ER Stress-Induced Secretion of Proteins and Their Extracellular Functions in the Heart by Bianca A. Meyer, Shirin Doroudgar

“…Cardiac integrity and function depend on the active secretion of mature proteins from a variety of cell types in the heart, a process that requires an intact ER environment for efficient protein folding and trafficking to the secretory pathway. As a consequence of ER stress, most protein secretion by the ER secretory pathway is decreased. …”
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Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin by Angela M Phillips, Michael B Doud, Luna O Gonzalez, Vincent L Butty, Yu-Shan Lin, Jesse D Bloom, Matthew D Shoulders

“…We systematically and quantitatively evaluate whether endoplasmic reticulum (ER) proteostasis factors impact the mutational tolerance of secretory pathway proteins. We focus on influenza hemaggluttinin (HA), a viral membrane protein that folds in the host’s ER via a complex pathway. …”
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A systematic approach to pair secretory cargo receptors with their cargo suggests a mechanism for cargo selection by Erv14. by Yonatan Herzig, Hayley J Sharpe, Yael Elbaz, Sean Munro, Maya Schuldiner

“…The rules that appear to guide Erv14 substrate recognition suggest that sorting of membrane proteins at multiple points in the secretory pathway could depend on the physical properties of TMDs. …”
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Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin by Phillips, Angela Marie, Gonzalez, Luna O., Butty, Vincent L G, Shoulders, Matthew D.

“…We systematically and quantitatively evaluate whether endoplasmic reticulum (ER) proteostasis factors impact the mutational tolerance of secretory pathway proteins. We focus on influenza hemaggluttinin (HA), a viral membrane protein that folds in the host’s ER via a complex pathway. …”
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Antiviral mechanisms of small molecules targeting the endoplasmic reticulum and Golgi apparatus by Howe, JD

“…Here, the antiviral mechanisms of three classes of small molecules targeting the secretory pathway and altering viral envelope glycosylation are investigated, using the HCV surrogate model, BVDV. …”

EGAD! There is an ERAD doppelganger in the Golgi by Fonseca, D, Carvalho, P

“…Disposal of membrane proteins in the late secretory pathway is thought to be exclusively facilitated by ESCRT‐dependent lysosomal degradation. …”

Stage-Specific COPII-Mediated Cargo Selectivity in African Trypanosomes by Mohamed Sharif, James D. Bangs

“…ABSTRACT A hallmark of eukaryotic cells is the ability to form a secretory pathway connecting many intracellular compartments. …”
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Transcription Factor CREB3L1 Regulates the Expression of the Sodium/Iodide Symporter (NIS) in Rat Thyroid Follicular Cells by Pablo Di Giusto, Mariano Martín, Macarena Funes Chabán, Luciana Sampieri, Juan Pablo Nicola, Cecilia Alvarez

“…In thyroid follicular cells, CREB3L1 is a downstream effector of thyrotropin (TSH), promoting the expression of proteins of the secretory pathway along with an expansion of the Golgi volume. …”
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Protein Extraction, Enrichment and MALDI MS and MS/MS Analysis from Bitter Orange Leaves (<i>Citrus</i> <i>aurantium</i>) by Donatella Aiello, Carlo Siciliano, Fabio Mazzotti, Leonardo Di Donna, Roberta Risoluti, Anna Napoli

“…The largest subcellular fraction was the secretory pathway, accounting for 25% of total proteins. …”
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The unfolded protein response protects from tau neurotoxicity in vivo. by Carin A Loewen, Mel B Feany

“…The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in modulating the effects of aggregation prone cytosolic proteins has received less attention. …”
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Structural organization of Trypanosoma cruzi by Wanderley de Souza

“…This review describes the present knowledge on the organization of the most important structures and organelles found in the protozoan, such as the cell surface, flagellum, cytoskeleton, kinetoplast-mitochondrion complex, glycosome, acidocalcisome, contractile vacuole, lipid inclusions, the secretory pathway, endocytic pathway and the nucleus.…”
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Substrates and physiological functions of secretase rhomboids proteases by Freeman, M, Lastun, V, Grieve, A

“…The secretase class of rhomboid proteases, distributed through the secretory pathway, are the most numerous in eukaryotes, but our knowledge of them is limited. …”

Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes by Shaun K. Bremner, Woroud S. Al Shammari, Roderick S. Milligan, Brian D. Hudson, Calum Sutherland, Nia J. Bryant, Gwyn W. Gould

“…We further show that the adipokine secretory pathways are impaired in Sx16 knockout cells. …”
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Echinococcus granulosus ubiquitin-conjugating enzymes (E2D2 and E2N) promote the formation of liver fibrosis in TGFβ1-induced LX-2 cells by Xiaodi Du, Ruiqi Hua, Xue He, Wei Hou, Shengqiong Li, Aiguo Yang, Guangyou Yang

“…In addition, the secretory pathway and their effects on the formation of liver fibrosis were also explored. …”
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Signal sequence-triage is activated by translocon obstruction sensed by an ER stress sensor IRE1α by Ashuei Sogawa, Ryota Komori, Kota Yanagitani, Miku Ohfurudono, Akio Tsuru, Koji Kadoi, Yukio Kimata, Hiderou Yoshida, Kenji Kohno

“…Secretory pathway proteins are cotranslationally translocated into the endoplasmic reticulum (ER) of metazoan cells through the protein channel, translocon. …”
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The Fast and the Furious: Golgi Contact Sites by Yotam David, Inês G. Castro, Maya Schuldiner

“…However, despite its central role in the secretory pathway, the Golgi apparatus and its contact sites remain largely unexplored. …”
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Granins as biochemical, immunohistochemical and metabolic markers of nonfunctioning pituitary adenomas

“…Granins are glycoproteins presented in granules of neuroendocrine cells, they regulate secretory pathway that is responsible for controlled delivery of peptides, hormones and neurotransmitters, and growth factors, organization of the granular matrix, and the mechanisms of administration after hormone secretion The highest accuracy has been observed in neuroendocrine tumors characterized by an intense secretory activity, but its specificity and sensitivity remain very high also in nonfunctioning tumors. …”
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Golgi Apparatus Regulates Plasma Membrane Composition and Function by Ilenia Agliarulo, Seetharaman Parashuraman

“…Golgi apparatus is the central component of the mammalian secretory pathway and it regulates the biosynthesis of the plasma membrane through three distinct but interacting processes: (a) processing of protein and lipid cargoes; (b) creation of a sharp transition in membrane lipid composition by non-vesicular transport of lipids; and (c) vesicular sorting of proteins and lipids at the trans-Golgi network to target them to appropriate compartments. …”
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Cargo selection in endoplasmic reticulum–to–Golgi transport and relevant diseases by Vi T. Tang, David Ginsburg

“…Most proteins destined for the extracellular space or various intracellular compartments must traverse the intracellular secretory pathway. The first step is the recruitment and transport of cargoes from the endoplasmic reticulum (ER) lumen to the Golgi apparatus by coat protein complex II (COPII), consisting of five core proteins. …”
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Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin. by Hennies, H, Kornak, U, Zhang, H, Egerer, J, Zhang, X, Seifert, W, Kühnisch, J, Budde, B, Nätebus, M, Brancati, F, Wilcox, W, Müller, D, Kaplan, P, Rajab, A, Zampino, G, Fodale, V, Dallapiccola, B, Newman, W, Metcalfe, K, Clayton-Smith, J, Tassabehji, M, Steinmann, B, Barr, F, Nürnberg, P, Wieacker, P

“…These results associate abnormalities of the secretory pathway with age-related changes in connective tissues.…”