Clinical Features and Correlates of Excessive Daytime Sleepiness in Parkinson's Disease by Ya-qin Xiang, Qian Xu, Qi-ying Sun, Zhi-qin Wang, Yun Tian, Liang-juan Fang, Yang Yang, Jie-qiong Tan, Xin-xiang Yan, Bei-sha Tang, Bei-sha Tang, Bei-sha Tang, Bei-sha Tang, Bei-sha Tang, Bei-sha Tang, Bei-sha Tang, Ji-feng Guo, Ji-feng Guo, Ji-feng Guo, Ji-feng Guo

“…Logistic regression analyses demonstrated that EDS was associated with male sex, age, cognitive impairment, PD-related sleep problems, rapid eye movement sleep behavior disorder (RBD), and worse quality of life (QoL).Conclusion: EDS is a general clinical manifestation in PD, and there were significant differences in clinical features between patients with and without EDS. …”
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Association of Plasma and Electroencephalography Markers With Motor Subtypes of Parkinson’s Disease by Xiaoxia Yang, Zhen Li, Lipeng Bai, Xiao Shen, Fei Wang, Xiaoxuan Han, Rui Zhang, Zhuo Li, Jinghui Zhang, Mengmeng Dong, Yanlin Wang, Tingyu Cao, Shujun Zhao, Chunguang Chu, Chen Liu, Xiaodong Zhu

“…For other non-motor symptoms, there were significant direct associations of kPLI theta with HAMD and HAMA, especially in the prefrontal region, and kPLI gamma was particularly correlated with Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire (RBDSQ) scores in the prefrontal, frontal, and parietal regions in the TD group. …”
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Mutational spectrum and clinical features of GBA1 variants in a Chinese cohort with Parkinson’s disease by Yangjie Zhou, Yige Wang, Juan Wan, Yuwen Zhao, Hongxu Pan, Qian Zeng, Xun Zhou, Runcheng He, Xiaoxia Zhou, Yaqin Xiang, Zhou Zhou, Bin Chen, Qiying Sun, Qian Xu, Jieqiong Tan, Lu Shen, Hong Jiang, Xinxiang Yan, Jinchen Li, Jifeng Guo, Beisha Tang, Heng Wu, Zhenhua Liu

“…Patients with GBA1 variants exhibited an earlier onset age and higher risk of probable rapid-eye-movement sleep behavior disorder, olfactory dysfunction, depression, and autonomic dysfunction than patients without GBA1 variants.…”
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Penerapan Decision Tree dan Random Forest dalam Deteksi Tingkat Stres Manusia Berdasarkan Kondisi Tidur by Sza Sza Amulya Larasati, Elok Nuraida Kusuma Dewi, Brahma Hanif Farhansyah, Fitra Abdurrachman Bachtiar, Fajar Pradana

“…The data used consists of continuous data with eight features: 'snoring rate' (snoring rate), 'respiration rate' (respiration rate), 'body temperature' (body temperature), 'limb movement' (limb movement), 'blood oxygen' (blood oxygen), 'rapid eye movement' (rapid eye movement), 'sleep hours' (sleep hours), and 'heart rate' (heart rate). …”
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Long-term neurological complications in COVID-19 survivors: study protocol of a prospective cohort study (NeurodegCoV-19) by Luis Ribeiro, Nuno Lunet, Samantha Morais, Natália Araújo, Susana Pereira, João Firmino-Machado, Ana Rute Costa, Luis Ruano, Pedro Freitas, Isa Silva, Patrícia Campos, Rita Correia, Margarida Calejo, Mariana Seco, Rita Rodrigues, Joana Pais, Vítor Tedim-Cruz

“…Baseline, 1-year and 2-year follow-up evaluations will include: cognitive performance assessed with the Montreal Cognitive Assessment (MoCA) and neuropsychological tests; the assessment of prodromal markers of PD with Rapid Eye Movement Sleep Behaviour Disorder single-question Screen and self-reported olfactory and gustative alterations; screening of PD with the 9-item PD screening questionnaire; gait evaluation with Timed Up&Go test. …”
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Neuronally derived extracellular vesicle α-synuclein as a serum biomarker for individuals at risk of developing Parkinson disease by Yan, S, Jiang, C, Janzen, A, Barber, TR, Seger, A, Sommerauer, M, Davis, JJ, Marek, K, Hu, MT, Oertel, WH, Tofaris, GK

“…The derivation group (n = 170) included participants with isolated rapid eye movement sleep behavior disorder (iRBD) and controls. …”

Spatiotemporal patterns of sleep spindle activity in human anterior thalamus and cortex by Hannah Bernhard, Frederic L.W.V.J. Schaper, Marcus L.F. Janssen, Erik D. Gommer, Bernadette M. Jansma, Vivianne Van Kranen-Mastenbroek, Rob P.W. Rouhl, Peter de Weerd, Joel Reithler, Mark J. Roberts, Louis G. Wagner, Albert J. Colon, Danny M.W. Hilkmann, Marielle C.G. Vlooswijk, Jeske Nelissen, Linda Ackermans, Yasin Temel

“…Sleep spindles (8 - 16 Hz) are transient electrophysiological events during non-rapid eye movement sleep. While sleep spindles are routinely observed in the cortex using scalp electroencephalography (EEG), recordings of their thalamic counterparts have not been widely studied in humans. …”
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Subtyping of early-onset Parkinson’s disease using cluster analysis: A large cohort study by Zhou Zhou, Zhou Zhou, Xiaoxia Zhou, Yaqin Xiang, Yuwen Zhao, Hongxu Pan, Juan Wu, Qian Xu, Yase Chen, Qiying Sun, Qiying Sun, Xinyin Wu, Jianping Zhu, Xuehong Wu, Jianhua Li, Xinxiang Yan, Xinxiang Yan, Jifeng Guo, Jifeng Guo, Jifeng Guo, Beisha Tang, Beisha Tang, Beisha Tang, Lifang Lei, Zhenhua Liu, Zhenhua Liu, Zhenhua Liu

“…Compared to patients with mild subtype, patients with the severe subtype were more likely to have rapid eye movement sleep behavior disorder, wearing-off, and dyskinesia, after adjusting for age and disease duration at baseline, and showed a more rapid progression in Unified Parkinson’s Disease Rating Scale (UPDRS) total score (P = 0.002), UPDRS part II (P = 0.014), and III (P = 0.001) scores, Hoehn and Yahr stage (P = 0.001), and Parkinson’s disease questionnaire-39 item version score (P = 0.012) at prospective follow-up.ConclusionWe identified three different clinical subtypes (mild, intermediate, and severe) using cluster analysis in a large EOPD cohort for the first time, which is important for tailoring therapy to individuals with EOPD.…”
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Association Between Sleep Microstructure and Incident Hypertension in a Population‐Based Sample: The HypnoLaus Study by Mathieu Berger, Andrew Vakulin, Camila Hirotsu, Nicola Andrea Marchi, Geoffroy Solelhac, Virginie Bayon, Francesca Siclari, José Haba‐Rubio, Julien Vaucher, Peter Vollenweider, Pedro Marques‐Vidal, Bastien Lechat, Peter G. Catcheside, Danny J. Eckert, Robert J. Adams, Sarah Appleton, Raphael Heinzer

“…Participants had at‐home polysomnography at baseline, allowing assessment of sleep macrostructure (nonrapid eye movement sleep stages 1, 2, and 3; rapid eye movement sleep stages; and total sleep time) and microstructure including power spectral density of electroencephalogram in nonrapid eye movement sleep and spindles characteristics (density, duration, frequency, amplitude) in nonrapid eye movement sleep stage 2. …”
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Sex Differences in Brain and Cognition in de novo Parkinson's Disease by Javier Oltra, Javier Oltra, Carme Uribe, Carme Uribe, Carme Uribe, Anna Campabadal, Anna Campabadal, Anna Inguanzo, Anna Inguanzo, Gemma C. Monté-Rubio, Maria J. Martí, Maria J. Martí, Maria J. Martí, Yaroslau Compta, Yaroslau Compta, Yaroslau Compta, Francesc Valldeoriola, Francesc Valldeoriola, Francesc Valldeoriola, Carme Junque, Carme Junque, Carme Junque, Barbara Segura, Barbara Segura, Barbara Segura

“…We aimed to investigate sex differences in brain atrophy and cognition in de novo Parkinson's disease (PD) patients.Methods: Clinical, neuropsychological and T1-weighted MRI data from 205 PD patients (127 males: 78 females) and 69 healthy controls (40 males: 29 females) were obtained from the PPMI dataset.Results: PD males had a greater motor and rapid eye movement sleep behavior disorder symptomatology than PD females. …”
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Sleep and Neurochemical Modulation by DZNep and GSK-J1: Potential Link With Histone Methylation Status by Eric Murillo-Rodríguez, Eric Murillo-Rodríguez, Gloria Arankowsky-Sandoval, Jorge Aparecido Barros, Jorge Aparecido Barros, Nuno Barbosa Rocha, Nuno Barbosa Rocha, Tetsuya Yamamoto, Tetsuya Yamamoto, Sérgio Machado, Sérgio Machado, Henning Budde, Henning Budde, Henning Budde, Diogo Telles-Correia, Diogo Telles-Correia, Diogo Monteiro, Diogo Monteiro, Diogo Monteiro, Luis Cid, Luis Cid, Luis Cid, André Barciela Veras, André Barciela Veras

“…DZNep dose-dependently (0.1, 1.0, or 10 mg/kg, i.p.) prolonged wakefulness (W) duration while decreased slow wave sleep (SWS) and rapid eye movement sleep (REMS) time spent during the lights-on period with no changes observed in dark phase. …”
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Seizures and electrophysiological features in familial cortical myoclonic tremor with epilepsy 1 by Yao Ding, Zhidong Cen, Yang Zheng, Xia Qiu, Yumao Ye, Xinhui Chen, Lingli Hu, Bo Wang, Zhongjin Wang, Houmin Yin, Chunhong Shen, Wenjie Ming, Yi Ge, Fei Xie, Dehao Yang, Zhiyuan Ouyang, Haotian Wang, Sheng Wu, Meiping Ding, Shuang Wang, Wei Luo

“…Overnight EEG of FCMTE patients displayed paradoxical sleep–wake fluctuation, with a higher average IED index of 0.82 ± 0.88/min during wakefulness and a lower IED index of 0.04 ± 0.06/min during non‐rapid eye movement sleep stages I–II. Interpretation FCMTE type 1 has a benign course of epilepsy and distinct clinical and electrophysiological features. …”
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The efficacy and safety of transcutaneous auricular vagus nerve stimulation in patients with mild cognitive impairment: A double blinded randomized clinical trial by Lei Wang, Jinling Zhang, Chunlei Guo, Jiakai He, Shuai Zhang, Yu Wang, Yanan Zhao, Liang Li, Junying Wang, Liwei Hou, Shaoyuan Li, Yifei Wang, Lixiao Hao, Yufeng Zhao, Mozheng Wu, Jiliang Fang, Peijing Rong

“…The secondary outcomes included auditory verbal learning test-HuaShan version (AVLT-H), shape trails test A&B (STT-A&B), animal fluence test (AFT), Boston naming test (BNT), Pittsburgh sleep quality index (PSQI), rapid eye movement sleep behavior disorder screening questionnaire (RBDSQ), Epworth sleepiness scale (ESS) and functional activities questionnaire (FAQ). …”
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Sleep spindles across youth affected by schizophrenia or anti-N-methyl-D-aspartate-receptor encephalitis by Maria E. Dimitriades, Maria E. Dimitriades, Andjela Markovic, Andjela Markovic, Andjela Markovic, Silvano R. Gefferie, Silvano R. Gefferie, Ashura Buckley, David I. Driver, Judith L. Rapoport, Margherita Nosadini, Margherita Nosadini, Kevin Rostasy, Stefano Sartori, Stefano Sartori, Agnese Suppiej, Salome Kurth, Maurizia Franscini, Susanne Walitza, Susanne Walitza, Susanne Walitza, Reto Huber, Reto Huber, Reto Huber, Reto Huber, Leila Tarokh, Leila Tarokh, Bigna K. Bölsterli, Bigna K. Bölsterli, Bigna K. Bölsterli, Bigna K. Bölsterli, Miriam Gerstenberg, Miriam Gerstenberg

“…Reductions in sleep spindles, a major electrophysiological oscillation during non-rapid eye movement sleep, have been identified in patients with schizophrenia as a potential biomarker representing the impaired integrity of the thalamocortical network. …”
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EEG spectral power during REM sleep in patients with frontal brain tumor by Laura Victoria Ortega-Leonard, Yolanda del Río-Portilla

“…Abstract Background The main objective of this research was to analyze the characteristics of electrical activity in the brain during REM (Rapid Eye Movements) sleep, by using an experimental model a pathology that affects the frontal lobes, such as brain tumors. …”
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End-of-Life in Oncologic Patients’ Dream Content by Alessandro Cicolin, Michele Boffano, Guglielmo Beccuti, Raimondo Piana, Alessandra Giordano

“…Both non-rapid eye movements and rapid eye movements sleep facilitate the strengthening of newly encoded memory traces, and dream content reflects this process. …”
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Sleep Paralysis from the Viewpoint of Persian Medicine by Mahdie Hajimonfarednejad, Babak Daneshfard, Mohammad Javad Raee, Dennis Cordato, Mohammad Mahdi Parvizi, Mohadeseh Ostovar

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COVID-19 lockdown by Ismail Dergaa, Achraf Ammar, Amine Souissi, Mohamed Saifeddin Fessi, Khaled Trabelsi, Jordan M. Glenn, Amine Ghram, Morteza Taheri, Khadijeh Irandoust, Hamdi Chtourou, Mohamed Romdhani, Helmi Ben Saad, Karim Chamari

“…Compared to pre-confinement, significant changes were registered for almost all parameters during the 1st and/or the 2nd month of confinements (p<0.001), with (i) higher values for resting heart rate, sleep latency, and total, light and rapid eye movements sleep times (% change=7-523 %), and (ii) lower values for PA parameters, calories/day spent, average and highest respiratory rates, and deep sleep time during the home confinement period (% change=5-36 %). …”
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