Multiple TLRs elicit alternative NLRP3 inflammasome activation in primary human monocytes independent of RIPK1 kinase activity by Sarah Unterberger, Lisa Mullen, Melanie S. Flint, Sandra Sacre

“…Together these data suggest that the alternative pathway operates independently of RIPK1 kinase activity, downstream of diverse TLRs including TLR4 in primary human monocytes and supports the potential for IL-1β release via GSDMD pores alongside other unconventional secretory pathways.…”
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Characterization of the late embryogenesis abundant (LEA) proteins family and their role in drought stress tolerance in upland cotton by Richard Odongo Magwanga, Pu Lu, Joy Nyangasi Kirungu, Hejun Lu, Xingxing Wang, Xiaoyan Cai, Zhongli Zhou, Zhenmei Zhang, Haron Salih, Kunbo Wang, Fang Liu

“…Majority of the LEA genes were involved in secretory pathways. Expression profile analysis indicated that most of the LEA genes were highly expressed in drought tolerant cultivars Gossypium tomentosum as opposed to drought susceptible, G. hirsutum. …”
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<i>Arabidopsis</i> SEC13B Interacts with Suppressor of Frigida 4 to Repress Flowering by Yanqi Yang, Hao Tian, Chunxue Xu, Haitao Li, Yan Li, Haitao Zhang, Biaoming Zhang, Wenya Yuan

“…SECRETORY13 (SEC13) is an essential member of the coat protein complex II (COPII), which was reported to mediate vesicular-specific transport from the endoplasmic reticulum (ER) to the Golgi apparatus and plays a crucial role in early secretory pathways. In <i>Arabidopsis</i>, there are two homologous proteins of SEC13: SEC13A and SEC13B. …”
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Network Pharmacology Integrated Molecular Docking and Dynamics to Elucidate Saffron Compounds Targeting Human COX-2 Protein by Aarif Ali, Amir Bashir Wani, Bashir Ahmad Malla, Jagadeesha Poyya, Nawab John Dar, Fasil Ali, Sheikh Bilal Ahmad, Muneeb U. Rehman, Ahmed Nadeem

“…Compartmentalized Protein–Protein Interaction identified 90 interactions with an average interaction score of 0.62, and the highest localization score of 0.99 found in secretory pathways. The Computed Atlas of Surface Topography of Proteins was used to identify binding pockets and important residues that could serve as drug targets. …”
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