Functional Progression after Dose Suspension or Discontinuation of Nintedanib in Idiopathic Pulmonary Fibrosis: A Real-Life Multicentre Study by Barbara Ruaro, Andrea Salotti, Nicolò Reccardini, Stefano Kette, Beatrice Da Re, Salvatore Nicolosi, Umberto Zuccon, Marco Confalonieri, Lucrezia Mondini, Riccardo Pozzan, Michael Hughes, Paola Confalonieri, Francesco Salton

“…Methods. We conducted a real-life retrospective study based on the experience of NTD use in two centers between 2015 and 2022. …”
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Tolerability Profile and Discontinuation Causes of Sacubitril/Valsartan Treatment in ‘Real-life’ Patients with Heart Failure and Reduced Ejection Fraction by M Rizzo, I Colomer-Asenjo, G Cabello-Molina, S Marín-López, M Sutil-Vega, C Roca-Guerrero, F Taibi-Hajjami, D García-Vega, M Panelo-Rubio, M Bonastre-Thio, A Martínez-Rubio

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A new one-parameter flexible family with variable failure rate shapes: Properties, inference, and real-life applications by Hisham Mahran, Mahmoud M. Mansour, Enayat M. Abd Elrazik, Ahmed Z. Afify

“…Furthermore, the flexibility of the two-parameter GKME distribution was explored by analyzing five real-life data applications from applied fields such as medicine, environment, and reliability. …”
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Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas: Real-Life Data over Three Years by Carolina Donelli, Mariano Suppa, Linda Tognetti, Jean Luc Perrot, Laura Calabrese, Javiera Pérez-Anker, Josep Malvehy, Pietro Rubegni, Elisa Cinotti

“…The positive predictive value (PPV) resulted in 0.74 (CI 0.69–0.78) for dermoscopy and 0.94 (CI 0.91–0.97) for LC-OCT, and the negative predictive value (NPV) was 0.89 (CI 0.81–0.95) for dermoscopy and 0.98 (CI 0.95–1.00) for LC-OCT. Finally, our real-life study showed a potentially important role of LC-OCT in the non-invasive diagnosis of NMSCs, especially BCC. …”
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Real-Life Safety Profile of the 9-Valent HPV Vaccine Based on Data from the Puglia Region of Southern Italy by Antonio Di Lorenzo, Paola Berardi, Andrea Martinelli, Francesco Paolo Bianchi, Silvio Tafuri, Pasquale Stefanizzi

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Performance Characteristics of Oncomine Focus Assay for Theranostic Analysis of Solid Tumors, A (21-Months) Real-Life Study by Jessica Bamba-Funck, Emmanuelle E. Fabre, Marianne Kambouchner, Olivier Schischmanoff

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Using Web-Based Content to Connect Young People With Real-life Mental Health Support: Qualitative Interview Study by Emily Adeane, Kerry Gibson

“…ConclusionsThis study offers recommendations for professionals and service providers on how to better engage young people with real-life mental health support using web-based content. …”
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Home-Based Spirometry in Patients with Interstitial Lung Diseases: A Real-Life Pilot “FACT” Study from Serbia by Miroslav Ilić, Jovan Javorac, Ana Milenković, Dejan Živanović, Dejan Miljković, Svetlana Kašiković Lečić, Nevena Savić, Kristina Tot Vereš, Dragica Kovačević, Emilija Vujičić, Ivan Kopitović

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Effects of specific allergen immunotherapy on biological markers and clinical parameters in asthmatic children: a controlled-real life study by I. Djuric-Filipovic, Marco Caminati, D. Filipovic, C. Salvottini, Z. Zivkovic

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Diabetic Macular Edema Treated with 577-nm Subthreshold Micropulse Laser: A Real-Life, Long-Term Study by Luisa Frizziero, Andrea Calciati, Tommaso Torresin, Giulia Midena, Raffaele Parrozzani, Elisabetta Pilotto, Edoardo Midena

“…This study suggests that 577-nm SMPL is a safe and repeatable treatment for mild DME that may be applied to real-life clinical settings using fixed parameters and protocols.…”
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Comparison of <i>BRAF</i> Mutation Screening Strategies in a Large Real-Life Series of Advanced Melanoma Patients by Maria Colombino, Carla Rozzo, Panagiotis Paliogiannis, Milena Casula, Antonella Manca, Valentina Doneddu, Maria Antonietta Fedeli, Maria Cristina Sini, Grazia Palomba, Marina Pisano, Paolo A. Ascierto, Corrado Caracò, Amelia Lissia, Antonio Cossu, Giuseppe Palmieri

“…The aim of this study was to compare <i>BRAF</i> mutational testing performed by conventional nucleotide sequencing approaches with either real-time polymerase chain reaction (rtPCR) or next-generation sequencing (NGS) assays in a real-life, hospital-based series of advanced MM patients. …”
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Efficacy and safety of leflunomide in patients with rheumatoid arthritis in real-life clinical practice (results of the Russian multicenter surveillance study) by R.M. Balabanova, T.B. Dubinina, D.V. Goryachev, E.L. Shakhramanova, O.N. Anoshenkova, N.R. Degula

“…This surveillance study was aimed at assessing the effectiveness and tolerability of ELAFRA in RA patients in real-life clinical practice. Material and Methods. …”
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Long-Term Efficacy and Safety of Risankizumab for Moderate to Severe Psoriasis: A 2-Year Real-Life Retrospective Study by Matteo Megna, Angelo Ruggiero, Teresa Battista, Laura Marano, Sara Cacciapuoti, Luca Potestio

“…Its efficacy and safety have been reported by clinical trials and real-life studies. However, even if long-term data from trials have already been reported (up to 172 weeks), data on long-term real-life experiences are still limited. …”
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Paradoxical real-life underuse of GLP-1 receptor agonists in type 2 diabetes patients with atherosclerotic cardiovascular disease by André J. Scheen

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Mepolizumab Improves Outcomes of Chronic Rhinosinusitis with Nasal Polyps in Severe Asthmatic Patients: A Multicentric Real-Life Study by Stefania Gallo, Paolo Castelnuovo, Luca Spirito, Marta Feduzi, Veronica Seccia, Dina Visca, Antonio Spanevello, Erica Statuti, Manuela Latorre, Claudio Montuori, Angela Rizzi, Cristina Boccabella, Matteo Bonini, Eugenio De Corso

“…The present study aimed to evaluate the effectiveness of mepolizumab on sinonasal outcomes of comorbid CRSwNP and severe asthma in a real-life setting. The primary endpoint was to evaluate changes in the SinoNasal Outcome Test (SNOT)-22 score, Nasal Polyp (NP) score, and blood eosinophil count during a 12-month treatment with mepolizumab. …”
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P1136: INTERIM IMAGING DOES NOT PREDICT CLINICAL EVOLUTION IN FOLLICULAR LYMPHOMA IN A REAL-LIFE CLINICAL SETTING by V. Ramos De Ascanio, L. Sánchez Paz, M. S. Infante, J. Churruca Sarasqueta, M. Á. Foncillas García, E. Landete Hernández, K. D. C. Marín Mori, C. Muñoz Novas, J. Á. Hernández Rivas, I. González Gascón y Marín

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What Is Left for Real-Life Lactate Monitoring? Current Advances in Electrochemical Lactate (Bio)Sensors for Agrifood and Biomedical Applications by Juan José García-Guzmán, Alfonso Sierra-Padilla, José María Palacios-Santander, Juan Jesús Fernández-Alba, Carmen González Macías, Laura Cubillana-Aguilera

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Hepatitis C Virus Infection in the Elderly in the Era of Direct-Acting Antivirals: Evidence from Clinical Trials and Real Life by Nicola Pugliese, Davide Polverini, Ivan Arcari, Stella De Nicola, Francesca Colapietro, Chiara Masetti, Monica Ormas, Roberto Ceriani, Ana Lleo, Alessio Aghemo

“…This narrative review aims to summarize the current scientific evidence on the efficacy and safety of DAAs in the elderly population, both in clinical trials and in real-life settings. Although there is still a paucity of real-world data and no clinical trials have yet been conducted in the population aged ≥ 75 years old, some considerations about the efficacy and safety of DAAs in the elderly can be made based on the results of these studies. …”
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Real-life experiences and barriers to adjuvant chemotherapy in Saudi patients with advanced stage II and stage III colon cancer by Mesnad S Alyabsi, Anwar H Alqarni, Adel F Almutairi, Nahar A Alselaim, Mohammed A Algarni, Kanan M Alshammari

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Real-Life International Normalized Ratio Profile in Patients with Non-Valvular Atrial Fibrillation Prescribed Vitamin K Antagonist by S. I. Farag, O. S. Arafa, A.A. E. Hassan, H. M. Mashhour, A. M. Bendary

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