Pregnancy outcome in relation to treatment of murine typhus and scrub typhus infection: a fever cohort and a case series analysis by McGready, R, Prakash, J, Benjamin, S, Watthanaworawit, W, Anantatat, T, Tanganuchitcharnchai, A, Ling, C, Tan, S, Ashley, E, Pimanpanarak, M, Blacksell, S, Day, N, Singhasivanon, P, White, N, Nosten, F, Paris, D

“…Methodology/Principal Findings Data were analyzed from: i) pregnant women with a diagnosis of scrub and/or murine typhus from a fever cohort studies; ii) case series of published studies in PubMed using the search terms “scrub typhus” (ST), “murine typhus” (MT), “Orientia tsutsugamushi”, “Rickettsia tsutsugamushi”, “Rickettsia typhi”, “rickettsiae”, “typhus”, or “rickettsiosis”; and “pregnancy”, until February 2014 and iii) an unpublished case series. …”

Accuracy of rapid IgM-based immunochromatographic and immunoblot assays for diagnosis of acute scrub typhus and murine typhus infections in Laos. by Blacksell, S, Jenjaroen, K, Phetsouvanh, R, Tanganuchitcharnchai, A, Phouminh, P, Phongmany, S, Day, N, Newton, P

“…We studied the diagnostic accuracy of a rapid immunochromatographic test (ICT) for detection of IgM against scrub typhus (ST ICT) and an immunoblot test for the detection of IgM against murine typhus (MT IBT) by using admission serum samples from 1,030 febrile patients in Laos. …”

Diagnostic accuracy of a loop-mediated isothermal PCR assay for detection of Orientia tsutsugamushi during acute Scrub Typhus infection by Paris, D, Blacksell, S, Nawtaisong, P, Jenjaroen, K, Teeraratkul, A, Chierakul, W, Wuthiekanun, V, Kantipong, P, Day, N

“… BACKGROUND: There is an urgent need to develop rapid and accurate point-of-care (POC) technologies for acute scrub typhus diagnosis in low-resource, primary health care settings to guide clinical therapy. …”

A case of acute encephalitis syndrome and cranial nerve palsy secondary to scrub typhus: A rare presentation from Western Nepal by Seshkanta Lamichhane, Eliz Achhami, Satyam Mahaju, Rabin Gautam, Amrit Adhikari

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Prospective study to assess the treatment modalities and fever defervescence in patients with scrub typhus from a tertiary care centre in South India by Rohit Barnabas, KPP Abhilash, George M Varghese, M Shubanker, I Ramya, JAJ Prakash

Subjects: “…scrub typhus; doxycycline; azithromycin; combination therapy; delayed defervesce…”
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INTRAVENOUS DOXYCYCLINE OR AZITHROMYCIN OR A COMBINATION OF THE TWO FOR TREATMENT OF SEVERE SCRUB TYPHUS: A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL by G. Varghese, D. Dayanand, K. Gunasekaran, D. Kundu, O. Abraham, N. Day

“…The optimal antibiotic treatment for severe scrub typhus is unclear. Methods: This multi-centre, double-blind, randomised controlled trial compared the efficacy of intravenous azithromycin, doxycycline, or a combination of both in treating severe scrub typhus. …”
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A STUDY ON CLINICAL AND LABORATORY PROFILE OF PATIENTS WITH ESCHAR-POSITIVE SCRUB TYPHUS; ADMITTED TO TERTIARY CARE CENTER IN NORTHERN SRI LANKA by N. Suganthan, R. Subhash, R. Nadarajah, S. Ramanan

“…Intro: Scrub typhus, caused by Orientia tsutsugbmushi, is a serious public health problem in the Asia-Pacific region and it is also endemic in the countries of south and southeast Asia. …”
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Edifications on Indirect IgM ELISA and Immunofluorescence assay (IFA) of scrub typhus in humans and erudition of Orientia tsutsugamushi in the vector of cohabiting rodents by Shubham Patil, Archana Patil, Sandip Chaudhari, Shilpshri Shinde, Sunil Kolte, Waqar Khan, Nitin Kurkure

Subjects: “…scrub typhus; cohabit rodents; chiggar mites; indirect igm elisa; immunofluorescence assay; mite index…”
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Risk factors for acute scrub typhus infection among housewives – A subgroup analysis of pooled community-based serosurvey in Gorakhpur, India by Suvarna Badekar, Arati Mane, Suvarna Sane, Suchit Kamble

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Immunization with a recombinant antigen composed of conserved blocks from TSA56 provides broad genotype protection against scrub typhus by Hong-Il Kim, Na-Young Ha, Gwanghun Kim, Chan-Ki Min, Yuri Kim, Nguyen Thi Hai Yen, Myung-Sik Choi, Nam-Hyuk Cho

Subjects: “…Scrub typhus…”
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Successful diagnosis and treatment of scrub typhus associated with haemophagocytic lymphohistiocytosis and multiple organ dysfunction syndrome: A case report and literature review by Hongxia Wu, Xiaofeng Xiong, Min Zhu, Kaiquan Zhuo, Yiyun Deng, Deyun Cheng

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Multiple Orientia clusters and Th1-skewed chemokine profile: a cross-sectional study in patients with scrub typhus from Nepal by Carina Chan-Song Münch, Bishnu Prashad Upadhaya, Binod Rayamajhee, Anurag Adhikari, Manuel Münch, Nora En-Nosse, Katharina Kowalski, Markus Eickmann, Christian Bauer, Krishna Das Manandhar, Christian Keller

Subjects: “…Scrub typhus…”
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A case of pulmonary tuberculosis patient complicated with hemorrhagic fever with renal syndrome and scrub typhus in Yunnan, China: a case report by Hao Huang, Yichen Kong, Hongmin Yin, Zi Yang, Tilian Ren, Yunzhi Zhang

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Expression of Concern: Use of eschar swabbing for the molecular diagnosis and genotyping of Orientia tsutsugamushi causing scrub typhus in Quang Nam province, Vietnam

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Determination of Optimal Diagnostic Cut-Offs for the Naval Medical Research Centre Scrub Typhus IgM ELISA in Chiang Rai, Thailand. by Phanichkrivalkosil, M, Tanganuchitcharnchai, A, Jintaworn, S, Kantipong, P, Laongnualpanich, A, Chierakul, W, Paris, D, Richards, A, Wangrangsimakul, T, Day, N, Blacksell, S

“…In this diagnostic accuracy study, we evaluated data from 135 febrile patients from Chiang Rai, to determine the optimal optical density (OD) cutoffs for an in-house scrub typhus IgM ELISA. Receiver operating characteristic curves were generated using a panel of reference assays, including an IgM immunofluorescence assay (IFA), PCR, in vitro isolation, presence of an eschar, or a combination of these. …”

An intradermal inoculation model of scrub typhus in Swiss CD-1 mice demonstrates more rapid dissemination of virulent strains of Orientia tsutsugamushi by Sunyakumthorn, P, Paris, D, Chan, T, Jones, M, Luce-Fedrow, A, Chattopadhyay, S, Jiang, J, Anantatat, T, Turner, G, Day, N, Richards, A

“…Scrub typhus is an important endemic disease of the Asia-Pacific region caused by Orientia tsutsugamushi. …”

State of the art of diagnosis of rickettsial diseases: the use of blood specimens for diagnosis of scrub typhus, spotted fever group rickettsiosis, and murine typhus by Paris, D, Dumler, J

“…With improved malaria control, acute undifferentiated febrile illness studies in tropical regions reveal a startling proportion of rickettsial illnesses, especially scrub typhus, murine typhus, and spotted fever group rickettsioses. …”

Microbiome and mitogenomics of the chigger mite Pentidionis agamae: potential role as an Orientia vector and associations with divergent clades of Wolbachia and Borrelia by Hadil A. Alkathiry, Samia Q. Alghamdi, Amit Sinha, Gabriele Margos, Alexandr A. Stekolnikov, Abdulaziz N. Alagaili, Alistair C. Darby, Benjamin L. Makepeace, Jing Jing Khoo

Subjects: “…Scrub typhus…”
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Prevalence of and factors associated with scrub typhus exposure among the hill tribe population living in high incidence areas in Thailand: a cross-sectional study by Nidanuch Tasak, Tawatchai Apidechkul, Andrew C. K. Law, Mohammad Yazid Abdad, Peeradone Srichan, Carlo Perrone, Ampai Tanganuchitcharnchai, Jantana Wongsantichon, Stuart D. Blacksell

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Orientia tsutsugamushi: A life between escapes by Lea Fromm, Jonas Mehl, Christian Keller

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