Single-Level Anterior Lumbar Interbody Fusion versus Minimally Invasive Transforaminal Lumbar Interbody Fusion at L5/S1 for an Obese Population by Madhav Rajesh Patel, Kevin Chacko Jacob, Cameron Zamanian, Hanna Pawlowski, Michael Clifford Prabhu, Nisheka Navin Vanjani, Kern Singh

“…After coarsened exact matching for Charlson comorbidity index score, degenerative spondylolisthesis, isthmic spondylolisthesis, degenerative scoliosis, foraminal stenosis, insurance, male, and ethnicity, 94 obese patients were included in the total cohort, with 59 receiving MIS TLIF and 35 receiving ALIF. …”
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Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration by Shangbin Cui, Wenyue Li, Graciosa Q. Teixeira, Cornelia Neidlinger‐Wilke, Hans‐Joachim Wilke, Lisbet Haglund, Hongwei Ouyang, R. Geoff Richards, Sibylle Grad, Mauro Alini, Zhen Li

“…Human IVD samples were obtained from patients diagnosed with lumbar disc herniation (LDH) or adolescent idiopathic scoliosis (AIS). After immunohistochemical (IHC) staining of Aggrecanase Cleaved C‐terminus Aggrecan Neoepitope (NB100), MMP Cleaved C‐terminus Aggrecan Neoepitope (MMPCC), Collagen Type 1α1 1/4 fragment (C1α1) and Collagenase Cleaved Type I and II Collagen Neoepitope (C1,2C), staining optical density (OD)/area in extracellular matrix (OECM) and pericellular zone (OPCZ) were analyzed. …”
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A Diagnostic Challenge in an Adolescent with Collagen VI-Related Myopathy and Emotional Disorder—Case Report by Mihaela Oros, Lucica Baranga, Adelina Glangher, Moldovan Adina-Diana, Gheorghita Jugulete, Carmen Pavelescu, Florin Mihaltan, Vasilica Plaiasu, Dan Cristian Gheorghe

“…Individuals with collagen VI-related myopathy are at risk of restrictive lung disease and sleep-disordered breathing due to the development of scoliosis associated with neuromuscular weakness. Typical signs of respiratory failure are not always present, and some patients are unaware that their respiratory muscles have become weaker. …”
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Senolytic Combination Treatment Is More Potent Than Single Drugs in Reducing Inflammatory and Senescence Burden in Cells from Painful Degenerating IVDs by Matthew Mannarino, Oliver Wu-Martinez, Kai Sheng, Li Li, Rodrigo Navarro-Ramirez, Peter Jarzem, Jean A. Ouellet, Hosni Cherif, Lisbet Haglund

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Fat infiltration of the posterior paraspinal muscles is inversely associated with the fat infiltration of the psoas muscle: a potential compensatory mechanism in the lumbar spine by Maximilian Muellner, Henryk Haffer, Erika Chiapparelli, Yusuke Dodo, Jennifer Shue, Ek T. Tan, Jiaqi Zhu, Matthias Pumberger, Andrew A. Sama, Frank P. Cammisa, Federico P. Girardi, Alexander P. Hughes

“…Exclusion criteria included previous spinal surgery at any level, lumbar scoliosis with a Cobb Angle > 20° and patients with incompatible MRIs. …”
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DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion by Chidambaran V, Zhang X, Martin LJ, Ding L, Weirauch MT, Geisler K, Stubbeman BL, Sadhasivam S, Ji H

“…Since deoxyribonucleic acid (DNA) methylation is a potent repressor of gene expression, DNA methylation was evaluated at the OPRM1 promoter, as a predictor of preoperative, acute, and chronic postsurgical pain (CPSP).Methods: A prospective observational cohort study was conducted in 133 adolescents with idiopathic scoliosis undergoing spine fusion under standard protocols. …”
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Dietary ascorbic acid requirement for the optimum growth performances and normal skeletal development in juvenile hybrid grouper, Epinephelus fuscoguttatus × Epinephelus lanceolatu... by Isabella Ebi, Annita Yong Seok Kian, Leong, Seng Lim, Rossita Shapawi

“…Multiple types of skeletal deformities (fusion, kyphosis, lordosis, and scoliosis) were observed in the fish fed with the diets containing less than 95 mg/kg of ascorbic acid. …”
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Optimization and characterization of nanoemulsion containing aripiprazole and its toxicity on zebrafish by Samiun, Wan Sarah

“…However, during the developmental toxicity, all the survived zebrafish larvae showed severe toxicity effect at high concentration of samples more than 250 μg/mL such as chronic pericardial edema, bradycardia, scoliosis and non-detachment of tail. Regardless of the presence of surfactant toxic effect, surfactant must be chosen wisely within the optimum concentration in producing formulation nanoemulsion.…”
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Clinical characteristics and proposed mechanism of pediatric spinal cord injury resulting from backbend practice by Shuang Guo, Shuang Guo, Huiming Gong, Huiming Gong, Peipei Xu, Peipei Xu, Yang Xie, Yang Xie, Degang Yang, Degang Yang, Zitong Liu, Yuwei Yang, Liang Chen, Liang Chen, Yongqi Xie, Yongqi Xie, Mingliang Yang, Mingliang Yang, Mingliang Yang

“…After one year, the most common complications were scoliosis (31, 74%) and abnormal hips (14, 33%). Injury of the caudal spinal cord torn by nerve roots was confirmed by surgical exploration in a case. …”
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Clinical and genetic characteristics of Chinese patients with congenital cranial dysinnervation disorders by Hongyan Jia, Qian Ma, Yi Liang, Dan Wang, Qinglin Chang, Bo Zhao, Zongrui Zhang, Jing Liang, Jing Song, Yidi Wang, Ranran Zhang, Zhanhan Tu, Yonghong Jiao

“…No definite pathogenic variants in known candidate genes of CCDDs were found in sporadic DRS, Möbius Syndrome (MBS) and Horizontal Gaze Palsy with Progressive Scoliosis (HGPPS) patients. The CFEOM patients harboring R380C, E410K and R262H variants in TUBB3 gene and F355S variant in KIF21A gene exhibited syndromic phenotypes. …”
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Postural assessment of girls between 7 and 10 years of age Avaliação postural em meninas de 7 a 10 anos by Patrícia Jundi Penha, Sílvia Maria Amado João, Raquel Aparecida Casarotto, Carlos Junichiro Amino, Daniela Caielli Penteado

“…RESULTS: The main postural deviations found were knock-knee, medial rotation of the hip, antepulsion, pelvic anteversion, knee hyperextension, lumbar hyperlordosis, valgus ankle, imbalanced shoulders, lateral pelvic inclination, scoliosis, trunk rotation, thoracic hyperkyphosis, winged scapula, shoulder protraction, abducted scapula, medial rotation of shoulders, and head tilt. …”
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Clinical Results of Utilizing the Satellite Rod Technique in Treating Ankylosing Spondylitis Kyphosis by Chao Liu, Fanqi Hu, Wenhao Hu, Zhen Zhang, Guoquan Zheng, Kai Song, Fangcai Li, Xuesong Zhang

“…Pre‐ and postoperative health‐related quality of life instruments, including the Bath Ankylosing Spondylitis Functional Index (Basfi) and Scoliosis Research Society outcomes instrument‐22 (SRS‐22), were recorded. …”
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Landscape of Secondary Findings in Chinese Population: A Practice of ACMG SF v3.0 List by Yingzhao Huang, Bowen Liu, Jile Shi, Sen Zhao, Kexin Xu, Liying Sun, Na Chen, Wen Tian, Jianguo Zhang, Nan Wu

“…In this study, we evaluated the genetic data of 2987 individuals from the Deciphering Disorders Involving Scoliosis and COmorbidities (DISCO) study group in accordance with the ACMG SF v3.0 list. …”
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Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages by Xin Zhao, Zhen Sun, Benchi Xu, Wei Duan, Le Chang, Kangwei Lai, Zhengxu Ye

“…Methods Nucleus pulposus (NP) tissue and nucleus pulposus cells (NPc) were collected from patients with intervertebral disc degeneration (IVDD) and idiopathic scoliosis. Immunohistochemistry analysis was performed to determine the number of M1 macrophages in NP tissue. …”
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Current Trends in Intraoperative Spinal Cord Monitoring: A Survey Analysis among Japanese Expert Spine Surgeons by Hideki Shigematsu, Go Yoshida, Shinji Morito, Masahiro Funaba, Nobuaki Tadokoro, Masaaki Machino, Kazuyoshi Kobayashi, Muneharu Ando, Shigenori Kawabata, Kei Yamada, Tsukasa Kanchiku, Yasushi Fujiwara, Shinichirou Taniguchi, Hiroshi Iwasaki, Masahito Takahashi, Kanichiro Wada, Naoya Yamamoto, Akimasa Yasuda, Hiroki Ushirozako, Jun Hashimoto, Kei Ando, Yukihiro Matsuyama, Shiro Imagama

“…Intramedullary spinal cord tumor, scoliosis (idiopathic, congenital, or neuromuscular in pediatric), and thoracic ossification of the posterior longitudinal ligament were representative diseases that require IONM. …”
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Supplementary orthopaedic screening for children and adolescents to prevent permanent skeletal deformities – protocol for the “OrthoKids” study by B. Scheckel, M. Naumann, D. Simic, S. Stock, O. Loose, M. Breig, K. Albrecht, K. Braun, R. Kucher, S. Deininger, L. Schmid, M. John, A. Grohnert, C. Giertz, T. Wirth

“…The primary outcome measure is the point prevalence of scoliosis, genu varum/valgum, hip dysplasia, and flat feet. …”
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The Effect of Halo‐Pelvic Traction on Bone Mineral Density of Vertebrae and Corresponding Risk Factors by Xianming Huang, Peng Xiu, Yi Shu, Yueming Song, Zhongjie Zhou, Chunguang Zhou, Ganjun Feng, Lei Wang, Limin Liu, Jing Tang, Xi Yang

“…Eleven patients had severe rigid scoliosis, while four had tuberculotic kyphosis. One expert measured the BMD values of 345 vertebrae using QCT. …”
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Osteotomias segmentares múltiplas para a correção da cifose Multiple segmental osteotomies to the kyphosis correction by Carlos Fernando Pereira da Silva Herrero, Maximiliano Aguiar Porto, Marcello Henrique Nogueira Barbosa, Helton Luiz Aparecido Defino

“…The radiographic parameters evaluated were the kyphosis, the lordosis and the scoliosis - whenever present. The presence of proximal and distal junctional kyphosis, loss of correction, and complications as implants loosening and breakage were also assessed. …”
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Predicting the risk for progression of acquired myopia in school-age children by T.E. Tsybulska, N.G. Zavgorodnia, O.E. Pashkova

“…The table included history-, accommodation-, and biometry-related predictors, as well as those related to the phenotypical signs of connective tissue dysplasia (CTD) as follows: history-related predictors: family history of myopia (PCmin, 1.249; PCmax, 4.34) and manifestations of myopia at age under 8 years (PCmin, 1.18; PCmax, 2.67); accommodation-related predictors: habitual accommodative tone ≥ 0.5 D (PCmin, 1.29; PCmax, 7.51), absolute reserve of accommodation < 1.5 D (PCmin, 1.25; PCmax, 4.6), relative reserve of accommodation < 1.0 D (PCmin, 1.3; PCmax, 7.94); ocular biometry-related predictors: corneal diameter > 12 mm (PCmin, 1.31; PCmax, 9.31), axial length of the eye > 25.0 mm (PCmin, 1.31; PCmax, 9.82), anterior chamber depth ≥ 4 mm (PCmin, 1.28; PCmax, 6.22), corneal hysteresis < 11.0 (PCmin, 1.21; PCmax, 3.29), corneal radius of curvature > 8 mm (PCmin, 1.17; PCmax, 2.5), corneal refractive power < 41.5 D (PCmin, 1.17; PCmax, 2.5), peripapillary retinal nerve fiber layer thickness (PCmin, 1.12; PCmax, 1.9), P < 0.05; CTD-related predictors: asthenic habitus (PCmin, 1.67; PCmax, 4.66), scoliosis and other postural anomalies (PCmin, 1.61; PCmax, 4.21), prominent venous network of the skin (PCmin, 1.75; PCmax, 5.97), cardiac valve prolapse and other minor cardiac anomalies (PCmin, 1.6; PCmax, 4.03), anomalies of tooth position and dentition (PCmin, 1.64; PCmax, 4.37), long digits (PCmin, 1.63; PCmax, 4.3), flat foot (PCmin, 1. 49; PCmax, 3.1), hypermobility of the joints (PCmin, 1.46; PCmax, 2.95), hyperelasticity of the skin (PCmin, 1.44; PCmax, 2.84), and congenital gallbladder anomalies (PCmin, 1.52; PCmax, 3.32), P < 0.05. …”
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Segmentation and Identification of Vertebrae in CT Scans Using CNN, <i>k</i>-Means Clustering and <i>k</i>-NN by Nicola Altini, Giuseppe De Giosa, Nicola Fragasso, Claudia Coscia, Elena Sibilano, Berardino Prencipe, Sardar Mehboob Hussain, Antonio Brunetti, Domenico Buongiorno, Andrea Guerriero, Ilaria Sabina Tatò, Gioacchino Brunetti, Vito Triggiani, Vitoantonio Bevilacqua

“…In addition, to evaluate the robustness of the segmentation and labeling algorithms, 12 CT scans from subjects affected by severe, moderate and mild scoliosis have been collected from a local medical clinic. …”
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