The Impact of Starting Positions and Breathing Rhythms on Cardiopulmonary Stress and Post-Exercise Oxygen Consumption after High-Intensity Metabolic Training: A Randomized Crossove... by Li, Yuanyuan, Wang, Jiarong, Li, Yuanning, Li, Dandan

“…Specifically, exercises initiated from prone positions under regulated breathing recorded a significantly higher maximum and average PHR than those from standing positions (maximum PHR: mean difference = 13.40, p < 0.001; average PHR: mean difference = 6.45, p < 0.001). …”
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Frataxin deficiency promotes endothelial senescence in pulmonary hypertension

“…The dynamic regulation of endothelial pathophenotypes in pulmonary hypertension (PH) remains undefined. …”
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Documentation as a Tool for Algorithmic Accountability by Curtis, Taylor Lynn

“…This work begins by establishing the ``hole'' in current approaches to AI risk regulation, the lack of a civil liability regime. It also highlights that civil liability is an already existing and effective regulatory tool that can be applied to AI. …”
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Dynamic interaction networks in a hierarchically organized tissue by Kirouac, Daniel C., Ito, Caryn, Csaszar, Elizabeth, Roch, Aline, Yu, Mei, Sykes, Edward A., Bader, Gary D., Zandstra, Peter W.

“…This represents the first systematic characterization of how stem cell fate decisions are regulated non‐autonomously through lineage‐specific interactions with differentiated progeny.…”
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Modeling the Impact of Electrolyte Flow on Heat Management in a Li-Ion Convection Cell by Gao, Weiran, Drake, Javit, Brushett, Fikile R

“…Finally, to illustrate the potential for dynamic temperature regulation, we simulate scenarios where cells already experiencing self-heating can instantly arrest temperature rise with the onset of convection.…”
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Discovery of a new predominant cytosine DNA modification that is linked to gene expression in malaria parasites by Hammam, Elie, Ananda, Guruprasad, Sinha, Ameya, Scheidig-Benatar, Christine, Bohec, Mylene, Preiser, Peter Rainer, Dedon, Peter C., Scherf, Artur, Vembar, Shruthi S.

“…DNA cytosine modifications are key epigenetic regulators of cellular processes in mammalian cells, with their misregulation leading to varied disease states. …”
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A weighting factor free model predictive control for a flying capacitor converter in a DC microgrid by Jayan, Vijesh, Amer Mohammad Yusuf Mohammad Ghias

“…Another notable aspect is that the controller employs an improved dynamic reference model to generate appropriate battery current reference for the DC bus voltage regulation, without necessitating a secondary control loop and additional current sensors. …”
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Super-enhancers, phase-separated condensates, and 3D genome organization in cancer by Tang, Seng Chuan, Vijayakumar, Udhaya, Zhang, Ying, Fullwood, Melissa Jane

“…3D chromatin organization plays an important role in transcription regulation and gene expression. The 3D genome is highly maintained by several architectural proteins, such as CTCF, Yin Yang 1, and cohesin complex. …”
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Board gender diversity, firm performance and corporate financial distress risk: international evidence from tourism industry by Lee, Kin Wai, Thong, Tiong Yang

“…Second, the positive association between firm performance and the proportion of female directors on the board is higher in (1) countries with stronger shareholder rights, (2) countries with stronger securities law regulation stipulating disclosure of board diversity, (3) countries with stronger economic empowerment of women, and (4) during the COVID-19 crisis. …”
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MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors by Kim, HaEun, Lebeau, Benjamin, Papadopoli, David, Jovanovic, Predrag, Russo, Mariana, Avizonis, Daina, Morita, Masahiro, Afzali, Farzaneh, Ursini-Siegel, Josie, Postovit, Lynne-Marie, Witcher, Michael, Topisirovic, Ivan

“…However, the relationship between the mechanistic target of rapamycin (mTOR), which is a pivotal metabolic regulator, and epigenetic modifications remains poorly understood. …”
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The role of EZH2-VAV interaction in tumorigenesis by Wong, Jong Fu

“…Here, we report that EZH2 interactions with VAV critically regulate cell adhesion, promote cellular transformation, tumor growth and metastasis through talin1 methylation. …”
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Worth the upgrade? : A preliminary study on diabetes self-care support functions in freemium health apps by Thai, My Linh

“…The lack of transparency in app markets was further confirmed, urging for future research and regulation efforts.…”
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Identification of alternative-splicing events in human monocyte differentiation by Sim, Donald Yuhui

“…During this project, 31 out of 47 splicing events were successfully validated, with SRRM2-regulated splicing events achieving a 92% validation rate. …”
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Structural and molecular characterization of ligands activating the orphan nuclear receptor Nurr1 (NR4A2) by Ng, Xin Yi

“…Extending from previous studies done by our lab, small molecule ligands were designed to target a plausible co-regulator binding pocket which was unveiled following L1 binding on the ligand binding domain (LBD) of Nurr1. …”
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Metronidazole causes skeletal muscle atrophy and modulates muscle chronometabolism by Manickam, Ravikumar, Oh, Hui Yun Penny, Tan, Chek Kun, Paramalingam, Eeswari, Wahli, Walter

“…In conclusion, metronidazole in SPF mice results in skeletal muscle atrophy and changes the expression of genes involved in the muscle peripheral circadian rhythm machinery and metabolic regulation.…”
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Deubiquitinases in muscle physiology and disorders by Olie, CS, O'Brien, DP, Jones, HBL, Liang, Z, Damianou, A, Sur-Erdem, I, Pinto-Fernández, A, Raz, V, Kessler, BM

“…In vivo, muscle and neuronal cells are post-mitotic, and their function is predominantly regulated by proteostasis, a multilayer molecular process that maintains a delicate balance of protein homeostasis. …”

The domestic gas sector in Russia – gradual progress towards a competitive market? by Henderson, J

“…In the mid-2000s the Russian authorities were firmly in control of the country’s gas sector; their influence was primarily reflected in their right to set the regulated price for gas sold by the dominant producer, Gazprom. …”

SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections by Rosenheim, J, Gupta, RK, Thakker, C, Mann, T, Bell, LCK, Broderick, CM, Madon, K, Papargyris, L, Dayananda, P, Kwok, AJ, Greenan-Barrett, J, Wagstaffe, HR, Conibear, E, Fenn, J, Hakki, S, Lindeboom, RGH, Dratva, LM, Lemetais, B, Weight, CM, Venturini, C, Kaforou, M, Levin, M, Kalinova, M, Mann, AJ, Knight, JC

“…Blood transcriptional biomarkers of acute viral infections typically reflect type 1 interferon (IFN) signalling, but it is not known whether there are biological differences in their regulation that can be leveraged for distinct translational applications. …”

Design of an inductor-based DC/DC buck converter by Deng, Jiacheng

“…The project mainly focuses on the design of the negative feedback system and the pulse-width modulation (PWM) circuit to regulate the output voltage. This report covers the theory of the buck DC-DC converter, negative feedback circuit as well as the simulations and results of overall system.…”
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Micro- and nanotechnologies for study of cell secretion by Huang, Yinxi, Cai, Dong, Chen, Peng

“…Constitutive exocytosis occurs constantly as a housekeeping activity to release proteins, metabolites, etc. Regulated exocytosis, on the other hand, is only triggered by specific stimuli to release signaling molecules. …”
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