Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. by Tyler M Sharp, Susana Guix, Kazuhiko Katayama, Sue E Crawford, Mary K Estes

“…Disassembly of the Golgi apparatus was also observed in cells replicating Norwalk virus, which may contribute to pathogenesis by interfering with cellular processes that are dependent on an intact secretory pathway. These results indicate that the ER export signal mimic is critical to the antagonistic function of p22, shown herein to be a novel antagonist of ER/Golgi trafficking. …”
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LIPIDS IN REGULATED EXOCYTOSIS: WHAT ARE THEY DOING? by Mohamed Raafet Ammar, Nawal eKassas, Sylvette eChasserot-Golaz, Marie-France eBader, Nicolas eVitale

“…TThe regulated secretory pathway in neuroendocrine cells ends with the release of hormones and neurotransmitters following a rise in cytosolic calcium. …”
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Protein Sorting in Plasmodium Falciparum by D.C. Ghislaine Mayer

“…From these studies, it is now evident that <i>P. falciparum</i> has repurposed the molecules of the endosomal system to the secretory pathway. Additionally, the sorting and vesicular trafficking mechanism seem to be conserved among apicomplexans. …”
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Formation of complexes at plasmodesmata for potyvirus intercellular movement is mediated by the viral protein P3N-PIPO. by Taiyun Wei, Changwei Zhang, Jian Hong, Ruyi Xiong, Kristin D Kasschau, Xueping Zhou, James C Carrington, Aiming Wang

“…We show that P3N-PIPO is a PD-located protein that physically interacts with CI in planta. The early secretory pathway, rather than the actomyosin motility system, is required for the delivery of P3N-PIPO and CI to PD. …”
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Current approaches on viral infection: proteomics and functional validations by Jie eZheng, Boon Huan eTan, Richard eSugrue, Kai eTang

“…These approaches involve drug inhibition of secretory pathway, immunofluorescence staining, dominant negative mutation of protein target, real time PCR, small interfering siRNA-mediated knockdown, and molecular cloning studies. …”
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Membrane trafficking in breast cancer progression: protein kinase D comes into play by Elena Gutiérrez-Galindo, Zeynep Hazal Yilmaz, Angelika Hausser, Angelika Hausser

“…Protein kinase D (PKD) is a serine/threonine kinase family that controls important cellular functions, most notably playing a key role in the secretory pathway at the trans-Golgi network. Aberrant expression of PKD isoforms has been found mainly in breast cancer, where it promotes various cellular processes such as growth, invasion, survival and stem cell maintenance. …”
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Endoplasmic reticulum calcium regulates the retrotranslocation of Trypanosoma cruzi calreticulin to the cytosol. by Carlos A Labriola, Ianina L Conte, Máximo López Medus, Armando J Parodi, Julio J Caramelo

“…For most secretory pathway proteins, crossing the endoplasmic reticulum (ER) membrane is an irreversible process. …”
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Stacking the odds for Golgi cisternal maturation by Somya Mani, Mukund Thattai

“…This motif precisely matches the cisternal maturation model of the Golgi, which was developed to explain many observed aspects of the eukaryotic secretory pathway. In our analysis cisternal maturation is a robust consequence of vesicle traffic homeostasis, independent of the underlying details of molecular interactions or spatial stacking. …”
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Analytical Technologies for Identification and Characterization of the Plant N-Glycoproteome by Eliel eRuiz-May, Theodore William Thannhauser, Sheng eZhang, Jocelyn Kenneth Campbell Rose

“…In this review, we summarize a range of existing technologies for large-scale N-glycoprotein analysis and highlight promising future approaches that may provide a better understanding of the plant N-glycoproteome, and therefore the cell wall proteome and other proteins associated with the secretory pathway.…”
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Ovulation in Drosophila is controlled by secretory cells of the female reproductive tract by Jianjun Sun, Allan C Spradling

“…Our results imply that proteins secreted during adulthood by the canonical secretory pathway from female reproductive glands are needed to store sperm, while a non-canonical glandular secretion stimulates ovulation. …”
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The Aspergillus nidulans peripheral ER: disorganization by ER stress and persistence during mitosis. by Ane Markina-Iñarrairaegui, Areti Pantazopoulou, Eduardo A Espeso, Miguel A Peñalva

“…The genetically amenable fungus Aspergillus nidulans is well suited for cell biology studies involving the secretory pathway and its relationship with hyphal tip growth by apical extension. …”
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Subcellular Targeting Domains of Sphingomyelin Synthase 1 and 2 by Yeang Calvin, Ding Tingbo, Chirico William J, Jiang Xian-Cheng

“…Brefeldin A treatment prevented SMS1 and SMS2 from exiting the ER, demonstrating that they transit through the classical secretory pathway. We created truncations and chimeras of SMS1 and SMS2 to define their targeting signals. …”
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Cell type-specific regulation of CFTR trafficking—on the verge of progress by Carlos M. Farinha, Lúcia Santos, João F. Ferreira

“…Exit from the endoplasmic reticulum (ER) is coupled with the acquisition of a compact structure that can be processed and traffic through the secretory pathway. Once reaching its final destination—the plasma membrane, CFTR stability is regulated through interaction with multiple protein partners that are involved in its post-translation modification, connecting the channel to several signaling pathways. …”
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Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation by Larry C. Cheng, Dinghai Zheng, Erdene Baljinnyam, Fangzheng Sun, Koichi Ogami, Percy Luk Yeung, Mainul Hoque, Chi-Wei Lu, James L. Manley, Bin Tian

“…Here the authors report global 3′ UTR shortening that is coupled to increased expression of secretory pathway genes in secretory cell differentiation.…”
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Sulfation of a FLAG tag mediated by SLC35B2 and TPST2 affects antibody recognition. by Xin-Yu Guo, Xiao-Dong Gao, Morihisa Fujita

“…Attention should be required when quantifying the FLAG-tagged proteins in the secretory pathway.…”
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Transmembrane domain quality control systems operate at the endoplasmic reticulum and Golgi apparatus. by Kit Briant, Nicholas Johnson, Eileithyia Swanton

“…Here, we have used chimeras based on the type I plasma membrane protein CD8 in which the endogenous TMD was substituted with transmembrane sequences derived from different polytopic membrane proteins as a mode to investigate the quality control of unassembled TMDs along the secretory pathway. We find that the three TMDs examined prevent trafficking of CD8 to the cell surface via potentially distinct mechanisms. …”
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The Regulated Secretion and Models of Intracellular Transport: The Goblet Cell as an Example by Alexander A. Mironov, Galina V. Beznoussenko

“…The transport pathways of luminal and at least initially soluble secretory proteins synthesized in the endoplasmic reticulum can be divided into two groups: the so-called constitutive secretory pathway and regulated secretion (RS) pathway, in which the RS proteins pass through the Golgi complex and are accumulated into storage/secretion granules (SGs). …”
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Rab GTPases and phosphoinositides fine-tune SNAREs dependent targeting specificity of intracellular vesicle traffic by Seiichi Koike, Reinhard Jahn

“…Abstract In the secretory pathway the destination of trafficking vesicles is determined by specific proteins that, with the notable exception of SNAREs, are recruited from soluble pools. …”
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TerC proteins function during protein secretion to metalate exoenzymes by Bixi He, Ankita J. Sachla, John D. Helmann

“…MeeF and MeeY copurify with proteins of the general secretory pathway, and in their absence the FtsH membrane protease is essential for viability. …”
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Viral and Host Factors Regulating HIV-1 Envelope Protein Trafficking and Particle Incorporation by Boris Anokhin, Paul Spearman

“…Env follows an unusual pathway to arrive at the site of particle assembly, first traversing the secretory pathway to the plasma membrane (PM), then undergoing endocytosis, followed by directed sorting to the site of particle assembly on the PM. …”
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