RAB7 GTPases as coordinators of plant endomembrane traffic by Cecilia Rodriguez-Furlan, Rita Borna, Oliver Betz

“…RAB7 activity regulates different pathways of endomembrane trafficking in plants: (1) endocytic traffic to the vacuole; (2) biosynthetic traffic to the vacuole; and (3) recycling from the late endosome to the secretory pathway. During certain developmental and stress related processes another pathway becomes activated (4) autophagic trafficking towards the vacuole that is also regulated by RAB7. …”
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Targeting of Proteins for Translocation at the Endoplasmic Reticulum by Martin R. Pool

“…The endoplasmic reticulum represents the gateway to the secretory pathway. Here, proteins destined for secretion, as well as soluble and membrane proteins that reside in the endomembrane system and plasma membrane, are triaged from proteins that will remain in the cytosol or be targeted to other cellular organelles. …”
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A voyage from the ER: spatiotemporal insights into polarized protein secretion in neurons by Noortje Kersten, Ginny G. Farías

“…This requires the polarized sorting of newly synthesized secretory and transmembrane proteins into different vesicle populations as they traverse the secretory pathway. Although the trans-Golgi-network is generally considered to be the main sorting hub, this sorting process may already begin at the ER and continue through the Golgi cisternae. …”
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Regulation of sumo mRNA during endoplasmic reticulum stress. by Kristin A Moore, Joshua J Plant, Deepika Gaddam, Jonathan Craft, Julie Hollien

“…The unfolded protein response (UPR) is a collection of pathways that maintains the protein secretory pathway during the many physiological and pathological conditions that cause stress in the endoplasmic reticulum (ER). …”
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Molecular characterization of malaria proteins involved in invasion of the host cell. by Liu, Bao Shan.

“…It might be transported to its respective location via the secretory pathway and is located neither in the microneme nor rhoptry site. …”
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The mammalian endoplasmic reticulum-associated degradation system. by Olzmann, J, Kopito, R, Christianson, J

“…The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic proteome and is accordingly endowed with specialized machinery to ensure that proteins deployed to the distal secretory pathway are correctly folded and assembled into native oligomeric complexes. …”

Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα by Wunderle, L, Knopf, J, Kühnle, N, Morlé, A, Hehn, B, Adrain, C, Strisovsky, K, Freeman, M, Lemberg, M

“…We propose that RHBDL4 reorganizes trafficking events within the early secretory pathway in response to GPCR signaling. Our work identifies RHBDL4 as a rheostat that tunes secretion dynamics and abundance of specific membrane protein cargoes.…”

Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer by Parker, J, Corey, R, Stansfeld, P, Newstead, S

“…Together these results provide further insight into how SLC35 family transporters function within the secretory pathway and sheds light onto the role that membrane lipids play in regulating transport across the membrane.…”

Perforin activity at membranes leads to invaginations and vesicle formation. by Praper, T, Sonnen, A, Kladnik, A, Andrighetti, A, Viero, G, Morris, K, Volpi, E, Lunelli, L, Dalla Serra, M, Froelich, C, Gilbert, R, Anderluh, G

“…The cytotoxic cell granule secretory pathway is essential for immune defence. How the pore-forming protein perforin (PFN) facilitates the cytosolic delivery of granule-associated proteases (granzymes) remains enigmatic. …”

Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity. by Brandhorst, D, Zwilling, D, Rizzoli, S, Lippert, U, Lang, T, Jahn, R

“…Membrane fusion in the secretory pathway is mediated by soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins. …”

FRMD8 is a novel regulator of iRhom-dependent ADAM17 activity by Künzel, U

“…Interaction studies revealed that FRMD8 binds to the cytosolic N-terminus of iRhom2 throughout the entire secretory pathway. FRMD8 loss does not affect the ER-to-Golgi trafficking of iRhom2 but plays a role in stabilising iRhom2 at the plasma membrane by preventing the lysosomal degradation of both iRhom2 and mature ADAM17.…”

Trafficking through COPII stabilises cell polarity and drives secretion during Drosophila epidermal differentiation. by Michaela Norum, Erika Tång, Tina Chavoshi, Heinz Schwarz, Dirk Linke, Anne Uv, Bernard Moussian

“…We show that they code for the Drosophila COPII vesicle-coating components Sec23 and Sec24, respectively, that organise vesicle transport from the ER to the Golgi apparatus.Taken together, epithelial differentiation during Drosophila embryogenesis is a concerted action of ECM formation, plasma membrane remodelling and maintenance of cell polarity that all three rely mainly, if not absolutely, on the canonical secretory pathway from the ER over the Golgi apparatus to the plasma membrane. …”
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Golgi Metal Ion Homeostasis in Human Health and Diseases by Jie Li, Yanzhuang Wang

“…The homeostasis of metal ions in the secretory pathway, which is required for proper function and stress response of the Golgi, is tightly regulated and maintained by transporters. …”
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Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. by Tyler M Sharp, Susana Guix, Kazuhiko Katayama, Sue E Crawford, Mary K Estes

“…Disassembly of the Golgi apparatus was also observed in cells replicating Norwalk virus, which may contribute to pathogenesis by interfering with cellular processes that are dependent on an intact secretory pathway. These results indicate that the ER export signal mimic is critical to the antagonistic function of p22, shown herein to be a novel antagonist of ER/Golgi trafficking. …”
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Protein Sorting in Plasmodium Falciparum by D.C. Ghislaine Mayer

“…From these studies, it is now evident that <i>P. falciparum</i> has repurposed the molecules of the endosomal system to the secretory pathway. Additionally, the sorting and vesicular trafficking mechanism seem to be conserved among apicomplexans. …”
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Membrane trafficking in breast cancer progression: protein kinase D comes into play by Elena Gutiérrez-Galindo, Zeynep Hazal Yilmaz, Angelika Hausser, Angelika Hausser

“…Protein kinase D (PKD) is a serine/threonine kinase family that controls important cellular functions, most notably playing a key role in the secretory pathway at the trans-Golgi network. Aberrant expression of PKD isoforms has been found mainly in breast cancer, where it promotes various cellular processes such as growth, invasion, survival and stem cell maintenance. …”
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Stacking the odds for Golgi cisternal maturation by Somya Mani, Mukund Thattai

“…This motif precisely matches the cisternal maturation model of the Golgi, which was developed to explain many observed aspects of the eukaryotic secretory pathway. In our analysis cisternal maturation is a robust consequence of vesicle traffic homeostasis, independent of the underlying details of molecular interactions or spatial stacking. …”
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Analytical Technologies for Identification and Characterization of the Plant N-Glycoproteome by Eliel eRuiz-May, Theodore William Thannhauser, Sheng eZhang, Jocelyn Kenneth Campbell Rose

“…In this review, we summarize a range of existing technologies for large-scale N-glycoprotein analysis and highlight promising future approaches that may provide a better understanding of the plant N-glycoproteome, and therefore the cell wall proteome and other proteins associated with the secretory pathway.…”
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Cell type-specific regulation of CFTR trafficking—on the verge of progress by Carlos M. Farinha, Lúcia Santos, João F. Ferreira

“…Exit from the endoplasmic reticulum (ER) is coupled with the acquisition of a compact structure that can be processed and traffic through the secretory pathway. Once reaching its final destination—the plasma membrane, CFTR stability is regulated through interaction with multiple protein partners that are involved in its post-translation modification, connecting the channel to several signaling pathways. …”
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The Regulated Secretion and Models of Intracellular Transport: The Goblet Cell as an Example by Alexander A. Mironov, Galina V. Beznoussenko

“…The transport pathways of luminal and at least initially soluble secretory proteins synthesized in the endoplasmic reticulum can be divided into two groups: the so-called constitutive secretory pathway and regulated secretion (RS) pathway, in which the RS proteins pass through the Golgi complex and are accumulated into storage/secretion granules (SGs). …”
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