A 3D In Vivo Model for Studying Human Renal Cystic Tissue and Mouse Kidney Slices by Eva-Marie Bichlmayer, Lina Mahl, Leo Hesse, Eric Pion, Victoria Haller, Andreas Moehwald, Christina Hackl, Jens M. Werner, Hans J. Schlitt, Siegfried Schwarz, Philipp Kainz, Christoph Brochhausen, Christian Groeger, Felix Steger, Oliver Kölbl, Christoph Daniel, Kerstin Amann, Andre Kraus, Björn Buchholz, Thiha Aung, Silke Haerteis

“…(1) Background: Autosomal dominant polycystic kidney disease (ADPKD) is a frequent monogenic disorder that leads to progressive renal cyst growth and renal failure. Strategies to inhibit cyst growth in non-human cyst models have often failed in clinical trials. …”
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Presenting Symptoms in Newly Diagnosed Myeloma, Relation to Organ Damage, and Implications for Symptom-Directed Screening: A Secondary Analysis from the Tackling Early Morbidity an... by Stella Bowcock, Catherine Atkin, Gulnaz Iqbal, Guy Pratt, Kwee Yong, Richard D. Neal, Tim Planche, Kamaraj Karunanithi, Stephen Jenkins, Simon Stern, Sarah Arnott, Peter Toth, Farooq Wandroo, Janet Dunn, Mark T. Drayson

“…Vertebral fractures are under-recognised as pathological and are the predominant irreversible organ damage (27% of patients), impacting the performance status (PS) and associated with back pain (odds ratio (OR) 6.14 [CI 4.47–8.44]), bone disease (OR 3.71 [CI 1.88–7.32]) and age >65 years (OR 1.58 [CI 1.15–2.17]). Renal failure is less frequent and associated with gastrointestinal symptoms (OR 2.23 [CI1.28–3.91]), age >65 years (OR 2.14 [CI1.28–3.91]) and absence of back pain (OR 0.44 [CI 0.29–0.67]). …”
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Pulmonary hypertension as a risk assessment factor for unfavorable outcome in patients with COVID-19 by E. Z. Golukhova, Inessa Viktorovna Slivneva, M. M. Rybka, M. L. Mamalyga, M. N. Alekhin, I. V. Klyuchnikov, D. E. Antonova, D. I. Marapov

“…In group 3, acute renal failure and systemic inflammatory response syndrome developed significantly more often than in group 1.Conclusion. …”
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Immunogenicity and safety of SARS-CoV-2 vaccine in hemodialysis patients: A systematic review and meta-analysis by Ren Peiyao, Ren Peiyao, Yu Mengjie, Shen Xiaogang, He Wenfang, Zheng Danna, Zeng Yuqun, Jin Juan, He Qiang

“…Dialysis patients may experience various adverse events after vaccination; however, the incidence of malignant events is very low, and no reports of death or acute renal failure after vaccination are available, indicating that vaccine regimens may be necessary.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.asp?…”
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Efficiency of lenalidomide, bortezomib and prednisone (RVP) in patients with newly diagnosed multiple myeloma by K. A. Belousov, T. A. Mitina, Yu. Yu. Chuksina, A. K. Golenkov, E. V. Kataeva, E. V. Trifonova, Yu. B. Chernykh, L. L. Vysotskaya, S. G. Zakharov, E. F. Klinushkina, A. N. Mitin

“…Nine (23.0 %) patients had renal failure, requiring the start of renal replacement therapy. …”
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Kinase Inhibition in Multiple Myeloma: Current Scenario and Clinical Perspectives by Igor Valentim Barreto, Caio Bezerra Machado, Davi Benevides Almeida, Flávia Melo Cunha de Pinho Pessoa, Renan Brito Gadelha, Laudreísa da Costa Pantoja, Deivide de Sousa Oliveira, Rodrigo Monteiro Ribeiro, Germison Silva Lopes, Manoel Odorico de Moraes Filho, Maria Elisabete Amaral de Moraes, André Salim Khayat, Edivaldo Herculano Correa de Oliveira, Caroline Aquino Moreira-Nunes

“…The accumulation of this production, both cells themselves and of the immunoglobulins, causes a series of problems for the patient, of a systemic and local nature, such as blood hyperviscosity, renal failure, anemia, bone lesions, and infections due to compromised immunity. …”
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Clinical, epidemiological, and mycological features of patients with candidemia: Experience in two tertiary referral centers in Iran by Mohammad Kord, Mohammadreza Salehi, Seyed Jamal Hashemi, Alireza Abdollahi, Neda Alijani, Ayda Maleki, Shahram Mahmoudi, Kazem Ahmadikia, Nasrin Parsameher, Masoud Moradi, Mahsa Abdorahimi, Sara Rezaie, Shirin Sadat Hashemi Fesharaki, Kiana Abbasi, Laura Alcazar-Fuoli, Sadegh Khodavaysi

“…The most common underlying disease was sepsis (48%) followed by malignancy (46%), renal failure/dialysis (44%), and hypertension (40%). …”
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Abstract Number ‐ 190: Acute Ischemic Stroke patients post Endovascular Thrombectomy complicated by gastrointestinal bleeding have worst clinical outcomes by Syed F Ali, Jose Dominguez, Masha Osman, Sarah Meadows, Ankita Das, Fawas Al‐Mufti

“…Furthermore, the GI bleed group had the following risk factors that were statistically significant: history of atrial fibrillation and chronic renal failure (46% vs 37.2% and 21.8% vs 15.1%, respectively). …”
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Vascular wall microenvironment: exosomes secreted by adventitial fibroblasts induced vascular calcification by Ming-Hui Zheng, Su-Kang Shan, Xiao Lin, Feng Xu, Feng Wu, Bei Guo, Fu-Xing-zi Li, Zhi-Ang Zhou, Yi Wang, Li-Min Lei, Ke-Xin Tang, Jia-Yue Duan, Yun-Yun Wu, Ye-Chi Cao, Xiao-Bo Liao, Ling-Qing Yuan

“…Abstract Vascular calcification often occurs in patients with chronic renal failure (CRF), which significantly increases the incidence of cardiovascular events in CRF patients. …”
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Plasma Drug Values of DOACs in Patients Presenting with Gastrointestinal Bleeding: A Prospective Observational Study by Dorotea Bozic, Damir Alicic, Dinko Martinovic, Ivan Zaja, Josipa Bilandzic-Ivisic, Rosana Sodan, Branka Kresic, Andre Bratanic, Zeljko Puljiz, Zarko Ardalic, Josko Bozic

“…Clinicians should be more judicious when prescribing dabigatran to the elderly and patients with renal failure. In these patients, dose adjustment, plasma drug monitoring, or substitution with other, more appropriate DOACs should be considered.…”
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Comparison of Early and Late Surgeries after Coronary Stent Implantation in Patients with Normal Preoperative Troponin Level: A Retrospective Study by Sang Hyun Lee, Eun Kyung Lee, Hyun Joo Ahn, Sangmin M. Lee, Jie Ae Kim, Mikyung Yang, Ji Won Choi, Jeayoun Kim, Heejoon Jeong, Seungmo Kim, Jinseo Kim, Joonghyun Ahn

“…The secondary outcomes were myocardial infarction, stent thrombosis, emergent coronary revascularization, major bleeding (bleeding requiring transfusion or intracranial bleeding), stroke, renal failure, heart failure, or death within 30 days post-operation. …”
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Post-marketing safety of immunomodulatory drugs in multiple myeloma: A pharmacovigilance investigation based on the FDA adverse event reporting system by Tingting Jiang, Hui Su, Yanping Li, Yuanlin Wu, Yue Ming, Chen Li, Ruoqiu Fu, Lu Feng, Ziwei Li, Li Li, Rui Ni, Yao Liu

“…Pneumonia, sepsis, and renal failure are common risk factors for death due to IMiDs. …”
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Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products by Chun Ge, Chun Ge, Sujie Zhang, Sujie Zhang, Huiwen Mu, Huiwen Mu, Shaojun Zheng, Shaojun Zheng, Zhaoyi Tan, Xintong Huang, Xintong Huang, Chen Xu, Jianjun Zou, Jianjun Zou, Yubing Zhu, Yubing Zhu, Dong Feng, Dong Feng, Jiye Aa

“…A large body of evidence suggests that ferroptosis is interrelated with various physiological and pathological processes, including tumor progression (neuro)degenerative diseases, and hepatic and renal failure. There is an urgent need for the discovery of novel effective ferroptosis-modulating compounds, even though some experimental reagents and approved clinical drugs have been well documented to have anti- or pro-ferroptotic properties. …”
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Independent Association of 25[OH]D Level on Reduced Glutathione and TNF-α in Patients ‎with Diabetes and/or Hypertension by AlRadini FA, El-Sheikh AAK, Al Shahrani AS, Alzamil NM, Fayed AA, Alsayed E, Alharbi SS, Altulihee MA, Andijani SA, AlShaiddi WK, Alamri FA

“…Patients receiving any kind of vitamin D or calcium supplements within the last three ‎months were excluded, as were those with a history of ‎renal failure, cancer, liver, thyroid, or any other chronic inflammatory diseases.Results: In total 424 T2DM and/or ‎hypertensive patients (mean age 55± 12 years) were recruited. …”
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Postoperative atrial fibrillation after thoracic surgery (PoAF): risk factors and outcome by Valentina Scheggi, Silvia Menale, Rossella Marcucci, Anna Dematté, Jacopo Giovacchini, Noemi Cenni, Giorgio Vitale, Bruno Alterini, Alberto Salvicchi, Matteo Tamburini, Salvatore Musmeci, Stefano Bongiolatti, Luca Voltolini, Niccolò Marchionni

“…Results PoAF occurred in 35/338 (10.4%) patients and was significantly more frequent in older patients, with a best predictive value of 71 years at ROC curve analysis (AUC 0.70, p < 0.001) and in those with chronic renal failure (p = 0.01). The left atrial area was also significantly associated with the risk of PoAF (AUC 0.78, p = 0.000). …”
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Heidihuangwan alleviates renal fibrosis in rats with 5/6 nephrectomy by inhibiting autophagy by Ying-Ying Li, Zeng-Hui Tian, Guang-Hui Pan, Ping Zhao, De-Jun Pan, Jun-Qing Zhang, Li-Ying Ye, Fa-Rong Zhang, Xiang-Dong Xu

“…Renal fibrosis is a common pathway for the progression of various chronic kidney diseases (CKD), and the formation and deterioration will eventually lead to end-stage renal failure, which brings a heavy medical burden to the world. …”
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ITGAM rs1143679 Variant in Systemic Lupus Erythematosus Is Associated with Increased Serum Calcification Propensity by Matthieu Halfon, Li Zhang, Driss Ehirchiou, Vishnuprabu Durairaj Pandian, Suzan Dahdal, Uyen Huynh-Do, Andreas Pasch, Camillo Ribi, Nathalie Busso

“…There were no differences between the groups in terms of global disease activity, kidney involvement, and chronic renal failure. Complement C3 levels were lower in A/A individuals compared to others (0.6 ± 0.08 vs. 0.9 ± 0.25 g/L; <i>p</i> = 0.02). …”
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The Effect of Warfarin Use on Postoperative Outcomes after Femoral Neck Surgery by Jeremy Dubin, Esequiel Palmanovich, Eitan Iohanes, Ronen Blecher, David Segal, Yaron Brin, Michael Drexler, Ran Atzmon

“…Risk factors included age, gender, Body Mass Index (BMI) > 30, Atrial Fibrillation (AF), Chronic Heart Failure (CHF), and Chronic Renal Failure (CRF). Postoperative outcomes were also collected at each of the patients’ follow-up visits, including number of hospitalization days, delays to theatre, and mortality rate. …”
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Use of Sorbent Based on Hypercrosslinked Styrene-Divinylbenzene Copolymer With Immobilized LPS-Selective Ligand In Hemoperfusion For Treatment of Patients With Septic Shock by M. A. Magomedov, T. G. Kim, S. V. Masolitin, A. V. Yaralian, E. Yu. Kalinin, V. M. Pisarev

“…During the first day, hemoperfudion caused a rapid decline in APACHE II and SOFA scores, while acute renal failure (estimated by urea and creatinine levels) resolved gradually by day 5. …”
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TIcagrelor in Rotational Atherectomy to Reduce TROPonin Enhancement: The TIRATROP Study, A Randomized Controlled Trial by Thibault Lhermusier, Pascal Motreff, Vincent Bataille, Guillaume Cayla, Bruno Farah, Jerome Roncalli, Meyer Elbaz, Nicolas Boudou, Fransisco Campello-Parada, Frederic Bouisset, Geraud Souteyrand, Emilie Berard, Vanina Bongard, Didier Carrie

“…Independent predictors for troponin enhancement were acute coronary syndrome presentation, renal failure, elevated C-Reactive protein and multiple lesions treated with RA. …”
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