Infectious Bursal Disease Virus Assembly Causes Endoplasmic Reticulum Stress and Lipid Droplet Accumulation by Yesica R. Frontini-López, Lautaro Rivera, Cristian A. Pocognoni, Julieta S. Roldán, María I. Colombo, Marina Uhart, Laura R. Delgui

“…Overall, our results represent further original data showing the interplay between IBDV and the secretory pathway, making a substantial contribution to the field of birnaviruses–host cell interactions.…”
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Zinc homeostasis governed by Golgi-resident ZnT family members regulates ERp44-mediated proteostasis at the ER-Golgi interface by Yuta Amagai, Momo Yamada, Toshiyuki Kowada, Tomomi Watanabe, Yuyin Du, Rong Liu, Satoshi Naramoto, Satoshi Watanabe, Junko Kyozuka, Tiziana Anelli, Tiziana Tempio, Roberto Sitia, Shin Mizukami, Kenji Inaba

“…ERp44, a chaperone operating in the early secretory pathway, also binds Zn2+ to regulate its client binding and release for the control of protein traffic and homeostasis. …”
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XBP1s activation can globally remodel N-glycan structure distribution patterns by Wong, Madeline Y., Dewal, Mahender, Taylor, Rebecca J., Whittaker, Charles A., Phyo, Pyae, Shoulders, Matthew D., Chen, Kenny,Ph. D.Massachusetts Institute of Technology.

“…Classically, the unfolded protein response (UPR) safeguards secretory pathway proteostasis. The most ancient arm of the UPR, the IRE1-activated spliced X-box binding protein 1 (XBP1s)-mediated response, has roles in secretory pathway maturation beyond resolving proteostatic stress. …”
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Regulated secretion from CD4+ T cells. by Jolly, C, Sattentau, Q

“…By contrast, regulated secretory pathways in CD4+ T cells have not been studied extensively. …”

Gateway to the Golgi: Molecular mechanisms of nucleotide sugar transporters by Parker, J, Newstead, S

“…The Golgi apparatus plays a central role in the secretory pathway as a hub for posttranslational modification, protein sorting and quality control. …”

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms. by Adrain, C, Freeman, M

“…The recently discovered iRhoms - inactive homologues of rhomboid proteases - have joined derlins and other members of the rhomboid-like clan in regulating the fate of proteins as they pass through the secretory pathway. There is a strong case that dead enzymes, which have been rather overlooked, may be a rich source of biological regulators.…”

Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila. by Lee, JR, Urban, S, Garvey, C, Freeman, M

“…Star is present throughout the secretory pathway and is required to export Spitz from the endoplasmic reticulum to the Golgi apparatus. …”

Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures by Shilpi Yadav, Jonathan K. Williamson, Maria A. Aronova, Andrew A. Prince, Irina D. Pokrovskaya, Richard D. Leapman, Brian Storrie

“…As platelets can synthesize proteins and contain many of the enzymes of the secretory pathway, one might expect all mature human platelets to contain a stacked Golgi apparatus, the central organelle of the secretory pathway. …”
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The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9 by Brian T Emmer, Geoffrey G Hesketh, Emilee Kotnik, Vi T Tang, Paul J Lascuna, Jie Xiang, Anne-Claude Gingras, Xiao-Wei Chen, David Ginsburg

“…Prior studies suggested the presence of an ER cargo receptor that recruits PCSK9 into the secretory pathway, but its identity has remained elusive. …”
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Interactions between the NLRP3-Dependent IL-1β and the Type I Interferon Pathways in Human Plasmacytoid Dendritic Cells by Dóra Bencze, Tünde Fekete, Walter Pfliegler, Árpád Szöőr, Eszter Csoma, Antónia Szántó, Tünde Tarr, Attila Bácsi, Lajos Kemény, Zoltán Veréb, Kitti Pázmándi

“…Collectively, our results show that the NLRP3-dependent IL-1β secretory pathway is inducible in pDCs; however, it may only prevail under inflammatory conditions, in which the type I IFN pathway is not dominant.…”
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Contribution of N-Linked Mannosylation Pathway to Candida parapsilosis and Candida tropicalis Biofilm Formation by Clavijo-Giraldo DM, Pérez-García LA, Hernández-Chávez MJ, Martínez-Duncker I, Mora-Montes HM

“…Disruption of this posttranslational modification affected the secretory pathway, offering a link between glycosylation and biofilm formation.Keywords: secretion, virulence factor, phospholipase, aspartyl proteinase, antifungal drug resistance…”
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Small GTPase Rab7 is involved in stress adaptation to carbon starvation to ensure the induced cellulase biosynthesis in Trichoderma reesei by Lin Liu, Zhixing Wang, Yu Fang, Renfei Yang, Yi Pu, Xiangfeng Meng, Weifeng Liu

“…However, little attention has been paid to the functional roles of the involved secretory pathway in the high-level production of cellulases in T. reesei. …”
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Exp1p is a cargo adaptor for Sec24p mediated export the plasma membrane H+̳ ATPase from the ER in S. cerevisiae by Morse, Darcy L. (Darcy Lee)

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Plasma membrane protein trafficking in plant-microbe interactions: a plant cell point of view by Nathalie eLeborgne-Castel, Karim eBouhidel

“…In order to ensure their physiological and cellular functions, plasma membrane (PM) proteins must be properly conveyed from their site of synthesis, i.e. the endoplasmic reticulum, to their final destination, the PM, through the secretory pathway. PM protein homeostasis also relies on recycling and/or degradation, two processes that are initiated by endocytosis. …”
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Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking by Kevin Bärlocher, Amanda Welin, Hubert Hilbi

“…Retrograde trafficking from the endosomal system through the Golgi apparatus back to the endoplasmic reticulum is an essential pathway in eukaryotic cells, serving to maintain organelle identity and to recycle empty cargo receptors delivered by the secretory pathway. Intracellular replication of several bacterial pathogens, including Legionella pneumophila, is restricted by the retrograde trafficking pathway. …”
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Role of N-glycan trimming in the folding and secretion of the pestivirus protein E(rns) by Branza-Nichita, N, Lazar, C, Dwek, R, Zitzmann, N

“…However, E(rns) secretion into the medium is severely impaired suggesting a role for N-glycosylation in the transport of the glycoprotein through the secretory pathway.…”

Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the 2 KDEL receptor by Brauer, P, Parker, J, Gerondopoulos, A, Zimmermann, I, Seeger, M, Barr, F, Newstead, S

“…Complementary in vitro binding and in vivo cell localization data explain how these features create a pH-dependent retrieval system in the secretory pathway.…”

Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin. by Gao, B, Adhikari, R, Howarth, M, Nakamura, K, Gold, M, Hill, AB, Knee, R, Michalak, M, Elliott, T

“…Suboptimally loaded class I molecules were released into the secretory pathway. This occurred despite the ability of newly synthesized class I to interact with the transporter associated with antigen processing (TAP) loading complex. …”

Improving recombinant protein production by yeast through genome-scale modeling using proteome constraints by Feiran Li, Yu Chen, Qi Qi, Yanyan Wang, Le Yuan, Mingtao Huang, Ibrahim E. Elsemman, Amir Feizi, Eduard J. Kerkhoven, Jens Nielsen

“…Due to the complexity of the protein secretory pathway, strategy suitable for the production of a certain recombination protein cannot be generalized. …”
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Assessment of α-synuclein secretion in mouse and human brain parenchyma. by Evangelia Emmanouilidou, Dimitris Elenis, Themis Papasilekas, Georgios Stranjalis, Kyriaki Gerozissis, Penelopi C Ioannou, Kostas Vekrellis

“…Recent data has suggested that the protein may be released from cells via a non-classical secretory pathway and may therefore exert paracrine effects in the extracellular environment. …”
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