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Whole-Retina Reduced Electrophysiological Activity in Mice Bearing Retina-Specific Deletion of Vesicular Acetylcholine Transporter.
Published 2015-01-01“…The current study investigates the effects of disrupting cholinergic signalling in mice, through deletion of vesicular acetylcholine transporter (VAChT) in the developing retina, pigmented epithelium, optic nerve and optic stalk, on electrophysiology and structure of the mature retina.A combination of electroretinography, optical coherence tomography imaging and histological evaluation assessed retinal integrity in mice bearing retina- targeted (embryonic day 12.5) deletion of VAChT (VAChTSix3-Cre-flox/flox) and littermate controls at 5 and 12 months of age. …”
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Red‐shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina
Published 2016-09-01Subjects: Get full text
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Retinal circulation time/arm-to-retina time ratio in the fluorescein angiography to evaluate retina-specific hemodynamics
Published 2022-10-01“…Moreover, RC/AR ratio revealed that circulatory changes peculiar to the retina may also be involved in retinal-disease pathogenesis. …”
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Posttranslational modifications of proteins in diseased retina
Published 2023-03-01“…Recent breakthroughs in protein purification strategies and current proteome technologies make it possible to identify the proteomics of healthy and diseased retinas. Despite these advantages, the research field identifying sets of posttranslationally modified proteins (PTMomes) related to diseased retinas is significantly lagging, despite knowledge of the major retina PTMome being critical to drug development. …”
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Mathematical model for glutathione dynamics in the retina
Published 2023-07-01“…Abstract The retina is highly susceptible to the generation of toxic reactive oxygen species (ROS) that disrupt the normal operations of retinal cells. …”
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Sphingolipids as Emerging Mediators in Retina Degeneration
Published 2019-06-01“…The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions. Their roles in the retina have gained increasing attention during the last decade since they emerge as mediators of proliferation, survival, migration, neovascularization, inflammation and death in retina cells. …”
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Thyroid Hormone Signaling in the Mouse Retina.
Published 2016-01-01“…In the adult retina, nearly all neurons of the ganglion cell layer (GCL, ganglion cells and displaced amacrine cells) showed strong β-gal labeling. …”
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Tissue Engineering Strategies for Retina Regeneration
Published 2021-02-01“…The retina is a complex and fragile photosensitive part of the central nervous system which is prone to degenerative diseases leading to permanent vision loss. …”
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Heidelberg Retina Tomograph for the Detection of Glaucoma
Published 2012-06-01“…Heidelberg Retina Tomograph (HRT) is a confocal scanning laser ophthalmoscope which acquires and analyzes 3-dimensional images of the optic nerve head. …”
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Electrical imaging of axonal stimulation in the retina
Published 2022-09-01“…In this work we electrically imaged axonal stimulation in ex vivo mouse retina using a high-density CMOS-based microelectrode array. …”
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Decalcified choroidal osteoma found in the retina
Published 2012-11-01“…Herein, we report a rare case of decalcified choroidal osteoma found in the retina. A 27-year-old woman presented with visual loss. …”
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Origins of direction selectivity in the primate retina
Published 2022-05-01“…Here, the authors establish an origin for direction selectivity in the retina of the macaque monkey.…”
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“NÃO ME AGUARDE NA RETINA”
Published 2018-12-01“…Because curatorship holds a strategic position within the system of culture and art, the text calls for reflection on the experience of three curatorial projects: the exhibition Diálogos Ausentes (2016/2017), the AfroTranscendence programme (2015 -) and “Não me aguarde na retina” for the Valongo International Festival of Image (2018).…”
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Neurotransmitter-Regulated Regeneration in the Zebrafish Retina
Published 2017-04-01“…Summary: Current efforts to repair damaged or diseased mammalian retinas are inefficient and largely incapable of fully restoring vision. …”
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Building a better model of the retina
Published 2019-10-01“…Researchers have combined organ-on-a-chip engineering with the benefits of organoids to make improved models of the human retina.…”
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Efficacy of Osthole in Management of Hypoperfused Retina
Published 2018-01-01“…To determine the effect of osthole on the retina in a chronic cerebral hypoperfusion (CCH) rat model and to investigate its therapeutic activity. …”
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Impact of bronchopulmonary dysplasia on brain and retina
Published 2016-04-01Subjects: Get full text
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Molecular mechanisms of NMDA excitotoxicity in the retina
Published 2023-10-01“…Meanwhile, decreased activity of the pro-inflammatory TNF signaling cascade and decreased levels of ferrous iron (Fe2+, required for free radical production) led to significant neuroprotection in NMDA-treated retinas. Since increased TNF signaling activity and high Fe2+ levels trigger regulated necrosis, which, in turn, lead to inflammation, we proposed an important role in NMDA excitotoxicity of a positive feedback loop in which regulated necrosis promotes inflammation, which subsequently triggers regulated necrosis.…”
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