Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation by Srijana Upadhyay, Xinping Xu, Xiaorong Lin

“…Our findings indicate that protein-protein interactions facilitate melanization by metabolic channeling, while posttranslational lipid modifications help recruit the atypical enzymes to the secretory pathway, which is critical for compartmentalization of secondary metabolism. …”
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A cilia-bound unconventional secretory pathway for Drosophila odorant receptors by Najat Dzaki, Mattias Alenius

“…Though most do so via an ordered ER-to-Golgi route, an increasing number of proteins are now shown to bypass this conventional secretory pathway. Results In the Drosophila olfactory sensory neurons (OSNs), odorant receptors (ORs) are trafficked from the ER towards the cilia. …”
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Regulation of secretory pathway kinase or kinase-like proteins in human cancers by Shaonan Du, Chen Zhu, Xiaolin Ren, Xin Chen, Xiao Cui, Shu Guan

Subjects: “…secretory pathway…”
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Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges by Daria Sicari, Aeid Igbaria, Eric Chevet

“…ER and Golgi functions ensure that only properly folded proteins are allowed to flow through the secretory pathway while improperly folded proteins have to be eliminated to not impinge on cellular functions. …”
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A highly sensitive assay for monitoring the secretory pathway and ER stress. by Christian E Badr, Jeffrey W Hewett, Xandra O Breakefield, Bakhos A Tannous

“…The secretory pathway is a critical index of the capacity of cells to incorporate proteins into cellular membranes and secrete proteins into the extracellular space. …”
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Branched Actin Maintains Acetylated Microtubule Network in the Early Secretory Pathway by Azumi Yoshimura, Stéphanie Miserey-Lenkei, Evelyne Coudrier, Bruno Goud

“…In the early secretory pathway, the delivery of anterograde cargoes from the endoplasmic reticulum (ER) exit sites (ERES) to the Golgi apparatus is a multi-step transport process occurring via the ER-Golgi intermediate compartment (IC, also called ERGIC). …”
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A two-hybrid assay to study protein interactions within the secretory pathway. by Danielle H Dube, Bin Li, Ethan J Greenblatt, Sadeieh Nimer, Amanda K Raymond, Jennifer J Kohler

“…The G2H detects protein-protein interactions that cannot be identified via traditional two-hybrid methods and should be broadly useful for probing previously inaccessible subsets of the interactome, including transcriptional activators and proteins that traffic through the secretory pathway.…”
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LRP1 modulates APP trafficking along early compartments of the secretory pathway by Elaine Waldron, Catherine Heilig, Andrea Schweitzer, Nirupa Nadella, Sebastian Jaeger, Anne M. Martin, Sascha Weggen, Klaudia Brix, Claus U. Pietrzik

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The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster by Guiran Xiao, Zhihui Wan, Qiangwang Fan, Xiaona Tang, Bing Zhou

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Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes by Anand Patwardhan, Sabine Bardin, Stéphanie Miserey-Lenkei, Lionel Larue, Bruno Goud, Graça Raposo, Cédric Delevoye

“…Here the authors show that RAB6 and ELKS function in the biogenesis of melanosome, demonstrating that the secretory pathway can be directed towards intracellular organelles of endosomal origin.…”
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Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion by Gaëlle Lentini, Rouaa Ben Chaabene, Oscar Vadas, Chandra Ramakrishnan, Budhaditya Mukherjee, Ved Mehta, Matteo Lunghi, Jonas Grossmann, Bohumil Maco, Rémy Visentin, Adrian B. Hehl, Volodymyr M. Korkhov, Dominique Soldati-Favre

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Protein release through nonlethal oncotic pores as an alternative nonclassical secretory pathway by Chirico William J

“…Four nonclassical secretory pathways have been described including direct transport (presumably through transporters in the plasma membrane), secretion via exosomes, lysosomal secretion, and blebbing. …”
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Translational landscape and protein biogenesis demands of the early secretory pathway in Komagataella phaffii by Troy R. Alva, Melanie Riera, Justin W. Chartron

“…To understand the flux through various routes into the early secretory pathway, we quantified the global and membrane-associated translatomes of Komagataella phaffii. …”
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Distant chaperones and N-glycan signals : new mechanisms of secretory pathway proteostasis by Wong, Madeline Y

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Use of the regulated secretory pathway to ease product recovery in animal cell culture by Stevenson, David M

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The ribosome collision sensor Hel2 functions as preventive quality control in the secretory pathway by Yoshitaka Matsuo, Toshifumi Inada

“…These findings provide insights into risk management in the secretory pathway that maintains cellular protein homeostasis.…”
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Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity by Ashley J. Evans, Sonam Gurung, Kevin A. Wilkinson, David J. Stephens, Jeremy M. Henley

“…It is well established that the transcription, translation, and endocytosis/recycling of iGluRs are all regulated by neuronal activity, but much less is known about the activity dependence of iGluR transport through the secretory pathway. Here, we use the kainate receptor subunit GluK2 as a model iGluR cargo to show that the assembly, early secretory pathway trafficking, and surface delivery of iGluRs are all controlled by neuronal activity. …”
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Human lipocalins bind and export fatty acids through the secretory pathway of yeast cells by Aslihan Ekim Kocabey, Roger Schneiter

“…Our findings reveal that directing these fatty-acid binding proteins into the secretory pathway effectively promotes fatty acid secretion from a sensitized quadruple mutant model strain (faa1∆ faa4∆ pry1∆ pry3∆). …”
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Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons by Javier Emperador Melero, Aishwarya G. Nadadhur, Desiree Schut, Jan V. Weering, Vivi M. Heine, Ruud F. Toonen, Matthijs Verhage

“…Here, we investigated the maturation of these two secretory pathways in micro-networks of human iPSC-derived neurons. …”
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Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway by Tolulope Sokoya, Jan Parolek, Mads Møller Foged, Dmytro I Danylchuk, Manuel Bozan, Bingshati Sarkar, Angelika Hilderink, Michael Philippi, Lorenzo D Botto, Paulien A Terhal, Outi Mäkitie, Jacob Piehler, Yeongho Kim, Christopher G Burd, Andrey S Klymchenko, Kenji Maeda, Joost CM Holthuis

“…Its production in the trans-Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol gradient along the secretory pathway. This gradient marks a fundamental transition in physical membrane properties that help specify organelle identify and function. …”
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