OntoPharma: ontology based clinical decision support system to reduce medication prescribing errors by Elena Calvo-Cidoncha, Concepción Camacho-Hernando, Faust Feu, Xavier Pastor-Duran, Carles Codina-Jané, Raimundo Lozano-Rubí

“…An advisory board selected four use cases: maximum dosage alert, drug-drug interaction checker, renal failure adjustment, and drug allergy checker. (2) Implementing the ontology in a formal representation. …”
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Morpho-functional characterisation of protective mechanisms of neutrophils in the patients at the terminal stage of chronic kidney disease by T. N. Melesh, I. A. Novikova

“…The aim of our study was to perform a comprehensive assessment of morphological and functional activity of neutrophils in patients at the terminal stage of chronic renal failure. We examined 49 patients (16 women, 33 men, 22 to 63 years old) with CKD 5 D (according to the K/DOQI classification, 2006), and 60 healthy individuals (controls). …”
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A deep intronic splice variant of the COL4A5 gene in a Chinese family with X-linked Alport syndrome by Pei Qian, Ying Bao, Hui-mei Huang, Lei Suo, Yan Han, Zhi-juan Li, Min Zhang

“…His maternal uncle developed renal failure at the age of 35 years. He was evaluated by renal biopsy,whole-exome sequencing (WES) and whole-genome sequencing (WGS) for Alport syndrome. …”
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Correlation of rheumatoid and cardiac biomarkers with cardiac anatomy and function in rheumatoid arthritis patients without clinically overt cardiovascular diseases: A cross-sectio... by Duangkamol Aiewruengsurat, Thanyakamol Phongnarudech, Tippawan Liabsuetrakul, Thanapon Nilmoje

“…Methods: A cross-sectional study was conducted among RA patients aged 18–65 years without other connective tissue diseases, overlap syndrome, heart disease, or renal failure were included. Main cardiac and rheumatoid biomarkers, including high-sensitivity troponin T (hsTropT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), rheumatoid factor, and anti-cyclic citrullinated peptide antibody (ACPA), were collected. …”
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Outcome and complications in peritoneal dialysis patients: A five-year single center experience by Jamal S Alwakeel, Abdulkareem Alsuwaida, Akram Askar, Nawaz Memon, Saira Usama, Mohammed Alghonaim, Niaz A Feraz, Iqbal Hamid Shah, Hamsaveni Wilson

“…Peritoneal dialysis (PD) is one of the modes of renal replacement therapy being utilized for the management of end-stage renal failure in King Khalid University Hospital, King Saud Uni-versity, Riyadh, for more than two decades. …”
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Date palm seed extract and herbal mixture mitigate gentamicin-induced renal injury in mice: Role of Protease-activated receptors (PARs) and Retinoid X receptor alpha (RXR-α) by Suliman Sohaim, Salman Mohammed, Elham Amin, Hussein M Ali, Mohamed Abdelbakky

“…Introduction: Gentamicin (Gen) causes renal toxicity by inhibiting protein synthesis in kidney cells, causing proximal tubule cell necrosis and renal failure. Herein, we examined the nephroprotective effect of date palm seed extract (DPSE) and one herbal mixture (HM; composed of Tribulus terrestris, Aerva lanata, Andrographis paniculata, and Raphanus sativus) against Gen-induced renal toxicity in mice with special reference to the possible role of retinoid X receptor alpha (RXR-α) and protease-activated receptor 2 (PAR-2) in this effect. …”
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Natural products in traditional Chinese medicine: molecular mechanisms and therapeutic targets of renal fibrosis and state-of-the-art drug delivery systems by Li Song, Wei Zhang, Shi-yun Tang, Si-min Luo, Pei-yu Xiong, Jun-yu Liu, Heng-chang Hu, Ying-qi Chen, Bo Jia, Qian-hua Yan, Song-qi Tang, Wei Huang

“…RF can eventually lead to renal dysfunction or even renal failure. A large body of evidence suggests that natural products in traditional Chinese medicine (TCM) have great potential for treating RF. …”
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Admission Hydration Status and Ischemic Stroke Outcome—Experience from a National Registry of Hospitalized Stroke Patients by Yoav Eizenberg, Ehud Grossman, David Tanne, Silvia Koton

“…Using a national registry, we identified hospitalized IS patients without renal failure. Disability or death at discharge, length of stay, in-hospital complications, and mortality during the first year were studied by UCR, and associations between UCR levels and each outcome were assessed adjusting for age, sex, stroke severity, comorbidities, use of statins, and use of diuretics. …”
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Potential protective effects of Huanglian Jiedu Decoction against COVID-19-associated acute kidney injury: A network-based pharmacological and molecular docking study by Wu Weichu, Zhang Yonghai, Liu Guoyuan, Chi Zepai, Zhang Aiping, Miao Shuying, Lin Chengchuang, Xu Qingchun, Zhang Yuanfeng

“…Potential targets related to “HLJDD,” “COVID-19,” and “Acute Kidney Injury/Acute Renal Failure” were identified from several databases. …”
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Evaluation of optimum dose of anti-snake venom required and its outcome based on severity of envenomation in snakebite case by Kavitha S, Nalini GK, Sahana GN

“…Ten percent of patients had developed renal failure and one required dialysis. 8.75% of patients developed respiratory failure and all required mechanical ventilation. …”
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Comparison of High-Flux and Low-Flux Hemodialysis Filters on Hemodialysis Adequacy in Under-Hemodialysis Patients with End-Stage Renal Disease by Rouhollah Narimani, Mohadeseh Pour-Pouneh, Saeed Mardani, Soleiman Kheiri, Hamid Nasri

“…Background: Hemodialysis is the most common alternative therapy in chronic renal failure and inadequate dialysis increases the mortality of patients; thus, the dialysis adequacy in these patients is important. …”
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Severe preeclampsia and eclampsia: incidence, complications, and perinatal outcomes at a low-resource setting, Mpilo Central Hospital, Bulawayo, Zimbabwe by Ngwenya S

“…Maternal mortality was 1.7% due to acute renal failure. Nearly half (49.6%) of the babies born were lost to stillbirths and early neonatal deaths. …”
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Validity of Routine Health Data To Identify Safety Outcomes of Interest For Covid-19 Vaccines and Therapeutics in the Context of the Emerging Pandemic: A Comprehensive Literature R... by Andresen K, Hinojosa-Campos M, Podmore B, Drysdale M, Qizilbash N, Cunnington M

“…We aimed to provide an overview of the availability of validated diagnostic algorithms for selected safety endpoints for Coronavirus disease 2019 (COVID-19) vaccines and therapeutics in the context of the emerging pandemic prior to December 2020.Methods: We reviewed the literature up to December 2020 to identify validation studies for various safety events of interest, including myocardial infarction, arrhythmia, myocarditis, acute cardiac injury, vasculitis/vasculopathy, venous thromboembolism, stroke, respiratory distress syndrome (RDS), pneumonitis, cytokine release syndrome (CRS), multiple organ dysfunction syndrome, and renal failure. We included studies published between 2015 and 2020 that were considered high quality assessed with QUADAS and that reported positive predictive values (PPVs).Results: Out of 43 identified studies, we found that diagnostic algorithms for cardiovascular outcomes were supported by the highest number of validation studies (n=17). …”
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Outcome results in children with IgA nephropathy: a single center experience by Kaplan Bulut I, Mir S, Sozeri B, Bulut MO, Sen S, Dincel N

“…At the end of follow-up time, 18 (46.1%) patients were normal, 15 (38.5%) had minor urinary abnormalities, three (7.7%) had active renal disease, and three (7.7%) developed renal failure.Conclusion: The results of the present study are better than those from most other series. …”
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Outcomes of surgery for acute type A dissection in octogenarians versus non-octogenarians: a systematic review and meta analysis by Aditya Eranki, Michael Merakis, Michael L. Williams, Campbell D. Flynn, Claudia Villanueva, Ashley Wilson-Smith, Yangsin Lee, Ross Mejia

“…Secondary endpoints were rates of postoperative complications, namely stroke, acute renal failure (ARF), re-exploration and intensive care unit (ICU) length of stay (LOS). …”
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Calcineurin and Systemic Lupus Erythematosus: The Rationale for Using Calcineurin Inhibitors in the Treatment of Lupus Nephritis by Carlos Rafael-Vidal, Irene Altabás, Nair Pérez, Coral Mourino Rodríguez, Jose M. Pego-Reigosa, Samuel Garcia

“…LN is characterized by the accumulation of immune complexes, ultimately leading to renal failure. Aberrant activation of T cells plays a critical role in the pathogenesis of both SLE and LN and is involved in the production of inflammatory cytokines, the recruitment of inflammatory cells to the affected tissues and the co-stimulation of B cells. …”
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Adverse Events and Drug Resistance in Critically Ill Patients Treated with Colistimethate Sodium: A Review of the Literature by Ahumada Topete VH, de Dios Sanchez KJ, Casas Aparicio GA, Hernandez Silva G, Lopez Vejar CE, Torres Espíndola LM, Aquino-Galvez A, Rodriguez Ganen O, Castillejos Lopez MDJ

“…Based on the search criteria, no randomized clinical trials were identified showing safety and efficacy with the use of Colistin, inferring that the application of the appropriate dose is governed by expert opinion and retrospective and prospective observational studies, which confounding factors such as the severity of the patient and the predisposition to develop acute renal failure are constant. In this review, we focus on identifying the mechanism of nephrotoxicity and bacterial resistance, where much remains to be known.Keywords: colistin, colistimethate, nephrotoxicity, neurotoxicity, resistance mechanism, multidrug-resistant gram-negative bacteria, risk factors, high doses, toxicity…”
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Relationship of Decayed, Missing, Filled, Teeth and Related Indexes of Glomerular Filtration Rate in Various Stages of Chronic Kidney Disease in Adults Residing in ShahediehCity, Y... by Abdolrahim Davari, Alireza Daneshkazemi, Sanaz Abbasi, Farzad Ziaei

“…Oral health problems in patients with chronic renal failure can endanger their systemic health. …”
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Effect of cyclosporin and tacrolimus on kidney function in liver recipients by Elena D. Kosmacheva, Anna E. Babich

“…Introduction. Chronic renal failure is a significant issue regarding treatment of patients after liver transplantation. …”
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Mobile Cellular Data and Wi-Fi Use Are Not Associated with Adverse Health Effects by Marziyei Rabie, Seyed Jalil Masoumi, Seyed Mohammad Javad Mortazavi, Samane Nematolahi, Masoud Haghani

“…In addition, the participants’ history of diabetes, hypertension, cardiac ischemia, myocardial infarction, renal failure, fatty liver, hepatitis, chronic lung disease, thyroid disease, kidney stone, gall bladder stone, rheumatoid disease, epilepsy, and chronic headache was recorded through face-to-face interviews.Results: 94% of people participating in this study reported using mobile/Wi-Fi internet. …”
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