Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors by Eszter Zavodszky, Ramanujan S Hegde

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Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2 by Karsten Nalbach, Martina Schifferer, Debjani Bhattacharya, Hung Ho-Xuan, Wei Chou Tseng, Luis A. Williams, Alexandra Stolz, Stefan F. Lichtenthaler, Zvulun Elazar, Christian Behrends

“…Moreover, we provide evidence that TECPR2’s interaction with the early secretory pathway is not restricted to COPII carriers. …”
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Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b. by Ding Ye, Xiaosi Wang, Changyong Wei, Mudan He, Houpeng Wang, Yanwu Wang, Zuoyan Zhu, Yonghua Sun

“…We concluded that the Marcksb modulates BMP signaling through regulating the secretory pathway of Bmp2b.…”
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The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway by Nils Stührwohldt, Stefan Scholl, Lisa Lang, Julia Katzenberger, Karin Schumacher, Andreas Schaller

“…We show here that the biogenesis of CLEL6 and CLEL9 peptides in Arabidopsis thaliana requires a series of processing events in consecutive compartments of the secretory pathway. Following cleavage of the signal peptide upon entry into the endoplasmic reticulum (ER), the peptide precursors are processed in the cis-Golgi by the subtilase SBT6.1. …”
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Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer by Simona Del Giudice, Valentina De Luca, Seyedehnegar Parizadeh, Domenico Russo, Alberto Luini, Rosaria Di Martino

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Defining the altered glycoproteomic space of the early secretory pathway by class I mannosidase pharmacological inhibition by Cristian V. A. Munteanu, Gabriela N. Chirițoiu, Andrei-Jose Petrescu, Ștefana M. Petrescu

“…Although these are vital processes in maintaining cellular homeostasis, large-scale analysis studies for this pool of molecules, further denoted as proteins from the early secretory pathway (ESP), were limited addressed. Here, using a custom workflow employing a combination of glycomics and deglycoproteomics analyses, using lectin affinity and selective Endoglycosidase H (Endo H) digestion, we scrutinize the steady-state oligomannosidic glycoprotein load and delineate ESP fraction in melanoma cells. …”
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The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole. by Guillermo Arango Duque, Armando Jardim, Étienne Gagnon, Mitsunori Fukuda, Albert Descoteaux

“…Our findings unveil a mechanism whereby a vacuolar pathogen takes advantage of the host cell's secretory pathway to promote egress of virulence factors beyond the PV.…”
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The regulated secretory pathway and human disease: insights from gene variants and single nucleotide polymorphisms by Stephen eSalton, Stephen eSalton, Wei Jye Lin

“…The regulated secretory pathway provides critical control of peptide, growth factor, and hormone release from neuroendocrine and endocrine cells, and neurons, maintaining physiological homeostasis. …”
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Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway by Inca A. Dieterich, Yusi Cui, Megan M. Braun, Alexis J. Lawton, Nicklaus H. Robinson, Jennifer L. Peotter, Qing Yu, Jason C. Casler, Benjamin S. Glick, Anjon Audhya, John M. Denu, Lingjun Li, Luigi Puglielli

“…Collectively our results indicate that AT-1 is essential to maintain proper organization and engagement of the secretory pathway.…”
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Laboratory evolution of fast-folding green fluorescent protein using secretory pathway quality control. by Adam C Fisher, Matthew P DeLisa

“…This prompted us to hypothesize that the folding quality control inherent to this secretory pathway could be used as a platform for engineering similar 'superfolded' proteins. …”
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The golgin tether giantin regulates the secretory pathway by controlling stack organization within Golgi apparatus. by Mayuko Koreishi, Thomas J Gniadek, Sidney Yu, Junko Masuda, Yasuko Honjo, Ayano Satoh

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The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis by Benjamin S. Roberts, Prasanna Satpute-Krishnan

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The Intra- and Intercellular Movement of Melon necrotic spot virus (MNSV) Depends on an Active Secretory Pathway by Ainhoa Genovés, Jose Antonio Navarro, Vicente Pallás

“…Hence, the secretory pathway inhibitor, Brefeldin A (BFA), and the overexpression of the GTPase-defective mutant of Sar1p, Sar1[H74L], fully retained the p7B within the ER, revealing that the protein is delivered to PD in a BFA-sensitive and COPII-dependent manner. …”
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Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion by Jahir M. Gutierrez, Amir Feizi, Shangzhong Li, Thomas B. Kallehauge, Hooman Hefzi, Lise M. Grav, Daniel Ley, Deniz Baycin Hizal, Michael J. Betenbaugh, Bjorn Voldborg, Helene Faustrup Kildegaard, Gyun Min Lee, Bernhard O. Palsson, Jens Nielsen, Nathan E. Lewis

“…The secretory pathway is used in the production of most biopharmaceuticals, but the associated biosynthetic costs are little understood. …”
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Phospholipase D2 Modulates the Secretory Pathway in RBL-2H3 Mast Cells. by Claudia Maria Meirelles Marchini-Alves, Valeria Cintra Barbosa Lorenzi, Elaine Zayas Marcelino da Silva, Vivian Marino Mazucato, Maria Celia Jamur, Constance Oliver

“…The aim of the present study was to clarify the role of PLD2 in the secretory pathway. RBL-2H3 cells, a mast cell line, transfected to overexpress catalytically active (PLD2CA) and inactive (PLD2CI) forms of PLD2 were used. …”
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BECLIN1 Is Essential for Podocyte Secretory Pathways Mediating VEGF Secretion and Podocyte-Endothelial Crosstalk by Tillmann Bork, Wei Liang, Oliver Kretz, Simon Lagies, Kosuke Yamahara, Camila Hernando-Erhard, Martin Helmstädter, Christoph Schell, Bernd Kammerer, Tobias B. Huber

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Isolation and characterization of mutations in SEC13, a gene required for multiple steps in the secretory pathway by Bickel, Stephen E

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Author Correction: Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2 by Karsten Nalbach, Martina Schifferer, Debjani Bhattacharya, Hung Ho-Xuan, Wei Chou Tseng, Luis A. Williams, Alexandra Stolz, Stefan F. Lichtenthaler, Zvulun Elazar, Christian Behrends

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Impact of interorganelle coordination between the conventional early secretory pathway and autophagy in cellular homeostasis and stress response by Diego Tapia, Viviana A. Cavieres, Patricia V. Burgos, Patricia V. Burgos, Jorge Cancino

“…The conventional early secretory pathway and autophagy are two essential interconnected cellular processes that are crucial for maintaining cellular homeostasis. …”
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The key target of neuroprotection after the onset of ischemic stroke: secretory pathway Ca 2+ -ATPase 1 by Li-hua Li, Xiang-rong Tian, Zhi-ping Hu

Subjects: “…nerve regeneration; brain injury; global cerebral ischemia; Golgi apparatus; Golgi stress; cytoplasmic Ca 2+ ; homeostasis; Golgi Ca 2+ ; Ca 2+ pump; secretory pathway Ca 2+ -ATPase 1; neural protection; NSFC grant; neural regeneration…”
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