Mutations in Membrin/GOSR2 Reveal Stringent Secretory Pathway Demands of Dendritic Growth and Synaptic Integrity by Roman Praschberger, Simon A. Lowe, Nancy T. Malintan, Carlo N.G. Giachello, Nian Patel, Henry Houlden, Dimitri M. Kullmann, Richard A. Baines, Maria M. Usowicz, Shyam S. Krishnakumar, James J.L. Hodge, James E. Rothman, James E.C. Jepson

“…Our study highlights how dendritic growth is vulnerable even to subtle secretory pathway deficits, uncovers a role for Membrin in synaptic function, and provides a comprehensive explanatory basis for genotype-phenotype relationships in GOSR2-PME.…”
Get full text

Kinetic evidence for both a fast and a slow secretory pathway for apolipoprotein A-I in humans by W R Fisher, V Venkatakrishnan, L A Zech, C M Hall, L L Kilgore, P W Stacpoole, M R Diffenderfer, K E Friday, A E Sumner, J B Marsh

Get full text

Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins by Takumi Wagatsuma, Eisuke Suzuki, Miku Shiotsu, Akiko Sogo, Yukina Nishito, Hideya Ando, Hisashi Hashimoto, Michael J. Petris, Masato Kinoshita, Taiho Kambe

Get full text

Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. by Vyacheslav M Labunskyy, Maxim V Gerashchenko, Joe R Delaney, Alaattin Kaya, Brian K Kennedy, Matt Kaeberlein, Vadim N Gladyshev

Get full text

Secretory pathway antagonism by calicivirus homologues of Norwalk virus nonstructural protein p22 is restricted to noroviruses by Sharp Tyler M, Crawford Sue E, Ajami Nadim J, Neill Frederick H, Atmar Robert L, Katayama Kazuhiko, Utama Budi, Estes Mary K

Subjects: Get full text

<it>In vivo </it>site-specific biotinylation of proteins within the secretory pathway using a single vector system by López-Requena Alejandro, Arnoldi Francesca, Predonzani Andrea, Burrone Oscar R

“…Upstream of the cDNA encoding BirA, a signal secretion leader sequence was added to allow translocation of the enzyme to the secretory pathway. Three different recombinant antibodies in the scFv format, a membrane bound and secretory truncated IgE Fc fragment and a soluble version of the human IgE high affinity receptor were shown to be efficiently biotinylated and to maintain their binding properties in immunofluorescence microscopy, flow cytometry and ELISA assays.…”
Get full text

Transcriptomic comparison of <it>Aspergillus niger </it>growing on two different sugars reveals coordinated regulation of the secretory pathway by van den Hondel Cees AMJJ, Goosen Theo, Jørgensen Thomas R, Ram Arthur FJ, Iversen Jens JL

“…It is known that the activities of certain secretory pathway enzymes involved <it>N</it>-glycosylation are elevated in response to carbon source induced secretion of the glycoprotein glucoamylase. …”
Get full text

Multiplexed CRISPR-mediated engineering of protein secretory pathway genes in the thermotolerant methylotrophic yeast Ogataea thermomethanolica. by Worarat Kruasuwan, Aekkachai Puseenam, Sutipa Tanapongpipat, Niran Roongsawang

“…Here, we refined CRISPR-based genome engineering tools for simultaneous mutagenesis and activation of multiple protein secretory pathway genes to improve heterologous protein secretion. …”
Get full text

Crosslinking assay to study a specific cargo-coat interaction through a transmembrane receptor in the secretory pathway. by Javier Manzano-Lopez, Sofia Rodriguez-Gallardo, Susana Sabido-Bozo, Alejandro Cortes-Gomez, Ana Maria Perez-Linero, Rafael Lucena, Antonio Cordones-Romero, Sergio Lopez, Auxiliadora Aguilera-Romero, Manuel Muñiz

Get full text

Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome by Amir Feizi, Francesco Gatto, Mathias Uhlen, Jens Nielsen

“…Gene expression: The human protein secretion pathway is tissue specific The secretory pathway, an ubiquitous cellular machinery in human cells, is here shown to have tissue-specific characteristics. …”
Get full text

Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans by Aruna Vedala, Wei Wang, Richard A. Neese, Mark P. Christiansen, Marc K. Hellerstein

Get full text

Combining manipulation of integration loci and secretory pathway on expression of an Aspergillus niger glucose oxidase gene in Trichoderma reesei by Wangli Ji, Xiaolu Wang, Xiaoqing Liu, Yuan Wang, Fangui Liu, Bo Xu, Huiying Luo, Tao Tu, Wei Zhang, Xinxin Xu, Xiaoyun Su

Subjects: Get full text

Hijack it, Change it: How do Plant Viruses Utilize the Host Secretory Pathway for Efficient Viral Replication and Spread? by Camilo ePatarroyo, Jean-François eLaliberté, Huanquan eZheng

“…The secretory pathway of eukaryotic cells has an elaborated set of endomembrane compartments involved in the synthesis, modification and sorting of proteins and lipids. …”
Get full text

Mutants of Xanthomonas oryzae pv. oryzae Deficient in General Secretory Pathway Are Virulence Deficient and Unable to Secrete Xylanase by Suvendra K. Ray, R. Rajeshwari, Ramesh V. Sonti

Get full text

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells by Isabel Gonçalves Silva, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Marco Bardelli, Luca Varani, Rohanah Hussain, Giuliano Siligardi, Giacomo Ceccone, Steffen M. Berger, Yuri A. Ushkaryov, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev

Get full text

A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure by Adam J Pollak, Canzhao Liu, Aparna Gudlur, Joshua E Mayfield, Nancy D Dalton, Yusu Gu, Ju Chen, Joan Heller Brown, Patrick G Hogan, Sandra E Wiley, Kirk L Peterson, Jack E Dixon

“…Our laboratory recently identified an atypical protein kinase, Fam20C, which is uniquely localized to the secretory pathway lumen. Here, we show that Fam20C phosphorylates several SR proteins involved in Ca2+ signaling, including calsequestrin2 and Stim1, whose biochemical activities are dramatically regulated by Fam20C mediated phosphorylation. …”
Get full text

Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases by Monilola A. Olayioye, Bettina Noll, Angelika Hausser

Subjects: Get full text

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion by Xiao-Wei Chen, He Wang, Kanika Bajaj, Pengcheng Zhang, Zhuo-Xian Meng, Danjun Ma, Yongsheng Bai, Hui-Hui Liu, Elizabeth Adams, Andrea Baines, Genggeng Yu, Maureen A Sartor, Bin Zhang, Zhengping Yi, Jiandie Lin, Stephen G Young, Randy Schekman, David Ginsburg

Subjects: “…Secretory pathway…”
Get full text

Influence of the purification of human adult pancreatic islets on insulin secretion by Nikolić Dragan M., Đorđević Predrag B., Dimitrijević-Srećković Vesna, Džingalašević Marina, Belij Sandra, Kalezić Nevena

Subjects: Get full text

Opening up new fronts in the fight against cholesterol by Russell A DeBose-Boyd, Jay D Horton

Subjects: “…Secretory pathway…”
Get full text