Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans. by Ming Zhu, Gang Wu, Yu-Xin Li, Julia Kathrin Stevens, Chao-Xuan Fan, Anne Spang, Meng-Qiu Dong

“…In addition, we found that sgk-1(RNAi) induced unfolded protein response in the ER, suggesting at least an indirect role of SGK-1 early in the secretory pathway. We propose that SGK-1 function is required for lipid homeostasis and that it acts at different intracellular trafficking steps.…”
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Ectopic expression of a Neospora caninum Kazal type inhibitor triggers developmental defects in Toxoplasma and Plasmodium. by Zoi Tampaki, Ramadhan S Mwakubambanya, Evi Goulielmaki, Sofia Kaforou, Kami Kim, Andrew P Waters, Vern B Carruthers, Inga Siden-Kiamos, Thanasis G Loukeris, Konstantinos Koussis

“…To validate such an approach, a Neospora caninum Kazal inhibitor (NcPI-S) was expressed ectopically in two apicomplexan species, Toxoplasma gondii tachyzoites and Plasmodium berghei ookinetes, with the aim to disrupt proteolytic processes taking place within the secretory pathway. NcPI-S negatively affected proliferation of Toxoplasma tachyzoites, while it had no effect on invasion and egress. …”
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Macrophage Migration Inhibitory Factor Secretion Is Induced by Ionizing Radiation and Oxidative Stress in Cancer Cells. by Yashi Gupta, Vinay Pasupuleti, Weinan Du, Scott M Welford

“…MIF secretion, however, is a poorly understood process owing to the fact that MIF is a leaderless polypeptide that follows a non-classical secretory pathway. Better understanding of MIF processing and release could have therapeutic implications. …”
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Functional amyloid formation within mammalian tissue. by Douglas M Fowler, Atanas V Koulov, Christelle Alory-Jost, Michael S Marks, William E Balch, Jeffery W Kelly

“…Intracellular Pmel17 amyloidogenesis is carefully orchestrated by the secretory pathway, utilizing membrane sequestration and proteolytic steps to protect the cell from amyloid and amyloidogenic intermediates that can be toxic. …”
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Identification of CkSNAP33, a gene encoding synaptosomal-associated protein from Cynanchum komarovii, that enhances Arabidopsis resistance to Verticillium dahliae. by Ping Wang, Xueyan Zhang, Xiaowen Ma, Yun Sun, Nana Liu, Fuguang Li, Yuxia Hou

“…In addition, the SNARE-mediated secretory pathway can deliver diverse defense products to infection sites during exocytosis-associated immune responses in plants. …”
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<i>N</i>-glycoproteins in Plant Cell Walls: A Survey by Hélène San Clemente, Elisabeth Jamet

“…In order to reach the extracellular space, CWPs are transported through the secretory pathway where they may undergo post-translational modifications, including <i>N</i>-glycosylations on the Asn residues in specific motifs (Asn-X-Ser/Thr-X, with X≠Pro). …”
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AAV-mediated overexpression of neuroserpin in the hippocampus decreases PSD-95 expression but does not affect hippocampal-dependent learning and memory. by Vicky W K Tsang, Deborah Young, Matthew J During, Nigel P Birch

“…A FLAG-tagged neuroserpin construct was initially characterized by in vitro transcription/translation and transfection into HEK293 cells and shown to interact with tPA and be targeted to the secretory pathway. Targeted injection of a chimeric AAV1/2 vector expressing FLAG-neuroserpin resulted in localized overexpression in the dorsal hippocampus. …”
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Tubule-guided cell-to-cell movement of a plant virus requires class XI myosin motors. by Khalid Amari, Alexander Lerich, Corinne Schmitt-Keichinger, Valerian V Dolja, Christophe Ritzenthaler

“…Here we show that PDLP1 is transported to PD through a specific route within the secretory pathway in a myosin-dependent manner. This transport relies primarily on the class XI myosins XI-K and XI-2. …”
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The Pathophysiology of Hereditary Angioedema by Bruce L Zuraw, MD

“…Type I HAE is caused by a diverse range of mutations, some of which cause the nascent protein to misfold and thus to be unable to enter the secretory pathway. The primary mediator of swelling in HAE is bradykinin, a product of the plasma contact system. …”
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Intracellular Trafficking of HBV Particles by Bingfu Jiang, Eberhard Hildt

“…Infectious viral particles and filaments are released via multivesicular bodies; spheres are secreted by the classic constitutive secretory pathway. The release of naked capsids is still not fully understood, autophagosomal processes are discussed. …”
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The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans. by Karin B Ackema, Ursula Sauder, Jachen A Solinger, Anne Spang

“…Small GTPases of the Sar/Arf family are essential to generate transport containers that mediate communication between organelles of the secretory pathway. Guanine nucleotide exchange factor (GEFs) activate the small GTPases and help their anchorage in the membrane. …”
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Identification and characterization of LysM effectors in Penicillium expansum. by Elena Levin, Ana Rosa Ballester, Ginat Raphael, Oleg Feigenberg, Yongsheng Liu, John Norelli, Luis Gonzalez-Candelas, Jing Ma, Christopher Dardick, Michael Wisniewski, Samir Droby

“…Eleven of the discovered LysM genes were found to have secretory pathway signal peptide, among them, 4 (PeLysM1 PeLysM2, PeLysM3 and PeLysM4) were found to be highly expressed during the infection and development of decay of apple fruit. …”
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ERManI is a target of miR-125b and promotes transformation phenotypes in hepatocellular carcinoma (HCC). by Shujuan Pan, Xiaoyun Cheng, Hongan Chen, Patricia D Castro, Michael M Ittmann, Anne W Hutson, Susan K Zapata, Richard N Sifers

“…By functioning as a "gate keeper" to prevent the inappropriate secretion of misfolded glycoproteins, it plays a critical role in maintaining protein homeostasis in the mammalian secretory pathway. In the present study, we identified that a conserved motif within the 3'UTR of ERManI is a target of miR-125b, a microRNA frequently down-regulated in numerous types of cancers, including hepatocellular carcinoma (HCC). …”
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Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains. by Cornelia J Geerts, Roberta Mancini, Ning Chen, Frank T W Koopmans, Ka Wan Li, August B Smit, Jan R T van Weering, Matthijs Verhage, Alexander J A Groffen

“…The secretory pathway in neurons requires efficient targeting of cargos and regulatory proteins to their release sites. …”
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Knocking Out Bcsas1 in Botrytis cinerea Impacts Growth, Development, and Secretion of Extracellular Proteins, Which Decreases Virulence by Zhanquan Zhang, Guozheng Qin, Boqiang Li, Shiping Tian

“…Rab GTPases play a central role in the secretory pathway. To explore the function of Rab/GTPase in filamentous fungi, we knocked out a Rab/GTPase family gene, Bcsas1, in Botrytis cinerea, an aggressive fungal pathogen that infects more than 200 plant species. …”
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Progress Towards the Tomato Fruit Cell Wall Proteome by Eliel eRuiz May, Jocelyn Kenneth Campbell Rose

“…In this review we describe a variety of orthogonal techniques that have been applied to identify CW localized proteins from tomato fruit, including approaches that: target the proteome of the CW and the overlying cuticle; functional ‘secretome’ screens; lectin affinity chromatography; and computational analyses to predict proteins that enter the secretory pathway. Each has its merits and limitations, but collectively they are providing important insights into CW proteome composition and dynamics, as well as some potentially controversial issues, such as the prevalence of non-canonical protein secretion.…”
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Comparison of the Cisterna Maturation-Progression Model with the Kiss-and-Run Model of Intra-Golgi Transport: Role of Cisternal Pores and Cargo Domains by Galina V. Beznoussenko, Hee-Seok Kweon, Irina S. Sesorova, Alexander A. Mironov

“…The Golgi complex is the central station of the secretory pathway. Knowledge about the mechanisms of intra-Golgi transport is inconsistent. …”
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The role of the cytosolic HSP70 chaperone system in diseases caused by misfolding and aberrant trafficking of ion channels by Jason C. Young

“…Wild-type forms are synthesized and integrated into the endoplasmic reticulum (ER) membrane system and, upon correct folding, are trafficked by the secretory pathway to the cell surface. Misfolded mutant forms traffic poorly, if at all, and are instead degraded by the ER-associated proteasomal degradation (ERAD) system. …”
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Vti1a/b support distinct aspects of TGN and cis-/medial Golgi organization by Danique M. van Bommel, Ruud F. Toonen, Matthijs Verhage

“…Our data underline the importance of retrograde trafficking for Golgi organization, DCV cargo sorting and the distribution of proteins of the regulated secretory pathway.…”
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Endomembrane remodeling in SARS-CoV-2 infection by Di Chen, Yan G. Zhao, Hong Zhang

“…Virions are assembled at the ER–Golgi intermediate compartment and released through the secretory pathway and/or lysosome-mediated exocytosis. …”
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