The Structure of <i>Clostridioides difficile</i> SecA2 ATPase Exposes Regions Responsible for Differential Target Recognition of the SecA1 and SecA2-Dependent Systems by Nataša Lindič, Jure Loboda, Aleksandra Usenik, Robert Vidmar, Dušan Turk

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Crosstalk among Calcium ATPases: PMCA, SERCA and SPCA in Mental Diseases by Tomasz Boczek, Marta Sobolczyk, Joanna Mackiewicz, Malwina Lisek, Bozena Ferenc, Feng Guo, Ludmila Zylinska

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Dimerization of the Vacuolar Receptors AtRMR1 and -2 from Arabidopsis thaliana Contributes to Their Localization in the trans-Golgi Network by Alessandro Occhialini, Guillaume Gouzerh, Gian-Pietro Di Sansebastiano, Jean-Marc Neuhaus

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A single polar residue and distinct membrane topologies impact the function of the infectious bronchitis coronavirus E protein. by Travis R Ruch, Carolyn E Machamer

“…We previously showed that the HD of the infectious bronchitis virus (IBV) E protein is required for the efficient release of infectious virus, an activity that correlated with disruption of the secretory pathway. Here we report that a single residue within the hydrophobic domain, Thr16, is required for secretory pathway disruption. …”
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Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease by Orkhontuya Tsedensodnom, Ana M. Vacaru, Deanna L. Howarth, Chunyue Yin, Kirsten C. Sadler

“…Recent data indicates that activation of the unfolded protein response (UPR) in response to secretory pathway dysfunction can cause steatosis. Here, we examined the relationship between alcohol metabolism, oxidative stress, secretory pathway stress and steatosis using zebrafish larvae. …”
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Formation of ER-lumenal intermediates during export of Plasmodium proteins containing transmembrane-like hydrophobic sequences. by Yvette S Levray, Bianca Bana, Sarah J Tarr, Emilia J McLaughlin, Peter Rossi-Smith, Anita Waltho, Georgina H Charlton, Riccardo Zenezini Chiozzi, Colin R Straton, Konstantinos Thalassinos, Andrew R Osborne

“…Exported proteins are trafficked via the parasite endoplasmic reticulum and secretory pathway, before being exported across the parasitophorous vacuole membrane into the erythrocyte. …”
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The ER Protein Translocation Channel Subunit Sbh1 Controls Virulence of Cryptococcus neoformans by Felipe H. Santiago-Tirado, Thomas Hurtaux, Jennifer Geddes-McAlister, Duy Nguyen, Volkhard Helms, Tamara L. Doering, Karin Römisch

“…Sbh1, the most divergent, contains multiple phosphorylation sites, which may allow it to regulate entry into the secretory pathway in a species- and protein-specific manner. …”
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ER exit in physiology and disease by Claire M. Robinson, Claire M. Robinson, Aislinn Duggan, Aislinn Duggan, Alison Forrester

“…The biosynthetic secretory pathway is comprised of multiple steps, modifications and interactions that form a highly precise pathway of protein trafficking and secretion, that is essential for eukaryotic life. …”
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Impact of Hypermannosylation on the Structure and Functionality of the ER and the Golgi Complex by Patricia Franzka, Svenja Caren Schüler, Takfarinas Kentache, Robert Storm, Andrea Bock, Istvan Katona, Joachim Weis, Katrin Buder, Christoph Kaether, Christian A. Hübner

“…Proteins of the secretory pathway undergo glycosylation in the endoplasmic reticulum (ER) and the Golgi apparatus. …”
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Stapled Golgi cisternae remain in place as cargo passes through the stack by Gregory Lavieu, Hong Zheng, James E Rothman

“…We have designed a membrane ‘staple’, which consists of membrane-anchored repeats of the trans-aggregating FM domain that face the lumen of the secretory pathway. In the presence of the disaggregating drug these proteins transit the secretory pathway. …”
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How Viruses Hijack and Modify the Secretory Transport Pathway by Zubaida Hassan, Nilima Dinesh Kumar, Fulvio Reggiori, Gulfaraz Khan

“…Numerous viruses, especially enveloped viruses, use and modify compartments of the secretory pathway to promote their replication, assembly and cell egression by hijacking the host cell machinery. …”
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Glycosylation network mapping and site-specific glycan maturation in vivo by Marie-Estelle Losfeld, Ernesto Scibona, Chia-wei Lin, Markus Aebi

“…Importantly, our model protein can take different routes of the cellular secretory pathway, resulting in an increased glycan complexity of the secreted protein.…”
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Pathways for glycoprotein degradation in mammalian cells by Kukushkin, N, Nikolay Kukushkin

“…Aberrant glycoproteins must be cleared from the secretory pathway. Several mechanisms for glycoprotein degradation exist, of which ER-associated degradation (ERAD) is most well-studied. …”

Blocking variant surface glycoprotein synthesis alters endoplasmic reticulum exit sites/Golgi homeostasis in Trypanosoma brucei by Ooi, C, Smith, T, Gluenz, E, Wand, N, Vaughan, S, Rudenko, G

“…We investigated the effect of blocking VSG synthesis on the secretory pathway. The number of Golgi decreased, particularly in post-mitotic cells, from 3.5 ± 0.6 to 2.0 ± 0.04 per cell. …”

An imaging-based RNA interference screen for modulators of the Rab6-mediated Golgi-to-ER pathway in mammalian cells by Linda F. Heffernan, Pia M. Suckrau, Teerna Banerjee, Margaritha M. Mysior, Jeremy C. Simpson

“…The secretory pathway is counterbalanced by the retrograde pathway, which is essential for the recycling of molecules from the Golgi back to the ER. …”
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Synchronized protein trafficking in Saccharomyces cerevisiae by Choo, Winifre Yun Xian

“…The system implemented in this study would serve as a valuable tool to gain new insights into the secretory pathway and further our understanding of vital cellular processes.…”
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A dynamin is required for the biogenesis of secretory organelles in Toxoplasma gondii. by Breinich, MS, Ferguson, D, Foth, B, van Dooren, G, Lebrun, M, Quon, D, Striepen, B, Bradley, P, Frischknecht, F, Carruthers, V, Meissner, M

“…We suggest that DrpB is required during replication to generate vesicles for the regulated secretory pathway that form the unique secretory organelles. …”

Exogenous peptides delivered by ricin require processing by signal peptidase for transporter associated with antigen processing-independent MHC class I-restricted presentation. by Smith, D, Gallimore, A, Jones, E, Roberts, B, Lord, J, Deeks, E, Cerundolo, V, Roberts, L

“…Defined viral peptide epitopes genetically fused to the N terminus of an attenuated ricin A subunit (RTA) that was reassociated with its partner B subunit were able to reach the early secretory pathway of sensitive cells, including TAP-deficient cells. …”

Combined biochemical and cytological analysis of membrane trafficking using lectins. by Morgan, G, Kail, M, Hollinshead, M, Vaux, D

“…We have tested the application of high-mannose-binding lectins as analytical reagents to identify N-glycans in the early secretory pathway of HeLa cells during subcellular fractionation and cytochemistry. …”

Alpha herpesvirus exocytosis from neuron cell bodies uses constitutive secretory mechanisms, and egress and spread from axons is independent of neuronal firing activity. by Anthony E Ambrosini, Kayla M Borg, Nikhil Deshmukh, Michael J Berry, Lynn W Enquist, Ian B Hogue

“…Using live-cell fluorescence microscopy, we show that Pseudorabies Virus (PRV) particles use the constitutive Rab6 post-Golgi secretory pathway to exit from the cell body of primary neurons, independent of local calcium signaling. …”
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