Causes of In-Hospital Death and Pharmaceutical Associations with Age of Death during a 10-Year Period (2011–2020) in Individuals with and without Diabetes at a Japanese Community G... by Minae Hosoki, Taiki Hori, Yousuke Kaneko, Kensuke Mori, Saya Yasui, Seijiro Tsuji, Hiroki Yamagami, Saki Kawata, Tomoyo Hara, Shiho Masuda, Yukari Mitsui, Kiyoe Kurahashi, Takeshi Harada, Shingen Nakamura, Toshiki Otoda, Tomoyuki Yuasa, Akio Kuroda, Itsuro Endo, Munehide Matsuhisa, Ken-ichi Aihara

“…Diabetic individuals had higher rates of hepato-pancreatic cancer and cardio-renal failure as causes of death. The prescription rates of antihypertensives, antiplatelets, and statins in diabetic individuals were larger than those in non-diabetic individuals. …”
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Extra-anatomic revascularization and a new cannulation strategy for preoperative cerebral malperfusion due to severe stenosis or occlusion of supra-aortic branch vessels in acute t... by Jingwei Sun, Chao Xue, Jinglong Zhang, Chen Yang, Kai Ren, Hanzhao Zhu, Bin Zhang, Xiayun Li, Hongliang Zhao, Zhenxiao Jin, Jincheng Liu, Weixun Duan

“…Of all the patients, 3.6% (1/28) had novel acute renal failure. No other deaths, secondary surgeries, or serious complications occurred during the early follow-up period. …”
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Linking renal hypoxia and oxidative stress in chronic kidney disease: Based on clinical subjects and animal models by Yizeng Xu, Fang Lu, Meng Wang, Lingchen Wang, Chaoyang Ye, Shuohui Yang, Chen Wang

“…The study indicates that decline in renal oxygenation and antioxidant capacity is associated with the severity of renal failure in CKD. Losartan can potentially alleviate renal hypoxia and oxidative stress in the treatment of CKD via Keap1-Nrf2/HO-1 pathway. …”
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Inappropriate Underdosing of Direct Oral Anticoagulants in Atrial Fibrillation Patients: Results from the START2-AF Registry by Daniela Poli, Emilia Antonucci, Walter Ageno, Martina Berteotti, Anna Falanga, Vittorio Pengo, Paolo Chiarugi, Benilde Cosmi, Carmelo Paparo, Antonio Chistolini, Antonio Insana, Domenico Lione, Giuseppe Malcangi, Giuliana Martini, Lucilla Masciocco, Simona Pedrini, Eugenio Bucherini, Daniele Pastori, Pasquale Pignatelli, Andrea Toma, Sophie Testa, Gualtiero Palareti, START AF Study Group

“…Age, body weight <60 kg, and renal failure were significantly associated with inappropriate LD DOAC prescription. …”
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Diversifying cardiac intensive care unit models: Successful example of an operating surgeon-led unitCentral MessagePerspective by Perry S. Choi, MD, Katharine C. Pines, MPH, Akshay Swaminathan, BA, Riya Nilkant, Michael A. Mendez, MSN, Hao He, PhD, Y. Joseph Woo, MD, Billie-Jean Martin, MD, PhD

“…Secondary outcomes included postoperative intensive care unit length of stay, 30-day mortality, 30-day Society of Thoracic Surgeons–defined morbidity (permanent stroke, renal failure, cardiac reoperation, prolonged intubation, deep sternal infection), packed red cell transfusions, and vasopressor use. …”
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Clinical correlates of CT imaging-derived phenotypes among lean and overweight patients with hepatic steatosis by Isabel Song, Elizabeth W. Thompson, Anurag Verma, Matthew T. MacLean, Jeffrey Duda, Ameena Elahi, Richard Tran, Pavan Raghupathy, Sophia Swago, Mohamad Hazim, Abhijit Bhattaru, Carolin Schneider, Marijana Vujkovic, Drew A. Torigian, Charles E. Kahn, James C. Gee, Arijitt Borthakur, Colleen M. Kripke, Christopher C. Carson, Rotonya Carr, Qasim Jehangir, Yi-An Ko, Harold Litt, Mark Rosen, David A. Mankoff, Mitchell D. Schnall, Haochang Shou, Julio Chirinos, Scott M. Damrauer, Marina Serper, Jinbo Chen, Daniel J. Rader, Penn Medicine BioBank, Walter R. T. Witschey, Hersh Sagreiya

“…Ten phenotypes were significant in the PheWAS, including chronic kidney disease, renal failure, and cardiovascular disease. Hepatic steatosis was found to be associated with cardiovascular, kidney, and metabolic conditions, separate from overweight BMI.…”
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Right dose, right now: bedside, real-time, data-driven, and personalised antibiotic dosing in critically ill patients with sepsis or septic shock—a two-centre randomised clinical t... by Luca F. Roggeveen, Tingjie Guo, Lucas M. Fleuren, Ronald Driessen, Patrick Thoral, Reinier M. van Hest, Ron A. A. Mathot, Eleonora L. Swart, Harm-Jan de Grooth, Bas van den Bogaard, Armand R. J. Girbes, Rob J. Bosman, Paul W. G. Elbers

“…Importantly, higher dosing did not lead to increased mortality or renal failure. Conclusions In critically ill patients, personalised dosing was feasible, safe and significantly improved target attainment for ciprofloxacin. …”
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Tratamento cirúrgico para ectasia ânulo-aórtica Surgical treatment for annulo-aortic ectasia by Ricardo García-Macedo, Renato A. K Kalil, Paulo Roberto Prates, Fernando A Lucchese, João Ricardo Sant'Ana, Edemar M Pereira, Altamiro Reis Costa, Raul Feck A Lara, Ivo A Nesralla

“…There was 1 (3.7%) hospital death, due to bleeding and renal failure. Significant early complications were represented by arrhythmias in 13 cases (48%) and bleeding in 3 (11%). …”
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Minimally invasive approach associated with lower resource utilization after aortic and mitral valve surgeryCentral MessagePerspective by NaYoung K. Yang, MPH, Fady K. Soliman, BA, Russell J. Pepe, MD, MSCTS, Nadia K. Palte, BA, Jin Yoo, BS, Sorasicha Nithikasem, BS, Kayla N. Laraia, BS, Abhishek Chakraborty, MS, Joshua C. Chao, MD, JD, Gengo Sunagawa, MD, Manabu Takebe, MD, Anthony Lemaire, MD, Hirohisa Ikegami, MD, Mark J. Russo, MD, Leonard Y. Lee, MD

“…FS patients were more likely to experience postoperative atrial fibrillation (P = .040) and renal failure (P = .027). Other outcomes did not differ between groups. …”
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Features of Development and Course of Disseminated Intravascular Coagulation Syndrome During Surgical Interventions in Children with Oncological Diseases by N. P. Leonov, V. V. Schukin, G. A. Novichkova, M. A. Maschan, F. I. Ataullakhanov, S. S. Yashin, A. M. Zeynalov, Е. A. Spiridonova

“…Multiple organ failure (MOF) was more severe and was represented by pulmonary, hepatic and renal failure in the group with identified DIC. The development of MOF was accompanied by a decrease in tissue perfusion and an increase in D-dimer. …”
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Cirurgia coronária com condutos arteriais múltiplos sem circulação extracorpórea Off-pump coronary artery bypass with multiple arterial conduits by Daniel Navia, Mariano Vrancic, Guillermo Vaccarino, Fernando Piccinini, Eduardo Iparraguirre, Marcelo Casas, Jorge Thierer

“…RESULTS: The postoperative incidence of atrial fibrillation was 12.8% (26), oligoanuric renal failure 3% (six), dialysis 0.49% (one), postoperative myocardial infarction 1.47% (three), low cardiac output 4% (eight), Redo for bleeding 1.47% (three), mediastinitis 1.47% (three), stroke 1.47% (three). …”
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Invasive Candidiasis in Adult Patients with COVID-19: Results of a Multicenter Study in St. Petersburg, Russia by Olga Kozlova, Ekaterina Burygina, Sofya Khostelidi, Olga Shadrivova, Andrey Saturnov, Denis Gusev, Aleksandr Rysev, Anatoliy Zavrazhnov, Maria Vashukova, Galina Pichugina, Mikhail Mitichkin, Sergey Kovyrshin, Tatiana Bogomolova, Yulia Borzova, Ellina Oganesyan, Natalya Vasilyeva, Nikolay Klimko, Working Group

“…The signs and symptoms of COVID-IC were non-specific: fever (59%), renal failure (33%), liver failure (23%), and cardiovascular failure (10%). …”
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Effects of Mean Artery Pressure and Blood pH on Survival Rate of Patients with Acute Kidney Injury Combined with Acute Hypoxic Respiratory Failure: A Retrospective Study by Chi-Hua Ko, Ying-Wei Lan, Ying-Chou Chen, Tien-Tsai Cheng, Shan-Fu Yu, Abdulkadir Cidem, Yu-Hsien Liu, Chia-Wen Kuo, Chih-Ching Yen, Wei Chen, Chuan-Mu Chen

“…<i>Background and Objectives:</i> In the intensive care unit (ICU), renal failure and respiratory failure are two of the most common organ failures in patients with systemic inflammatory response syndrome (SIRS). …”
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Identification of palliative care needs and prognostic factors of survival in tailoring appropriate interventions in advanced oncological, renal and pulmonary diseases: a prospecti... by Stefano Nava, Romina Rossi, Marco Maltoni, Augusto Caraceni, Oriana Nanni, Maria Caterina Pallotti, Loretta Zambianchi, Giovanni Mosconi, Emanuela Scarpi, Vanessa Valenti, Monia Dall'Agata, Ilaria Bassi, Paola Cravero, Gaetano La Manna, Giacomo Magnoni, Martina Marchello, Ilario Giovanni Rapposelli, Marianna Ricci, Anna Scrivo, Alessandra Spazzoli, Danila Valenti

“…The aim of this project is to investigate whether the combined use of the NECPAL CCOMS-ICO and Palliative Prognostic (PaP) Score tools offers valuable screening methods to identify patients suffering from advanced chronic disease with limited life prognosis and likely to need palliative care, such as cancer, chronic renal or chronic respiratory failure.Methods and analysis This multicentre prospective observational study includes three patient populations: 100 patients with cancer, 50 patients with chronic renal failure and 50 patients with chronic pulmonary failure. …”
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Multimorbidity Profile of COVID-19 Deaths in Portugal during 2020 by Paulo Jorge Nogueira, Miguel de Araújo Nobre, Cecília Elias, Rodrigo Feteira-Santos, António C.-V. Martinho, Catarina Camarinha, Leonor Bacelar-Nicolau, Andreia Silva Costa, Cristina Furtado, Liliane Morais, Juan Rachadell, Mário Pereira Pinto, Fausto Pinto, Antó Vaz Carneiro

“…Uncomplicated hypertension, uncomplicated diabetes mellitus, congestive heart failure, renal failure, cardiac arrhythmias, dementia, and cerebrovascular disease were observed among COVID-19 deceased patients, with prevalences higher than 10%. …”
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Colloids versus crystalloids in objective-guided fluid therapy, systematic review and meta-analysis. Too early or too late to draw conclusions by Javier Ripollés, Ángel Espinosa, Rubén Casans, Ana Tirado, Alfredo Abad, Cristina Fernández, José Calvo

“…After the decision of European Medicines Agency, there is such controversy regarding its use, benefits, and possible contribution to renal failure. The objective of this systematic review and meta-analysis is to compare the use of last-generation colloids, derived from corn, with crystalloids in GDFT to determine associated complications and mortality. …”
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Prognostic Analysis of IgA Nephropathy Patients with High Risk of CKD Progression Treated with Glucocorticoid: a Retrospective Study by GAO Ge, ZHANG Xinyue, FENG Yuhua, DOU Jingyu, WU Xueying, CHENG Genyang

“…Conclusions In IgAN patients with high risk of CKD progression, compared with simple supportive treatment, glucocorticoid treatment can significantly improve the renal remission rate and reduce the risk of renal function decline and renal failure. However, it is still necessary to be alert to its adverse reactions.…”
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Case Report: Atypical Manifestations Associated With FOXP3 Mutations. The “Fil Rouge” of Treg Between IPEX Features and Other Clinical Entities? by Micaela Gentile, Micaela Gentile, Maurizio Miano, Paola Terranova, Stefano Giardino, Maura Faraci, Filomena Pierri, Enrico Drago, Daniela Verzola, Gianmarco Ghiggeri, Enrico Verrina, Andrea Angeletti, Barbara Cafferata, Alice Grossi, Isabella Ceccherini, Gianluca Caridi, Francesca Lugani, Lorenzo Nescis, Enrico Fiaccadori, Enrico Fiaccadori, Luca Lanino, Daniela Fenoglio, Daniela Fenoglio, Edoardo La Porta, Edoardo La Porta

“…Membranous nephropathy leading to renal failure completed in both cases the clinical phenotypes that should be included in the clinical panorama of FOXP3 failure.…”
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Revascularização total do miocárdio sem circulação extracorpórea em pacientes com disfunção ventricular esquerda Off-pump total myocardial revascularization in patients with left v... by Rodrigo Milani, Brofman Paulo, José Augusto Moutinho, Barboza Laura, Guimarães Maximiliano, Barbosa Alexandre, Zitynski Lidia, Précoma Dalton, Varela Alexandre, Marcel Rogers Ravanelli, Francisco Maia

“…As to complications, 2 patients (0.49%) had renal failure, 2 had mediastinitis (0.49%), 7 (1.7%) needed to be reoperated because of bleeding, 5 patients (1.2%) suffered acute myocardial infarction, and 70 patients (17.3%) experienced atrial fibrillation. …”
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Factors Predictive of Mortality among Geriatric Patients Sustaining Low-Energy Blunt Trauma by Nikhil Patel, Timothy N. Le, Seleshi Demissie, Shreya Pandya, Thomas Kania, Michael Copty, Sara Alothman, Amy Rost, Chris Governo, Frank DiRoma, Galina Glinik, Krassimir Atanassov, Boris Khodorkovsky, Anita Szerszen, Asaf Gave, Duraid Younan

“…Comorbidities collected included a history of chronic renal failure, COPD, Hypertension and Myocardial Infarction. …”
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