Negative auto-regulation of myostatin expression is mediated by SMAD3 and microRNA-27 by Ge, XiaoJia, McFarlane, Craig, Vajjala, Anuradha, Arigela, Harikumar, Lokireddy, Sudarsanareddy, Bonala, Sabeera, Manickam, Ravikumar, Kambadur, Ravi, Sharma, Mridula

“…These data highlight a novel auto-regulatory mechanism in which Mstn, via Smad3 signaling, regulates miR-27a/b and in turn its own expression. …”
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Low magnetic field exposure alters prostate cancer cell properties by Lange, Sigrun, Inal, Jameel, Kraev, Igor, Dart, Dafydd Alwyn, Uysal-Onganer, Pinar

“…Overall, our findings suggest that changes in magnetic field exposures modulate EV-mediated and miR-regulatory processes in PCa metastasis, providing a basis for exploring novel therapeutic strategies.…”
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Identification of proteins and genes as potential biomarkers in brown-marbled grouper (Epinephelus fuscoguttatus forsskal) resistance to Vibrio sp by Low, Chen Fei

“…Upregulated unigenes in the cell killing class included transporter-associated with antigen processing 2, and cytotoxic and regulatory T cell protein. KEGG pathway annotation identified eight immune-related pathways and also seven non-immune response-related pathways that were significantly enriched in differentially expressed genes. …”
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Combating Household Bankruptcy: Developing a New Integrated Financial Education Model for Malaysian (S/O 13585) by Sawandi, Norfaiezah, Abu Bakar, Abu Sufian, Shaari, Hasnah, Amran, Noor Afza, Saad, Ram Al Jaffri

“…Number of bankruptcy cases involving Malaysian that is rising from year to year has received growing concern from many parties including the government, regulatory bodies and NGOs (Utusan Malaysia Online, Feb 27, 2016 & Jun 26, 2015; Mstar, Jun 22, 2015). …”
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Tracing RNA biography: in situ transcriptome profiling by novel spatial omics technologies by Ren, Jingyi (Rena)

“…This advantage is important for mapping the complex network of transcriptional and post-transcriptional gene regulatory mechanisms inherent in cells and tissues. …”
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Radiation Shielding Design and Radioactive Waste Assessment of Horizontal Compact High Temperature Gas-Cooled Reactor by Kudriavtseva, Anna

“…It was found that for locations of the reactor building where the dose rates during normal operation were greater than the Nuclear Regulatory Commission (NRC) limit of 0.1 rem/hr, 175 cm of borated concrete is required. …”
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The U.S. Indo-Pacific strategy and its implications for U.S.-ASEAN economic governance architecture by Pitakdumrongkit, Kaewkamol

“…Moreover, the text authorizes $1.5 billion to “the Department of State, United States Agency for International Development [USAID], and, as appropriate, the Department of Defense . . . for each of the fiscal years 2019 through 2023, which shall be used” to achieve several objectives including ensuring “the regulatory environments for trade, infrastructure, and investment in partner countries are transparent, open, and free of corruption.” …”
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Changes in cerebrospinal fluid balance of TNF and TNF receptors in naïve multiple sclerosis patients : early involvement in compartmentalised intrathecal inflammation by Magliozzi, Roberta, Pezzini, Francesco, Pucci, Mairi, Rossi, Stefania, Facchiano, Francesco, Marastoni, Damiano, Montagnana, Martina, Lippi, Giuseppe, Reynolds, Richard, Calabrese, Massimiliano

“…Finally, the CSF TNFR2-associated pattern (encompassing high CSF levels of IFN-β, IFN-λ2, sIL-6Rα) was linked to Th cell differentiation and regulatory cytokine signalling. In conclusion, dysregulation of TNF and TNF-R1/2 pathways associates with specific clinical/MRI profiles and can be identified at a very early stage in MS patients, at the time of diagnosis, contributing to the prediction of the disease outcome.…”
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Cryogelation of human hair keratins by Chua, Huei Min

“…The emergence of HHK in biomedical applications is attributed to their proven biocompatibility as well as their potential to promote cell adhesion and proliferation due to the presence of LDV (leucine-aspartic-valine) cell adhesion motifs and residual regulatory molecules. In a clinical setting, HHK-based templates could also serve as autologous alternatives which minimise the risk of xenogeneic infections or chemically induced cyto-toxicity. …”
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Autoinhibition releasing provides a platform for developing p21-activated kinase-1 (PAK1) activators for hypertrophic heart diseases by He, Y

“…Moreover, molecular dynamics simulations, combined with crystallographic and kinase kinetic studies provided evidence elucidating that these molecules activate PAK1 through neutralising its autoinhibitory regulation, and mapped out detailed conformational states that PAK1 undergoes during this regulatory process.</p> <p>Furthermore, ligand optimisation and validation were conducted through both virtual screening and high-throughput physical screening. …”

Quantifying the energy consumption of the water use cycle by Cardenes Trujillo, I

“…For example, water treatment was shown to be the largest consumer of energy within the whole system, compared with pumping or wastewater treatment; but wastewater treatment energy consumption was shown to be the fastest growing over time due to changes in water quality regulatory frameworks. The results show that more stringent effluent standards could result in at least a doubling of electricity consumption and an increase of between 1.29 and 2.30 additional million tonnes of CO2 a year from treating wastewater in large works in the UK. …”

Filamentous oligomer structure reconstruction and a new filament picking method for Cryo-EM micrographs by Xu, Chenrui

“…Atomic-resolution structures of CARD oligomers help to reveal details of signaling regulatory mechanisms, which are highly sought after for drug development and mending-related autoimmunity diseases. …”
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Evaluating & enhancing deep learning systems via out-of-distribution detection by Christopher, Berend David

“…So far, the principles of robustness, fairness and security have been outlined in trustworthy initiatives from an expectations point of view under ISO or regulatory acts under the European Commission\cite{ai_act}. …”
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Investigating S-acylation in the metabolic dysfunction of the T2D heart by Dennis, KMJH

“…The changes in CD36 were accompanied by a 25% increase in fatty acid oxidation (FAO) rates and 65% increase in triglyceride (TG) concentrations in diabetes. The regulatory S-acylating enzyme, DHHC4, was increased 2.5-fold in diabetes compared with controls. …”

Structural and mechanistic insights into the Rel protein of Mycobacterium tuberculosis by Singal, Bharti

“…Overall, the work has guided in identifying species-specific epitopes in various domains and regulation by regulatory domains which can aid in structure aided drug discovery and therapeutic development.…”
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Identification of genetic effects underlying type 2 diabetes in South Asian and European populations by Loh, Marie, Zhang, Weihua, Ng, Hong Kiat, Schmid, Katharina, Lamri, Amel, Tong, Lin, Meraj Ahmad, Lee, Jung-Jin, Ng, Maggie C. Y., Petty, Lauren E., Spracklen, Cassandra N., Takeuchi, Fumihiko, Md. Tariqul Islam, Jasmine, Farzana, Kasturiratne, Anuradhani, Muhammad Kibriya, Mohlke, Karen L., Paré, Guillaume, Prasad, Gauri, Mohammad Shahriar, Chee, Miao Ling, de Silva, H. Janaka, Engert, James C., Gerstein, Hertzel C., Mani, K. Radha, Sabanayagam, Charumathi, Vujkovic, Marijana, Wickremasinghe, Ananda R., Wong, Tien Yin, Yajnik, Chittaranjan S., Salim Yusuf, Habibul Ahsan, Bharadwaj, Dwaipayan, Anand, Sonia S., Below, Jennifer E., Boehnke, Michael, Bowden, Donald W., Chandak, Giriraj R., Cheng, Ching-Yu, Kato, Norihiro, Mahajan, Anubha, Sim, Xueling, McCarthy, Mark I., Morris, Andrew P., Kooner, Jaspal S., Saleheen, Danish, Chambers, John C.

“…The loci are enriched for regulatory features, including DNA methylation and gene expression in relevant tissues, and highlight CHMP4B, PDHB, LRIG1 and other genes linked to adiposity and glucose metabolism. …”
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Meta-cognitive learning algorithm for neuro-fuzzy inference systems by Kartick Subramanian

“…A Takagi-Sugeno-Kang type neuro-fuzzy inference system forms the cognitive component and a self-regulatory learning mechanism is its meta-cognitive component. …”
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Improving the diagnostic yield of whole genome sequencing: neurodevelopmental and epilepsy disorders by Hashim, M

“…</p> <p>Amongst the disrupted a novel gene was PPP2R2A, which encodes for the regulatory subunit of Protein phosphatase 2 complex enzyme. …”

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes by McAllan, Liam, Baranasic, Damir, Villicaña, Sergio, Brown, Scarlett, Zhang, Weihua, Lehne, Benjamin, Adamo, Marco, Jenkinson, Andrew, Elkalaawy, Mohamed, Mohammadi, Borzoueh, Hashemi, Majid, Fernandes, Nadia, Lambie, Nathalie, Williams, Richard, Christiansen, Colette, Yang, Youwen, Zudina, Liudmila, Lagou, Vasiliki, Tan, Sili, Castillo-Fernandez, Juan, King, James W. D., Soong, Richie, Elliott, Paul, Scott, James, Prokopenko, Inga, Cebola, Inês, Loh, Marie, Lenhard, Boris, Batterham, Rachel L., Bell, Jordana T., Chambers, John Campbell, Kooner, Jaspal S., Scott, William R.

“…Targeted methylation sequencing, CRISPR-activation and gene silencing in adipocytes, further identifies regional methylation variations, underlying regulatory elements and novel cellular metabolic effects. …”
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Antidiabetic activity of Curculigo latifolia extracts in vitro and in vivo studies by Ishak, Nur Akmal

“…Furthermore, 50, 100 and 200 mg/kg b.w of C. latifolia fruit:root extracts showed that urea, creatinine, ALT and GGT levels in diabetic-induced rats were reduced towards normalcy after 30 days of treatment. The regulatory effects of C. latifolia fruit:root extracts on genes involved in glucose and lipid metabolisms were further studied. …”
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