A systematic approach to pair secretory cargo receptors with their cargo suggests a mechanism for cargo selection by Erv14. by Yonatan Herzig, Hayley J Sharpe, Yael Elbaz, Sean Munro, Maya Schuldiner

“…The rules that appear to guide Erv14 substrate recognition suggest that sorting of membrane proteins at multiple points in the secretory pathway could depend on the physical properties of TMDs. …”
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mTOR controls endoplasmic reticulum–Golgi apparatus trafficking of VSVg in specific cell types by Alicja Koscielny, Ewa Liszewska, Katarzyna Machnicka, Michalina Wezyk, Katarzyna Kotulska, Jacek Jaworski

“…Results We found that mTOR inhibition led to the overall enhancement of VSVg transport through the secretory pathway in PC12 cells and primary human fibroblasts. …”
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Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin by Phillips, Angela Marie, Gonzalez, Luna O., Butty, Vincent L G, Shoulders, Matthew D.

“…We systematically and quantitatively evaluate whether endoplasmic reticulum (ER) proteostasis factors impact the mutational tolerance of secretory pathway proteins. We focus on influenza hemaggluttinin (HA), a viral membrane protein that folds in the host’s ER via a complex pathway. …”
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Antiviral mechanisms of small molecules targeting the endoplasmic reticulum and Golgi apparatus by Howe, JD

“…Here, the antiviral mechanisms of three classes of small molecules targeting the secretory pathway and altering viral envelope glycosylation are investigated, using the HCV surrogate model, BVDV. …”

The Par3 polarity protein is an exocyst receptor essential for mammary cell survival by Syed Mukhtar Ahmed, Ian G. Macara

“…The exocyst delivers basolateral proteins from the secretory pathway to the plasma membrane of epithelial cells close to tight junctions. …”
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EGAD! There is an ERAD doppelganger in the Golgi by Fonseca, D, Carvalho, P

“…Disposal of membrane proteins in the late secretory pathway is thought to be exclusively facilitated by ESCRT‐dependent lysosomal degradation. …”

Stage-Specific COPII-Mediated Cargo Selectivity in African Trypanosomes by Mohamed Sharif, James D. Bangs

“…ABSTRACT A hallmark of eukaryotic cells is the ability to form a secretory pathway connecting many intracellular compartments. …”
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Transcription Factor CREB3L1 Regulates the Expression of the Sodium/Iodide Symporter (NIS) in Rat Thyroid Follicular Cells by Pablo Di Giusto, Mariano Martín, Macarena Funes Chabán, Luciana Sampieri, Juan Pablo Nicola, Cecilia Alvarez

“…In thyroid follicular cells, CREB3L1 is a downstream effector of thyrotropin (TSH), promoting the expression of proteins of the secretory pathway along with an expansion of the Golgi volume. …”
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Protein Extraction, Enrichment and MALDI MS and MS/MS Analysis from Bitter Orange Leaves (<i>Citrus</i> <i>aurantium</i>) by Donatella Aiello, Carlo Siciliano, Fabio Mazzotti, Leonardo Di Donna, Roberta Risoluti, Anna Napoli

“…The largest subcellular fraction was the secretory pathway, accounting for 25% of total proteins. …”
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LysoPC acyltransferase/PC transacylase activities in plant plasma membrane and plasma membrane-associated endoplasmic reticulum by Tjellström Henrik, Kjellberg J Magnus, Larsson Karin E, Sandelius Anna

“…Phospholipid delivery to the mitochondria and chloroplasts of plant cells also bypasses the secretory pathway and here it has been proposed that lysophospholipids are transported at contact sites between specific regions of the ER and the respective organelle, followed by lysophospholipid acylation in the target organelle. …”
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The unfolded protein response protects from tau neurotoxicity in vivo. by Carin A Loewen, Mel B Feany

“…The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in modulating the effects of aggregation prone cytosolic proteins has received less attention. …”
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Structural organization of Trypanosoma cruzi by Wanderley de Souza

“…This review describes the present knowledge on the organization of the most important structures and organelles found in the protozoan, such as the cell surface, flagellum, cytoskeleton, kinetoplast-mitochondrion complex, glycosome, acidocalcisome, contractile vacuole, lipid inclusions, the secretory pathway, endocytic pathway and the nucleus.…”
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Functional Coupling between the Unfolded Protein Response and Endoplasmic Reticulum/Golgi Ca²⁺-ATPases Promotes Stress Tolerance, Cell Wall Biosynthesis, and Virulence o... by Martin Weichert, José Guirao-Abad, Vishukumar Aimanianda, Karthik Krishnan, Christina Grisham, Patrick Snyder, Alex Sheehan, Ruthvik R. Abbu, Hong Liu, Scott G. Filler, Eric I. Gruenstein, Jean-Paul Latgé, David S. Askew

“…We demonstrate that acute ER stress increases transcription of the srcA gene, encoding a member of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) family, as well as that of pmrA, encoding a secretory pathway Ca2+-ATPase (SPCA) in the Golgi membrane. …”
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Host Retromer Protein Sorting Nexin 2 Interacts with Human Respiratory Syncytial Virus Structural Proteins and is Required for Efficient Viral Production by Ricardo S. Cardoso, Lucas Alves Tavares, Bruna Lais S. Jesus, Miria F. Criado, Andreia Nogueira de Carvalho, Juliano de Paula Souza, Sukhmani Bedi, Marcos Michel de Souza, Maria Lucia Silva, Guilherme Pauperio Lanfredi, Brenda Cristina Vitti, Orlando Bonito Scudero, Vitor Marcel Faça, Akira Ono, Armando M. Ventura, Luis Lamberti P. daSilva, Eurico Arruda

“…ABSTRACT Human respiratory syncytial virus (HRSV) envelope glycoproteins traffic to assembly sites through the secretory pathway, while nonglycosylated proteins M and N are present in HRSV inclusion bodies but must reach the plasma membrane, where HRSV assembly happens. …”
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Substrates and physiological functions of secretase rhomboids proteases by Freeman, M, Lastun, V, Grieve, A

“…The secretase class of rhomboid proteases, distributed through the secretory pathway, are the most numerous in eukaryotes, but our knowledge of them is limited. …”

Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes by Shaun K. Bremner, Woroud S. Al Shammari, Roderick S. Milligan, Brian D. Hudson, Calum Sutherland, Nia J. Bryant, Gwyn W. Gould

“…We further show that the adipokine secretory pathways are impaired in Sx16 knockout cells. …”
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Echinococcus granulosus ubiquitin-conjugating enzymes (E2D2 and E2N) promote the formation of liver fibrosis in TGFβ1-induced LX-2 cells by Xiaodi Du, Ruiqi Hua, Xue He, Wei Hou, Shengqiong Li, Aiguo Yang, Guangyou Yang

“…In addition, the secretory pathway and their effects on the formation of liver fibrosis were also explored. …”
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Signal sequence-triage is activated by translocon obstruction sensed by an ER stress sensor IRE1α by Ashuei Sogawa, Ryota Komori, Kota Yanagitani, Miku Ohfurudono, Akio Tsuru, Koji Kadoi, Yukio Kimata, Hiderou Yoshida, Kenji Kohno

“…Secretory pathway proteins are cotranslationally translocated into the endoplasmic reticulum (ER) of metazoan cells through the protein channel, translocon. …”
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The Golgi complex in stress and death by Carolyn eMachamer

“…The Golgi complex is a central organelle of the secretory pathway where sorting and processing of cargo occurs. …”
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The Fast and the Furious: Golgi Contact Sites by Yotam David, Inês G. Castro, Maya Schuldiner

“…However, despite its central role in the secretory pathway, the Golgi apparatus and its contact sites remain largely unexplored. …”
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