A 48-week update of a multicentre real-life experience of dupilumab in adult patients with moderate-to-severe atopic dermatitis by M. C. Fargnoli, M. Esposito, S. Ferrucci, G. Girolomoni, A. Offidani, A. Patrizi, K. Peris, A. Costanzo, G. Malara, G. Pellacani, M. Romanelli, P. Amerio, A. Cristaudo, M. L. Flori, A. Motolese, P. Betto, C. Patruno, P. Pigatto, C. Peccianti, G. Stinco, I. Zalaudek, L. Bianchi, V. Boccaletti, S. P. Cannavo, F. Cusano, S. Lembo, R. Mozzillo, R. Gallo, C. Potenza, F. Rongioletti, R. Tiberio, T. Grieco, G. Micali, S. Persechino, M. Pettinato, S. Pucci, L. Stingeni, C. Caruso, G. Argenziano

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Clinical Presentation and Outcomes in Real-Life Management of Elderly Patients Aged ≥75 Years Presenting with Acute Myocardial Infarction by Öner Özdoğan, Meral Kayıkcıoğlu, Mustafa Kılıçkap, Cenk Ekmekçi, Murat Küçükukur, Ahmet Arif Yalçın, Mustafa Kemal Erol

“…Background: The aim of this study was to provide insight into the real-life clinical presentation and outcomes of the elderly presenting with acute myocardial infarction from the Turkish Myocardial Infarction registry database. …”
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Dalbavancin real-life utilization among diabetic patients suffering from infections in Italy and Spain: The DALBADIA retrospective cohort study by Laura Morata Ruiz, Alessandro Ruggieri, Marco Falcone, Juan Pasquau Liaño, Ivan Gentile, Miguel Salavert Lletí, Leonor Moreno Núñez, Antonio Cascio, Carlo Tascini, Maria Loeches Yagüe, Francesco Giuseppe De Rosa, Alessandra Ori, Alessandro Comandini, Agnese Cattaneo, Paolo Antonio Grossi

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Prognostic factors for regorafenib treatment in patients with refractory metastatic colorectal cancer: A real-life retrospective multi-center study by Sabin Goktas Aydin, Engin Eren Kavak, Atakan Topcu, Ayberk Bayramgil, Fahri Akgul, Seda Kahraman, Musa Baris Aykan, Yunus Emre Altıntas, Kaan Helvaci, Yuksel Urun, Ahmet Bilici, Mesut Seker, Mehmet Ali Nahit Sendur, Omer Fatih Olmez, Ozgur Acikgoz, Irfan Cicin

“…Our study aimed to evaluate prognostic factors influencing regorafenib treatment and assess the optimal dosing regimen in a real-life setting. We retrospectively analysed 263 patients with mCRC from multiple medical oncology clinics in Turkey. …”
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Cefiderocol-Based Combination Therapy for “Difficult-to-Treat” Gram-Negative Severe Infections: Real-Life Case Series and Future Perspectives by Davide Fiore Bavaro, Alessandra Belati, Lucia Diella, Monica Stufano, Federica Romanelli, Luca Scalone, Stefania Stolfa, Luigi Ronga, Leonarda Maurmo, Maria Dell’Aera, Adriana Mosca, Lidia Dalfino, Salvatore Grasso, Annalisa Saracino

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Real-Life Multicenter Experience of Venetoclax in Combination with Hypomethylating Agents in Previously Untreated Adult Patients with Acute Myeloid Leukemia in Greece by Theodora Chatzilygeroudi, Ismini Darmani, Natali El Gkotmi, Pinelopi Vryttia, Stavroula Douna, Anthi Bouchla, Vasiliki Labropoulou, Maria Kotsopoulou, Argiris Symeonidis, Maria Pagoni, Vasiliki Pappa, Sotirios G. Papageorgiou

“…To assess the efficacy and safety challenges in the real-life setting of the combination of hypomethylated agent (HMA) and venetoclax, we conducted a multi-center retrospective study. …”
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When best friendships end: young adolescents' responses to hypothetical best friendship dissolution and associations with real-life friendship outcomes by Julie C. Bowker, Jenna P. Weingarten, Rebecca G. Etkin, Melanie A. Dirks

“…Path models revealed unique linkages between several responses, such as vengeful coping and the real-life friendship-specific outcomes.DiscussionFindings suggest variability in how young adolescents respond to hypothetical best friendship dissolutions and that such variability may explain differences in their real-life friendships.…”
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Effectiveness of Dupilumab in the Treatment of Patients with Severe Uncontrolled CRSwNP: A “Real-Life” Observational Study in the First Year of Treatment by Eugenio De Corso, Stefano Settimi, Claudio Montuori, Marco Corbò, Giulio Cesare Passali, Davide Paolo Porru, Simone Lo Verde, Camilla Spanu, Daniele Penazzi, Giuseppe Alberto Di Bella, Eleonora Nucera, Matteo Bonini, Gaetano Paludetti, Jacopo Galli

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Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal: Baseline Results from the Non-Interventional Multicentre AWARE Study by Ana Célia Costa, Isabel Rosmaninho, Arminda Guilherme, José Ferreira, Joana Antunes, Ana Pina, Sara Prates, João Gaspar Marques, Filomena Azevedo, Ana Paula Cunha, Celeste Brito, António Massa, João Teles de Sousa, Glória Cunha Velho, Inês Raposo, Gabriela Marques Pinto, Virgínia Sousa, Ana Rodrigues Martins

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Pancreatic enzyme replacement therapy in subjects with exocrine pancreatic insufficiency and diabetes mellitus: a real-life, case–control study by Laure Alexandre-Heymann, Fetta Yaker, Pierre Bel Lassen, Danièle Dubois-Laforgue, Etienne Larger

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Molecular Landscape and Validation of New Genomic Classification in 2668 Adult AML Patients: Real Life Data from the PETHEMA Registry by Claudia Sargas, Rosa Ayala, María José Larráyoz, María Carmen Chillón, Estrella Carrillo-Cruz, Cristina Bilbao-Sieyro, Esther Prados de la Torre, David Martínez-Cuadrón, Rebeca Rodríguez-Veiga, Blanca Boluda, Cristina Gil, Teresa Bernal, Juan Miguel Bergua, Lorenzo Algarra, Mar Tormo, Pilar Martínez-Sánchez, Elena Soria, Josefina Serrano, Juan Manuel Alonso-Domínguez, Raimundo García-Boyero, María Luz Amigo, Pilar Herrera-Puente, María José Sayas, Esperanza Lavilla-Rubira, Joaquín Martínez-López, María José Calasanz, Ramón García-Sanz, José Antonio Pérez-Simón, María Teresa Gómez-Casares, Joaquín Sánchez-García, Eva Barragán, Pau Montesinos, on behalf of PETHEMA group

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Impact of Bivalirudin on Patients with Acute Coronary Syndrome Undergoing Rotational Atherectomy in Real-Life Setting: A Retrospective Cohort Study by Longwei Li, Hao Hu, Hongwu Chen, Buchun Zhang, Jianyuan Pan, Junling Zhou, Xiangyong Kong, Jinsheng Hua, Dongbiao Yu, Jiawei Wu, Dan Li, Likun Ma

“…Conclusion: Bivalirudin appears to exhibit a similar impact as unfractionated heparin on patients with acute coronary syndrome undergoing rotational atherectomy in real-life setting.…”
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Real life persistence rate with antimuscarinic treatment in patients with idiopathic or neurogenic overactive bladder: a prospective cohort study with solifenacin by Marloes J. Tijnagel, Jeroen R. Scheepe, Bertil F. M. Blok

“…We have investigated the persistence of solifenacin in real life by means of telephonic interviews in a prospective cohort. …”
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Evaluation under real-life conditions of a lifestyle intervention for diabetes prevention developed by the municipal health services of Madrid, Spain by Carmen Martin-Ridaura, Darío Ochoa-Esteban, Carmen Berlinches-Zapero, Dolores Ruiz-Fernández, Vanessa Sanz-Martín, Rosario Gavira-Izquierdo, Sebastià March, María López-Toribio, Mercedes Ceinos-Arcones, The ALAS Project Working Group

“…This study evaluated the effectiveness of the ALAS intervention implemented under real-life conditions between 2016 and 2019. The intervention was evaluated with a pre- and post-intervention study with follow-up performed 6 and 12 months from the start of the program. …”
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Real-life data on monoclonal antibodies and antiviral drugs in Italian inborn errors of immunity patients during COVID-19 pandemic by Giulia Garzi, Francesco Cinetto, Francesco Cinetto, Davide Firinu, Giulia Di Napoli, Gianluca Lagnese, Alessandra Punziano, Patrick Bez, Patrick Bez, Bianca Laura Cinicola, Giulia Costanzo, Riccardo Scarpa, Riccardo Scarpa, Federica Pulvirenti, Marcello Rattazzi, Marcello Rattazzi, Giuseppe Spadaro, Isabella Quinti, Cinzia Milito

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PB1867: ACUTE MYELOID LEUKEMIA WITH MUTATED NPM1 – REAL-LIFE EXPERIENCE IN THE REDEFINITION OF EUROPEAN LEUKEMIANET RISK CLASSIFICATION by Rita S Gomes, Pedro Amorim Machado, Adriana Roque, Margarida Coucelo, Teresa Simões, Ana Oliveira, Telma Nascimento, Sandra Marini, Marta Pereira, Emilia Cortesão

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Real-life experience with inotersen at CEPARM, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro by Moises Dias, Luiz Felipe Pinto, Marcus Vinícius Pinto, Renata Gervais, Paula Accioli, Gabriela Amorim, Mariana Guedes, Carlos Perez Gomes, Roberto Coury Pedrosa, Márcia Waddington-Cruz

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Opioids Prescribing Among Patients with Zoster-Related Pain in Real-Life: A Retrospective, Cohort Study Based on the Clinical Database by Su W, Liu D, Yang P, Ye L

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Variability of the Center of Mass in Trained Triathletes in Running After Cycling: A Preliminary Study Conducted in a Real-Life Setting by Stuart A. Evans, Daniel James, David Rowlands, James B. Lee

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Rationale, design, and methodology of the Evaluation of Perceptions, Knowledge, and Compliance with the Guidelines in Real Life Practice: A Survey on the Under-treatment of Hypercholesterolemia by Volkan Doğan, Özcan Başaran, Bülent Özlek, Oğuzhan Çelik, Eda Özlek, Kadir Uğur Mert, İbrahim Rencüzoğulları, Gurbet Özge Mert, Marwa Mouline Doğan, Murat Biteker, Meral Kayıkçıoğlu

“…Methods: The Evaluation of Perceptions, Knowledge, and Compliance with the Guidelines in Real Life Practice: A Survey on the Under-treatment of Hypercholesterolemia (EPHESUS) trial (ClinicalTrials.gov number NCT02608645) will be an observational, multicenter, non-interventional study. …”
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