326 Integrated Analysis of Genetic Databases Identifies miRNA Associated With Poor Survival In Melanoma by Reid McCallister, Chitra Subramanian, Nikhil Mantena, Mark Cohen

“…Pathway analysis indicated that PPAR, phosphatidylinositol signaling, Rap1 signaling, and p53 signaling pathways were enriched by downregulated genes while the NF-kB pathway was enriched up regulated genes. …”
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Assessing the Performance of Ridge Regression Method-6 in Genomic Evaluation of Discrete Threshold Traits with Additive and Dominance Genetic Architecture by Farhad Ghafouri-Kesbi

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Network pharmacology and molecular docking-based prediction of active compounds and mechanisms of action of Cnidii Fructus in treating atopic dermatitis by Shakeel Ahmad Khan, Ying Wu, Amy Sze-Man Li, Xiu-Qiong Fu, Zhi-Ling Yu

“…KEGG pathway analyses showed that PI3K-Akt signaling, calcium signaling, Rap1 signaling, and cAMP signaling pathways are the main pathways involved in the anti-AD effects of CF. …”
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Generation and Characterization of Torudokimab (LY3375880): A Monoclonal Antibody That Neutralizes Interleukin-33 by Okragly AJ, Corwin KB, Elia M, He D, Schroeder O, Zhang Q, Shiyanova T, Bright S, Dicker SB, Chlewicki L, Truhlar SME, Davies J, Patel CN, Benschop RJ

“…It is a member of the IL-1 family and binds to a heterodimer receptor consisting of ST2 and IL-1RAP to induce the production of a wide range of cellular mediators, including the type 2 cytokines IL-4, IL-5 and IL-13. …”
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Physiological and molecular effects of gibberellic acid and paclobutrazol on young clonal palm growth and development by Chai, Sook Keat

“…These physiological changes were associated with a higher expression of cell cycle-related genes such as MYB3R-1, E2FB, CK1d, CDK5RAP3 and SRO1 and cellulose synthase CSLC5 (five-fold) and CCR1 (three-fold) for lignin synthesis. …”
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Enhancing the support-execution model of strategy execution: A moderated mediation effect of strategy engagement and strategy communication by Chuah, Chin Wei, Teoh, Kenny, Abdullah, Haim Hilman

“…Strategy execution, a term that is commonly associated as the subsequent process of strategic planning (Bourgeois & Brodwin, 1984; Cater & Pucko, 2010) is now widely regarded as the most important problem in the field of strategic management (Speculand, 2009).Recent statistics shown that the success rate for strategy execution stands between 10% to 30% (Farsight Leadership Organization, 2007; Raps, 2004).Such poor success rate of strategy execution indicates that there is much to be explored about strategy execution. …”
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Idiopathic Pulmonary Arterial Hypertension in Paediatrics Represents Still a Serious Challenge: A Case Series Study by Pier Paolo Bassareo, Paola Argiento, Colin Joseph McMahon, Esme Dunne, Kevin Patrick Walsh, Maria Giovanna Russo, Michele D’Alto

“…The RHC data showed that mPAP was 61.8 ± 23.1 mmHg (<i>p</i> = 0.0017 with RVSP on echocardiography), mRAP was 10.7 ± 3.8 mmHg, CI was 2.6 ± 1 L·min⁻¹·m⁻², PVRi was 16.8 ± 12.6 WU·m², and SVO₂ was 63.6 ± 14.8%. …”
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Agronomic and Physiological Performance of the <i>Indica</i> Rice Varieties Differing in Tolerance to Low Phosphorus by Zhiwei Sun, Shengfeng Qiao, Yuemei Xu, Dongling Ji, Weiyang Zhang, Junfei Gu, Kuanyu Zhu, Zhiqin Wang, Jianhua Zhang, Jianchang Yang

“…Additionally, the STVs demonstrated better root traits, such as higher root biomass, root oxidative activity (ROA), root acid phosphatase (RAP) activity, and greater root IAA and Z + ZR contents. …”
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The interplay of DNA methyltransferases and demethylases with tuberization genes in potato (Solanum tuberosum L.) genotypes under high temperature by Madhushree Dutta, Madhushree Dutta, Vidhi Raturi, Vidhi Raturi, Vijay Gahlaut, Akhil Kumar, Paras Sharma, Vipasha Verma, Vijai Kishor Gupta, Salej Sood, Gaurav Zinta, Gaurav Zinta

“…Several positive (StSP6A and StBEL5) and negative (StSP5G, StSUT4, and StRAP1) regulators are involved in the potato tuberization. …”
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Preliminary Study on New Alternative Binders through Re-Refined Engine Oil Bottoms (REOBs) and Industrial By-Product Additives by Michele Porto, Paolino Caputo, Valeria Loise, Abraham A. Abe, Giulia Tarsi, Cesare Sangiorgi, Francesco Gallo, Cesare Oliviero Rossi

“…An even larger amount of virgin and non-renewable resources can be saved using these new potential alternative binders together with the RAP aggregates. Thus, the reduction in the use of virgin materials is applied at the binder and the asphalt mixture levels. …”
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Bovine aortic endothelial cells express a variant of the very low density lipoprotein receptor that lacks the O-linked sugar domain1 by Jordi Magrané, Manuel Reina, Roser Pagan, Ana Luna, Ricardo P. Casaroli-Marano, Bo Angelin, Mats Gåfvels, Senén Vilaró

“…We present several lines of evidence showing that bovine aortic endothelial cells exclusively express a VLDL receptor isoform that lacks the O-linked sugar domain i) Western and receptor-associated protein (RAP) ligand blotting gave a single band of about 99 kDa in membrane extracts of bovine aortic endothelial cells (BAEC). ii) Screening of the BAEC cDNA library with the previously characterized human VLDL receptor cDNA as a probe gave several C-terminal-positive clones; all lacked the 84 nucleotides corresponding to exon 16. …”
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Therapeutic role of Wuda granule in gastrointestinal motility disorder through promoting gastrointestinal motility and decreasing inflammatory level by Zhi Jiang, Qiuping Zou, Qiuping Zou, Qicheng Chen, Junhong Zhang, Hailin Tang, Jingbao Chen, You Qin, Liming Yang, Zhiqiang Chen, Lixing Cao

“…The mechanism was mainly involved in the regulation of PI3K-Akt signaling pathway and Rap1 signaling pathway. In addition, molecular docking analysis suggested that eight key active compounds of WDG may be mainly responsible for the effect of WDG on GMD by targeting HARS, AKT, and PIK3CA, respectively. …”
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Mechanisms of ag85a/b DNA vaccine conferred immunotherapy and recovery from Mycobacterium tuberculosis‐induced injury by Nan Wang, Yan Liang, Qianqian Ma, Jie Mi, Yong Xue, Yourong Yang, Lan Wang, Xueqiong Wu

“…The pancreatic secretion pathway downregulated and the Rap1 signal pathway upregulated had particularly significant changes during the immunotherapy of the ag85a/b DNA vaccine on the mouse TB model. …”
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Identification of Robust and Key Differentially Expressed Genes during C2C12 Cell Myogenesis Based on Multiomics Data by Song Zhang, Yuanyuan Zhang, Choulin Chen, Qingqing Hu, Yang Fu, Lingna Xu, Chao Wang, Yuwen Liu

“…Further functional annotation of KLF5-binding sites suggested that KLF5 may regulate myogenesis through the PI3K-AKt signaling pathway, Rap1 signaling pathway, and the Hippo signaling pathway. …”
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Perspectives of clinical stakeholders and patients from four VA liver clinics to tailor practice facilitation for implementing evidence-based alcohol-related care by Elena M. Soyer, Madeline C. Frost, Olivia V. Fletcher, George N. Ioannou, Judith I. Tsui, E. Jennifer Edelman, Bryan J. Weiner, Rachel L. Bachrach, Jessica A. Chen, Emily C. Williams

“…Interviews were transcribed and qualitatively analyzed using a Rapid Assessment Process (RAP) guided by the CFIR. Results We interviewed 46 clinical stakeholders and 41 patient participants and analyzed findings based on the CFIR. …”
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Coastal landforms and fetch influence shoreline restoration effectiveness by Jason D. Toft, Kerry L. Accola, Simone Des Roches, Simone Des Roches, Julia N. Kobelt, Hannah S. Faulkner, Jason R. Morgan, Bianca S. Perla, Maria Metler, Megan N. Dethier

“…Shoreline “hardening” – the construction of armor including seawalls, bulkheads, or rip-rap – is a common modification that has substantial negative ecological effects. …”
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The blue light signal transduction module FaCRY1-FaCOP1-FaHY5 regulates anthocyanin accumulation in cultivated strawberry by Yongqiang Liu, Yongqiang Liu, Li Tang, Yiping Wang, Lianxi Zhang, Shiqiong Xu, Xiao Wang, Wen He, Yunting Zhang, Yuanxiu Lin, Yan Wang, Mengyao Li, Xiaorong Wang, Yong Zhang, Ya Luo, Qing Chen, Haoru Tang, Haoru Tang

“…Moreover, dual-luciferase assays showed that FaHY5 could increase the activity of FaRAP (anthocyanin transport gene) promoter and that this function relied on other, likely B-box protein FaBBX22, factors. …”
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Whole-Genome Sequencing Reveals the Genomic Characteristics and Selection Signatures of Hainan Black Goat by Qiaoling Chen, Yuan Chai, Wencan Zhang, Yiwen Cheng, Zhenxing Zhang, Qi An, Si Chen, Churiga Man, Li Du, Wenguang Zhang, Fengyang Wang

“…The melanin biosynthetic process, circadian entrainment, regulation of cyclic adenosine 3,5-monophosphate (cAMP)-mediated signaling, and the Rap-1 signaling pathway were significantly enriched in Hainan Black and Alashan Cashmere goats. …”
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Breast Cancer knowledge, perceptions and practices in a rural Community in Coastal Kenya by Shahin Sayed, Anthony K. Ngugi, Megan R. Mahoney, Jaameeta Kurji, Zohray M. Talib, Sarah B. Macfarlane, Theresa A. Wynn, Mansoor Saleh, Amyn Lakhani, Esther Nderitu, Felix Agoi, Zul Premji, Jo Anne Zujewski, Zahir Moloo

“…Elements of the Rapid Assessment Process (RAP) were used to guide analysis of the FGDs and the KIIs. …”
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Metabolite and Proteomic Profiling of Serum Reveals the Differences in Molecular Immunity between Min and Large White Pig Breeds by Liyu Yang, Xin Liu, Xiaoyu Huang, Longchao Zhang, Hua Yan, Xinhua Hou, Lixian Wang, Ligang Wang

“…Moreover, seven of them co-localized with both immune and PUFA QTLs, including proteasome 20S subunit beta 8 (PSMB8), mannose binding lectin 1 (MBL1), and interleukin-1 receptor accessory protein (IL1RAP). These proteins may play important roles in regulating the production or metabolism of unsaturated fatty acids and immune factors. …”
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