Alterations in the Ca2+ toolkit in oesophageal adenocarcinoma by Alana L. Cutliffe, Sharon L. McKenna, Darshan S. Chandrashekar, Alvin Ng, Ginny Devonshire, Rebecca C. Fitzgerald, Tracey R. O'Donovan, John J. Mackrill

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A single polar residue and distinct membrane topologies impact the function of the infectious bronchitis coronavirus E protein. by Travis R Ruch, Carolyn E Machamer

“…We previously showed that the HD of the infectious bronchitis virus (IBV) E protein is required for the efficient release of infectious virus, an activity that correlated with disruption of the secretory pathway. Here we report that a single residue within the hydrophobic domain, Thr16, is required for secretory pathway disruption. …”
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N-glycosylation Triggers a Dual Selection Pressure in Eukaryotic Secretory Proteins by Máximo Lopez Medus, Gabriela E. Gomez, Lucía F. Zacchi, Paula M. Couto, Carlos A. Labriola, María S. Labanda, Rodrigo Corti Bielsa, Eugenia M. Clérico, Benjamin L. Schulz, Julio J. Caramelo

“…Abstract Nearly one third of the eukaryotic proteome traverses the secretory pathway and most of these proteins are N-glycosylated in the lumen of the endoplasmic reticulum. …”
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Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease by Orkhontuya Tsedensodnom, Ana M. Vacaru, Deanna L. Howarth, Chunyue Yin, Kirsten C. Sadler

“…Recent data indicates that activation of the unfolded protein response (UPR) in response to secretory pathway dysfunction can cause steatosis. Here, we examined the relationship between alcohol metabolism, oxidative stress, secretory pathway stress and steatosis using zebrafish larvae. …”
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Imbalance of heterologous protein folding and disulfide bond formation rates yields runaway oxidative stress by Tyo Keith EJ, Liu Zihe, Petranovic Dina, Nielsen Jens

“…<p>Abstract</p> <p>Background</p> <p>The protein secretory pathway must process a wide assortment of native proteins for eukaryotic cells to function. …”
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Incomplete posttranslational prohormone modifications in hyperactive neuroendocrine cells by Martens Gerard JM, Strating Jeroen RPM

“…When the cargo load in the secretory pathway of the hyperactive cells was pharmacologically reduced, the relative amount of complex glycosylated POMC markedly increased.…”
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Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like. by Yuhki Saito, Mayu Akiyama, Yoichi Araki, Akio Sumioka, Maki Shiono, Hidenori Taru, Tadashi Nakaya, Tohru Yamamoto, Toshiharu Suzuki

“…In general, mature APP (mAPP, N- and O-glycosylated form) is subject to successive cleavages by α- or β-, and γ-secretases in the late protein secretory pathway and/or at plasma membrane, while immature APP (imAPP, N-glycosylated form) locates in the early secretory pathway such as endoplasmic reticulum or cis-Golgi, in which imAPP is not subject to metabolic cleavages. …”
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Formation of ER-lumenal intermediates during export of Plasmodium proteins containing transmembrane-like hydrophobic sequences. by Yvette S Levray, Bianca Bana, Sarah J Tarr, Emilia J McLaughlin, Peter Rossi-Smith, Anita Waltho, Georgina H Charlton, Riccardo Zenezini Chiozzi, Colin R Straton, Konstantinos Thalassinos, Andrew R Osborne

“…Exported proteins are trafficked via the parasite endoplasmic reticulum and secretory pathway, before being exported across the parasitophorous vacuole membrane into the erythrocyte. …”
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The ER Protein Translocation Channel Subunit Sbh1 Controls Virulence of Cryptococcus neoformans by Felipe H. Santiago-Tirado, Thomas Hurtaux, Jennifer Geddes-McAlister, Duy Nguyen, Volkhard Helms, Tamara L. Doering, Karin Römisch

“…Sbh1, the most divergent, contains multiple phosphorylation sites, which may allow it to regulate entry into the secretory pathway in a species- and protein-specific manner. …”
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The membrane-associated form of α(s1)-casein interacts with cholesterol-rich detergent-resistant microdomains. by Annabelle Le Parc, Edith Honvo Houéto, Natascha Pigat, Sophie Chat, Joëlle Leonil, Eric Chanat

“…There is a growing body of evidence to support the concept that α(s1)-casein takes center stage in casein micelle building and transport in the secretory pathway of mammary epithelial cells. Here we have investigated the membrane-associated form of α(s1)-casein in rat mammary epithelial cells. …”
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Hepatitis C virus replication and Golgi function in brefeldin a-resistant hepatoma-derived cells. by Rayan Farhat, Lucie Goueslain, Czeslaw Wychowski, Sandrine Belouzard, Lucie Fénéant, Catherine L Jackson, Jean Dubuisson, Yves Rouillé

“…Despite this partially effective secretory pathway in the presence of BFA, the HCV infection was almost as sensitive to BFA as in Huh-7 cells. …”
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A Role for Lipids in Protein Sorting? by Manuel Muñiz, Auxiliadora Aguilera-Romero

“…This compositional heterogeneity is maintained by the secretory pathway, which feeds newly synthesized proteins and lipids to the endomembrane systems. …”
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Analysis of Yeast Killer Toxin K1 Precursor Processing via Site-Directed Mutagenesis: Implications for Toxicity and Immunity by Stefanie Gier, Manfred J. Schmitt, Frank Breinig

“…Based on the data generated in this study, we were able to update the current model of toxin processing, validating the temporary inactivation of the toxic α subunit during maturation in the secretory pathway of the killer yeast.…”
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Importance of post-translational modifications for functionality of a chloroplast-localized carbonic anhydrase (CAH1) in Arabidopsis thaliana. by Stefan Burén, Cristina Ortega-Villasante, Amaya Blanco-Rivero, Andrea Martínez-Bernardini, Tatiana Shutova, Dmitriy Shevela, Johannes Messinger, Laszlo Bako, Arsenio Villarejo, Göran Samuelsson

“…BACKGROUND: The Arabidopsis CAH1 alpha-type carbonic anhydrase is one of the few plant proteins known to be targeted to the chloroplast through the secretory pathway. CAH1 is post-translationally modified at several residues by the attachment of N-glycans, resulting in a mature protein harbouring complex-type glycans. …”
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The Functional Classification of ORF8 in SARS-CoV-2 Replication, Immune Evasion, and Viral Pathogenesis Inferred through Phylogenetic Profiling by Muhamad Fahmi, Hiromu Kitagawa, Gen Yasui, Yukihiko Kubota, Masahiro Ito

“…Collectively, our results classified potential genes that might be associated with SARS-CoV-2 viral pathogenesis, specifically related to acute respiratory distress syndrome, and the secretory pathway. Here, we discuss the possible role of ORF8 in viral pathogenesis and in assisting viral replication and immune evasion via secretory pathway, as well as the possible factors associated with the rapid evolution of ORF8.…”
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Molecular determinants and dynamics of hepatitis C virus secretion. by Kelly E Coller, Nicholas S Heaton, Kristi L Berger, Jacob D Cooper, Jessica L Saunders, Glenn Randall

“…The current model of hepatitis C virus (HCV) production involves the assembly of virions on or near the surface of lipid droplets, envelopment at the ER in association with components of VLDL synthesis, and egress via the secretory pathway. However, the cellular requirements for and a mechanistic understanding of HCV secretion are incomplete at best. …”
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α_S1-casein, which is essential for efficient ER-to-Golgi casein transport, is also present in a tightly membrane-associated form by Le Parc Annabelle, Leonil Joëlle, Chanat Eric

“…<p>Abstract</p> <p>Background</p> <p>Caseins, the main milk proteins, aggregate in the secretory pathway of mammary epithelial cells into large supramolecular structures, casein micelles. …”
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ER exit in physiology and disease by Claire M. Robinson, Claire M. Robinson, Aislinn Duggan, Aislinn Duggan, Alison Forrester

“…The biosynthetic secretory pathway is comprised of multiple steps, modifications and interactions that form a highly precise pathway of protein trafficking and secretion, that is essential for eukaryotic life. …”
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Impact of Hypermannosylation on the Structure and Functionality of the ER and the Golgi Complex by Patricia Franzka, Svenja Caren Schüler, Takfarinas Kentache, Robert Storm, Andrea Bock, Istvan Katona, Joachim Weis, Katrin Buder, Christoph Kaether, Christian A. Hübner

“…Proteins of the secretory pathway undergo glycosylation in the endoplasmic reticulum (ER) and the Golgi apparatus. …”
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Role of adaptor proteins in secretory granule biogenesis and maturation by Mathilde L Bonnemaison, Betty A Eipper, Richard E Mains

“…In the regulated secretory pathway, secretory granules (SGs) store peptide hormones that are released on demand. …”
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