M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells. by Yasushi Hara, Yuuki Obata, Keita Horikawa, Yasutaka Tasaki, Kyohei Suzuki, Takatsugu Murata, Isamu Shiina, Ryo Abe

“…Here, we show a strategy for inhibition of the Kit-PI3K-Akt pathway in neoplastic mast cells by M-COPA (2-methylcoprophilinamide), an inhibitor of this secretory pathway. In M-COPA-treated cells, Kit localization in the ER is significantly increased, whereas endolysosomal Kit disappears, indicating that M-COPA blocks the biosynthetic transport of Kit from the ER. …”
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Crosstalk between autophagy inhibitors and endosome-related secretory pathways: a challenge for autophagy-based treatment of solid cancers by Martina Raudenska, Jan Balvan, Michal Masarik

“…Some factors with key signalling functions do not enter the conventional secretory pathway but can be secreted in an autophagy-mediated manner. …”
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Identification of ER proteins involved in the functional organisation of the early secretory pathway in Drosophila cells by a targeted RNAi screen. by Vangelis Kondylis, Yang Tang, Florian Fuchs, Michael Boutros, Catherine Rabouille

“…<h4>Conclusions</h4>This work has identified novel proteins involved in the organisation of the Drosophila early secretory pathway. It contributes to the effort of assigning protein functions to gene annotation in the secretory pathway, and analysis of the MG hits revealed an enrichment of ER proteins. …”
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The Role of BiP Retrieval by the KDEL Receptor in the Early Secretory Pathway and its Effect on Protein Quality Control and Neurodegeneration by Hisayo Jin, Mari Komita, Tomohiko Aoe

“…Protein quality control in the early secretory pathway is a ubiquitous eukaryotic mechanism for adaptation to endoplasmic reticulum (ER) stress. …”
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The knottin-like Blufensin family regulates genes involved in nuclear import and the secretory pathway in barley-powdery mildew interactions by Weihui eXu, Yan eMeng, Yan eMeng, Priyanka eSurana, Priyanka eSurana, Greg eFuerst, Dan eNettleton, Roger Philip Wise

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An Alternative Terminal Step of the General Secretory Pathway in <named-content content-type="genus-species">Staphylococcus aureus</named-content> by Arryn Craney, Melissa M. Dix, Ramkrishna Adhikary, Benjamin F. Cravatt, Floyd E. Romesberg

“…ABSTRACT Type I signal peptidase (SPase) is essential for viability in wild-type bacteria because the terminal step of the bacterial general secretory pathway requires its proteolytic activity to release proteins from their membrane-bound N-terminal leader sequences after translocation across the cytoplasmic membrane. …”
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Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. by Kazunori Gomi, Vanessa Arbelaez, Ronald G Crystal, Matthew S Walters

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Roles of Ca2+ and secretory pathway Ca2+-ATPase pump type 1 (SPCA1) in intra-Golgi transport by Massimo Micaroni, Alexander A. Mironov

“…Additionally, the secretory pathway Ca2+-ATPase Ca2+ pump (SPCA1) plays an essential role at this stage. …”
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Investigating Constraints Along the Plant Secretory Pathway to Improve Production of a SARS-CoV-2 Spike Vaccine Candidate by Emmanuel Margolin, Emmanuel Margolin, Emmanuel Margolin, Emmanuel Margolin, Matthew Verbeek, Warren de Moor, Warren de Moor, Ros Chapman, Ros Chapman, Ann Meyers, Georgia Schäfer, Georgia Schäfer, Georgia Schäfer, Anna-Lise Williamson, Anna-Lise Williamson, Anna-Lise Williamson, Edward Rybicki, Edward Rybicki

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Inhibitory effects of gallic acid on the activity of exosomal secretory pathway in breast cancer cell lines: A possible anticancer impact by Nasrollah Jabbari, Maryam Feghhi, Omid Esnaashari, Hamid Soraya, Jafar Rezaie

“…However, the mechanism underlying its anticancer effect on the exosomal secretory pathway is still unclear. We investigated the effect of gallic acid on exosome biogenesis in breast cancer cell lines. …”
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Functional comparison of wild type human secretory pathway Ca2+/Mn2+ ATPase with Hailey Hailey disease mutants by Fairclough, R, Dode, L, Vanocvelen, J, Monaco, A, Missiaen, L, Raeymaekers, L, Wuytack, F, Hovnanian, A

Sec24 phosphorylation regulates autophagosome abundance during nutrient deprivation by Saralin Davis, Juan Wang, Ming Zhu, Kyle Stahmer, Ramya Lakshminarayan, Majid Ghassemian, Yu Jiang, Elizabeth A Miller, Susan Ferro-Novick

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Recent Developments in Deciphering the Biological Role of Plant Complex N-Glycans by Richard Strasser

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Structure of protein O-mannose kinase reveals a unique active site architecture by Qinyu Zhu, David Venzke, Ameya S Walimbe, Mary E Anderson, Qiuyu Fu, Lisa N Kinch, Wei Wang, Xing Chen, Nick V Grishin, Niu Huang, Liping Yu, Jack E Dixon, Kevin P Campbell, Junyu Xiao

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The regulated secretory pathway in CD4(+) T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapse. by Clare Jolly, Sonja Welsch, Stefanie Michor, Quentin J Sattentau

“…We propose that HIV-1 hijacks the regulated secretory pathway of CD4(+) T cells to enhance its dissemination.…”
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Vesicle Docking Is a Key Target of Local PI(4,5)P2 Metabolism in the Secretory Pathway of INS-1 Cells by Chen Ji, Fan Fan, Xuelin Lou

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Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells by Saumel Pérez-Rodriguez, Tune Wulff, Bjørn G. Voldborg, Claudia Altamirano, Mauricio A. Trujillo-Roldán, Norma A. Valdez-Cruz

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An amphipathic alpha-helix in the prodomain of cocaine and amphetamine regulated transcript peptide precursor serves as its sorting signal to the regulated secretory pathway. by Elías H Blanco, Carlos F Lagos, María Estela Andrés, Katia Gysling

“…The L34F mutation does not modify the amphipathicity of proCART alpha-helix and consistently proCARTL34F was efficiently sorted to the regulated secretory pathway. However, four additional mutations to proCARTL34F that reduced its alpha-helix amphipathicity resulted in the missorting of the mutated proCART toward the constitutive secretory pathway. …”
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The regulated secretory pathway in CD4+ T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapse by Jolly, C, Welsh, S, Michor, S, Sattentau, Q

“…We propose that HIV-1 hijacks the regulated secretory pathway of CD4⁺T cells to enhance its dissemination.…”

The regulated secretory pathway in CD4(+) T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapse. by Jolly, C, Welsch, S, Michor, S, Sattentau, Q

“…We propose that HIV-1 hijacks the regulated secretory pathway of CD4(+) T cells to enhance its dissemination.…”