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Synthesis studies towards daphlongeranine B
Published 2013“…This chapter also features our retrosynthetic analysis of daphlongeranine B.</p> <p><strong>Chapter 2</strong> details the synthesis of the model spirocyclic enone 72 which was the vital building block needed to investigate the key intramolecular Michael addition. …”
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Opportunities for Machine Learning and Artificial Intelligence to Advance Synthetic Drug Substance Process Development
Published 2025“…The focus of these efforts has primarily centered on the task of retrosynthetic analysis, as seen from the perspective of a medicinal chemist. …”
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Application of new synthetic methodologies to access 2,6-anti-tetrahydropyrans : towards the total synthesis of apicularen A
Published 2014“…The progress from preliminary retrosynthetic analysis, alongside with its synthetic route, to the revised versions, was described and elaborated to the best of the author’s knowledge. …”
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4
Design and syntheses of ortho-, meta- and paraxylylguanidinium-Zn²⁺- cyclen complexes and their interactions with DNA / Nor Amin Hassan
Published 2018“…Three new zinc ions (Zn²⁺) complexes, C¹, C² and Cᶟ, were designed and synthesized by coordination of Zn²⁺into the integrated 1,4,7,10-tetraazacyclododecane (cyclen) and ortho-, meta- and para-bromoxylylguanidinium pendants group. A retrosynthetic analysis was carried out to identify and solve problems with regard the selection of organic reactions. …”
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5
Total synthesis of (+)-11,11′-dideoxyverticillin A
Published 2018“…This study, however, describes a biosynthetically inspired enantioselective first total synthesis of (+)-1 that features stereoselective and chemoselective advanced-stage tetrahydroxylation and tetrathiolation reactions. The retrosynthetic analysis of (+)-1 (Fig. 2) mimics a biosynthesis pathway connecting dimeric epidithiodiketopiperazines to common α-amino acid precursors. …”
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