Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines by Aaron B Bowen, Ashley M Bourke, Brian G Hiester, Cyril Hanus, Matthew J Kennedy

“…Following ER exit, the AMPA-type glutamate receptor GluA1 and neuroligin 1 undergo spatially restricted entry into the dendritic secretory pathway and accumulate in recycling endosomes (REs) located in dendrites and spines before reaching the plasma membrane. …”
Get full text

Spatial partitioning of secretory cargo from Golgi resident proteins in live cells by White Jamie, Keller Patrick, Stelzer Ernst HK

“…</p> <p>Conclusions</p> <p>Our results establish domain formation via rapid lateral partitioning as a general cellular strategy for segregating different transmembrane proteins along the secretory pathway and provide a framework for consideration of molecular mechanisms of secretory transport.…”
Get full text

Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate. by Elizabeth Stansell, Maria Panico, Kevin Canis, Poh-Choo Pang, Laura Bouché, Daniel Binet, Michael-John O'Connor, Elena Chertova, Julian Bess, Jeffrey D Lifson, Stuart M Haslam, Howard R Morris, Ronald C Desrosiers, Anne Dell

“…As HIV-1-encoded envelope protein traverses the secretory pathway, it may be modified with N- and O-linked carbohydrate. …”
Get full text

Synchronized proinsulin trafficking reveals delayed Golgi export accompanies β-cell secretory dysfunction in rodent models of hyperglycemia by Cierra K. Boyer, Casey J. Bauchle, Jianchao Zhang, Yanzhuang Wang, Samuel B. Stephens

“…In this report, we utilized the synchronous protein trafficking system, RUSH, in primary β-cells to evaluate proinsulin transit through the secretory pathway leading to insulin granule formation. …”
Get full text

Activators and Effectors of the Small G Protein Arf1 in Regulation of Golgi Dynamics During the Cell Division Cycle by Catherine L. Jackson

“…The Golgi apparatus, the central sorting and modification station of the secretory pathway, disassembles during mitosis, a process that depends on Arf1 and its regulators and effectors. …”
Get full text

Comparative transcriptomics reveals CrebA as a novel regulator of infection tolerance in D. melanogaster. by Katia Troha, Joo Hyun Im, Jonathan Revah, Brian P Lazzaro, Nicolas Buchon

“…Upon infection, CrebA is upregulated by both the Toll and Imd pathways in the fat body, where it is required to induce the expression of secretory pathway genes. Loss of CrebA during infection triggered endoplasmic reticulum (ER) stress and activated the unfolded protein response (UPR), which contributed to infection-induced mortality. …”
Get full text

Morpho-functional architecture of the Golgi complex of neuroendocrine cells by Emma eMartínez-Alonso, Mónica eTomás, José A. eMartínez-Menárguez

“…The Golgi complex is considered the central station of the secretory pathway of proteins and lipids en route to their final destination. …”
Get full text

The molecular basis of chaperone-mediated interleukin 23 assembly control by Susanne Meier, Sina Bohnacker, Carolin J. Klose, Abraham Lopez, Christian A. Choe, Philipp W. N. Schmid, Nicolas Bloemeke, Florian Rührnößl, Martin Haslbeck, Julia Esser-von Bieren, Michael Sattler, Po-Ssu Huang, Matthias J. Feige

“…It is unclear how unassembled secretory pathway proteins are discriminated from misfolded ones. …”
Get full text

Proprotein Convertases and the Complement System by József Dobó, Andrea Kocsis, Ráhel Dani, Péter Gál

“…Prohormones are typically processed in the regulated secretory pathway, while most plasma proteins travel though the constitutive pathway. …”
Get full text

GABA_Areceptor dynamics and constructing GABAergic synapses by Verena Tretter, Stephen J Moss, Stephen J Moss

“…Like all multisubunit membrane proteins the GABA_A receptor is assembled in the ER and travels through the Golgi and remaining secretory pathway to the cell surface, where it mediates GABA actions either directly at the synapses or at extrasynaptic sites responding to ambient GABA to provide a basal tonic inhibitory state. …”
Get full text

Secretion of pro-oncogenic AGR2 protein in cancer by Nurshahirah Ashikin Moidu, Nisa Syakila A Rahman, Saiful Effendi Syafruddin, Teck Yew Low, M. Aiman Mohtar

“…Anterior gradient-2 (AGR2) protein mediates the formation, breakage and isomerization of disulphide bonds during protein maturation in the endoplasmic reticulum (ER) and contributes to the homoeostasis of the secretory pathway. AGR2 promotes tumour development and metastasis and its elevated expression is almost completely restricted to malignant tumours. …”
Get full text

Nutrient Regulation of Pancreatic Islet β-Cell Secretory Capacity and Insulin Production by Kristen E. Rohli, Cierra K. Boyer, Sandra E. Blom, Samuel B. Stephens

“…Furthermore, we will highlight potential defects in the secretory pathway that limit or delay insulin granule biosynthesis, which may contribute to the decline in β-cell function during the pathogenesis of T2D.…”
Get full text

Silico Functional Annotation and Molecular Characterization of an Uncharacterized Protein MBO_502153 of Mycobacterium Tuberculosis Variant Bovis by Tarhima Jerin, Nahid Sharmin, Sheikh Raihan

“…The uncharacterized protein MBO_502153 also does not involve any non-classical secretory pathway. Conclusion: It can be concluded that the purposeful annotation of uncharacterized supermolecule showed some chemical activities, particularly degradation of the environmental waste product 4-chlorobenzoate and xenobiotics and synthesis of polyhydroxyalkanoate (PHA), which play an important role in environmental biodegradability and biocompatibility.…”
Get full text

Role of PCSK5 expression in mouse ovarian follicle development: identification of the inhibin α- and β-subunits as candidate substrates. by Monica Antenos, Lei Lei, Min Xu, Anjali Malipatil, Sarah Kiesewetter, Teresa K Woodruff

“…Furin is a subtilisin-like proprotein convertase (proconvertase) that activates precursor proteins by cleavage at basic sites during their transit through the secretory pathway and/or at the cell surface. We hypothesized that furin-like proconvertases are central regulators of inhibin α- and β-subunit processing within the ovary. …”
Get full text

Engineering the vaccinia virus L1 protein for increased neutralizing antibody response after DNA immunization by Moss Bernard, Irvine Kari R, Wyatt Linda S, Shinoda Kaori

“…When expressed by vaccinia virus, the unglycosylated, myristoylated L1 protein attaches to the viral membrane via a C-terminal transmembrane anchor without traversing the secretory pathway. The purpose of the present study was to investigate modifications of the gene expressing the L1 protein that would increase immunogenicity in mice when delivered by a gene gun.…”
Get full text

Nuclear variants of bone morphogenetic proteins by Meinhart Christopher A, Gaufin Stephanie L, Sperry Daniel K, Jensen J Daniel, Loos Trina J, Mayo Jaime L, Felin Jenny E, Moss Jennie B, Bridgewater Laura C

“…The resulting proteins lack N-terminal signal peptides and are therefore translated in the cytoplasm rather than the endoplasmic reticulum, thus avoiding proteolytic processing in the secretory pathway. Instead, the uncleaved proteins (designated nBmp2, nBmp4, and nGdf5) containing the intact NLSs are translocated to the nucleus. …”
Get full text

PAWH1 and PAWH2 are plant-specific components of an Arabidopsis endoplasmic reticulum-associated degradation complex by Liangguang Lin, Congcong Zhang, Yongwu Chen, Yi Wang, Dinghe Wang, Xiaolei Liu, Muyang Wang, Juan Mao, Jianjun Zhang, Weiman Xing, Linchuan Liu, Jianming Li

“…Endoplasmic reticulum (ER)-associated degradation (ERAD) removes misfolded proteins from the secretory pathway. Here the authors identify two plant-specific proteins in Arabidopsis, PAWH1 and PAWH2, that bind to and stabilise the ER-anchored ubiquitin ligase Hrd1.…”
Get full text

Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid β protein by Lopez-Coviella Ignacio, Balcz Brigitte A, Carey Robyn M, Slack Barbara E

“…<p>Abstract</p> <p>Background</p> <p>The amyloid precursor protein (APP) is transported via the secretory pathway to the cell surface, where it may be cleaved within its ectodomain by α-secretase, or internalized within clathrin-coated vesicles. …”
Get full text

Quantitative proteomics reveals the effect of protein glycosylation in soybean root under flooding stress by Ghazala eMUSTAFA, Ghazala eMUSTAFA, Setsuko eKomatsu

“…Also the accumulation level of glycoproteins localized in the secretory pathway (e.g., peroxidases and plycosyl hydrolases) decreased under flooding stress. …”
Get full text

Systematic mutational analysis of the intracellular regions of yeast Gap1 permease. by Ahmad Merhi, Nicolas Gérard, Elsa Lauwers, Martine Prévost, Bruno André

“…Finally, a mutation in L6 causes missorting of Gap1 from the secretory pathway to the vacuole. Interestingly, this direct vacuolar sorting seems to be independent of Gap1 ubiquitylation.…”
Get full text