Cellular Release of Infectious Hepatitis C Virus Particles via Endosomal Pathways by Lin Deng, Muchamad Ridotu Solichin, Dewa Nyoman Murti Adyaksa, Maria Alethea Septianastiti, Rhamadianti Aulia Fitri, Gede Ngurah Rsi Suwardan, Chieko Matsui, Takayuki Abe, Ikuo Shoji

“…While the exact mechanisms of HCV particle release remain poorly understood, emerging evidence suggests that HCV utilizes intracellular membrane trafficking and secretory pathways. These pathways include the Golgi secretory pathway and the endosomal trafficking pathways, such as the recycling endosome pathway and the endosomal sorting complex required for transport (ESCRT)-dependent multivesicular bodies (MVBs) pathway. …”
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A Golgi-Located Transmembrane Nine Protein Gene TMN11 Functions in Manganese/Cadmium Homeostasis and Regulates Growth and Seed Development in Rice by He Li, Chao Li, Xuesong Liu, Zhimin Yang

“…As ScPMR1 mediates cellular Mn efflux via a vesicle-secretory pathway, the results suggest that OsTMN11 functions in a similar manner. …”
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Functional Analysis of the P-Type ATPases Apt2-4 from <i>Cryptococcus neoformans</i> by Heterologous Expression in <i>Saccharomyces cerevisiae</i> by Sarina Veit, Sabine Laerbusch, Rosa L. López-Marqués, Thomas Günther Pomorski

“…Despite its inability to transport fluorescent lipids, the Apt3p/Cdc50p complex still rescued the cold-sensitive phenotype of <i>dnf1Δdnf2Δdrs2Δ</i>, suggesting a functional role for the flippase in the secretory pathway. Apt4p, the closest homolog to Saccharomyces Neo1p, which does not require a Cdc50 protein, was unable to complement several flippase-deficient mutant phenotypes, neither in the presence nor absence of a β-subunit. …”
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Requirement of a functional ion channel for Sindbis virus glycoprotein transport, CPV-II formation, and efficient virus budding. by Zeinab Elmasri, Vashi Negi, Richard J Kuhn, Joyce Jose

“…Using live-cell imaging of SINV with a miniSOG-tagged 6K and mCherry-tagged E2, we further demonstrate that 6K and E2 colocalize with the Golgi apparatus in the secretory pathway. To contextualize the localization of 6K in the Golgi, we analyzed cells infected with SINV and SINV-ion channel chimeras using transmission electron microscopy. …”
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Alterations of the Coxiella burnetii Replicative Vacuole Membrane Integrity and Interplay with the Autophagy Pathway by Frank Lafont, María I. Colombo, María E. Mansilla Pareja, Antonino Bongiovanni

“…Galectins are β-galactoside-binding lectins that accumulate in the cytosol before being secreted via a non-conventional secretory pathway. It has been shown that Galectin-3, -8, -9 monitor bacteria vacuolar rupture and endosomal and lysosomal loss of membrane integrity through binding of host glycans exposed in the cytoplasm after membrane damage. …”
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<i>Trypanosoma cruzi</i> Presenilin-Like Transmembrane Aspartyl Protease: Characterization and Cellular Localization by Guilherme C. Lechuga, Paloma Napoleão-Pêgo, Carolina C. G. Bottino, Rosa T. Pinho, David W. Provance-Jr, Salvatore G. De-Simone

“…The results suggest that the parasitic presenilin-like enzyme could have a role in the secretory pathway and serve as a target for the generation of new therapeutics specific to the <i>T. cruzi</i>.…”
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Cytosolic N-terminal arginine-based signals together with a luminal signal target a type II membrane protein to the plant ER by Ritzenthaler Christophe, Kiefer-Meyer Marie-Christine, Garidou Frédéric, Plasson Carole, Pagny-Salehabadi Sophie, Herranz-Gordo Marie-Carmen, Saint-Jore-Dupas Claude, Boulaflous Aurélia, Faye Loïc, Gomord Véronique

“…This is particularly true for the endoplasmic reticulum (ER), the main "gateway of the secretory pathway", where biosynthesis of sterols, lipids, membrane-bound and soluble proteins, and glycoproteins occurs. …”
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Lack of GABARAP-Type Proteins Is Accompanied by Altered Golgi Morphology and Surfaceome Composition by Julia L. Sanwald, Jochen Dobner, Indra M. Simons, Gereon Poschmann, Kai Stühler, Alina Üffing, Silke Hoffmann, Dieter Willbold

“…With the Golgi apparatus being central within the secretory pathway, we sought to investigate the role of the GABARAP-type proteins for cell surface protein trafficking. …”
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‘2TM proteins’: an antigenically diverse superfamily with variable functions and export pathways by Jasweer Kaur, Rachna Hora

“…The role of RIFINs in modulation of host immune response and presence of protective antibodies against these surface exposed molecules in patient sera highlights them as attractive targets of antimalarial therapies and vaccines. 2TM proteins are Plasmodium export elements positive, and several of these are exported to the infected erythrocyte surface after exiting through the classical secretory pathway within parasites. Cleaved and modified proteins are trafficked after packaging in vesicles to reach Maurer’s clefts, while information regarding delivery to the iRBC surface is sparse. …”
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Xylella fastidiosa Requires the Type II Secretion System for Pathogenicity and Survival in Grapevine by Brian Ingel, Claudia Castro, Lindsey Burbank, Nancy Her, N. Itzel De Anda, Hannah Way, Peng Wang, M. Caroline Roper

“…Several of these virulence factors are predicted to be secreted via the type II secretion system (T2SS), the main terminal branch of the Sec-dependent general secretory pathway. In this study, we constructed null mutants in xpsE and xpsG, which encode for the ATPase that drives the T2SS and the major structural pseudopilin of the T2SS, respectively. …”
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Plant production of a virus-like particle-based vaccine candidate against porcine reproductive and respiratory syndrome by Jordan T. VanderBurgt, Jordan T. VanderBurgt, Ondre Harper, Ondre Harper, Christopher P. Garnham, Christopher P. Garnham, Susanne E. Kohalmi, Rima Menassa, Rima Menassa

“…A modified tobacco mosaic virus coat protein (TMVc) was transiently expressed in Nicotiana benthamiana leaves and targeted to three subcellular compartments along the secretory pathway to introduce glycosylation patterns important for M-GP5 epitope immunogenicity. …”
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Optimized Signal Peptide for Secretory Expression of Human Recombinant Somatropin in E. coli by Zeynab Ahmadi, Safar Farajnia, Davoud Farajzadeh, Naser Pouladi, Neda Pourvatan, Mohammad Karbalaeimahdi, Fahime Shayegh, Maryam Arya

“…The prediction of the secretory pathway and the cleavage position was determined by the signalP5 server. …”
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XBP1s Links the Unfolded Protein Response to the Molecular Architecture of Mature N-Glycans by Antonopoulos, Aristotelis, Haslam, Stuart M., Dell, Anne, Dewal, Mahender, DiChiara, Andrew Stephen, Taylor, Rebecca J., Harmon, Chyleigh J., Shoulders, Matthew D.

“…The unfolded protein response (UPR) is classically responsible for maintaining proteostasis in the secretory pathway by defining levels of chaperones and quality control proteins. …”
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Bacterial N-Glycosylation Efficiency is Dependent on the Structural Context of Target Sequons by Silverman, Julie, Imperiali, Barbara

“…Furthermore, in vivo glycosylation studies in both glyco-competent Escherichia coli and the native system, C. jejuni, revealed that efficient glycosylation of glycoproteins, AcrA and PEB3, depends on translocation to the periplasmic space via the general secretory pathway. Our studies provide quantitative evidence that many acceptor proteins are likely to be N-linked-glycosylated before complete folding and suggest that PglB activity is coupled to general secretion-mediated translocation to the periplasm. …”
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Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor by Chen, Kenny, Shoulders, Matthew D.

“…Protein disulfide isomerase A1 (PDIA1) is an endoplasmic reticulum (ER)-localized thiol-disulfide oxidoreductase that is an important folding catalyst for secretory pathway proteins. PDIA1 contains two active-site domains (a and a′), each containing a Cys-Gly-His-Cys (CGHC) active-site motif. …”
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Investigating the role of the Caenorhabditis elegans unfolded protein response in immunity and development by Richardson, Claire E

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Structural and functional studies of the antiviral target proteins HCV p7 and ER alpha-glucosidase II by Hensen, M

“…While correctly matured glycoproteins proceed through the secretory pathway to their final destination, immature glycoproteins are discarded eventually by the ER associated degradation pathway.…”

AnalyzER v1 by Fricker, M

“…The endoplasmic reticulum (ER) is a highly dynamic polygonal membrane network composed of interconnected tubules and sheets (cisternae) that forms the first compartment in the secretory pathway involved in protein translocation, folding, glycosylation, quality control, lipid synthesis, calcium signalling, and metabolon formation. …”

An effective extracellular protein secretion by an ABC transporter system in Escherichia coli: statistical modeling and optimization of cyclodextrin glucanotransferase secretory pr... by Kheng, Oon Low, Mahadi, Nor Muhammad, Abdul Rahim, Raha, Rabu, Amir, Abu Bakar, Farah Diba, Abdul Murad, Abdul Munir, Md. Illias, Rosli

“…We showed that a synergistic balance of transported protein and secretory pathway is important for efficient protein transport. …”
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Signal Peptide Features Determining the Substrate Specificities of Targeting and Translocation Components in Human ER Protein Import by Sven Lang, Duy Nguyen, Pratiti Bhadra, Martin Jung, Volkhard Helms, Richard Zimmermann

“…In human cells, approximately 30% of all polypeptides enter the secretory pathway at the level of the endoplasmic reticulum (ER). …”
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