Itm2a expression in the developing mouse first lower molar, and the subcellular localization of Itm2a in mouse dental epithelial cells. by Makiko Kihara, Tamotsu Kiyoshima, Kengo Nagata, Hiroko Wada, Hiroaki Fujiwara, Kana Hasegawa, Hirotaka Someya, Ichiro Takahashi, Hidetaka Sakai

“…These findings suggest that Itm2a may play a role in cell differentiation during odontogenesis, rather than during the initiation of tooth germ formation, and may be related to the targeting of proteins associated with enamel and dentin matrices in the secretory pathway.…”
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LncRNAs and CircRNAs in Endoplasmic Reticulum Stress: A Promising Target for Cardiovascular Disease? by Francisco José Martinez-Amaro, Carlos Garcia-Padilla, Diego Franco, Houria Daimi

“…The endoplasmic reticulum (ER) is a principal subcellular organelle responsible for protein quality control in the secretory pathway, preventing protein misfolding and aggregation. …”
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When Supply Does Not Meet Demand-ER Stress and Plant Programmed Cell Death by Brett eWilliams, Jeanmarie eVerchot, Martin eDickman

“…The endoplasmic reticulum (ER) is the central organelle in the eukaryotic secretory pathway. The ER functions in protein synthesis and maturation and is crucial for proper maintenance of cellular homeostasis and adaptation to adverse environments. …”
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A genetically encoded toolkit of functionalized nanobodies against fluorescent proteins for visualizing and manipulating intracellular signalling by David L. Prole, Colin W. Taylor

“…These include fluorescent sensors for visualization of Ca2+, H+ and ATP/ADP dynamics; oligomerising or heterodimerising modules that allow recruitment or sequestration of proteins and identification of membrane contact sites between organelles; SNAP tags that allow labelling with fluorescent dyes and targeted chromophore-assisted light inactivation; and nanobodies targeted to lumenal sub-compartments of the secretory pathway. We also developed two methods for crosslinking tagged proteins: a dimeric nanobody, and RFP-targeting and GFP-targeting nanobodies fused to complementary hetero-dimerizing domains. …”
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The CELF1 RNA-Binding Protein Regulates Decay of Signal Recognition Particle mRNAs and Limits Secretion in Mouse Myoblasts. by Joseph Russo, Jerome E Lee, Carolina M López, John Anderson, Thuy-Mi P Nguyen, Adam M Heck, Jeffrey Wilusz, Carol J Wilusz

“…We previously identified several mRNAs encoding components of the secretory pathway, including signal recognition particle (SRP) subunit mRNAs, among transcripts associated with the RNA-binding protein CELF1. …”
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Canonical and Non-Canonical Roles of SNX1 and SNX2 in Endosomal Membrane Dynamics by Juliane Da Graça, Etienne Morel

“…In this context, their primary identified biological roles—and their partnership—are tightly associated with the retromer and endosomal SNX–BAR sorting complex for promoting exit 1 complex trafficking, facilitating the transport of cargoes from early endosomes to the secretory pathway. However, recent literature indicates that these proteins also possess biological functions in other aspects of endosomal features and sorting processes. …”
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Specific targeting of a plasmodesmal protein affecting cell-to-cell communication. by Carole L Thomas, Emmanuelle M Bayer, Christophe Ritzenthaler, Lourdes Fernandez-Calvino, Andrew J Maule

“…PDLP1a is targeted to plasmodesmata via the secretory pathway in a Brefeldin A-sensitive and COPII-dependent manner, and resides at plasmodesmata with its C-terminus in the cytoplasmic domain and its N-terminus in the apoplast. …”
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Microglial microvesicles secretion and intercellular signalling by Elena eTurola, Elena eTurola, Roberto eFurlan, Fabio eBianco, Michela eMatteoli, Michela eMatteoli, Michela eMatteoli, Claudia eVerderio, Claudia eVerderio

“…In this review, we summarize first evidence indicating that MV shedding is a process activated by the ATP receptor P2X7 and that shed MVs represent a secretory pathway for the inflammatory cytokine IL-1beta We then discuss subsequent findings which clarify how IL-1beta can be locally processed and released from MVs into the extracellular environment. …”
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ATP7A-Regulated Enzyme Metalation and Trafficking in the Menkes Disease Puzzle by Nina Horn, Pernilla Wittung-Stafshede

“…We here summarize the current knowledge of the roles of copper enzyme function in Menkes disease, with a focus on ATP7A-mediated enzyme metalation in the secretory pathway. By establishing mechanistic relationships between copper-dependent cellular processes and Menkes disease symptoms in patients will not only increase understanding of copper biology but will also allow for the identification of an expanding range of copper-dependent enzymes and pathways. …”
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New Insights into the Control of Pulsatile GnRH Release: the Role of Kiss1/Neurokinin B Neurons by Víctor M. Navarro

“…Kisspeptins, secreted from hypothalamic Kiss1 neurons, are poised as major conduits to regulate this dual secretory pathway. Kiss1 neurons are diverse in origin, nature and function, convening distinct neuronal populations in two main hypothalamic nuclei: the arcuate nucleus (ARC) and the anteroventral periventricular nucleus (AVPV). …”
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The Nβ motif of NaTrxh directs secretion as an endoplasmic reticulum transit peptide and variations might result in different cellular targeting. by Andre Zaragoza-Gómez, Emilio García-Caffarel, Yuridia Cruz-Zamora, James González, Víctor Hugo Anaya-Muñoz, Felipe Cruz-García, Javier Andrés Juárez-Díaz

“…During translation, the signal peptide is recognised by the signal recognition particle and results in a co-translational translocation to the endoplasmic reticulum to continue the secretory pathway. However, soluble secretory proteins lacking a signal peptide are also abundant, and several unconventional (endoplasmic reticulum/Golgi independent) pathways have been proposed and some demonstrated. …”
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The Dynamic Landscape of Capsid Proteins and Viral RNA Interactions in Flavivirus Genome Packaging and Virus Assembly by Anastazia Jablunovsky, Joyce Jose

“…During the maturation process, which involves the low pH-mediated structural rearrangement of prM and E and furin cleavage of prM in the secretory pathway, the spiky immature virus with a partially ordered nucleocapsid core becomes a smooth, mature virus with no discernible nucleocapsid. …”
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Investigation of ER to Golgi trafficking during mitosis by Wong, Karuno Song Yao

“…The secretory pathway facilitates movement of newly synthesized proteins (cargos) to the extracellular space to maintain cellular homeostasis. …”
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Secreted proteins defy the expression level–evolutionary rate anticorrelation by Feyertag, F, Berninsone, P, Alvarez-Ponce, D

“…We hypothesize that each of these factors (the secretory pathway quality control and extracellular location) may reduce the strength of the E–R anticorrelation. …”

Perforin rapidly induces plasma membrane phospholipid flip-flop. by Metkar, S, Wang, B, Catalan, E, Anderluh, G, Gilbert, R, Pardo, J, Froelich, C

“…The cytotoxic cell granule secretory pathway is essential for host defense. This pathway is fundamentally a form of intracellular protein delivery where granule proteases (granzymes) from cytotoxic lymphocytes are thought to diffuse through barrel stave pores generated in the plasma membrane of the target cell by the pore forming protein perforin (PFN) and mediate apoptotic as well as additional biological effects. …”

Syntaxin of plants71 plays essential roles in plant development and stress response via regulating pH homeostasis by Hailong Zhang, Jingwen Zhou, Xiaoyue Kou, Yuqi Liu, Xiaonan Zhao, Xiaonan Zhao, Guochen Qin, Mingyu Wang, Guangtao Qian, Wen Li, Yongshun Huang, Xiaoting Wang, Zhenjie Zhao, Shuang Li, Xiaoqian Wu, Lixi Jiang, Xianzhong Feng, Jian-Kang Zhu, Jian-Kang Zhu, Lixin Li

“…Furthermore, we identified AtSYP71 partners and propose that AtSYP71 forms distinct SNARE complexes to mediate multiple membrane fusion steps in secretory pathway. Our findings suggest that AtSYP71 plays an essential role in plant development and stress response via regulating pH homeostasis through secretory pathway.…”
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Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling by Adam Graham Grieve, Hongmei Xu, Ulrike Künzel, Paul Bambrough, Boris Sieber, Matthew Freeman

“…Here, we reveal that iRhom2 remains associated with TACE throughout the secretory pathway, and is stabilised at the cell surface by this interaction. …”
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S100A12 suppresses pro-inflammatory, but not pro-thrombotic functions of serum amyloid A. by Yuen Ming Chung, Jesse Goyette, Nicodemus Tedla, Kenneth Hsu, Carolyn L Geczy

“…S100A12 did not alter cytokine mRNA stability or the cytokine secretory pathway. S100A12 and serum amyloid A did not appear to form complexes and although they may have common receptors, suppression was unlikely via receptor competition. …”
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The ArfGAP2/3 Glo3 and ergosterol collaborate in transport of a subset of cargoes by Alejandro F. Estrada, Gopinath Muruganandam, Cristina Prescianotto-Baschong, Anne Spang

“…Proteins reach the plasma membrane through the secretory pathway in which the trans Golgi network (TGN) acts as a sorting station. …”
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Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model. by Winston T Stauffer, Asha Z Goodman, Michael Bobardt, Daren R Ure, Robert T Foster, Philippe Gallay

“…Further investigation is necessary to determine whether the specific role of CypB in the endoplasmic reticulum secretory pathway is of significance to its effect on NASH development.…”
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