Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11. by Wu-Lin Charng, Shinya Yamamoto, Manish Jaiswal, Vafa Bayat, Bo Xiong, Ke Zhang, Hector Sandoval, Gabriela David, Stephen Gibbs, Hsiang-Chih Lu, Kuchuan Chen, Nikos Giagtzoglou, Hugo J Bellen

“…A partial dysfunction of Rab1 affects Scabrous and Delta in the secretory pathway. In addition, a partial loss Rab11 affects trafficking of Delta. …”
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Genetics of clusterin isoform expression and Alzheimer's disease risk. by I-Fang Ling, Jiraganya Bhongsatiern, James F Simpson, David W Fardo, Steven Estus

“…Since CLU1 and CLU2 are predicted to encode intracellular and secreted proteins, respectively, we compared their expression; for both CLU1 and CLU2 transfected cells, clusterin is present in the secretory pathway, accumulates in the extracellular media, and is similar in size to clusterin in human brain. …”
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Thematic review series: Lipid Posttranslational Modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipid... by Orlean Peter, Anant K. Menon

“…GPI proteins transit the secretory pathway to the cell surface; in yeast, many become covalently attached to the cell wall. …”
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A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion. by Amy Huei-Yi Lee, Brenden Hurley, Corinna Felsensteiner, Carmen Yea, Wenzislava Ckurshumova, Verena Bartetzko, Pauline W Wang, Van Quach, Jennifer D Lewis, Yulu C Liu, Frederik Börnke, Stephane Angers, Andrew Wilde, David S Guttman, Darrell Desveaux

“…Furthermore, HopZ1a requires its acetyltransferase activity to cause a dramatic decrease in Arabidopsis thaliana microtubule networks, disrupt the plant secretory pathway and suppress cell wall-mediated defense. …”
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Inter-species complementation of the translocon beta subunit requires only its transmembrane domain. by Alexandre Leroux, Luis A Rokeach

“…In eukaryotes, proteins enter the secretory pathway through the translocon pore of the endoplasmic reticulum. …”
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Membrane-Bound Meet Membraneless in Health and Disease by Chujun Zhang, Catherine Rabouille

“…First, inhibition of membrane trafficking in the early secretory pathway leads to the formation of biocondensates (P-bodies and Sec bodies). …”
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Role of Glycoproteins during Fruit Ripening and Seed Development by Angela Mendez-Yañez, Patricio Ramos, Luis Morales-Quintana

“…Approximately thirty percent of the proteins synthesized in animal or plant cells travel through the secretory pathway. Seventy to eighty percent of those proteins are glycosylated. …”
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Refining protein subcellular localization. by Michelle S Scott, Sara J Calafell, David Y Thomas, Michael T Hallett

“…Disagreements between these methods generally involve proteins that transit through or reside in the secretory pathway. We used our multi-compartmental predictions to refine the localization annotations of yeast proteins primarily by distinguishing between soluble lumenal proteins and soluble proteins peripherally associated with organelles. …”
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Toxoplasma gondii Syntaxin 6 Is Required for Vesicular Transport Between Endosomal-Like Compartments and the Golgi Complex by Jackson, A, Clucas, C, Mamczur, N, Meissner, M, Ferguson, D

“…It therefore appears that Toxoplasma has retained a plant-like secretory pathway. © 2013 The Authors.…”

A rab1 GTPase is required for transport between the endoplasmic reticulum and golgi apparatus and for normal golgi movement in plants. by Batoko, H, Zheng, H, Hawes, C, Moore, I

“…We describe a green fluorescent protein (GFP)-based assay for investigating membrane traffic on the secretory pathway in plants. Expression of AtRab1b(N121I), predicted to be a dominant inhibitory mutant of the Arabidopsis Rab GTPase AtRab1b, resulted in accumulation of a secreted GFP marker in an intracellular reticulate compartment reminiscent of the endoplasmic reticulum. …”

Characterisation of Plasmodium invasive organelles; an ookinete microneme proteome. by Lal, K, Prieto, J, Bromley, E, Sanderson, S, Yates, JR, Wastling, J, Tomley, F, Sinden, R

“…We further identified numerous proteins with established vesicle trafficking and signaling functions consistent with micronemes being part of a regulated secretory pathway. Previously uncharacterised proteins comprise the largest functional group of the microneme proteome and will include secreted proteins important to invasion.…”

Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles by Li, MY, Naik, TS, Siu, LYL, Acuto, O, Spooner, E, Wang, P, Yang, X, Lin, Y, Bruzzone, R, Ashour, J, Evans, MJ, Sanyal, S

“…This process depends on Ulk1, Rab GTPases and SNARE complexes implicated in secretory but not degradative autophagy and occur with significantly faster kinetics than the conventional secretory pathway. Our study reveals a previously undiscovered Lyn-dependent exit route of flaviviruses in LC3+ secretory organelles that enables them to evade circulating antibodies and might affect tissue tropism.…”

The KDEL trafficking receptor exploits pH to tune the strength of an unusual short hydrogen bond by Wu, Z, Newstead, S, Biggin, PC

“…During protein synthesis, ER luminal chaperones are swept along the secretory pathway and must be retrieved to maintain cell viability. …”

Allelic differences affecting invariant chain dependency of MHC class II subunit assembly. by Bikoff, E, Germain, R, Robertson, E

“…The conserved invariant chain associates with highly polymorphic alpha and beta subunits guiding class II transport through the secretory pathway. Early associations of these three polypeptides inside antigen-presenting cells are poorly understood. …”

Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk by Inca A. Dieterich, Alexis J. Lawton, Yajing Peng, Qing Yu, Timothy W. Rhoads, Katherine A. Overmyer, Yusi Cui, Eric A. Armstrong, Porsha R. Howell, Maggie S. Burhans, Lingjun Li, John M. Denu, Joshua J. Coon, Rozalyn M. Anderson, Luigi Puglielli

“…The Endoplasmic Reticulum acetylation machinery ensures proper quality control and disposal of newly folded proteins transiting the secretory pathway. Here, the authors show that this machinery acts as a metabolic regulator of acetyl-CoA homeostasis, impacting intracellular crosstalk.…”
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Modulation of heterologous protein secretion in the thermotolerant methylotrophic yeast Ogataea thermomethanolica TBRC 656 by CRISPR-Cas9 system. by Worarat Kruasuwan, Aekkachai Puseenam, Chitwadee Phithakrotchanakoon, Sutipa Tanapongpipat, Niran Roongsawang

“…Heterologous proteins are often retained intracellularly in yeast resulting in endoplasmic reticulum (ER) stress and poor secretion, and despite efforts to engineer protein secretory pathways, heterologous protein production is often lower than expected. …”
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A strategy for O-glycoproteomics of enveloped viruses--the O-glycoproteome of herpes simplex virus type 1. by Ieva Bagdonaite, Rickard Nordén, Hiren J Joshi, Sally Dabelsteen, Kristina Nyström, Sergey Y Vakhrushev, Sigvard Olofsson, Hans H Wandall

“…We show that HSV-1 infection distorts the secretory pathway and that infected cells accumulate glycoproteins with truncated O-glycans, nonetheless retaining the ability to elongate most of the surface glycans. …”
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An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes. by Katrin Kremer, Dirk Kamin, Eva Rittweger, Jonathan Wilkes, Halley Flammer, Sabine Mahler, Joanne Heng, Christopher J Tonkin, Gordon Langsley, Stefan W Hell, Vernon B Carruthers, David J P Ferguson, Markus Meissner

“…In order to define the secretory pathway of apicomplexans, we performed an overexpression screen of Rabs in Toxoplasma gondii and identified Rab5A and Rab5C as important regulators of traffic to micronemes and rhoptries. …”
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Biochemistry of the Endocrine Heart by Jens P. Goetze, Emil D. Bartels, Theodor W. Shalmi, Lilian Andraud-Dang, Jens F. Rehfeld

“…In several ways, intracellular granules in the cells contain not only peptides destined for secretion but also important granin molecules involved in maintaining a regulated secretory pathway. In this review, we will highlight the biochemical phenotype of the endocrine heart recapitulating that the cardiac myocytes are capable endocrine cells. …”
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Cell polarity protein Spa2 coordinates Chs2 incorporation at the division site in budding yeast. by Magdalena Foltman, Yasmina Filali-Mouncef, Damaso Crespo, Alberto Sanchez-Diaz

“…The process by which the secretory pathway promotes specific incorporation of key factors into the cytokinetic machinery is poorly understood. …”
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