Eek Mariampillai, Sissel Hauge, Karoline Kongsrud, Randi G. Syljuåsen

“…IntroductionInhibitors of the ATR kinase act as radiosensitizers through abrogating the G2 checkpoint and reducing DNA repair. …”
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Stereotactic radiosurgery of brain metastases: a retrospective study by Isabella Gruber, Karin Weidner, Marius Treutwein, Oliver Koelbl

“…Conclusions Our results indicate a reasonable 1-year local control of brain metastases with radiosensitive histology. Radioresistant metastases show a comparatively poor local control. …”
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Systemic therapy in the curative treatment of head and neck squamous cell cancer: a systematic review by Eric Winquist, Chika Agbassi, Brandon M. Meyers, John Yoo, Kelvin K. W. Chan, the Head and Neck Disease Site Group

“…Other than cetuximab, no targeted agents and radiosensitizers studied in RCTs were shown effective. …”
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Antitumor efficiency of contact radiotherapy in combination with a chlorin-based photosensitizer in experiment by D. A. Tzerkovsky, Ya. L. Protopovich, D. I. Kozlovsky, V. A. Suslova

“…The data obtained indicate that further studies of the radiosensitizing properties of PS are promising.…”
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DIRECTIONS FOR THE RECOVERY OF AGRICULTURAL PRODUCTION ON RADIOACTIVELY CONTAMINATED LANDS by Kustovska O.V., Lebedeva E.V.

“…The main danger of the accumulation by plants of radionuclides lies in the fact that they are a major link in the migratory chain of transmission of radionuclides to the more radiosensitive species and, above all, human. Economic feature of agricultural production in the study area is insufficient pricesambien, transformation of land use, violations of industrial-economic relations, the structure of agricultural production, changes in the natural-cost structure commodity products, the reform of the organizational structure of agricultural production. …”
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Clinical benefits of oral capecitabine over intravenous 5-fluorouracyl regimen in case of neoadjuvant chemoradiotherapy followed by surgery for locally advanced rectal cancer by Attila Paszt, Aurel Ottlakan, Szabolcs Abraham, Zsolt Simonka, Marton Vas, Aniko Maraz, Zoltan Szepes, Laszlo Tiszlavicz, Tibor Nyari, Judit Olah, Gyorgy Lazar

“…Background: During the last decade, one of the most important treatment options for locally advanced, potencially resectable rectal tumours was neoadjuvant chemoradiotherapy (CRT) followed by surgery.Methods: Effects of the neoadjuvant treatment on surgical outcomes were retrospectively analysed in 185 patients with stage T2–T4 and N0–2, resectable rectal tumour among two patient groups defined by radiosensitizer agents. Group 1 (n = 94) involved radiotherapy (RT) with 50.4 Gy total dose (25 × 1.8 Gy + 3 × 1.8 Gy tumour bed boost), and intravenous 5-fluorouracil (5-FU) (350 mg/m2) with leucovorin (20 mg/m2) on the 1–5 and 21–25 days, while Group 2 (n = 91) RT and orally administrated capecitabine (daily 2 × 825 mg/m2) on RT days. …”
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Pre-Administration of PLX-R18 Cells Protects Mice from Radiation-Induced Hematopoietic Failure and Lethality by Vidya P. Kumar, Shukla Biswas, Gregory P. Holmes-Hampton, Michal Sheleg, Sasha Stone, Betre Legesse, Racheli Ofir, Sanchita P. Ghosh

“…Acute Radiation Syndrome (ARS) is a syndrome involving damage to multiple organs caused by exposure to a high dose of ionizing radiation over a short period of time; even low doses of radiation damage the radiosensitive hematopoietic system and causes H-ARS. …”
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Electron beam dose distribution in electron treatment planning system with the presence of high density dental amalgam in radiotherapy treatment / Mohd Zahri Abdul Aziz by Abdul Aziz, Mohd Zahri

“…With the number of vital and radiosensitive organs in head and neck regions, MAR technique was compulsory in this case. …”
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Optimization on radiation dose and image quality in paediatric computed tomography examination by Muhammad, Nor Azura

“…The final phase of this study observed the impact of dose in radiosensitive organ and its influence towards image quality in CT Chest-Abdomen-Pelvis (CAP) examination after applying CT optimization process. …”
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A role for ceruloplasmin in the control of human glioblastoma cell responses to radiation by Charlotte Roy, Sylvie Avril, Claire Legendre, Bénédicte Lelièvre, Honorine Vellenriter, Sébastien Boni, Jérôme Cayon, Catherine Guillet, Yannick Guilloux, Michel Chérel, François Hindré, Emmanuel Garcion

“…Methods and results After analysis of radiation responses (Hoechst staining, LDH release, Caspase 3 activation) in U251-MG and U87-MG human GB cell lines, described as radiosensitive and radioresistant respectively, the expression of 9 iron partners (TFR1, DMT1, FTH1, FTL, MFRN1, MFRN2, FXN, FPN1, CP) were tested by RTqPCR and western blots at 3 and 8 days following 4 Gy irradiation. …”
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Systemic therapy of inflammatory breast cancer with type 2 diabetes mellitus – Prevention of high risk of radiation-induced progression of tumor tissue cancer by Oleksii Volodymyrovich Movchan, Irina Yuriivna Bagmut, Ivan Ivanovich Smolanka (Senior), Michael Ivanovich Sheremet, Lidia Anatolyivna Sukhanova, Oleksandr Vasyliovych Bagmut, Igor Leonidovich Kolisnyk, Olexksii Oleksandrovich Halmiz, Andriy Oleksandrovich Lyashenko, Irina Viktorivna Dosenko, Anton Dmitrovich Loboda, Oksana Mykolaivna Ivankova, Vitaliy Vasyliovych Maksymyuk, Volodymir Volodymyrovich Tarabanchuk

“…Hyperglycemia, higher total RT doses, and radiosensitizers are a few techniques that can improve the impact of RT on local-regional management. …”
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Radiation Enhancer Effect of Platinum Nanoparticles in Breast Cancer Cell Lines: In Vitro and In Silico Analyses by Marie Hullo, Romain Grall, Yann Perrot, Cécile Mathé, Véronique Ménard, Xiaomin Yang, Sandrine Lacombe, Erika Porcel, Carmen Villagrasa, Sylvie Chevillard, Emmanuelle Bourneuf

“…In this context, the potential of platinum nanoparticles (PtNPs) as radiosensitizers was investigated in two breast cancer cell lines, T47D and MDA-MB-231, showing a different radiation sensitivity. …”
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