HSV-1 amplicon system for human artificial chromosome formation in human ES/iPS cells and pluripotency induction by Khoja, S

“…HAC offers many potential advantages including the provision for carrying large genes with corresponding regulatory elements to obtain long-term regulated gene expression. …”

Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry by Arman, BY, Clarke, R, Bharucha, T, Fernandez, LG, Walsby-Tickle, J, Deats, M, Mosca, S, Lin, Q, Banerjee, S, Chunekar, SR, Patil, KD, Gairola, S, Dunachie, S, Merchant, HA, Stokes, R, Kuwana, R, Maes, A, Charrier, J, Probert, F, Caillet, C, Matousek, P, McCullagh, J, Newton, PN, Zitzmann, N, Gangadharan, B

“…This approach has the potential to be integrated into the national regulatory standards and WHO’s Prevent, Detect, and Respond strategy as a novel effective tool for detecting falsified vaccines.…”

Elucidating the function of the suppressor of ppi1 locus 2 by Broad, W

“…This was determined to involve a strong negative regulatory effect on the abundance of the TOC proteins, which was reminiscent of the effect of the SP1 locus. …”

A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life by Vedovato, N, Salguero, MV, Greeley, SAW, Yu, CH, Philipson, LH, Ashcroft, FM

“…Loss-of-function mutations in either the pore-forming (inwardly rectifying potassium channel 6.2 [Kir6.2], encoded by KCNJ11) or regulatory (sulfonylurea receptor 1, encoded by ABCC8) subunits result in congenital hyperinsulinism, whereas gain-of-function mutations cause neonatal diabetes. …”

BRCA1 regulation of breast cancer cell motility by Hernandez Nuñez, ZE

“…These models were used in conjunction with the siRNA knockdown of candidate proteins from the <em>in-silico</em> analysis. siRNA knockdown of SART3 significantly enhanced motility in cells lacking BRCA’s ubiquitin ligase activity, highlighting its potential role in promoting cell motility and emphasising the regulatory role of BRCA1’s ubiquitin ligase activity in breast cancer progression.…”

Modulatory effects of isolated Lactobacillus paracasei from Malaysian water kefir grains on the intestinal barrier and gut microbiota in diabetic mice by Talib, Noorshafadzilah, Mohamad, Nurul Elyani, Chai, Ling Ho, Masarudin, Mas Jaffri

“…The present study aimed to evaluate the regulatory effects of Lactobacillus paracasei isolated from Malaysian water kefir grains (MWKG) on the alterations of intestinal barrier and gut microbiota in diabetic mice via histopathological analysis of the distal colon and 16S rRNA gene sequencing on fecal microbiome. …”

Sygyzium claviflorum fruit extract preadipocyte differentiation inhibition in 3T3-L1 cells by Zohdi, Rozaini M., Adli, Muhammad A., Mukhtar, Shahida M., Awang Junaidi, Awang H., Bakar, Md Zuki A.

“…Moreover, SCFE suppressed sterol regulatory element binding protein-1 (SREBP-1), peroxisome proliferator-activated receptor-gamma (PPAR-γ), and CCAAT/enhancer-binding protein-alpha (C/EBP-α) gene expressions during preadipocyte differentiation into adipocytes. …”
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Suspect screening in mussels cultured in straits of Tebrau leading to public perception and awareness survey on pharmaceuticals and personal care products (PPCPs) by Yong, Zhi Yuan, Chong, Yen San, Mohamad Hanafi, Muhammad Arif Haikal, Abdul Wahab, Mohd. Firdaus, Lee, Hooi Ling, Bakar, Mohd. Bakri, Abdul Majid, Zaiton, Basar, Norazah, Chandren, Sheela, Hasbullah, Hasrinah, Othman, Mohd. Hafiz Dzarfan, Chan, Wei Yee, Jaafar, Siti Nur Tahirah, Yong, Ee Ling

“…The findings highlight the urgent need for detailed suspect screening with targeted analysis in order to establish relevant regulatory measures apart from providing public education on the proper disposal of PPCPs to mitigate contamination.…”

Pro-inflammatory feedback loops define immune responses to pathogenic Lentivirus infection by Wilk, Aaron J., Marceau, Joshua O., Kazer, Samuel W., Fleming, Ira, Miao, Vincent N., Galvez-Reyes, Jennyfer, Kimata, Jason T., Shalek, Alex K., Holmes, Susan, Overbaugh, Julie, Blish, Catherine A.

“…Immune responses to highly pathogenic Lentivirus infection are characterized by amplifying regulatory circuits of pro-inflammatory cytokines with dense longitudinal connectivity. …”
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From emissions to resources: mitigating the critical raw material supply chain vulnerability of renewable energy technologies by Mertens, Jan, Dewulf, Jo, Breyer, Christian, Belmans, Ronnie, Gendron, Corinne, Geoffron, Patrice, Goossens, Luc, Fischer, Carolyn, Du Fornel, Elodie, Hayhoe, Katharine, Hirose, Katsu, Le Cadre-Loret, Elodie, Lester, Richard, Maigné, Fanny, Maitournam, Habibou, de Miranda, Paulo Emilio Valadão, Verwee, Peter, Sala, Olivier, Webber, Michael, Debackere, Koenraad

“…Hence, the study underscores the significance of increased research, innovation, and regulatory initiatives, along with raising social awareness, in effectively addressing the challenges faced by the CRM supply chain and contributing to a sustainable energy transition.…”
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Use of Transient Transfection for cGMP Manufacturing of eOD-GT8 60mer, a Self-Assembling Nanoparticle Germline-Targeting HIV-1 Vaccine Candidate by Sharma, Vaneet K., Menis, Sergey, Brower, Evan T., Sayeed, Eddy, Ackland, Jim, Lombardo, Angela, Cottrell, Christopher A., Torres, Jonathan L., Hassell, Thomas, Ward, Andrew B., Tsvetnitsky, Vadim, Schief, William R.

“…The cGMP clinical trial material was tested in a Phase 1 clinical trial (NCT03547245), is currently being stored at &minus;80 &deg;C, and is on a stability testing program as per regulatory guidelines. The methods described here illustrate the utility of transient transfection for cGMP production of complex products such as glycosylated self-assembling nanoparticles.…”
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Envisioning Water: Sustainability and Future-Making in Dubai and Los Angeles by Christidi, Nadia

“…As such, I show, for instance, how Dubai’s highly centralized governance structure and foreign-investment development model produce an emphasis on sustainability’s enhancement of the city-state’s competitiveness agenda that can belie larger eco-realities, while LA’s fragmented institutional, regulatory, and financing scapes complicate collaboration on recycling projects which span across and exceed individual institutional mandates. …”
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Industrial symbiosis and the successional city : adapting exchange networks to energy constraints by Terway, Timothy M. (Timothy Michael)

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BswR controls bacterial motility and biofilm formation in Pseudomonas aeruginosa through modulation of the small RNA RsmZ by Wang, Chao, Ye, Fuzhou, Kumar, Veerendra, Gao, Yong-Gui, Zhang, Lian-Hui

“…Taken together, our results unveiled a novel regulatory mechanism, in which BswR controls the motility and biofilm formation of P. aeruginosa by modulating the transcription of small RNA rsmZ.…”
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RNA G-quadruplex structures mediate gene regulation in bacteria by Shao, Xiaolong, Zhang, Weitong, Mubarak Ishaq Umar, Wong, Hei Yuen, Seng, Zijing, Xie, Yingpeng, Zhang, Yingchao, Yang, Liang, Kwok, Chun Kit, Deng, Xin

“…Overall, our study uncovers important regulatory functions of rG4s in bacterial pathogenicity and metabolic pathways and strongly suggests that rG4s exist and can be detected in a wide range of bacterial species.…”
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Recalled parental bonding interacts with oxytocin receptor gene polymorphism in modulating anxiety and avoidance in adult relationships by Cataldo, Ilaria, Bonassi, Andrea, Lepri, Bruno, Foo, Jia Nee, Setoh, Peipei, Esposito, Gianluca

“…Early interactions with significant individuals affect social experience throughout the course of a lifetime, as a repeated and prolonged perception of different levels of care, independence, or control influences the modulation of emotional regulatory processes. As many factors play a role in shaping the expectations and features of social interaction, in this study, we considered the influence of parental bonding and genetic allelic variation of oxytocin receptor gene polymorphism (rs53576) over levels of experienced anxiety and avoidance in 313 young adults belonging to two different cultural contexts, namely Italy and Singapore. …”
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Present and future of functionalized Cu current collectors for stabilizing lithium metal anodes by Liu Yuhang, Li, Yifan, Sun, Jinmeng, Du, Zhuzhu, Hu, Xiaoqi, Bi, Jingxuan, Liu, Chuntai, Ai, Wei, Yan, Qingyu

“…Functionalized Cu current collectors have so far exhibited significant regulatory effects on stabilizing Li metal anodes (LMAs), and hold a great practical potential owing to their easy fabrication, low-cost and good compatibility with the existing battery technology. …”
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Molecular and biochemical characterisation of human casein kinase I alpha splice variants by Yong, Thomas Joon Kin.

“…Human CKkxT lacks the catalytic subdomains I to Vlb (as defined by Hanks et al., 1988)but contains a nine novel amino acids at the amino terminal, followed by the 28 amino acids identified as the insertion and the subdomains VII to XI of the catalytic domain. The regulatory domain of human CKIaT is identical to that of human CKIas but contains an additional eight amino acids at the carboxyl terminal not previously reported in any other CKI alpha. …”
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Transcriptional regulation of type I interferon responses of myeloid antigen presenting cells by Sin, Wei Xiang

“…Production of the pro-inflammatory cytokine IL-1β, via caspase-11 activation during Gram-negative bacterial infections, and of the pro-regulatory cytokine IL-10, are dependent on signaling by the pleiotropic type I interferon (IFN), IFN-β. …”
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Supported lipid bilayer platforms for investigating complement activation, termination and regulation by Saziye Yorulmaz Avsar

“…In the fourth study, the inhibitory action of vitronectin and clusterin against the membrane attack complex assembly was evaluated, offering insight into the different mechanisms by which these two regulatory proteins inhibit complement activation. …”
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