Changes in organelle position and epithelial architecture associated with loss of CrebA by Rebecca M. Fox, Deborah J. Andrew

“…Whereas mutations in core secretory pathway genes lead to organelle localization defects similar to those of CrebA mutants, they have no effect on SJ-associated membrane. …”
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Genetic Evidence for the Role of the Vacuole in Supplying Secretory Organelles with Ca2+ in Hansenula polymorpha. by Anastasia V Fokina, Maria B Chechenova, Azamat V Karginov, Michael D Ter-Avanesyan, Michael O Agaphonov

“…These data indicate that ret1-27, pmc1 and vps35 affect a previously unknown Pmr1-independent route of the Ca2+ delivery to the secretory pathway. We also observed that the vacuolar protein carboxypeptidase Y receives additional modifications of its glycoside chains if it escapes the Vps10-dependent sorting to the vacuole.…”
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A role for the membrane in regulating Chlamydomonas flagellar length. by William Dentler

“…These studies reveal the importance of the secretory pathway to assemble and maintain full-length flagella.…”
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Stapled Golgi cisternae remain in place as cargo passes through the stack by Gregory Lavieu, Hong Zheng, James E Rothman

“…We have designed a membrane ‘staple’, which consists of membrane-anchored repeats of the trans-aggregating FM domain that face the lumen of the secretory pathway. In the presence of the disaggregating drug these proteins transit the secretory pathway. …”
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Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane by Hemma Brandstaetter, Antonina J. Kruppa, Folma Buss

“…Interestingly, heterozygous fibroblasts from a Huntington’s disease patient with a 180Q expansion displayed no obvious defects in the early secretory pathway. Thus, our results highlight the requirement for wild-type huntingtin at distinct steps along the secretory pathway.…”
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How Viruses Hijack and Modify the Secretory Transport Pathway by Zubaida Hassan, Nilima Dinesh Kumar, Fulvio Reggiori, Gulfaraz Khan

“…Numerous viruses, especially enveloped viruses, use and modify compartments of the secretory pathway to promote their replication, assembly and cell egression by hijacking the host cell machinery. …”
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Glycosylation network mapping and site-specific glycan maturation in vivo by Marie-Estelle Losfeld, Ernesto Scibona, Chia-wei Lin, Markus Aebi

“…Importantly, our model protein can take different routes of the cellular secretory pathway, resulting in an increased glycan complexity of the secreted protein.…”
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Quantitative peptidomics of Purkinje cell degeneration mice. by Iryna Berezniuk, Juan J Sironi, Jonathan Wardman, Raymond C Pasek, Nicolas F Berbari, Bradley K Yoder, Lloyd D Fricker

“…Unexpectedly, levels of peptides derived from secretory pathway proteins were altered in adult pcd mouse brain. …”
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Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes. by Haojun Yang, Martina Ralle, Michael J Wolfgang, Neha Dhawan, Jason L Burkhead, Susana Rodriguez, Jack H Kaplan, G William Wong, Norman Haughey, Svetlana Lutsenko

“…The loss of SSAO-dependent regulation due to Cu deficiency, limited Cu transport to the secretory pathway, or SSAO inactivation shifts metabolism towards lipid-dependent pathways and results in adipocyte hypertrophy and fat accumulation. …”
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Disparate effects of p24alpha and p24delta on secretory protein transport and processing. by Jeroen R P M Strating, Gerrit Bouw, Theo G M Hafmans, Gerard J M Martens

“…CONCLUSIONS/SIGNIFICANCE: Transgenic expression of two distinct p24 family members has disparate effects on secretory pathway functioning, illustrating the specificity and non-redundancy of our transgenic approach. …”
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Functional identification of a Streptomyces lividans FKBP-like protein involved in the folding of overproduced secreted proteins by R. L. Vicente, S. Marín, J. R. Valverde, C. Palomino, R. P. Mellado, S. Gullón

“…Although the mechanisms governing the major secretory pathway (Sec route) and the minor secretory pathway (Tat route) are reasonably well described, the function of proteins responsible for the extracellular secretory protein folding is not characterized as yet. …”
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Pathways for glycoprotein degradation in mammalian cells by Kukushkin, N, Nikolay Kukushkin

“…Aberrant glycoproteins must be cleared from the secretory pathway. Several mechanisms for glycoprotein degradation exist, of which ER-associated degradation (ERAD) is most well-studied. …”

Blocking variant surface glycoprotein synthesis alters endoplasmic reticulum exit sites/Golgi homeostasis in Trypanosoma brucei by Ooi, C, Smith, T, Gluenz, E, Wand, N, Vaughan, S, Rudenko, G

“…We investigated the effect of blocking VSG synthesis on the secretory pathway. The number of Golgi decreased, particularly in post-mitotic cells, from 3.5 ± 0.6 to 2.0 ± 0.04 per cell. …”

The carboxy-terminal region of human lipoprotein lipase is necessary for its exit from the endoplasmic reticulum by Roser Buscà, Mònica Martínez, Elisabet Vilella, Julia Peinado, Josep Lluis Gelpi, Samir Deeb, Johan Auwerx, Manuel Reina, Senén Vilaró

“…Certain missense substitutions on the human lipase (hLPL) gene produce mutated proteins that are retained in different compartments along the secretory pathway. The purpose of the present study was to elucidate whether the C-terminal domain of the hLPL molecule could be important for secretion. …”
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In vitro and in vivo studies identify important features of dengue virus pr-E protein interactions. by Aihua Zheng, Mahadevaiah Umashankar, Margaret Kielian

“…Flaviviruses bud into the endoplasmic reticulum and are transported through the secretory pathway, where the mildly acidic environment triggers particle rearrangement and allows furin processing of the prM protein to pr and M. …”
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Electrical Stimulation-Induced Release of β-Endorphin from Genetically Modified Neuro-2a Cells by Volker Storn, Michael Kirschbaum, Burkhard Schlosshauer, Andreas F. Mack, Cornelia Fricke

“…The secretion of a therapeutic agent can be regulated if the agent is targeted to the regulated secretory pathway and stored in the secretory granules until its release. …”
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Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3. by Daniel W Sirkis, Robert H Edwards, Cédric S Asensio

“…LDCVs form at the trans-Golgi network, but the mechanisms that sort proteins to this regulated secretory pathway and the cytosolic machinery that produces LDCVs remain poorly understood. …”
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An imaging-based RNA interference screen for modulators of the Rab6-mediated Golgi-to-ER pathway in mammalian cells by Linda F. Heffernan, Pia M. Suckrau, Teerna Banerjee, Margaritha M. Mysior, Jeremy C. Simpson

“…The secretory pathway is counterbalanced by the retrograde pathway, which is essential for the recycling of molecules from the Golgi back to the ER. …”
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Substrate-favored lysosomal and proteasomal pathways participate in the normal balance control of insulin precursor maturation and disposal in β-cells. by Xiaoping Zhang, Qingxin Yuan, Wei Tang, Jingyu Gu, Kwame Osei, Jie Wang

“…The findings provide the first clear demonstration that lysosomal and proteasomal pathways both play roles in the normal maintenance of PIHO for insulin production, and defined the physiological participation of lysosomal autophagy in the protein quality control at the early secretory pathway of pancreatic β-cells.…”
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Novel binding partners for Prenylated Rab Acceptor 1 identified by a split-ubiquitin yeast two-hybrid screen by Ameair Abu Irqeba, Judith Mosinger Ogilvie

“…Abstract Objective Prenylated Rab Acceptor 1 (PRA1) is a transmembrane protein localized to the early secretory pathway. It has been found to interact with an array of Rab GTPases, leading to its hypothesized function in the recycling of Rab GTPases. …”
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