Live-cell visualization of intracellular interaction between a nuclear migration protein (hNUDC) and the thrombopoietin receptor (Mpl). by Yuan-Bin Zheng, Ying-Ying Xiao, Peng Tan, Qing Zhang, Peilin Xu

“…Thus, we provide the first evidence that the N-terminal region of hNUDC contains all of the necessary information to complex with Mpl and traffic through the secretory pathway.…”
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The Feline Immunodeficiency Virus Envelope Signal Peptide Is a Tetherin Antagonizing Protein by James H. Morrison, Eric M. Poeschla

“…ABSTRACT Signal peptides are N-terminal peptides, generally less than 30 amino acids in length, that direct translocation of proteins into the endoplasmic reticulum and secretory pathway. The envelope glycoprotein (Env) of the nonprimate lentivirus feline immunodeficiency virus (FIV) contains the longest signal peptide of all eukaryotic, prokaryotic, and viral proteins (175 amino acids), yet the reason is unknown. …”
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GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain by Hung-Hsiang Huang, Antti Hassinen, Subha Sundaram, Andrej-Nikolai Spiess, Sakari Kellokumpu, Pamela Stanley

“…However, it is not known where in the secretory pathway GnT1IP-L inhibits MGAT1, nor whether GnT1IP-L inhibits other N-glycan branching N-acetylglucosaminyltransferases of the medial Golgi. …”
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Protection of recombinant mammalian antibodies from development-dependent proteolysis in leaves of Nicotiana benthamiana. by Stéphanie Robert, Moustafa Khalf, Marie-Claire Goulet, Marc-André D'Aoust, Frank Sainsbury, Dominique Michaud

“…Here we characterised cysteine (C1A) and aspartate (A1) protease profiles in leaves of the widely used expression host Nicotiana benthamiana, in relation with the production of a murine IgG, C5-1, targeted to the cell secretory pathway. Agroinfiltration significantly altered the distribution of C1A and A1 proteases along the leaf age gradient, with a correlation between leaf age and the level of proteolysis in whole-cell and apoplast protein extracts. …”
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Activation-induced colocalisation of SCAMP5 with IFNα in human plasmacytoid dendritic cells by Timothy R D J Radstake, Marianne Boes, Emmerik F A Leijten, Juliëtte N Pouw, Michel A M Olde Nordkamp, Tom G O'Toole

“…Recent work in transfected HEK cells connects SCAMP5 to the type I IFN secretory pathway. To further study the role of SCAMP5 in IFNα secretion by pDCs, we focused on the subcellular distribution of SCAMP5 in human pDCs freshly isolated from peripheral blood.Methods We measured SCAMP5 expression by flow cytometry in peripheral blood mononuclear cells of healthy subjects (n=8). …”
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Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling by Aleksandra Gedaj, Dominika Zukowska, Natalia Porebska, Marta Pozniak, Mateusz Krzyscik, Aleksandra Czyrek, Daniel Krowarsch, Malgorzata Zakrzewska, Jacek Otlewski, Lukasz Opalinski

“…Most of FGFs are released by cells using the conventional secretory pathway and are N-glycosylated, yet the role of FGFs glycosylation is largely unknown. …”
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XBP-1 Remodels Lipid Metabolism to Extend Longevity by Soudabeh Imanikia, Ming Sheng, Cecilia Castro, Julian L. Griffin, Rebecca C. Taylor

“…Summary: The endoplasmic reticulum unfolded protein response (UPRER) is a cellular stress response that maintains homeostasis within the secretory pathway, regulates glucose and lipid metabolism, and influences longevity. …”
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Exploring the eukaryotic Yip and REEP/Yop superfamily of membrane-shaping adapter proteins (MSAPs): A cacophony or harmony of structure and function? by Timothy Angelotti

“…Polytopic cargo proteins are synthesized and exported along the secretory pathway from the endoplasmic reticulum (ER), through the Golgi apparatus, with eventual insertion into the plasma membrane (PM). …”
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Imaging-Based Reporter Systems to Define CVB-Induced Membrane Remodeling in Living Cells by Nicholas J. Lennemann, Azia S. Evans, Carolyn B. Coyne

“…To define the dynamic process of enterovirus membrane remodeling of major secretory pathway organelles, we have developed plasmid-based reporter systems that utilize viral protease-dependent release of a nuclear-localized fluorescent protein from the endoplasmic reticulum (ER) membrane during infection, while retaining organelle-specific fluorescent protein markers such as the ER and Golgi. …”
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Regulation of myeloid and lymphoid cell development by O-glycans on Notch by Pamela Stanley, Ankit Tanwar

“…Additional sugars are added in the Golgi compartment during passage through the secretory pathway to the plasma membrane. Of particular significance for Notch signaling is the addition of GlcNAc to O-fucose on an EGF repeat by the Fringe GlcNAc-transferases LFNG, MFNG or RFNG. …”
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Vegetative Insecticidal Protein Vip3Aa Is Transported via Membrane Vesicles in <i>Bacillus thuringiensis</i> BMB171 by Yizhuo Zhang, Xuelian Li, Hongwei Tian, Baoju An, Bing Yan, Jun Cai

“…This work demonstrates that Vip3Aa is not secreted by the General Secretion (Sec) System. To reveal the secretory pathway of Vip3A, we purified the membrane vesicles (MVs) of <i>B. thuringiensis</i> BMB171 and observed by TEM. …”
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Autophagy-Dependent Secretion: Crosstalk between Autophagy and Exosome Biogenesis by Ekaterina Zubkova, Alexander Kalinin, Anastasya Bolotskaya, Irina Beloglazova, Mikhail Menshikov

“…Secretory authophagy, initiated by various stress stimuli, prompts the selective release of proteins implicated in inflammation, including leaderless proteins that bypass the conventional endoplasmic reticulum–Golgi secretory pathway. This reflects the significant impact of stress-induced autophagy on cellular secretion profiles, including the modulation of exosome release. …”
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Proprotein convertase 1/3 (PC1/3) in the rat alveolar macrophage cell line NR8383: localization, trafficking and effects on cytokine secretion. by Hugo Gagnon, Sarah Refaie, Sandra Gagnon, Roxane Desjardins, Michel Salzet, Robert Day

“…The proprotein convertase 1/3 (PC1/3) is an important post-translational processing enzyme for the activation of precursor proteins within the regulated secretory pathway. Well characterized for its role in the neural and endocrine systems, we recently reported an unconventional role of PC1/3 as a modulator of the Toll-like receptor innate immune response. …”
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The mesoscale organization of syntaxin 1A and SNAP25 is determined by SNARE–SNARE interactions by Jasmin Mertins, Jérôme Finke, Ricarda Sies, Kerstin M Rink, Jan Hasenauer, Thorsten Lang

“…SNARE proteins have been described as the effectors of fusion events in the secretory pathway more than two decades ago. The strong interactions between SNARE domains are clearly important in membrane fusion, but it is unclear whether they are involved in any other cellular processes. …”
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Inhibition of Rab1B Impairs Trafficking and Maturation of SARS-CoV-2 Spike Protein by Christopher Veeck, Nadine Biedenkopf, Cornelius Rohde, Stephan Becker, Sandro Halwe

“…Using confocal microscopy, we showed that S and Rab1B substantially colocalized in compartments of the early secretory pathway. Co-expression of dominant-negative (DN) Rab1B N121I leads to an aberrant distribution of S into perinuclear spots after ectopic expression and in SARS-CoV-2-infected cells caused by either structural rearrangement of the ERGIC or Golgi or missing interaction between Rab1B and S. …”
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Unfolding the Endoplasmic Reticulum of a Social Amoeba: Dictyostelium discoideum as a New Model for the Study of Endoplasmic Reticulum Stress by Eunice Domínguez-Martín, Mariana Hernández-Elvira, Olivier Vincent, Roberto Coria, Ricardo Escalante

“…Nearly one third of the proteins trafficking through the secretory pathway are folded and matured in the ER. Additionally, it acts as calcium storage, and it is a main source for lipid biosynthesis. …”
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The Emerging Roles of Endoplasmic Reticulum Stress in Balancing Immunity and Tolerance in Health and Diseases: Mechanisms and Opportunities by Anqi Li, Anqi Li, No-Joon Song, Brian P. Riesenberg, Zihai Li, Zihai Li, Zihai Li

“…The endoplasmic reticulum (ER) is an organelle equipped with mechanisms for proper protein folding, trafficking, and degradation to maintain protein homeostasis in the secretory pathway. As a defense mechanism, perturbation of ER proteostasis by ER stress agents activates a cascade of signaling pathways from the ER to the nucleus known as unfolded protein response (UPR). …”
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Membrane and luminal proteins reach the apicoplast by different trafficking pathways in the malaria parasite Plasmodium falciparum by Rahul Chaudhari, Vishakha Dey, Aishwarya Narayan, Shobhona Sharma, Swati Patankar

“…The secretory pathway in Plasmodium falciparum has evolved to transport proteins to the host cell membrane and to an endosymbiotic organelle, the apicoplast. …”
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Regulated Mucin Secretion from Airway Epithelial Cells by Kenneth Bruce Adler, Michael J. Tuvim, Burton F Dickey

“…The large size of mucin polymers imposes constraints on their packaging into transport vesicles along the secretory pathway. Sugar side chains account for &gt;70% of the mass of mucins, and their attachment to the protein core by O-glycosylation occurs in the Golgi. …”
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Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking by William R. Critchley, Caroline Pellet-Many, Benjamin Ringham-Terry, Michael A. Harrison, Ian C. Zachary, Sreenivasan Ponnambalam

“…Different RTKs exhibit both basal and ligand-stimulated ubiquitination, linked to trafficking through different intracellular compartments including the secretory pathway, plasma membrane, endosomes and lysosomes. …”
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