Showing 1 - 20 results of 464 for search '"secretory pathway"', query time: 0.39s Refine Results
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    The Unfolded Protein Response as a Guardian of the Secretory Pathway by Toni Radanović, Robert Ernst

    Published 2021-10-01
    “…As the entry point to the secretory pathway, it handles more than 10,000 different secretory and membrane proteins. …”
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    Engineering receptors in the secretory pathway for orthogonal signalling control by Mohamed Mahameed, Pengli Wang, Shuai Xue, Martin Fussenegger

    Published 2022-11-01
    “…Artificial receptors targeted to the secretory pathway often fail to exhibit the expected activity due to post-translational modifications and/or improper folding. …”
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    A cilia-bound unconventional secretory pathway for Drosophila odorant receptors by Najat Dzaki, Mattias Alenius

    Published 2024-04-01
    “…Though most do so via an ordered ER-to-Golgi route, an increasing number of proteins are now shown to bypass this conventional secretory pathway. Results In the Drosophila olfactory sensory neurons (OSNs), odorant receptors (ORs) are trafficked from the ER towards the cilia. …”
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    Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges by Daria Sicari, Aeid Igbaria, Eric Chevet

    Published 2019-10-01
    “…ER and Golgi functions ensure that only properly folded proteins are allowed to flow through the secretory pathway while improperly folded proteins have to be eliminated to not impinge on cellular functions. …”
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    Branched Actin Maintains Acetylated Microtubule Network in the Early Secretory Pathway by Azumi Yoshimura, Stéphanie Miserey-Lenkei, Evelyne Coudrier, Bruno Goud

    Published 2021-12-01
    “…In the early secretory pathway, the delivery of anterograde cargoes from the endoplasmic reticulum (ER) exit sites (ERES) to the Golgi apparatus is a multi-step transport process occurring via the ER-Golgi intermediate compartment (IC, also called ERGIC). …”
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    Human lipocalins bind and export fatty acids through the secretory pathway of yeast cells by Aslihan Ekim Kocabey, Roger Schneiter

    Published 2024-01-01
    “…Our findings reveal that directing these fatty-acid binding proteins into the secretory pathway effectively promotes fatty acid secretion from a sensitized quadruple mutant model strain (faa1∆ faa4∆ pry1∆ pry3∆). …”
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    Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons by Javier Emperador Melero, Aishwarya G. Nadadhur, Desiree Schut, Jan V. Weering, Vivi M. Heine, Ruud F. Toonen, Matthijs Verhage

    Published 2017-03-01
    “…Here, we investigated the maturation of these two secretory pathways in micro-networks of human iPSC-derived neurons. …”
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    Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway by Tolulope Sokoya, Jan Parolek, Mads Møller Foged, Dmytro I Danylchuk, Manuel Bozan, Bingshati Sarkar, Angelika Hilderink, Michael Philippi, Lorenzo D Botto, Paulien A Terhal, Outi Mäkitie, Jacob Piehler, Yeongho Kim, Christopher G Burd, Andrey S Klymchenko, Kenji Maeda, Joost CM Holthuis

    Published 2022-09-01
    “…Its production in the trans-Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol gradient along the secretory pathway. This gradient marks a fundamental transition in physical membrane properties that help specify organelle identify and function. …”
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    Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2 by Karsten Nalbach, Martina Schifferer, Debjani Bhattacharya, Hung Ho-Xuan, Wei Chou Tseng, Luis A. Williams, Alexandra Stolz, Stefan F. Lichtenthaler, Zvulun Elazar, Christian Behrends

    Published 2023-02-01
    “…Moreover, we provide evidence that TECPR2’s interaction with the early secretory pathway is not restricted to COPII carriers. …”
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    The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway by Nils Stührwohldt, Stefan Scholl, Lisa Lang, Julia Katzenberger, Karin Schumacher, Andreas Schaller

    Published 2020-04-01
    “…We show here that the biogenesis of CLEL6 and CLEL9 peptides in Arabidopsis thaliana requires a series of processing events in consecutive compartments of the secretory pathway. Following cleavage of the signal peptide upon entry into the endoplasmic reticulum (ER), the peptide precursors are processed in the cis-Golgi by the subtilase SBT6.1. …”
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    Defining the altered glycoproteomic space of the early secretory pathway by class I mannosidase pharmacological inhibition by Cristian V. A. Munteanu, Gabriela N. Chirițoiu, Andrei-Jose Petrescu, Ștefana M. Petrescu

    Published 2023-01-01
    “…Although these are vital processes in maintaining cellular homeostasis, large-scale analysis studies for this pool of molecules, further denoted as proteins from the early secretory pathway (ESP), were limited addressed. Here, using a custom workflow employing a combination of glycomics and deglycoproteomics analyses, using lectin affinity and selective Endoglycosidase H (Endo H) digestion, we scrutinize the steady-state oligomannosidic glycoprotein load and delineate ESP fraction in melanoma cells. …”
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