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1481
Searching for a Paradigm Shift in Auger-Electron Cancer Therapy with Tumor-Specific Radiopeptides Targeting the Mitochondria and/or the Cell Nucleus
Published 2022-06-01“…These differences can be attributed to the augmented uptake of <b><sup>99m</sup>Tc-TPP-BBN</b> in the mitochondria and enhanced uptake of <b><sup>99m</sup>Tc-AO-BBN</b> in the nucleus, allowing the irradiation of these radiosensitive organelles with the short path-length AEs emitted by <sup>99m</sup>Tc. …”
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1482
The RelB-BLNK Axis Determines Cellular Response to a Novel Redox-Active Agent Betamethasone during Radiation Therapy in Prostate Cancer
Published 2022-06-01“…Targeted disruptions of RelB-BLNK expressions mitigate the radioprotective effect of BET on normal cells and the radiosensitizing effect of BET on PCa cells. Our study identified a novel RelB complementary partner and reveals a complex redox-mediated mechanism showing that the RelB-BLNK axis, at least in part, triggers differential responses to the redox-active agent BET by stimulating adaptive responses in normal cells but pushing PCa cells into oxidative stress overload.…”
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1483
From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy
Published 2023-02-01“…(1) Background: Mild hyperthermia (mHT, 39–42 °C) is a potent cancer treatment modality when delivered in conjunction with radiotherapy. mHT triggers a series of therapeutically relevant biological mechanisms, e.g., it can act as a radiosensitizer by improving tumor oxygenation, the latter generally believed to be the commensurate result of increased blood flow, and it can positively modulate protective anticancer immune responses. …”
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1484
The addition of arginine deiminase potentiates Mithramycin A-induced cell death in patient-derived glioblastoma cells via ATF4 and cytochrome C
Published 2023-02-01“…Results MitA monotherapy induced a time- and dose-dependent cytotoxicity in eight patient-derived GBM cell lines and had a radiosensitizing effect in all but one cell line. Combination treatment boosted the effects of the monotherapy in 2D- and 3D models. …”
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1485
Stereotactic Magnetic Resonance-Guided Adaptive and Non-Adaptive Radiotherapy on Combination MR-Linear Accelerators: Current Practice and Future Directions
Published 2023-03-01“…Stereotactic MR-guided adaptive radiation therapy (SMART) has enabled the safe delivery of ablative doses to tumors adjacent to radiosensitive tissues throughout the body. Although it is still a relatively new RT technique, SMART has demonstrated significant opportunities to improve disease control and reduce toxicity. …”
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1486
Effects of neoadjuvant zoledronate and radiation therapy on cell survival, cell cycle distribution, and clinical status in canine osteosarcoma
Published 2024-01-01“…However, the exact mechanism of ZOL’s radiosensitization has not been fully elucidated.MethodsWe investigated ZOL’s ability to induce apoptosis in canine osteosarcoma cell lines treated with various doses of megavoltage external beam radiotherapy. …”
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1487
European survey on the use of patient contact shielding during radiological examinations
Published 2023-06-01“…Abstract Objectives Contact shielding (CS) of patients during X-ray studies has been used for decades to protect radiosensitive organs. This practice has not changed much despite increasing evidence that CS is not useful in many cases. …”
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1488
METHOD OF TREATMENT FOR ANAL CANCER AFFECTING THE SKIN
Published 2019-06-01“…The positive effect of the proposed method for ARC treatment is determined by the combination of therapeutic factors including the action of a radiosensitizing agent introduced into tumor tissues.…”
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1489
Immunogenic cell death after combined treatment with radiation and ATR inhibitors is dually regulated by apoptotic caspases
Published 2023-06-01“…IntroductionInhibitors of the ATR kinase act as radiosensitizers through abrogating the G2 checkpoint and reducing DNA repair. …”
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1490
Stereotactic radiosurgery of brain metastases: a retrospective study
Published 2023-12-01“…Conclusions Our results indicate a reasonable 1-year local control of brain metastases with radiosensitive histology. Radioresistant metastases show a comparatively poor local control. …”
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1491
Systemic therapy in the curative treatment of head and neck squamous cell cancer: a systematic review
Published 2017-04-01“…Other than cetuximab, no targeted agents and radiosensitizers studied in RCTs were shown effective. …”
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1492
Antitumor efficiency of contact radiotherapy in combination with a chlorin-based photosensitizer in experiment
Published 2021-08-01“…The data obtained indicate that further studies of the radiosensitizing properties of PS are promising.…”
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1493
DIRECTIONS FOR THE RECOVERY OF AGRICULTURAL PRODUCTION ON RADIOACTIVELY CONTAMINATED LANDS
Published 2016-05-01“…The main danger of the accumulation by plants of radionuclides lies in the fact that they are a major link in the migratory chain of transmission of radionuclides to the more radiosensitive species and, above all, human. Economic feature of agricultural production in the study area is insufficient pricesambien, transformation of land use, violations of industrial-economic relations, the structure of agricultural production, changes in the natural-cost structure commodity products, the reform of the organizational structure of agricultural production. …”
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1494
Clinical benefits of oral capecitabine over intravenous 5-fluorouracyl regimen in case of neoadjuvant chemoradiotherapy followed by surgery for locally advanced rectal cancer
Published 2022-12-01“…Background: During the last decade, one of the most important treatment options for locally advanced, potencially resectable rectal tumours was neoadjuvant chemoradiotherapy (CRT) followed by surgery.Methods: Effects of the neoadjuvant treatment on surgical outcomes were retrospectively analysed in 185 patients with stage T2–T4 and N0–2, resectable rectal tumour among two patient groups defined by radiosensitizer agents. Group 1 (n = 94) involved radiotherapy (RT) with 50.4 Gy total dose (25 × 1.8 Gy + 3 × 1.8 Gy tumour bed boost), and intravenous 5-fluorouracil (5-FU) (350 mg/m2) with leucovorin (20 mg/m2) on the 1–5 and 21–25 days, while Group 2 (n = 91) RT and orally administrated capecitabine (daily 2 × 825 mg/m2) on RT days. …”
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1495
Pre-Administration of PLX-R18 Cells Protects Mice from Radiation-Induced Hematopoietic Failure and Lethality
Published 2022-09-01“…Acute Radiation Syndrome (ARS) is a syndrome involving damage to multiple organs caused by exposure to a high dose of ionizing radiation over a short period of time; even low doses of radiation damage the radiosensitive hematopoietic system and causes H-ARS. …”
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1496
Electron beam dose distribution in electron treatment planning system with the presence of high density dental amalgam in radiotherapy treatment / Mohd Zahri Abdul Aziz
Published 2013“…With the number of vital and radiosensitive organs in head and neck regions, MAR technique was compulsory in this case. …”
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Book Section -
1497
Optimization on radiation dose and image quality in paediatric computed tomography examination
Published 2021“…The final phase of this study observed the impact of dose in radiosensitive organ and its influence towards image quality in CT Chest-Abdomen-Pelvis (CAP) examination after applying CT optimization process. …”
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1498
A role for ceruloplasmin in the control of human glioblastoma cell responses to radiation
Published 2022-08-01“…Methods and results After analysis of radiation responses (Hoechst staining, LDH release, Caspase 3 activation) in U251-MG and U87-MG human GB cell lines, described as radiosensitive and radioresistant respectively, the expression of 9 iron partners (TFR1, DMT1, FTH1, FTL, MFRN1, MFRN2, FXN, FPN1, CP) were tested by RTqPCR and western blots at 3 and 8 days following 4 Gy irradiation. …”
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1499
Systemic therapy of inflammatory breast cancer with type 2 diabetes mellitus – Prevention of high risk of radiation-induced progression of tumor tissue cancer
Published 2022-12-01“…Hyperglycemia, higher total RT doses, and radiosensitizers are a few techniques that can improve the impact of RT on local-regional management. …”
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1500
Radiation Enhancer Effect of Platinum Nanoparticles in Breast Cancer Cell Lines: In Vitro and In Silico Analyses
Published 2021-04-01“…In this context, the potential of platinum nanoparticles (PtNPs) as radiosensitizers was investigated in two breast cancer cell lines, T47D and MDA-MB-231, showing a different radiation sensitivity. …”
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