Proprotein convertase 1/3-mediated down-regulation of brain-derived neurotrophic factor in cortical neurons induced by oxygen-glucose deprivation by Xiang-Yang Zhang, Feng Liu, Yan Chen, Wei-Chun Guo, Zhao-Hui Zhang

“…Proprotein convertase 1/3 (PC1/3) has a key role in the cleavage of protein precursors that are directed to regulated secretory pathways; however, it is not clear whether PC1/3 mediates the change in BDNF levels caused by ischemia. …”
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Bone Metastatic Breast Cancer: Advances in Cell Signaling and Autophagy Related Mechanisms by Ahmad Othman, Marcus Winogradzki, Linus Lee, Manish Tandon, Alan Blank, Jitesh Pratap

“…While transcriptional regulation of the metastatic process has been well established, recent findings from our and other research groups highlight the role of the autophagy and secretory pathways in interactions between resident and tumor cells during bone metastatic tumor growth. …”
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<i>Saccharomyces cerevisiae</i> and <i>Candida albicans</i> Yeast Cells Labeled with Fe(III) Complexes as MRI Probes by Akanksha Patel, Didar Asik, Eric M. Snyder, Joseph A. Spernyak, Paul J. Cullen, Janet R. Morrow

“…Appending a fluorescence dye to Fe(TOB) led to uptake through secretory pathways, as shown by confocal fluorescence microscopy and by the incomplete retrieval of the Fe(III) complex by the maltol treatment. …”
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In Vitro Organoid-Based Assays Reveal SMAD4 Tumor-Suppressive Mechanisms for Serrated Colorectal Cancer Invasion by Kevin Tong, Manisha Bandari, Jillian N. Carrick, Anastasia Zenkevich, Om A. Kothari, Eman Shamshad, Katarina Stefanik, Katherine S. Haro, Ansu O. Perekatt, Michael P. Verzi

“…RNA-Seq analysis reveals that SMAD4 expression in organoids rapidly regulates transcripts associated with extracellular matrix and secreted proteins, suggesting that the mechanisms employed by SMAD4 to inhibit invasion are associated with regulation of extracellular matrix and secretory pathways. These findings indicate new models to study SMAD4 regulation of tumor invasion and an additional layer of complexity in the tumor-suppressive function of the SMAD4/Tgfβ pathway.…”
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Ozone and procaine increase secretion of platelet-derived factors in platelet-rich plasma by Chiara Rita Inguscio, Barbara Cisterna, Maria Assunta Lacavalla, Franco Donati, Osvaldo Angelini, Gabriele Tabaracci, Manuela Malatesta

“…Therefore, ozone and procaine proved to have a remarkable stimulating potential without causing any damage to platelets, probably because they act through physiological, although different, secretory pathways. …”
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A Novel Dual-Reporter System Reveals Distinct Characteristics of Exosome-Mediated Protein Secretion in Human Cells by Christopher Olson, Pengyang Zhang, Joy Ku, Renceh Flojo, Darin Boyes, Biao Lu

“…Results Our results demonstrated that the engineered dual-reporters effectively monitored both exosome-mediated and ER-Golgi-mediated secretory pathways in a specific and quantitative manner. …”
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Unconventional secretion of tau by VAMP8 impacts its intra- and extracellular cleavage by Julie Pilliod, Maude Gélinas-Faucher, Nicole Leclerc, Nicole Leclerc

“…Consistent with this, several laboratories including ours have shown that Tau is secreted by neurons through unconventional secretory pathways. Recently, we reported that VAMP8, an R-SNARE found on late endosomes, increased Tau secretion and that secreted Tau was cleaved at the C-terminal. …”
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Loss of mfsd8 alters the secretome during Dictyostelium aggregation by Robert J. Huber, Joshua Gray, William D. Kim

“…GO term enrichment analyses showed that many of the proteins aberrantly released by mfsd8- cells localize to compartments and regions of the cell associated with the endo-lysosomal and secretory pathways. Mass spectrometry also revealed proteins previously known to be impacted by the loss of mfsd8 (e.g., cathepsin D), as well as proteins that may underlie mfsd8-deficiency phenotypes during aggregation. …”
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Application of Autoencoder Interpolation to Enhance the Accuracy of Single-Cell Transcriptomic Analysis in Early Porcine Embryos by Zehang HUANG, Zhiqiang DU

“…Functional enrichment analysis further unearthed key biological processes and signaling pathways that were significantly different among the three different types of embryos, such as basic biological processes and cellular metabolism in porcine in vivo fertilized embryos, gonadal development and sex determination in porcine in vitro fertilized embryos and immune defenses and regulation of secretory pathways in orphaned embryos.【Conclusion】The autoencoder was adopted to improve the analytical accuracy of single-cell transcriptome data, whereby the key genes and signaling pathways affecting early embryonic development in three embryonic activation modes were revealed, which provided new ideas for further in-depth study of the molecular mechanisms underlying early embryonic development in porcine.…”
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Neuronal Trafficking of the Amyloid Precursor Protein—What Do We Really Know? by Tong Lin, Lars O. Tjernberg, Sophia Schedin-Weiss

“…In this review, we summarize critical mechanisms underlying neuronal APP transport, which we divide into separate parts: (1) secretory pathways and (2) endocytic and autophagic pathways. …”
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Signal peptide discrimination and cleavage site identification using SVM and NN by Kazemian, Hassan, Yusuf, Syed A., White, Kenneth

“…About 15% of all proteins in a genome contain a signal peptide (SP) sequence, at the N-terminus, that targets the protein to intracellular secretory pathways. Once the protein is targeted correctly in the cell, the SP is cleaved, releasing the mature protein. …”
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Cell-Clearing Systems Bridging Repeat Expansion Proteotoxicity and Neuromuscular Junction Alterations in ALS and SBMA by Fiona Limanaqi, Carla Letizia Busceti, Francesca Biagioni, Federica Cantini, Paola Lenzi, Francesco Fornai

“…In fact, autophagy and the UPS intermingle with endocytic/secretory pathways to regulate axonal homeostasis and neurotransmission by interacting with key proteins which operate at the NMJ, such as agrin, acetylcholine receptors (AChRs), and adrenergic beta2 receptors (B2-ARs). …”
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Annexin A6 Polymorphism Is Associated with Pro-atherogenic Lipid Profiles and with the Downregulation of Methotrexate on Anti-Atherogenic Lipid Profiles in Psoriasis by Fuxin Zhang, Ling Han, Bing Wang, Qiong Huang, Nikhil Yawalkar, Zhenghua Zhang, Kexiang Yan

“…Background: Annexin A6 (AnxA6) is a lipid-binding protein that regulates cholesterol homeostasis and secretory pathways. However, the correlation of AnxA6 polymorphism with lipometabolism has never been studied in psoriasis. …”
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The Early Endocytosis Gene <i>PAL1</i> Contributes to Stress Tolerance and Hyphal Formation in <i>Candida albicans</i> by Miranda Yu, Dakota Ma, Susan Eszterhas, Christiane Rollenhagen, Samuel A. Lee

“…The endocytic and secretory pathways of the fungal pathogen <i>Candida albicans</i> are fundamental to various key cellular processes such as cell growth, cell wall integrity, protein secretion, hyphal formation, and pathogenesis. …”
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Respiratory Syncytial Virus Infection Induces Chromatin Remodeling to Activate Growth Factor and Extracellular Matrix Secretion Pathways by Xiaofang Xu, Dianhua Qiao, Morgan Mann, Roberto P. Garofalo, Allan R. Brasier

“…These induced chromatin modifications are associated with complex gene expression profiles controlling tyrosine kinase growth factor signaling and extracellular matrix (ECM) secretory pathways. Of these, RSV induces formation of nucleosome-free regions on <i>TGFB1/JUNB//FN1/MMP9</i> genes and the rate limiting enzyme in the hexosamine biosynthetic pathway (HBP), Glutamine-Fructose-6-Phosphate Transaminase 2 (<i>GFPT2</i>). …”
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Metabolomic Analysis of Extracellular Vesicles from the Cereal Fungal Pathogen <i>Fusarium graminearum</i> by Donovan Garcia-Ceron, Thy T. Truong, Julian Ratcliffe, James A. McKenna, Mark R. Bleackley, Marilyn A. Anderson

“…Despite the huge impact of <i>F. graminearum</i> on food security and mammalian health, the mechanisms used by <i>F. graminearum</i> to export virulence factors during infection are not fully understood and may involve non-classical secretory pathways. Extracellular vesicles (EVs) are lipid-bound compartments produced by cells of all kingdoms that transport several classes of macromolecules and are implicated in cell–cell communication. …”
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Physiologically-Based Pharmacokinetic Modeling for Drug-Drug Interactions of Procainamide and N-Acetylprocainamide with Cimetidine, an Inhibitor of rOCT2 and rMATE1, in Rats by Yoo-Seong Jeong, Anusha Balla, Kwang-Hoon Chun, Suk-Jae Chung, Han-Joo Maeng

“…Considering that these drugs could share similar renal secretory pathways (e.g., via rOCT2 and rMATE1), a physiologically-based pharmacokinetic (PBPK) model incorporating semi-mechanistic kidney compartments was devised to predict drug-drug interactions (DDIs). …”
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The SARS-Coronavirus Infection Cycle: A Survey of Viral Membrane Proteins, Their Functional Interactions and Pathogenesis by Nicholas A. Wong, Milton H. Saier

“…We compare the various structural and nonstructural proteins within the Coronaviridae family to elucidate potential overlaps and parallels in function, focusing primarily on the transmembrane proteins and their influences on host membrane arrangements, secretory pathways, cellular growth inhibition, cell death and immune responses during the viral replication cycle. …”
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Genetic regulation of membrane trafficking, exosome secretion, growth and dense-core granule biogenesis in the Drosophila accessory gland by Redhai, S

“…<p>Many epithelial cell types, particularly those in glands, employ distinct regulated and constitutive secretory pathways to perform their functions. Understanding how membrane trafficking and secretion are coupled to other cellular functions like growth, which is also thought to be linked to secretory and endocytic functions, is fundamental to cell biology and to certain pathologies such as diabetes and cancer. …”

Peroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape by Barbora Salovska, Alexandra Kondelova, Kristyna Pimkova, Zuzana Liblova, Miroslav Pribyl, Ivo Fabrik, Jiri Bartek, Marie Vajrychova, Zdenek Hodny

“…Subsequent SILAC-iodoTMT and secretome analysis after PRDX6 silencing showed the downregulation of PRDX6 in IRIS affected protein secretory pathways, decreased expression of extracellular matrix proteins, and led to unexpected attenuation of senescence-associated secretory phenotype (SASP). …”
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