The Targeting of Native Proteins to the Endoplasmic Reticulum-Associated Degradation (ERAD) Pathway: An Expanding Repertoire of Regulated Substrates by Deepa Kumari, Jeffrey L. Brodsky

“…Approximately one-quarter to one-third of all proteins synthesized in eukaryotic cells access the ER because they are destined for transport to the extracellular space, because they represent integral membrane proteins, or because they reside within one of the many compartments of the secretory pathway. However, proteins that mature inefficiently are subject to ER-associated degradation (ERAD), a multi-step pathway involving the chaperone-mediated selection, ubiquitination, and extraction (or “retrotranslocation”) of protein substrates from the ER. …”
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FAM20A is a golgi-localized Type II transmembrane protein by Mohammad Faizan Siddiqui, Jiahe Li, Suzhen Wang, Hua Zhang, Chunlin Qin, Yongbo Lu

“…Abstract Family with sequence similarity 20, member A (FAM20A) is a pseudo-kinase in the secretory pathway and is essential for enamel formation in humans. …”
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Cilia Provide a Platform for the Generation, Regulated Secretion, and Reception of Peptidergic Signals by Raj Luxmi, Stephen M. King

“…Biochemical dissection of this complex ciliary secretory pathway provides a paradigm for understanding cilia-based peptidergic signaling in mammals and other eukaryotes.…”
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The regulation of the cell wall by glycosylphosphatidylinositol-anchored proteins in Arabidopsis by Ke Zhou

“…Ultimately, mature proteins reach the plasma membrane via the secretory pathway facing toward the apoplast and cell wall in plants. …”
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COPI selectively drives maturation of the early Golgi by Effrosyni Papanikou, Kasey J Day, Jotham Austin II, Benjamin S Glick

“…COPI coated vesicles carry material between Golgi compartments, but the role of COPI in the secretory pathway has been ambiguous. Previous studies of thermosensitive yeast COPI mutants yielded the surprising conclusion that COPI was dispensable both for the secretion of certain proteins and for Golgi cisternal maturation. …”
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Identification and network-enabled characterization of auxin response factor genes in Medicago truncatula by David J. Burks, Rajeev K. Azad, Rajeev K. Azad

“…Furthermore, the topological clustering and single enrichment analysis of several network models revealed the roles of individual members of the MtARF family in nitrogen regulation, nodule initiation, and post-embryonic development through a specialized protein packaging and secretory pathway. In summary, this study not just shines new light on an important gene family, but also provides a guideline for identification of new members of gene families and their functional characterization through network analyses.…”
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Genetics of clusterin isoform expression and Alzheimer's disease risk. by I-Fang Ling, Jiraganya Bhongsatiern, James F Simpson, David W Fardo, Steven Estus

“…Since CLU1 and CLU2 are predicted to encode intracellular and secreted proteins, respectively, we compared their expression; for both CLU1 and CLU2 transfected cells, clusterin is present in the secretory pathway, accumulates in the extracellular media, and is similar in size to clusterin in human brain. …”
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Membrane-Bound Meet Membraneless in Health and Disease by Chujun Zhang, Catherine Rabouille

“…First, inhibition of membrane trafficking in the early secretory pathway leads to the formation of biocondensates (P-bodies and Sec bodies). …”
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Role of Glycoproteins during Fruit Ripening and Seed Development by Angela Mendez-Yañez, Patricio Ramos, Luis Morales-Quintana

“…Approximately thirty percent of the proteins synthesized in animal or plant cells travel through the secretory pathway. Seventy to eighty percent of those proteins are glycosylated. …”
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Toxoplasma gondii Syntaxin 6 Is Required for Vesicular Transport Between Endosomal-Like Compartments and the Golgi Complex by Jackson, A, Clucas, C, Mamczur, N, Meissner, M, Ferguson, D

“…It therefore appears that Toxoplasma has retained a plant-like secretory pathway. © 2013 The Authors.…”

A rab1 GTPase is required for transport between the endoplasmic reticulum and golgi apparatus and for normal golgi movement in plants. by Batoko, H, Zheng, H, Hawes, C, Moore, I

“…We describe a green fluorescent protein (GFP)-based assay for investigating membrane traffic on the secretory pathway in plants. Expression of AtRab1b(N121I), predicted to be a dominant inhibitory mutant of the Arabidopsis Rab GTPase AtRab1b, resulted in accumulation of a secreted GFP marker in an intracellular reticulate compartment reminiscent of the endoplasmic reticulum. …”

Characterisation of Plasmodium invasive organelles; an ookinete microneme proteome. by Lal, K, Prieto, J, Bromley, E, Sanderson, S, Yates, JR, Wastling, J, Tomley, F, Sinden, R

“…We further identified numerous proteins with established vesicle trafficking and signaling functions consistent with micronemes being part of a regulated secretory pathway. Previously uncharacterised proteins comprise the largest functional group of the microneme proteome and will include secreted proteins important to invasion.…”

Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles by Li, MY, Naik, TS, Siu, LYL, Acuto, O, Spooner, E, Wang, P, Yang, X, Lin, Y, Bruzzone, R, Ashour, J, Evans, MJ, Sanyal, S

“…This process depends on Ulk1, Rab GTPases and SNARE complexes implicated in secretory but not degradative autophagy and occur with significantly faster kinetics than the conventional secretory pathway. Our study reveals a previously undiscovered Lyn-dependent exit route of flaviviruses in LC3+ secretory organelles that enables them to evade circulating antibodies and might affect tissue tropism.…”

The KDEL trafficking receptor exploits pH to tune the strength of an unusual short hydrogen bond by Wu, Z, Newstead, S, Biggin, PC

“…During protein synthesis, ER luminal chaperones are swept along the secretory pathway and must be retrieved to maintain cell viability. …”

Allelic differences affecting invariant chain dependency of MHC class II subunit assembly. by Bikoff, E, Germain, R, Robertson, E

“…The conserved invariant chain associates with highly polymorphic alpha and beta subunits guiding class II transport through the secretory pathway. Early associations of these three polypeptides inside antigen-presenting cells are poorly understood. …”

Biochemistry of the Endocrine Heart by Jens P. Goetze, Emil D. Bartels, Theodor W. Shalmi, Lilian Andraud-Dang, Jens F. Rehfeld

“…In several ways, intracellular granules in the cells contain not only peptides destined for secretion but also important granin molecules involved in maintaining a regulated secretory pathway. In this review, we will highlight the biochemical phenotype of the endocrine heart recapitulating that the cardiac myocytes are capable endocrine cells. …”
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<i>N</i>-glycoproteins in Plant Cell Walls: A Survey by Hélène San Clemente, Elisabeth Jamet

“…In order to reach the extracellular space, CWPs are transported through the secretory pathway where they may undergo post-translational modifications, including <i>N</i>-glycosylations on the Asn residues in specific motifs (Asn-X-Ser/Thr-X, with X≠Pro). …”
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Intracellular Trafficking of HBV Particles by Bingfu Jiang, Eberhard Hildt

“…Infectious viral particles and filaments are released via multivesicular bodies; spheres are secreted by the classic constitutive secretory pathway. The release of naked capsids is still not fully understood, autophagosomal processes are discussed. …”
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Identification and characterization of LysM effectors in Penicillium expansum. by Elena Levin, Ana Rosa Ballester, Ginat Raphael, Oleg Feigenberg, Yongsheng Liu, John Norelli, Luis Gonzalez-Candelas, Jing Ma, Christopher Dardick, Michael Wisniewski, Samir Droby

“…Eleven of the discovered LysM genes were found to have secretory pathway signal peptide, among them, 4 (PeLysM1 PeLysM2, PeLysM3 and PeLysM4) were found to be highly expressed during the infection and development of decay of apple fruit. …”
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Knocking Out Bcsas1 in Botrytis cinerea Impacts Growth, Development, and Secretion of Extracellular Proteins, Which Decreases Virulence by Zhanquan Zhang, Guozheng Qin, Boqiang Li, Shiping Tian

“…Rab GTPases play a central role in the secretory pathway. To explore the function of Rab/GTPase in filamentous fungi, we knocked out a Rab/GTPase family gene, Bcsas1, in Botrytis cinerea, an aggressive fungal pathogen that infects more than 200 plant species. …”
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