LipidA-IDER to explore the global lipid A repertoire of drug-resistant gram-negative bacteria by Guan, Xue Li, Loh, Johnathan Yi-Xiong, Lizwan, Marco, Chan, Sharon Cui Mun, Kwan, Jeric Mun Chung, Lim, Tze Peng, Koh, Tse Hsien, Hsu, Li Yang, Lee, Bernett Teck Kwong

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Outer-membrane permeabilization, LPS transport inhibition: activity, interactions, and structures of thanatin derived antimicrobial peptides by Swaleeha Jaan Abdullah, Yan, Bernice Tan Siu, Palanivelu, Nithya, Dhanabal, Vidhya Bharathi, Bifani, Juan Pablo, Bhattacharjya, Surajit

“…Currently, viable antibiotics available to mitigate infections caused by drug-resistant Gram-negative bacteria are highly limited. Thanatin, a 21-residue-long insect-derived antimicrobial peptide (AMP), is a promising lead molecule for the potential development of novel antibiotics. …”
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Linking dual mode of action of host defense antimicrobial peptide thanatin: structures, lipopolysaccharide and LptAm binding of designed analogs by Sinha, Sheetal, Dhanabal, Vidhya Bharathi, Sperandeo, Paola, Polissi, Alessandra, Bhattacharjya, Surajit

“…At present, antibiotics options to cure infections caused by drug resistant Gram-negative pathogens are highly inadequate. …”
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Designer broad-spectrum polyimidazolium antibiotics by Zhong, Wenbin, Shi, Zhenyu, Mahadevegowda, Surendra H., Liu, Bo, Zhang, Kaixi, Koh, Chong Hui, Ruan, Lin, Chen, Yahua, Zeden, Merve S., Pee, Carmen J. E., Marimuthu, Kalisvar, De, Partha Pratim, Ng, Oon Tek, Zhu, Yabin, Chi, Robin Yonggui, Hammond, Paula T., Yang, Liang, Gan, Yunn-Hwen, Pethe, Kevin, Greenberg, E. Peter, Gründling, Angelika, Chan-Park, Mary B.

“…We synthesized several cationic peptide mimics, main-chain cationic polyimidazoliums (PIMs), and discovered that, although select PIMs show little acute mammalian cell toxicity, they are potent broad-spectrum antibiotics with activity against even pan-antibiotic-resistant gram-positive and gram-negative bacteria, and mycobacteria. …”
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