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Ribozymes as therapeutic tools for genetic disease.
Published 1998“…The hammerhead ribozyme, one of the smallest ribozymes identified, is able to induce site-specific cleavage of RNA, with ribozyme and substrate being two different oligoribonucleotides with regions of complementarity. …”
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Computational approaches to the identification of ribozyme target sites.
Published 1997Journal article -
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Modulation of Group I Ribozyme Activity by Cationic Porphyrins
Published 2015-03-01Subjects: Get full text
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Molecular Crowding Facilitates Ribozyme-Catalyzed RNA Assembly
Published 2023-08-01Get full text
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RNA ligase ribozymes with a small catalytic core
Published 2023-05-01“…Many natural ribozymes and laboratory evolved ribozymes exhibit efficient catalysis mediated by elaborate catalytic cores within complex tertiary structures. …”
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Ribozyme-mediated trans-splicing of a trinucleotide repeat.
Published 1998“…Ribozyme-mediated RNA repair may thus form a novel therapeutic strategy for diseases associated with repeat expansions.…”
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Ribozymes and siRNA for the treatment of diseases of the nervous system.
Published 2003“…Naturally occurring catalytic RNA molecules (ribozymes), their synthetic DNA counterparts (deoxyribozymes or DNAzymes), as well as the exciting, emerging technology of small interfering RNA which utilizes the highly conserved cellular RNA interference pathway, are being developed for therapeutic gene silencing purposes. …”
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An RNA Triangle with Six Ribozyme Units Can Promote a <i>Trans</i>-Splicing Reaction through Trimerization of Unit Ribozyme Dimers
Published 2021-03-01Subjects: Get full text
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Reconciling Ligase Ribozyme Activity with Fatty Acid Vesicle Stability
Published 2014-12-01“…Here, we report on the activity of a short L1 ligase ribozyme in the presence of myristoleic acid (MA) vesicles at varying concentrations of Mg2+. …”
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Ribozyme activity modulates the physical properties of RNA–peptide coacervates
Published 2023-06-01Subjects: “…ribozyme…”
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Aptamers, Riboswitches, and Ribozymes in <i>S. cerevisiae</i> Synthetic Biology
Published 2021-03-01Subjects: Get full text
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Co-Localization of Hammerhead Ribozymes and HIV RNA’s by Rev Multimerization
Published 2004-06-01Subjects: Get full text
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RNA Synthesis by in Vitro Selected Ribozymes for Recreating an RNA World
Published 2015-01-01Subjects: Get full text
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Ribozyme-mediated RNA synthesis and replication in a model Hadean microenvironment
Published 2023-03-01Get full text
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Ribozyme Assays to Quantify the Capping Efficiency of In Vitro-Transcribed mRNA
Published 2022-01-01Subjects: Get full text
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Inhibition of HIV-1 replication by ribozymes that show poor activity in vitro.
Published 1993“…Self-cleaving RNAs (ribozymes) can be engineered to cleave target RNAs of choice in a sequence-specific manner (1). …”
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