Calcium Binding Proteins] by Berivan Tandoğan, N. Nuray Ulusu

“…Calcium binding proteins are also an important molecularchaperones involved in the protein synthesis within secretory pathways. Theirmajor role is assumed to be buffering, transport of calcium, and regulation of variousenzyme systems. …”
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Improved expression of secreted and membrane-targeted proteins in insect cells. by Hitchman, R, Possee, R, Siaterli, E, Richards, K, Clayton, A, Bird, L, Owens, R, Carpentier, D, King, F, Danquah, J, Spink, K, King, L

“…There may be many reasons for this, including degradation of recombinant proteins by proteases, competition for cellular resources between native and recombinant proteins, and physical blockage of the secretory pathways. In the present study, we describe the construction of a baculovirus in which chiA (chitinase) and cath (cathepsin) genes have been deleted and show improved recombinant protein expression using this vector. …”

Nitric oxide and the resolution of inflammation: implications for atherosclerosis by Catherine A Shaw, Emma L Taylor, Ian L Megson, Adriano G Rossi

“…Apoptosis results in shutdown of secretory pathways and renders effete, but potentially highly histotoxic, cells instantly recognisable for non-inflammatory clearance by phagocytes (e.g., macrophages). …”
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Phylogenetic analysis of Amphioxus genes of the proprotein convertase family, including aPC6C, a marker of epithelial fusions during embryology by Stéphanie Bertrand, Alain Camasses, Mathilde Paris, Nicholas D. Holland, Hector Escriva

“…<p>The proprotein convertases (PCs) comprise a family of subtilisin-like endoproteases that activate precursor proteins (including, prohormones, growth factors, and adhesion molecules) during their transit through secretory pathways or at the cell surface. To explore the evolution of the PC gene family in chordates, we made a phylogenetic analysis of PC genes found in databases, with special attention to three PC genes of the cephalochordate amphioxus, the closest living invertebrate relative to the vertebrates. …”
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Flexible approaches are required for successful production of recombinant proteins in plants by Nilufer Gun, Tarlan Mamedov

“…Therefore, molecular engineering of plant secretory pathways has provided an opportunity to develop next-generation pharmaceuticals with targeted biological functions. …”
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The movement of carriers from the Golgi to the plasma membrane by Chua, Paula-Teresa Hui Yee

“…The complexity of the cellular structural components and regulators involved in the secretory pathways has garnered the interest of many cell biologists. …”
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Organelle mapping in dendrites of human iPSC-derived neurons reveals dynamic functional dendritic Golgi structures by Jingqi Wang, Maciej Daniszewski, Marlene M. Hao, Damián Hernández, Alice Pébay, Paul A. Gleeson, Lou Fourriere

“…Summary: Secretory pathways within dendrites of neurons have been proposed for local transport of newly synthesized proteins. …”
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The mechanism of chronic intracellular infection with Brucella spp. by Xiaoyi Guo, Hui Zeng, Mengjuan Li, Yu Xiao, Guojing Gu, Zhenhui Song, Xuehong Shuai, Jianhua Guo, Qingzhou Huang, Bo Zhou, Yuefeng Chu, Hanwei Jiao, Hanwei Jiao

“…Once inside cells, Brucella resides in a vacuole, designated the BCV, which interacts with components of the endocytic and secretory pathways to ensure bacterial survival. Numerous studies conducted recently have revealed that Brucella’s ability to cause a chronic infection depends on how it interacts with the host. …”
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Turning Inside Out: Filamentous Fungal Secretion and Its Applications in Biotechnology, Agriculture, and the Clinic by Timothy C. Cairns, Xiaomei Zheng, Ping Zheng, Jibin Sun, Vera Meyer

“…Additionally, we discuss how the control of secretory pathways and the polar growth of filamentous hyphae can be utilized in diverse settings, including industrial biotechnology, agriculture, and the clinic.…”
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Multielectrode Arrays as a Means to Study Exocytosis in Human Platelets by Rosalía González Brito, Pablo Montenegro, Alicia Méndez, Valentina Carabelli, Giulia Tomagra, Ramtin E. Shabgahi, Alberto Pasquarelli, Ricardo Borges

“…Moreover, these devices constitute a valuable platform for the rapid testing of novel drugs that act on secretory pathways in human tissues.…”
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Cdc42 regulates cytokine expression and trafficking in bronchial epithelial cells by Rowayna Shouib, Gary Eitzen

“…This underscores the role of Cdc42 in coupling receptor activation to downstream gene expression and also as a regulator of cytokine secretory pathways.…”
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Ca(2+)- and GTP-dependent exocytosis in mouse pancreatic beta-cells involves both common and distinct steps. by Proks, P, Eliasson, L, Ammälä, C, Rorsman, P, Ashcroft, F

“…Our results are interpreted in terms of a model in which the secretory pathways stimulated by Ca2+ and GTP contain both common and separate parts.…”

Complex of Proline-Specific Peptidases in the Genome and Gut Transcriptomes of Tenebrionidae Insects and Their Role in Gliadin Hydrolysis by Valeriia F. Tereshchenkova, Irina Y. Filippova, Irina A. Goptar, Yakov E. Dunaevsky, Mikhail A. Belozersky, Elena N. Elpidina

“…Studies of the localization of PSPs, evaluation of the expression level of their genes in gut transcriptomes, and prediction of the presence of signal peptides determining secretory pathways made it possible to propose a set of peptidases that can directly participate in the hydrolysis of food proteins in the larvae guts. …”
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Metabolism Regulation and Redox State: Insight into the Role of Superoxide Dismutase 1 by Simona Damiano, Concetta Sozio, Giuliana La Rosa, Bruna Guida, Raffaella Faraonio, Mariarosaria Santillo, Paolo Mondola

“…Indeed, SOD1 is secreted through unconventional secretory pathways, carries out paracrine functions and circulates in the blood bound to lipoproteins. …”
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Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection. by Xiaoyuan Lin, Beibei Fu, Yan Xiong, Na Xing, Weiwei Xue, Dong Guo, Mohamed Zaky, Krishna Pavani, Dusan Kunec, Jakob Trimpert, Haibo Wu

“…Mechanistically, ORF8 is a secretory protein that can be secreted by infected epithelial cells via both conventional and unconventional secretory pathways. Conventionally secreted ORF8 is glycosylated and loses the ability to recognize interleukin 17 receptor A of macrophages, possibly due to the steric hindrance imposed by N-glycosylation at Asn78. …”
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Synchronized membrane protein trafficking in Saccharomyces cerevisiae by Tay, Vivian Yu En

“…S. cerevisiae has long been utilized as a model organism since secretory pathways are highly conserved amongst eukaryotes. …”
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Effects of a Shift of the Signal Peptide Cleavage Site in Signal Peptide Variant on the Synthesis and Secretion of SARS-CoV-2 Spike Protein by Zhikai Zhang, Xuan Wan, Xinyue Li, Chengsong Wan

“…Here, we not only investigated the structure of the N-terminal signal peptide of the SARS-CoV-2 spike protein but also considered possible secretory pathways. We suggest that the development of drugs that target the signal peptide of the SARS-CoV-2 spike protein may have potential to treat COVID-19 in the future.…”
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Modulation of Endosome Function, Vesicle Trafficking and Autophagy by Human Herpesviruses by Eduardo I. Tognarelli, Antonia Reyes, Nicolás Corrales, Leandro J. Carreño, Susan M. Bueno, Alexis M. Kalergis, Pablo A. González

“…Understanding how herpesviruses modulate autophagy, endolysosomal and secretory pathways, as well as other prominent trafficking vesicles within the cell, could enable the engineering of novel antiviral therapies to treat these viruses and counteract their negative health effects.…”
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Arf GTPases Are Required for the Establishment of the Pre-Assembly Compartment in the Early Phase of Cytomegalovirus Infection by Valentino Pavišić, Hana Mahmutefendić Lučin, Gordana Blagojević Zagorac, Pero Lučin

“…Shortly after entering the cells, cytomegaloviruses (CMVs) initiate massive reorganization of cellular endocytic and secretory pathways, which results in the forming of the cytoplasmic virion assembly compartment (AC). …”
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A Subset of Colon Cancer Cell Lines Displays a Cytokine Profile Linked to Angiogenesis, EMT and Invasion Which Is Modulated by the Culture Conditions In Vitro by Jacqueline Bersano, Kanstantsin Lashuk, Anna Edinger, Julia Schueler

“…The dysregulation of secretory pathways is a crucial driver of CRC progression, since it modulates cell proliferation, angiogenesis and survival. …”
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