Showing 1 - 20 results of 171 for search '"ribozyme"', query time: 0.55s Refine Results
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    Ribozymes as therapeutic tools for genetic disease. by Phylactou, L, Kilpatrick, M, Wood, M

    Published 1998
    “…The hammerhead ribozyme, one of the smallest ribozymes identified, is able to induce site-specific cleavage of RNA, with ribozyme and substrate being two different oligoribonucleotides with regions of complementarity. …”
    Journal article
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    RNA ligase ribozymes with a small catalytic core by Yoko Nomura, Yohei Yokobayashi

    Published 2023-05-01
    “…Many natural ribozymes and laboratory evolved ribozymes exhibit efficient catalysis mediated by elaborate catalytic cores within complex tertiary structures. …”
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    Article
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    Ribozyme-mediated trans-splicing of a trinucleotide repeat. by Phylactou, L, Darrah, C, Wood, M

    Published 1998
    “…Ribozyme-mediated RNA repair may thus form a novel therapeutic strategy for diseases associated with repeat expansions.…”
    Journal article
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    Ribozymes and siRNA for the treatment of diseases of the nervous system. by Wood, M, Trülzsch, B, Abdelgany, A, Beeson, D

    Published 2003
    “…Naturally occurring catalytic RNA molecules (ribozymes), their synthetic DNA counterparts (deoxyribozymes or DNAzymes), as well as the exciting, emerging technology of small interfering RNA which utilizes the highly conserved cellular RNA interference pathway, are being developed for therapeutic gene silencing purposes. …”
    Journal article
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    Reconciling Ligase Ribozyme Activity with Fatty Acid Vesicle Stability by Fabrizio Anella, Christophe Danelon

    Published 2014-12-01
    “…Here, we report on the activity of a short L1 ligase ribozyme in the presence of myristoleic acid (MA) vesicles at varying concentrations of Mg2+. …”
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    Article
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    Inhibition of HIV-1 replication by ribozymes that show poor activity in vitro. by Crisell, P, Thompson, S, James, W

    Published 1993
    “…Self-cleaving RNAs (ribozymes) can be engineered to cleave target RNAs of choice in a sequence-specific manner (1). …”
    Journal article