Secretome and Tunneling Nanotubes: A Multilevel Network for Long Range Intercellular Communication between Endothelial Cells and Distant Cells by Béatrice Charreau

“…This intercellular crosstalk operates through the extracellular space and is orchestrated in part by the secretory pathway and the exocytosis of Weibel Palade Bodies (WPBs), secretory granules and extracellular vesicles (EVs). …”
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Critical Determinants in ER-Golgi Trafficking of Enzymes Involved in Glycosylation by Ning Zhang, Olga A. Zabotina

“…Therefore, delivery of these enzymes to the proper locations, the glycosylation sites, in the cell is essential and involves numerous secretory pathway components. This review presents the current state of knowledge about the mechanisms of protein trafficking between ER and Golgi. …”
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Functional Amyloid Formation within Mammalian Tissue.

“…Intracellular Pmel17 amyloidogenesis is carefully orchestrated by the secretory pathway, utilizing membrane sequestration and proteolytic steps to protect the cell from amyloid and amyloidogenic intermediates that can be toxic. …”
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ER stress proteins in autoimmune and inflammatory diseases by Daisuke eMorito, Kazuhiro eNagata

“…Recently, a growing body of evidence suggested that the other class of stress proteins such as, endoplasmic reticulum (ER) stress proteins, which originally act as protein quality control factors in the secretory pathway and are induced by ER stress in inflammatory lesions, also participate in inflammation and autoimmunity. …”
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The Targeting of Native Proteins to the Endoplasmic Reticulum-Associated Degradation (ERAD) Pathway: An Expanding Repertoire of Regulated Substrates by Deepa Kumari, Jeffrey L. Brodsky

“…Approximately one-quarter to one-third of all proteins synthesized in eukaryotic cells access the ER because they are destined for transport to the extracellular space, because they represent integral membrane proteins, or because they reside within one of the many compartments of the secretory pathway. However, proteins that mature inefficiently are subject to ER-associated degradation (ERAD), a multi-step pathway involving the chaperone-mediated selection, ubiquitination, and extraction (or “retrotranslocation”) of protein substrates from the ER. …”
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Bax function in the absence of mitochondria in the primitive protozoan Giardia lamblia. by Adrian B Hehl, Attila Regos, Elisabeth Schraner, André Schneider

“…However, specialized compartments of the regulated secretory pathway are completely ablated by Bax. As a consequence, maturing cyst wall proteins that are sorted into these organelles are released into the cytoplasm, causing a developmental arrest and cell death. …”
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FAM20A is a golgi-localized Type II transmembrane protein by Mohammad Faizan Siddiqui, Jiahe Li, Suzhen Wang, Hua Zhang, Chunlin Qin, Yongbo Lu

“…Abstract Family with sequence similarity 20, member A (FAM20A) is a pseudo-kinase in the secretory pathway and is essential for enamel formation in humans. …”
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Intracellular degradation of newly synthesized apolipoprotein B by Z Yao, K Tran, R S McLeod

“…Intracellular degradation of newly synthesized apolipoprotein (apo) B can occur at every stage of the secretory pathway, from the protein translation, polypeptide translocation across the membrane of endoplasmic reticulum (ER), to vesicular transport. …”
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Cilia Provide a Platform for the Generation, Regulated Secretion, and Reception of Peptidergic Signals by Raj Luxmi, Stephen M. King

“…Biochemical dissection of this complex ciliary secretory pathway provides a paradigm for understanding cilia-based peptidergic signaling in mammals and other eukaryotes.…”
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Lipid-deprived diet perturbs O-glycosylation of secretory proteins in rat mammary epithelial cells by F. Lavialle, E. Chanat

“…These data provide evidence that O-glycosylation of milk proteins in the secretory pathway of mammary epithelial cells is modulated by the lipid content of experimental diets.…”
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Conditional Expression of the Small GTPase ArfA Impacts Secretion, Morphology, Growth, and Actin Ring Position in Aspergillus niger by Markus R. M. Fiedler, Timothy C. Cairns, Oliver Koch, Christin Kubisch, Vera Meyer

“…Taken together, our results demonstrate that ArfA fulfills multiple functions in the secretory pathway of A. niger.…”
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Subcellular Compartmentalization and Trafficking of the Biosynthetic Machinery for Fungal Melanin by Srijana Upadhyay, Xinping Xu, David Lowry, Jennifer C. Jackson, Robert W. Roberson, Xiaorong Lin

“…We find that all enzymes involved in the early steps of melanin biosynthesis are recruited to endosomes through a non-conventional secretory pathway. In contrast, late melanin enzymes accumulate in the cell wall. …”
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A novel predicted calcium-regulated kinase family implicated in neurological disorders. by Małgorzata Dudkiewicz, Anna Lenart, Krzysztof Pawłowski

“…Unusually high cysteine content and presence of signal peptides in some of the family members suggest that FAM69 proteins may be involved in phosphorylation of proteins in the secretory pathway and/or of extracellular proteins.…”
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The regulation of the cell wall by glycosylphosphatidylinositol-anchored proteins in Arabidopsis by Ke Zhou

“…Ultimately, mature proteins reach the plasma membrane via the secretory pathway facing toward the apoplast and cell wall in plants. …”
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COPI selectively drives maturation of the early Golgi by Effrosyni Papanikou, Kasey J Day, Jotham Austin II, Benjamin S Glick

“…COPI coated vesicles carry material between Golgi compartments, but the role of COPI in the secretory pathway has been ambiguous. Previous studies of thermosensitive yeast COPI mutants yielded the surprising conclusion that COPI was dispensable both for the secretion of certain proteins and for Golgi cisternal maturation. …”
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Surveying the floodgates: Estimating protein flux into the endoplasmic reticulum lumen in Saccharomyces cerevisiae by Michael eVincent, Mark eWhidden, Santiago eSchnell, Santiago eSchnell, Santiago eSchnell

“…Endoplasmic reticulum resident proteins, along with all proteins traveling through the secretory pathway must enter endoplasmic reticulum lumen through membrane-embedded translocons. …”
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The Role of Lectin-Carbohydrate Interactions in the Regulation of ER-Associated Protein Degradation by Monika Słomińska-Wojewódzka, Kirsten Sandvig

“…Proteins entering the secretory pathway are translocated across the endoplasmic reticulum (ER) membrane in an unfolded form. …”
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Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration. by Jillian N Pearring, Jovenal T San Agustin, Ekaterina S Lobanova, Christopher J Gabriel, Eric C Lieu, William J Monis, Michael W Stuck, Lara Strittmatter, Samer M Jaber, Vadim Y Arshavsky, Gregory J Pazour

“…Arf4 is proposed to be a critical regulator of membrane protein trafficking in early secretory pathway. More recently, Arf4 was also implicated in regulating ciliary trafficking, however, this has not been comprehensively tested in vivo. …”
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Molecular and cellular dynamics of the Toll-like receptor 4 pathway. by Nick eGay, Ardiyanto eLiaunardy-Jopeace, Ardiyanto eLiaunardy-Jopeace

“…In this article we review how TLR4 traffics from the early secretory pathway, the cis/trans Golgi to the cell surface and endolysosomal compartments. …”
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Identification and network-enabled characterization of auxin response factor genes in Medicago truncatula by David J. Burks, Rajeev K. Azad, Rajeev K. Azad

“…Furthermore, the topological clustering and single enrichment analysis of several network models revealed the roles of individual members of the MtARF family in nitrogen regulation, nodule initiation, and post-embryonic development through a specialized protein packaging and secretory pathway. In summary, this study not just shines new light on an important gene family, but also provides a guideline for identification of new members of gene families and their functional characterization through network analyses.…”
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